Gene 95569.m00077 (T.vaginalis)

95569.m00077

Species: T.vaginalis
Alias: TvagK0509, 95569.m00077
External Links:
Annotation:

Classification

Group: CK1
Family: CK1
Subfamily: CK1-D

Sequence

Name Sequence Type Origin Length Description Download
95569.m00077.AA Protein None 353 None Fasta, JSON
95569.m00077.kin_dom Protein Kinase Domain None 206 None Fasta, JSON

Protein domain

Protein domains of 95569.m00077.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 95569.m00077.AA CK1 20-278 45 1.6e-121 409.98 In-house 1-271 (271) Show / Hide 
Range on Protein: 20-278
Range on HMM: 1-271/271
Sequence Identity: 45% (125 aa)

FIIRRHLGGGSFGDVYEAEDMETQQI---VALKFETGAATNPQLPNEYKCYKTLDG------GTNIPKIYGLFDY--QKSRVLAMEKMGPSLESLYKRCG
. . | .| |||||.|....| |..    || |.|   . .|||. |.| || | |      . .||..|       ..  .. |.  |||||.|.. |.
YRVGRKIGQGSFGDIYLGINM-TNGEENHVAIKLEKNKSKHPQLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDLFNFCN

KRFNLKTVLMIADQMLRAIEYVHNSGLLHRDIKPHNFLVGR-NENRHRIYIIDFGVSTQYIDPRTKEHYMYTSNNGLIGTAHYVSVNTHLGELQSRRDDL
..| |||||||||||.. |||||| ...|||||| |||.|| . . |..|||||| . .|.|..|..|  |  | .|.||| | |.|||||  ||||||.
RKFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDM

ESIAYVLIRFLKGSLPWQSIKVKSVEERNEKITQMKIQTQPDILCAG-LPREFKEFYKYARRLKYEETPKYA
||..|||. ||.|||||| .| .. ... |||  .|..| .. ||.| .| || .. .|.|.|..||.|.|.
ESLGYVLMYFLRGSLPWQGLKANTKKQKYEKIMEKKMSTPVEQLCKGNFPNEFAMYLNYCRQLHFEEKPDYM
Kinase 95569.m00077.AA CK1-Unclassified 20-252 47 7.69999999999e-121 358.36 In-house 1-244 (244) Show / Hide 
Range on Protein: 20-252
Range on HMM: 1-244/244
Sequence Identity: 47% (117 aa)

FIIRRHLGGGSFGDVYEAEDMETQQIVALKFETGAATNPQLPNEYKCYKTLDGGT-------NIPKIYGLFDYQK--SRVLAMEKMGPSLESLYKRCGKR
. . . .| ||||..|.. .|.|.. ||.|.|   . .|||. | | .. | .|        .|||.|  .  ..    .. |.  |||||.| . |...
YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSKHPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDLFNMCNRK

FNLKTVLMIADQMLRAIEYVHNSGLLHRDIKPHNFLVG-RNENRHRIYIIDFGVSTQYIDP-RTKEHYMYTSNNGLIGTAHYVSVNTHLGELQSRRDDLE
|.|||||||||||.  |||.|| ...|||||| |||.| .. |.|..|||||| |  |||. .|..|  |  | .|.||| | |.|.|||  ||||||||
FSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINAHLGIEQSRRDDLE

SIAYVLIRFLKGSLPWQSIKVKSVEERNEKITQMKIQTQPDILC
|..|||| ||||||||| || .. .|. |||  ||..| .. ||
SLGYVLIYFLKGSLPWQNIKANNKKEKYEKIMEMKMSTPVEQLC
Kinase 95569.m00077.AA CK1 20-280 32 5.8e-100 338.41 In-house 1-339 (339) Show / Hide 
Range on Protein: 20-280
Range on HMM: 1-339/339
Sequence Identity: 32% (110 aa)

FIIRRHLGGGSFG-DVYEA-----EDMETQ-----QIVALKFET-GAATN-PQLPNEYKCYKTLDGG---------------------TNIPKIYGLFDY
. . ...|.|.|| ..|..     .||...     . .|.| |   ..   |||  ||. || | ||                       .. .|. .. 
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED

QKSRVLAMEKMGPSLESLYK---RCGKRFNLKTVLMIADQMLRAIEYVHNSGLLHRDIKPHNFLVGR-------------NENRHRIYIIDFGVST-QYI
.. ... |.  ||.||.| |    |...|..||.||||.||| |.||.|. | .|||||| ||..||             |......|.|||| .  .|.
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR

DP-----------RTKEHYMYTS---NNGLIG-TAHYVSVNTHLGELQSRRDDLESIAYVLIRFLKGS--LPWQSIKVKSV-------EERNEKITQMKI
|.           .|..| .. .   . |..| || |.|.|.|||  |.|||||.| .|.|| .|||.  |||| .| ..        ..  |.|. .| 
DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKM

QTQPDILCAG-----LPREFKEFYKYARRLKYEETPKYAWI
.|... || .     .|.|| ...|| | |||...|.|. |
STPFF-LCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI
Kinase 95569.m00077.AA CK1-D 20-280 45 2e-98 333.28 In-house 1-261 (261) Show / Hide 
Range on Protein: 20-280
Range on HMM: 1-261/261
Sequence Identity: 45% (120 aa)

FIIRRHLGGGSFGDVYEAEDMETQQIVALKFETGAATNPQLPNEYKCYKTLDGGTNIPKIYGLFDYQKSRVLAMEKMGPSLESLYKRCGKRFNLKTVLMI
. | | .|.|||||.|  ....|   ||.| |.  .  |||  | | ||.. ||  ||.|  .       |. |. .||||| |.  |...| ||||||.
YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTKHPQLHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFNYCHRKFSLKTVLML

ADQMLRAIEYVHNSGLLHRDIKPHNFLVGRNENRHRIYIIDFGVSTQYIDPRTKEHYMYTSNNGLIGTAHYVSVNTHLGELQSRRDDLESIAYVLIRFLK
||||.. |||.|    .|||||| |||.|     . .||||||.. .| |.||..|  |  |  | ||| | |.|||.|  |||||||||. |||. | .
ADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVLMYFNR

GSLPWQSIKVKSVEERNEKITQMKIQTQPDILCAGLPREFKEFYKYARRLKYEETPKYAWI
|||||| .|     .. |.|.. |..|. | ||.|.| ||...  |.|.||... | |...
GSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL
Kinase 95569.m00077.AA CK1-G 20-280 43 9.7e-96 324.37 In-house 1-266 (266) Show / Hide 
Range on Protein: 20-280
Range on HMM: 1-266/266
Sequence Identity: 43% (115 aa)

FIIRRHLGGGSFGDVYEAEDMETQQIVALKFETGAATNPQLPNEYKCYKTLDGGT-NIPKIYGLFDYQKSRVLAMEKMGPSLESLYKRCGKRFNLKTVLM
. . .  | |.|| ..| . | .   || |||      |||  ||. || | |   .||..|      |  .. |. .||||| |.  |. .| .|||.|
YRVGKKIGCGNFGELFEGKNMYNNEHVAIKFEPMKSRAPQLHDEYRFYKILNGCPEGIPQVYYFGQCGKYNIMVMDLLGPSLEDLFDWCDRKFSVKTVCM

IADQMLRAIEYVHNSGLLHRDIKPHNFLVGR--NENRHRIYIIDFGVSTQYIDPRTKEHYMYTSNNGLIGTAHYVSVNTHLGELQSRRDDLESIAYVLIR
.| ||.. .||||   |. ||.|| |||.||  |.. | |.|||||   |||||.|| |  |     | ||| | |.|||||  ||||||.|..  . . 
VAIQMIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQHVIHIIDFGMAKQYIDPETKQHIPYREHKSLTGTARYMSINTHLGREQSRRDDMEALGHMFMY

FLKGSLPWQSIKVKSVEERNEKITQMKIQTQPDILCAG--LPREFKEFYKYARRLKYEETPKYAWI
|| ||||||  |     || .|| . | .| .. || .  .| .|  . .|.|||...|.| | ..
FLRGSLPWQGLKADNNKERYQKIGDTKRKTNIEDLCQNNAFPEQFATYLRYVRRLDFFECPDYDYL
Kinase 95569.m00077.AA CK1-A 20-280 43 6.1e-90 305.1 In-house 1-261 (261) Show / Hide 
Range on Protein: 20-280
Range on HMM: 1-261/261
Sequence Identity: 43% (113 aa)

FIIRRHLGGGSFGDVYEAEDMETQQIVALKFETGAATNPQLPNEYKCYKTLDGGTNIPKIYGLFDYQKSRVLAMEKMGPSLESLYKRCGKRFNLKTVLMI
. . |..| |||||.| .  ..  . ||.| |   |  |||  | | |. |.|.  ||..      .   |. |. .||||| |.  | .|| .|||||.
YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKARHPQLIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFNFCKRRFTMKTVLML

ADQMLRAIEYVHNSGLLHRDIKPHNFLVGRNENRHRIYIIDFGVSTQYIDPRTKEHYMYTSNNGLIGTAHYVSVNTHLGELQSRRDDLESIAYVLIRFLK
||||.  |||||. . .|||||| |||.| .    ....||||.. .| |.||..|  |     |.||| | |.| |||  ||||||.||..||.. | .
ADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVMMYFNR

GSLPWQSIKVKSVEERNEKITQMKIQTQPDILCAGLPREFKEFYKYARRLKYEETPKYAWI
|.|||| .| .  . . |||   |. |  . || | | ||  . .|.| |..||.| | ..
GKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL
Kinase 95569.m00077.AA TTBKL 20-284 27 1.5e-46 155.25 In-house 1-288 (288) Show / Hide 
Range on Protein: 20-284
Range on HMM: 1-288/288
Sequence Identity: 27% (81 aa)

FIIRRHLGGGSFGDVYEAEDMETQQIVALKFETGAA-TNPQ--LPNEYKCYKTLD--GGTNIPKIYGLFDYQKSRVLAMEKMGPSLESLYKRCGKR--FN
. | . .|.| || ||...||.... .| . |      .    .  | .  . |   | . .||...   ... . ..|.  ||.|  |.|.   .  |.
WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS

LKTVLMIADQMLRAIEYVHNSGLLHRDIKPHNFLVGRNEN----RHRIYIIDFGVSTQYIDPRT--------KEHYMYTSNN-----GLIGTAHYVSVNT
  |.. |. | | |. ..|  | .|||.|| |. .| ...    ....|.|||| . ||...          .. .| .  |     .. ||  |.|.| 
DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNM

HLGELQSRRDDLESIAYVLIRFLKGSLPWQSIKVKSVEERNEKITQMKIQTQPDILCAG------LPREFKEFYKYARRLKYEETPKYAWIRQMF
|..  |.| ||| |  |..| ...| |||...      |  ..| .|| ..  . |. .      .|.|| .|.|. |.|.| ..| |  |.. |
HDRKEQGRHDDLWSWMYMIIELHCG-LPWTNM------EDKMEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF
Kinase 95569.m00077.AA TTBK 22-280 33 2.8e-44 153.43 In-house 3-257 (257) Show / Hide 
Range on Protein: 22-280
Range on HMM: 3-257/257
Sequence Identity: 33% (89 aa)

IRRHLGGGSFGDVYEAEDMETQ-QIVALKFETGAATNPQLPNEYKCYKTLDGGTNIPKIYGLFDYQKSRVLAMEKMGPSLESLYKRCGK-RFNLKTVLMI
. .  ||| || .|||.|| ..   ||.| |   ..   |  |    | | |   . . .|     |   . |.  | .|  |     .  |.| | | .
VVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQPKQVLKMEVAVLKKLQGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLSTTLRL

ADQMLRAIEYVHNSGLLHRDIKPHNFLVGRN-ENRHRIYIIDFGVSTQYIDPRTKEHYMYTSNNGLIGTAHYVSVNTHLGELQSRRDDLESIAYVLIRFL
  |.| .|| .|. | ||||||| || .||| ... ..|..|||   ||.   . |     .  |  ||. | |.| |.     |.||| |. |.|. |.
GVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTN-ACGEVRPPREVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEFV

KGSLPWQSIKVKSVEERNEKITQMKIQTQPDILCAGLPREFKEFYKYARRLKYEETPKYAWI
.| |||  || |      ... .|| .    .|   .| ||. | .  . |.||..| |. |
QGQLPWRKIKDK------DQVGEMKEKYDHRMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI
Kinase 95569.m00077.AA Worm6 20-280 28 8.5e-40 138.53 In-house 1-279 (279) Show / Hide 
Range on Protein: 20-280
Range on HMM: 1-279/279
Sequence Identity: 28% (81 aa)

FIIRRHLGGGSFGDVYEAEDMETQQ--IVALKFET--GAATNPQLPNEYKCYKTLDGGT--NIPKIYGLFDYQKSRV-----LAMEKMGPSLESLYKRC-
. ... .| |.||.||..|| ..     .|.| |     .  ..|. |.   |..  .   . .||   .|. | .      . |.  |..|. | | . 
WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKI---EDRGKVDNRGFNYIVMTLVGKNLWDLRKNRP

GKRFNLKTVLMIADQMLRAIEYVHNSGLLHRDIKPHNFLVGR-----NENRHRIYIIDFGVST--QYIDPRTKEHYMYTSNNGLIGTAHYVSVNTHLGEL
...| . | | || |.|.||| .|| | .|||.|| || .||     ....|.||..||| .   .|..  .. .     . |  ||  | ... | |  
DRKFSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQE

QSRRDDLESIAYVLIRFLKGSLPWQSIKVKSVEERNEKITQMKIQTQPDILCAG-LPR-EFKEFYKYARRLKYEETPKYAWI
|.|.||.||  |... ...| |||. .| .. .|.. | .  ...     .  |  |. ||..  .|   ..|...| |. |
QCRKDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI
Kinase 95569.m00077.AA Pkinase 20-262 21 1.1e-33 120.23 Pfam 1-269 (293) Show / Hide 
Range on Protein: 20-262
Range on HMM: 1-269/293
Sequence Identity: 21% (60 aa)

FIIRRHLGGGSFGDVYEAEDMETQQIVALKFETGAATNPQLP------NEYKCYKTLDGGTNIPKIYGLFDYQKSRVLAMEKMGPSLESLYKRC------
. | | .| |||| ||.. .  |..|||.|      .... .      .| .  | | .  || ..|. | . ..  . || ..  |. .   .      
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLY-VMDLFDYISTW

-GKRF--NLKTVLMIADQMLRAIEYVHNSGLLHRDIKPHNFLVGRNENR-HRIYIIDFGVSTQYIDPRTKEHYMYTSNNGLIGTAHYVSVNTHL-GELQS
 ...|    ... ... |.||..|| |. | .|||.|| |.|. .| .   .. |.|||.. |.       .  .. .... || .|..   .. |.  .
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD------Y-NNS-MTTFCGTPWYMAPEVIRGGQYYG

RRDDLESIAYVLIRFLKGSLPWQSI----KVKSVEERNEKITQMKIQTQPDILCAGL----------------PREFKEF
.. |  |.  .|. .| | .|...     .  .  .. ..| . ..  . . .| .                 ..|.|.|
PKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDF
Kinase 95569.m00077.AA Ciliate-E2 20-192 20 1e-24 81.79 In-house 1-255 (365) Show / Hide 
Range on Protein: 20-192
Range on HMM: 1-255/365
Sequence Identity: 20% (53 aa)

FIIRRHLGGGSFGDVYEAEDMETQQIVALK-----------------FETGAATN-----PQLPNEYKCYKTLDGGT----------------NIPKIYG
... . .| |.||.||.... ..|. .|.|                 ..    ..      |. .| . .....                   || |.| 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINC-FYKKINEKNILEQLNHPNIIKMYE

LFD--YQKSRVLAMEKM-GPSLES-LYKRCGKR---------FNLKTVLMIADQMLR---------------AIEYVHNSG-LLHRDIKPHNFLVGRNEN
 |    ...  | ||   | .|.. ..... ||         |..| .. |  | |.               |.|| |. .  .|||||| | |.     
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

RHRIYIIDFGVSTQYIDPRT-----KEHYMYTSNNG--------------------LIGTAHYVS
   | ||||| |..| |..      .....|.  ..                    ..||..|..
---IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMA
Kinase 95569.m00077.AA S_TKc 20-280 21 7.1e-23 83.23 SMART 1-231 (231) Show / Hide 
Range on Protein: 20-280
Range on HMM: 1-231/231
Sequence Identity: 21% (62 aa)

FIIRRHLGGGSFGDVYEAEDMETQQIVALKFETGAATNPQLPNEYKCYKTLDGGTNIPKIYGLFDYQKSRVLAMEKMGP---SLESLYKRCGKR-----F
. | |..| |.|| || . . .|..|||.|         .. .| .. |   .  || |.|. |.  ..  . || ..    .| .. |..|..     |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

NLKTVLMIADQMLRAIEYVHNSGLLHRDIKPHNFLVGRNENRHRIYIIDFGVSTQYIDPRTKEHYMYTSNNGLIGTAHYVSVNTHLGELQSRRDDLESIA
.  ..  .. |...|.|| |. | .|||.|| | |. .     .| |.|||...|.              . ..|| .|..          .. |  |. 
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL--------------TTFCGTPWYMAPEVL--GYGKCKCDWWSCG

YVLIRFLKGSLPWQSIKVKSVEERNEKITQMKIQTQPDILCAGLPREFKEF------YKYARRLKYEETPK-------YAWI
 .|. .| |  |..          ... .  ||           ..|.|.|      .  ..|.   |  .         |.
CILYEMLCGYPPFP----------QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 95569.m00077.AA TyrKc 20-222 16 0.000366 -155.32 SMART 1-280 (280) Show / Hide 
Range on Protein: 20-222
Range on HMM: 1-280/280
Sequence Identity: 16% (48 aa)

FIIRRHLGGGSFGDVYEAEDMETQQIVALKFETGAATNPQLPNEYKCYKTL-DGGTNIPKIYGLFDYQ-------KSRVLAMEKMGP-SLESLYKRCGKR
    . || | || ||...     . || |     |    . .| .  . |     || ..||    |       .   . || |   .| .  ......
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

FNLKTVLMIADQMLRAIEYVHNSGLLHRDIKPHNFLVGRNENRHRIYIIDFG-----VST-------QYIDP----RTK-------------EHYMYTSN
...|. | .. |  .  || |  .. |||.   | |||.|    .. | |||      .        .|...     .|              ....|. 
LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTK

---------------------NGLI---GTAHYVSVNTHLGELQSRRDD--------LESIAYVLIR--------------FLKGSL
                      | |    ..  |  .   |.   . ..          .  | ...               ..  .
SDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF