Gene 89233.m00043 (T.vaginalis)

89233.m00043

Species: T.vaginalis
Alias: TvagK0401, 89233.m00043
External Links:
Annotation:

Classification

Group: AGC
Family: Akt

Sequence

Name Sequence Type Origin Length Description Download
89233.m00043.AA Protein None 326 None Fasta, JSON
89233.m00043.kin_dom Protein Kinase Domain None 252 None Fasta, JSON

Protein domain

Protein domains of 89233.m00043.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 89233.m00043.AA AGC 4-255 26 1.7e-136 355.14 In-house 1-395 (395) Show / Hide 
Range on Protein: 4-255
Range on HMM: 1-395/395
Sequence Identity: 26% (105 aa)

FEVVSVIGRGHFGKVVLAKRK------TTGDFCAIKSIKKKC---LIDRAQLSLIVSE------------RNTLTKIS----------HPFVVN-ILFAF
||.. |||.|.|||| |...|      .||...|.| .|||    .... ..  . .|            || |.|..          |||.|.   ..|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTWSK--FYIGMEYVP---------GG-DLIGLMR---RVGKLSMNDVIIYAGE-------VALALEFIHS-KEIVYRD-LKPENLVINSDGHLKLADFG
|. ..   |. |||.|         || .|   ..   . |... . . .|| |       ..||||..|| . |..|| |||||.....|||.||.|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LSKDISES---------------------------------------------------KLTNTFCG--TSEYMAPEMLFKKFYDYSVDWWA--FGILVY
|.| .  .                                                   ..|.||||  | ||||||.|    |....|||.  .|.| |
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMIFDATPFHSEL----------KDSTFSKIK------YADPTYP----------EGTDPNIISFINGFLEKDPHKRTK----------YSDVENHPFW
||..  .||...           .. .| ||.        ....|          .  .|.  ..|...|.||| ||            .... |||. 
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 89233.m00043.AA Akt 4-255 39 2.5e-102 327.91 In-house 1-264 (264) Show / Hide 
Range on Protein: 4-255
Range on HMM: 1-264/264
Sequence Identity: 39% (104 aa)

FEVVSVIGRGHFGKVVLAKRKTTGDFC-AIKSIKKKCLIDRAQLSLIVSERNTLTKISHPFVVNILFAFQTWSKFYIGMEYVPGGDLIGLMRRVGKLSMN
|... |.|.| ||||.|.| | |...  |.|..||. .|.. |.  .. ||| | .. |||.||  ..|||  | |. |.|..||.|  ...| .. | .
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

DVIIYAGEVALALEFIHSKEIVYRD-LKPENLVINSDGHLKLADFGLSK-D-ISESKLTNTFCGTSEYMAPEMLFKKFYDYSVDWWA-FGILVYEMIFDA
    |. |. ||.|. ||| |.||| |||||... .|||..|.||||.| . |..   |.||||| ||.|||.| .. .. .||||. .|.. |||.. .
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGR

TPFHSELKDSTFSKIKYADPTYP--EGTDPNIISFINGFLEKDPHKRT--KYS---DVENHPFW
 ||... ..  | |||...  .|  .  .|.  ..|.| |.|||.||   ...   .. .||. 
PPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase 89233.m00043.AA SGK 4-255 37 8.1e-95 293.24 In-house 1-283 (283) Show / Hide 
Range on Protein: 4-255
Range on HMM: 1-283/283
Sequence Identity: 37% (105 aa)

FEVVSVIGRGHFGKVVLAKRKTT------------------GDFCAIKSIKKKCLI-------DRAQLSLIVSER-NTLTKISHPFVVNILFAFQTWSKF
|.  .||| | |||| ..|.| .                  ..| |.| ..|.  |        . .  .| .|| . | ...||| ||  .||||  | 
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

YIGMEYVPGGDLIGLMRRVGKLSMNDVIIYAGEVALALEFIHSKEIVYRDLKPENLVINSDGHLKLADFGLSK-DISESKLTNTFCGTSEYMAPEMLFKK
|  |.|| ||..   ..| ....   . .|| |...|||  ||. |.||||||||..  ..||..| ||||.| .| ... | ||||| ||.|||.| |.
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRKQ

FYDYSVDWWAFGILVYEMIFDATPFHSELKDSTFSKIKYADPTYPEGTDPNIISFINGFLEKDPHKR--TK--YSDVENHPFW
 .| .||||  |.. |||.. . || |  |   . .|   .   | .  .   . |.| |.||| ||  ||    .. |||| 
PHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPFF
Kinase 89233.m00043.AA AktR 4-255 39 1.3e-92 314.02 In-house 1-268 (268) Show / Hide 
Range on Protein: 4-255
Range on HMM: 1-268/268
Sequence Identity: 39% (105 aa)

FEVVSVIGRGHFGKVVLAKRK-TTGDFCAIKSIKKKCLIDRAQLSLIVSERNTLT-KISHPFVVNILFAFQTWSKFYIGMEYVPGGDLIGLMRRVGKLSM
|.|  ..|.| ||||.|...| ..... |.|.|||| .|.| | . .  ||| .  ...||| |.  ..||| .| .. |||.|||.|    .. .|.| 
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

NDVIIYAGEVALALEFIHSK-EIVYRDLKPENLVINSDGHLKLADFGLSK---DISESKLTNTFCGTSEYMAPEMLFK-KFYDYSVDWWAFGILVYEMIF
... .|. .. ||||. |..  |.||||||||... .|||.|..||||||   ..... ....|||| |||||||..| | ...|||||||||..|||..
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVT

DATPFHSELKDSTFSKIKYAD---PTYPEGTDPNIISFIN-GFLEKDPHKRTK-----YSDVENHPFW
  .|| .. .   | |||. .   ..||.   ..  ..|. . | |.| || .      ... .||. 
GCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase 89233.m00043.AA S_TKc 4-255 33 7.1e-88 299.16 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-255
Range on HMM: 1-231/231
Sequence Identity: 33% (89 aa)

FEVVSVIGRGHFGKVVLAKRKTTGDFCAIKSIKKKCLIDRAQLSLIVSERNTLTKISHPFVVNILFAFQTWSKFYIGMEYVPG--GDLIGLMRRVGK---
.|.. .||.| |||| ... | ||  .||| ||            | .|.. | |  ||..|... .||. ...|. |||..|  |||  .... |.   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LSMNDVIIYAGEVALALEFIHSKEIVYRDLKPENLVINSDGHLKLADFGLSKDISESKLTNTFCGTSEYMAPEMLFKKFYDY-SVDWWAFGILVYEM
   ..  ..  |. ....|||..||. |..|||||||. ...  |.|..||||.. .      .||||| .|||||.|    |.. ..|||..|...|||
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

IFDATPFHSELKDSTFSKIKYADPTYPEGTDPNIISFINGFLEKDPHKRTKYSDVEN-------HPFW
.   .||.    . .| ||.          .|  ..||.. |.||| ||    .. .       ||. 
LCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 89233.m00043.AA PKC 4-255 39 9.4e-86 277.92 In-house 1-262 (262) Show / Hide 
Range on Protein: 4-255
Range on HMM: 1-262/262
Sequence Identity: 39% (103 aa)

FEVVSVIGRGHFGKVVLAKRKTTGDFCAIKSIKKKCLIDRAQLSLIVSERNTLTKIS-HPFVVNILFAFQTWSKFYIGMEYVPGGDLIGLMRRVGKLSMN
|. . |.|.| ||||.||.|| |  ..||| .||   |.         |.  |   . ||| ..    ||| .. .  |||| ||||   . ......  
FNFLKVLGKGSFGKVMLAERKGTDEYYAIKVLKKDVIIQDDDVECTMTEKRVLALAWKHPFLTHLHCCFQTMDRLFFVMEYVNGGDLMFHIQQQRRFKEE

DVIIYAGEVALALEFIHSKEIVYRDLKPENLVINSDGHLKLADFGLSKD-ISESKLTNTFCGTSEYMAPEMLFKKFYDYSVDWWAFGILVYEMIFDATPF
  . || |...|| | |.| |.||||| .|  . ..|| |.||||..|. . . . |.||||| .|.||| |  . |  ||||||||.| |||     ||
HARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNGDTTSTFCGTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMMAGQSPF

HSELKDSTFSKIKYADPTYPEGTDPNIISFINGFLEKDPHKRTKY--------SDVENHPFW
| |  |  |  |   .| ||      . | . ||..|.|.||            |.  ||| 
HGEDEDELFQSIMHDNPHYPRWLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIREHPFF
Kinase 89233.m00043.AA PKA 4-255 37 3.3e-84 286.07 In-house 1-263 (263) Show / Hide 
Range on Protein: 4-255
Range on HMM: 1-263/263
Sequence Identity: 37% (99 aa)

FEVVSVIGRGHFGKVVLAKRKTTGDFCAIKSIKKKCLIDRAQLSLIVSERNTLTKISHPFVVN-ILFAFQTWSKFYIGMEYVPGGDLIGLMRRVGKLSMN
|| . ..|.| ||.| |.. |..|...|.| .||   ... |   . .|.| |. |.|||.|.   . ||. .. |  |||||||..   .|..|..|  
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP

DVIIYAG-EVALALEFIHSKEIVYRDLKPENLVINSDGHLKLADFGLSKDISESKLTNTFCGTSEYMAPEMLFKK-FYDYSVDWWAFGILVYEMIFDATP
.  .||  .. ||||..||..|.||||||||. |...||.|..||| .| . .   | | ||| ||.|||..  |  .  ||||||.|||.||| .  .|
HAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAKKVDD--RTWTLCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGYPP

FHSE--LKDSTFSKIKYADPTYPEGTDPNI---ISFINGFLEKDPHKRT---KY--SDVENHPFW
|  .   . ... ||  ..  .|.  |..     ..|.  |..|. ||    |    |. ||.. 
FYDHNRDPMQIYEKICNGKIKFPRHFDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF
Kinase 89233.m00043.AA RSK 7-255 33 7.6e-79 268.26 In-house 1-278 (278) Show / Hide 
Range on Protein: 7-255
Range on HMM: 1-278/278
Sequence Identity: 33% (93 aa)

VSVIGRGHFGKVVLAKRK---TTGDFCAIKSIKKKCLIDRAQ-LSLIVSERNTLTKIS-HPFVVNILFAFQTWSKFYIGMEYVPGGDLIGLMRRVGK---
..| |.| .||| | ...    ||   | | .||. .. |.  .     ||| |  .  |||.|.   |||| .|.|. |||..||.|    .. .    
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

LSMNDVIIYAGEVALALEFIHSKEIVYRDLKPENLVINS---DGHLKLADFGLSKD--ISESKLTNTFCGTSEYMAPEMLF---KKF-YDYSVDWWAFGI
.| ... .|. |..||.|..|.. |..||||||| . ..   .||.|| |||..|   ......|.|||.| ||||||||    ..  .| ..||| .|.
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LVYEMIFDATPFHS---ELKDSTFSKIKYAD--PTYP--EGTDPNIISFINGFLEKDPHKRTK-----YSDVENHPFW
| ||| . ..||..   . .. .. .|. ..  .| |  .   ..  ..|.. |..||||| .      ... .||..
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 89233.m00043.AA Pkinase 4-255 28 5.8e-73 253.5 Pfam 1-293 (293) Show / Hide 
Range on Protein: 4-255
Range on HMM: 1-293/293
Sequence Identity: 28% (83 aa)

FEVVSVIGRGHFGKVVLAKRKTTGDFCAIKSIKKKCLIDRAQLSLIVS--ERNTLTKISHPFVVNILFAFQTWSKFYIGMEYVPGG----DLIGLMR--R
......||.| ||.| ....| ||.  |.| |||.  ..  ..   .   |   . ...||..| .. .|.. .. |. |||..||    ||  ...  |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

VGKL--SMNDVIIYAGEVALALEFIHSKEIVYRDLKPENLVINSDGHL----KLADFGLSKD--ISESKLTNTFCGTSEYMAPEMLF-KKFYDYSVDWWA
 |..  |..... |. ... .||..||. |..|||||||. |...||.    |..||||.|   .  .  ..|||||..||||| .   . |...||.|.
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

FGILVYEMIFDATPFHSE------LKDSTFSKIKYADPTYPEGTD---------------------PNIISFINGFLEKDPHKRTKYSDVENHPFW
.|...|||..  .|| ..       ..  . .|..... ... ..                     .. ..||.. |.|||.||    .. .||..
CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 89233.m00043.AA Ciliate-E2 4-255 22 8.8e-73 248.11 In-house 1-365 (365) Show / Hide 
Range on Protein: 4-255
Range on HMM: 1-365/365
Sequence Identity: 22% (86 aa)

FEVVSVIGRGHFGKVVLAKR-----------------------KTTGDFCAIKSIKKKCLIDRAQLSLIV----------SERNTLTKISHPFVVNILFA
.... .||.| ||.| ..|.                       |... . |.|..||. ..   |   |            |.| | ...||.....  .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FQ--TWSKFYIGMEYVPGGDLIGLMR------------RVGKLSMNDVIIYAGEVAL---------------ALEFIHSKE-IVYRDLKPENLVINSDGH
||  . ...|. |||. ||||  ...              ...... .. .  ...                |||..|||  |..||.||||...     
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

LKLADFGLSKDISES--------------------------------KLTNTFCGTSEYMAPEMLFKKF---------YDYSVDWWAFGILVYEMIFDAT
.|..||||||.....                                 ..||.||| .|||||.| .|          |||..|.|..|.. |||.|  .
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PFHSELKDSTFSKIKYADPTYP------------------EGTDPNIISFING----FLEKDPHKRTK-YSDVENHPFW
||        . .||  .  .|                  .  ... . .|.      |.||| ||   .... |||. 
PF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 89233.m00043.AA Ciliate-E2-Unclassified 4-255 24 9.1e-71 241.41 In-house 1-352 (352) Show / Hide 
Range on Protein: 4-255
Range on HMM: 1-352/352
Sequence Identity: 24% (86 aa)

FEVVSVIGRGHFGKVVLAKRKTTGDFC-----AIKSIKKKCLIDRAQLSLIVSERNTLTKIS-------------------HPFVVNILFAFQTWSKFYI
.... .||.| |||| ....| .. .      ..|....| .. . .   |. | ... ...                   |||.|. ...||.  ..||
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

GMEYVPGGDLIGLMRRVGK-----------------LSMNDVI-----IYAGEVALALEFIHSKE-IVYRDLKPENLVINSDG---HLKLADFGLSKDIS
 |||..||||.  ..  .|                 .. . ..      |. .. ..||..|.|  |..||.||||......|   ..|..|||.|| . 
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

E----------------SKLTNTFCGTSEYM----APEMLFKKFYD----YSVDWWAFGILVYEMIFDATPFHSELKDS----------------TFSKI
.                .....||||| .||    |||.| .. ||    |..|.|..|.. |||.|   || .. ...                 ...|
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI

K---YADPTYPE-----GTDPNIISFIN----GFLEKDPHKRTKYSDVENHPFW
|   .  | .|.     . .|. . |||      |.|.| ||  .... |||. 
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 89233.m00043.AA Alpha 4-255 40 1.2e-70 241.03 In-house 1-259 (259) Show / Hide 
Range on Protein: 4-255
Range on HMM: 1-259/259
Sequence Identity: 40% (105 aa)

FEVVSVIGRGHFGKVVLAKRKTTGDFCAIKSIKKKCLIDRAQLSLIVSERNTLTKISHP-FVVNILFAFQTWSKFYIGMEYVPGGDLIGLMRRVGKLSMN
|  ..|.|.| |||| || ||.|    |||  ||   |    . .   |.  |   . | | | .   |||    |  |||| ||||   . .|||    
FNFLMVLGKGSFGKVMLAERKGTDELYAIKILKKDVIIQDDDVECTMVEKRVLALPGKPPFLVQMHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGKFKEP

DVIIYAGEVALALEFIHSKEIVYRDLKPENLVINSDGHLKLADFGLSK-DISESKLTNTFCGTSEYMAPEMLFKKFYDYSVDWWAFGILVYEMIFDATPF
  . || |.| .| | |.| |.|||||  |  ....|| |.||||..| .. | . | ||||| .|.|||      |  ||||||||.| |||.    ||
HAVFYAAEIAIGLFFLHEKGIIYRDLKLDNVMLDAEGHIKIADFGMCKENMWEDQTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMMAGQPPF

HSELKDSTFSKIKYADPTYPEGTDPNIISFINGFLEKDPHKR-----TKYSDVENHPFW
  |  |  |  |.   ..||       .. . ||| | | ||     .   |.  ||| 
DGEDEDELFQAIMEHNVSYPKSMSKEAVDICKGFLTKHPNKRLGCGPDGEQDIREHPFF
Kinase 89233.m00043.AA TyrKc 4-255 20 7.4e-21 76.53 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-255
Range on HMM: 1-280/280
Sequence Identity: 20% (59 aa)

FEVVSVIGRGHFGKVVLAKRKTTGDFCAIKSIKKKCLIDRAQLSLIVSERNTLTKI--SHPFVVNILFAFQTW-------SKFYIGMEYVPGGDLIGLMR
 .   ..|.|.||.|.... |     .|.|..|. .      .  . .| . ..|.  .|| .|... .  .           .| |||.|.|||    |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

RVGK-LSMNDVIIYAGEVALALEFIHSKEIVYRDLKPENLVINSDGHLKLADFGLSKDISES------KLTNTFCG--TSE------YMAPEMLFKKFYD
. .. |.| | . ..  .|   |..||| .. |||   |  ...... | .|||||.|| .       | . .  .   .        |||| .... . 
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

YSVDWWAFGILVYEMIFDATPFHSE-----LKDSTFSKIKYAD--PTYPEG--------TDPNIISFINGFLEKDPHKRTKYSDVENHPFW
   | |.||.. .|.  .  . ...     ....   .   .   .  |.           . . . .    . ||..|   |..  | ..
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 89233.m00043.AA Pkinase_Tyr 4-195 25 3.1e-19 65.75 Pfam 1-208 (270) Show / Hide 
Range on Protein: 4-195
Range on HMM: 1-208/270
Sequence Identity: 25% (54 aa)

FEVVSVIGRGHFGKVVLAKRK----TTGDFCAIKSIKKKCLIDRAQ--LSLIVSERNTLTKI-SHPFVVNILFAFQ-TWSK--FYIGMEYVPGGDLIGLM
 .   ..|.|.||.|.... |     |.  .|.|..  |   .  |  .    .| ...... .|| .|. . .          || |||.|.|||    
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML--KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

RR----VGKLSMNDVIIYAGEVALALEFIHSKEIVYRDLKPENLVINSDGHLKLADFGLSKDI----SE-SKLTNTFCGTSEYMAPEMLFKKFYDYSVDW
|.     ..|.| | . .. ..| ..|. .|| .. |||   |  ...... | .||||..||        | ...       |||| .. . .    | 
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGK-LPIKWMAPECINYGKFTTKSDV

WAFGILVYEMI
|.||.| .|..
WSFGVLMWEIF
Kinase 89233.m00043.AA S_TK_X 256-316 25 4.4e-05 20.24 SMART 1-79 (79) Show / Hide 
Range on Protein: 256-316
Range on HMM: 1-79/79
Sequence Identity: 25% (20 aa)

QGLTREDILS--KKRSPQFIPIMG----KSISTEYFDSKFTEENPFESVAEPMLDDN------------DIFFGFSYMG
 |.  .....  |.  | |.|         . |..|| .|||| | .....|.| ..            | | ||.|. 
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase 89233.m00043.AA Pkinase_C 282-318 30 0.000947 16.54 Pfam 8-46 (46) Show / Hide 
Range on Protein: 282-318
Range on HMM: 8-46/46
Sequence Identity: 30% (12 aa)

TEYFDSKFTEENPFESV---AEPMLDDNDIFFGFSYMGSE
|..||  ||.| | ...      .  |.. | ||.|  ..
TSNFDPEFTDEPPMDTPPDWR-MSSGDQEPFRGFTYVNPD