Gene 86393.m00081 (T.vaginalis)

86393.m00081

Species: T.vaginalis
Alias: TvagK0387, 86393.m00081
External Links:
Annotation:

Classification

Group: AGC
Family: PDK1

Sequence

Name Sequence Type Origin Length Description Download
86393.m00081.AA Protein None 400 None Fasta, JSON
86393.m00081.kin_dom Protein Kinase Domain None 263 None Fasta, JSON

Protein domain

Protein domains of 86393.m00081.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 86393.m00081.AA AGC 10-272 22 1.6e-100 260.0 In-house 1-395 (395) Show / Hide 
Range on Protein: 10-272
Range on HMM: 1-395/395
Sequence Identity: 22% (91 aa)

FIVESPIGQGAFGQIYKAIEI------KSGKTFALKALNRRF---LIK--MKKQSLAT----------QEKDALTKAA----------SPFVVK-LYGTF
| .  .||.|.||. | . .        .|| .|.| |. .    ..|  | .. ..           .|.. |.|.           .||.|| |. .|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

KDASN--LYFVLDYAE----------HGDLAEAVN---DLGSLNTKATTYVCAQ-------LLEAISTLHA-KNIIHRD-IKIENILLNYKNYIMLTDFG
.| ..  ||||..|..           ..|        . |... ... . .|.       .. |.  ||  ..||||| .| |||||. . .|.|||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

TAMMTDNDD------------------------------------------------SGFRPSSVVG--TPDFVAPELLNDGHICYGSDMWA--FGCVIF
 . .  ||.                                                 ..| .. .|  ||...||| |      .  | |.  .||...
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

NLLTGKAPFEGNS----------TPELMSNIVARK---ICSDI------------EKLPKASQNIITSLLEIDPKKRLGYNENS---KGYPSIRNHPFF
 .|||. || |..            |.. .|  ..    .               ... .  ...|. ||. ||.||||...|    ||.  |.|||.|
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 86393.m00081.AA PDK1 10-212 33 6.7e-82 250.59 In-house 1-241 (307) Show / Hide 
Range on Protein: 10-212
Range on HMM: 1-241/307
Sequence Identity: 33% (81 aa)

FIVESPIGQGAFGQIYKAIEIKS----GKTFALKALNRRFLIKMKKQSLATQEKDALTKAAS-----PFVVKLYGTFKDASNLYFVLDYAEHGDLAEAVN
||... || |...  |.|.|...    .| .|.| .. | .|. ||.   . ||..... .      |..||||.||.| ..|||||.|...||| .. .
FIFGKNIGEGSYSTVYLAREKETKNDENKMYAIKICEKRYIIREKKVKYVHREKEIMCHLNNECNGHPGIVKLYFTFQDEQCLYFVLEYCPNGDLLHYMK

D--LGSLNTKATTYVCAQLLEAISTLHAKNIIHRDIKIENILLNYKNYIMLTDFGTA----MMT----------------DNDDSG-------FRPSSVV
   .||..   . .  |... |.  || ..|||||.| |||||. .. ||.||||||     ..                .|. ..        | .| |
KQPFGSFDMDCCRFYAAEIIDALEHLHSNGIIHRDLKPENILLDKDMHIMITDFGTAGFDKILPEYQSQQQNQFQQQFQQHNKGMDKPEEDKQTRCKSFV

GTPDFVAPELLNDGHICYGSDMWAFGCVIFNLLTGKAPFEG
||  .| ||||.|. .....| ||.|| |. ...|. || |
GTAEYVSPELLTDKECTPSCDIWALGCIIYQMVAGQPPFRG
S_TKc 86393.m00081.AA S_TKc 10-272 27 1.2e-79 271.87 SMART 1-231 (231) Show / Hide 
Range on Protein: 10-272
Range on HMM: 1-231/231
Sequence Identity: 27% (76 aa)

FIVESPIGQGAFGQIYKAIEIKSGKTFALKALNRRFLIKMKKQSLATQEKDALTKAASPFVVKLYGTFKDASNLYFVLDYAEH--GDLAEAVNDLGS---
. .  .||.||||. ||....|.|. .|.| ..            . .| . | |   |..||||..| | ..||.|..|...  ||| .   . |.   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LNTKATTYVCAQLLEAISTLHAKNIIHRDIKIENILLNYKNYIMLTDFGTAMMTDNDDSGFRPSSVVGTPDFVAPELLNDGHICY-GSDMWAFGCVI
   ..   . ....|...|.  .| ..|||||.| |||||.    |...||| |            ....|||...|||.|   .  .  .|.|..||..
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCIL

FNLLTGKAPFEGNSTPELMSNIVARKICSDIEKLPKASQNIITSLLEIDPKKRLGYNENSKGYPSIRNHPFF
. .|.|. ||.   ....| ...           ..   ..|  .|. ||.||..  |  ..   |..||.|
YEMLCGYPPFP---QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 86393.m00081.AA Pkinase 10-272 25 1.5e-69 242.17 Pfam 1-293 (293) Show / Hide 
Range on Protein: 10-272
Range on HMM: 1-293/293
Sequence Identity: 25% (78 aa)

FIVESPIGQGAFGQIYKAIEIKSGKTFALKALNRRFLIKMKKQSLAT-QEKDALTKAASPFVVKLYGTFKDASNLYFVLDYAEHG----DLAEAVN--DL
. ....||.|.||. ||......||..|.| ...|   . |.|...  .|   . .  .|..|.||..| | ...|.|..|.|.|    ||.. .   . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GSL--NTKATTYVCAQLLEAISTLHAKNIIHRDIKIENILLNYKNYI----MLTDFGTAMMTDNDDSGFRPSSVVGTPDFVAPELLN-DGHICYGSDMWA
|..    .    .. |.|...  .|...|||||.| ||||.. ...|     ..||| |   |   ..  .....|||...|||... . .. . .|||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

FGCVIFNLLTGKAPFEGN----STPELMSNIVARKICSDIEKLP-----------------------KASQNIITSLLEIDPKKRLGYNENSKGYPSIRN
.||... .|.|. || |     .  . |  |. .. .   .  |                       .. . .|...|. |||||..        . | .
CGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-------AEQILQ

HPFF
||.|
HPWF
Kinase 86393.m00081.AA Ciliate-E2-Unclassified 10-272 23 1.2e-63 217.8 In-house 1-352 (352) Show / Hide 
Range on Protein: 10-272
Range on HMM: 1-352/352
Sequence Identity: 23% (83 aa)

FIVESPIGQGAFGQIYKAIEIKSGKTFALKALNRRFLIKMKKQSL---------ATQEKD-------------ALTKAASPFVVKLYGTFKDASNLYFVL
...   ||||.||..||....| .. .|.| ..    .|.|..           . ..|               |    .||.||.. .|.|  |.|.|.
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

DYAEHGDLAEAVNDLGS-----------------LNTKATT-----YVCAQLLEAISTLHAKN-IIHRDIKIENILLNYKN---YIMLTDFGTAMMTDND
.|.|.||| .  .. ..                 .  ...      . .||.|.... || || ||||||| ||||.. ..   || ..||| ..  ...
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN

---DSGFR-----------PSSVVGTPDFV----APELLNDGHIC----YGSDMWAFGCVIFNLLTGKAPFEGNSTPE----------------LMSNIV
   | ..             ....||| .     |||.|   .      | .|.|..|.... .|.|. ||..|.  .                | .|| 
NNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIK

ARKICSDI-------EKLPKASQNIITSLLEIDPKKRLGYNENSKGYPSIRNHPFF
...|. .         ....  ...|. ||  ..||.....    ... | |||.|
QKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRI---TFEQILNHPWF
Kinase 86393.m00081.AA CAMK 15-272 17 9.2e-63 200.77 In-house 1-425 (425) Show / Hide 
Range on Protein: 15-272
Range on HMM: 1-425/425
Sequence Identity: 17% (75 aa)

PIGQGAFGQIYKAIEIKSG------------KTFALKALNRRFLIK-------------------------MKKQSLATQEKDALTKAA-------SPFV
 .|.|.||. ...|.....            . .| | .... | .                          |..    .| . . |          | .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKLYGTFKDASN-------------------LYFVL---DYAEHG----DLAEAVNDLGS---------------LNTKATTYVCAQLLEAISTLHAKNI
.||| .. |...                   .|.|.   .|.. |    || . . . |.               .. . . ..  |...|.  .| .||
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IHRDIKIENILLNYKN----------------Y-IMLTDFGTAMMTDNDDSGF---------------------RPSSVVGTPDFVA-PELLND------
.|||.| |||||...|                . | ..||| | . | ... |                       . ..||| ..| ||.||       
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------GHICYGSDMWAFGCVIFNLLTGKAPFEGN-------------STPELMSNIVARKICSDIEKLPK-----------------------ASQN
          . . .|||. |.. . .|.|. ||.|              . .||. .| . |   . .....                         ..
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

IITSLLEIDPKKRLGYNENSKGYPSIRNHPFF
 | ..|. ||.||.   .       . |||..
LIRKMLQVDPEKRMTIEQ-------CLNHPWM
Kinase 86393.m00081.AA Ciliate-E2 10-272 22 4.1e-61 208.51 In-house 1-365 (365) Show / Hide 
Range on Protein: 10-272
Range on HMM: 1-365/365
Sequence Identity: 22% (87 aa)

FIVESPIGQGAFGQIYKAIEIKSG-----------------------KTFALKAL--NRRFLIKMKKQSL---------ATQEKDALTKAASPFVVKLYG
...   ||||.||..||.  .| .                       | .|.| .  |  . ||.... .           .||  | .  .|...|.| 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKI-NEKNILEQLNHPNIIKMYE

TFK--DASNLYFVLDYAEHGDLAEAVN------------DLGSLNTKATTYVCAQLLE---------------AISTLHAKN-IIHRDIKIENILLNYKN
.|.  | .|.|.|..|...||| .  .            | .... |   |. .|.|.               |.  || || ||||||| ||||.    
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----

YIMLTDFGTA-----------------MMTDNDDSGFRPSS-------------VVGTPDFVAPELLNDGH---------ICYGSDMWAFGCVIFNLLTG
 | ..|||..                 ....      | ..             ..||| ..||| || .            | .|.|..|.... .|.|
-IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFG

KAPFEGNSTPELMSNIVARKICS----------------------DIEKLPKASQNIITS----LLEIDPKKRLGYNENSKGYPSIRNHPFF
| ||              ..|.                       . .|...  ...|      .|. ||.||..      |.  | |||.|
KPPF-------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT------GWEQILNHPWF
Kinase 86393.m00081.AA RSK 12-272 25 1.5e-49 170.94 In-house 1-278 (278) Show / Hide 
Range on Protein: 12-272
Range on HMM: 1-278/278
Sequence Identity: 25% (73 aa)

VESP--IGQGAFGQIYKAIEIKSGKTFALKALNRRFLIKMKK-QSLATQEKDALTKAA-SPFVVKLYGTFKDASNLYFVLDYAEHGDLAEAVNDLGS---
..    .|.|.. .  | .  ..|. .| | |... ... .| .  . .| . |     .||.|.|. .|.. . || ...| . |.| .     ..   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

LNTKATTYVCAQLLEAISTLHAKNIIHRDIKIENILLNY---KNYIMLTDFGTAMMTDNDDSGFRPSSVVGTPDFVAPELLNDGH-IC-YGS--DMWAFG
.  .   .. |..  |.. || . |||||.| ||||..       |.||||| .  ...|. ...  . ..| ...|||.|...   . ..   | | .|
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDH-NQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLG

CVIFNLLTGKAPFEG---NSTPELMSNIVARKICSDIE---KLPKASQNIITSLLEIDPKKRLGYNENSKGYPSIRNHPFF
.... .|||. || |   |.  |.| .|   |.  ...   .| .. ...|. .|. ||.||||.. .  .   |..||.|
VLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQ--DAEEIKQHPWF
Kinase 86393.m00081.AA ULK 10-272 22 4.1e-49 169.5 In-house 1-329 (329) Show / Hide 
Range on Protein: 10-272
Range on HMM: 1-329/329
Sequence Identity: 22% (74 aa)

FIVESPIGQGAFGQIYKAIEIKS----GKTFALKALNRRFLIKMKKQS-------LATQEKDALTKAA----SPF----VVKLYGTFKDA--SNLYFVLD
...   .|.|.||. ||.. .|.    .. .| | . .  ... ....       | ..| . . |      ...    .||||  |...   |.|....
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YAEHGDLAEAVNDLGSLNTKA----------TTYVCAQLLEAISTLHAKNIIHRDIKIENILLNYKN------------YIMLTDFGTAMMTDND-DSGF
| ..||| .  .  . |. .           .  .. |.|..   || .|||||||| .|||.. ..             . ..||| | . ||| .. .
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

RPSSVV------GTPDFVAPELLNDG----HIC-YGSDMWAFGCVIFNLLTGKAPFEGN-STPE---LMSNIVARKICS--------------DIEKLPK
   . |      ||| . ||..|..     . . | .|.| .||... .|.|| ||... ..     ....|  .. .               .. .. .
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISP

ASQNIITSLLEIDPKKRLGYNENSKGYPSIRNHPFF
 ....|  .|..|.|.|    |       . |||.|
ECKDLIRRMLQYDEKDRISWEE-------LFNHPWF
Kinase 86393.m00081.AA ULK 10-272 23 6.5e-49 168.83 In-house 1-324 (324) Show / Hide 
Range on Protein: 10-272
Range on HMM: 1-324/324
Sequence Identity: 23% (79 aa)

FIVESPIGQGAFG-QIYKAIEIKS---GKTFALKALNRRFLIKMKKQS-------LATQEKDALTKAA---SPF--VVKLYGTFKDA--SNLYFVLDYAE
...   .|.|.|| . ||.. .|.   .. .| |  ..  ..| |...       |  .|   . |     .|.  .||||  |...   |.|....| .
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

HGDLAEAVNDLGSLNTKA----------TTYVCAQLLEAISTLHAKNIIHRDIKIENILLNYKN------------YIMLTDFGTAMMTDNDDSGFRPS-
.||| .  .  . |.             .  .. |....   || .|||||||| .|||.. ..             . ..||| | . ||..       
GGDLEQYIKKNKKLPE-TEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQ

SVV------GTPDFVAPELLNDG----HIC-YGSDMWAFGCVIFNLLTGKAPFEGNSTPEL----------------MSN--IVARKICSDIEKLPKASQ
. |      ||| . ||..|..     . . | .|.| .||... .|.|| ||... ...                 . |  |  .| . .. |. . ..
TCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSWFNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPP-KDPKISPECK

NIITSLLEIDPKKRLGYNENSKGYPSIRNHPFF
..|  .|..|.|.|    |       | |||.|
DLIRRMLQYDEKDRISWEE-------IFNHPWF
Kinase 86393.m00081.AA Delta 10-272 29 9.2e-47 161.67 In-house 1-259 (259) Show / Hide 
Range on Protein: 10-272
Range on HMM: 1-259/259
Sequence Identity: 29% (77 aa)

FIVESPIGQGAFGQIYKAIEIKSGKTFALKALNRRFLIKMKKQSLATQEKDALTKAA-SPFVVKLYGTFKDASNLYFVLDYAEHGDLAEAVNDLGSLNTK
|...  .|.|.||..  |   .  | .|.|.| .  ...         |.  |. |. .||. .|. ||.  ..|.||..|   |||   . . .  . |
FHFHKVLGKGSFGKVMLAELKGKNKYYAIKCLKKDVVLEDDDVECTMVERRVLALAWEHPFLCHLFCTFQTKEHLFFVMEYLNGGDLMYHIQQCHRFDEK

ATTYVCAQLLEAISTLHAKNIIHRDIKIENILLNYKNYIMLTDFGTAMMTDNDDSGFRPSSVVGTPDFVAPELLNDGHICYGSDMWAFGCVIFNLLTGKA
 ...  . .. ..  || |.|| ||.|..|.|| .   | . ||| .    . .   . |.  ||||..|||..   .     | |.|| ... .| |..
RARFYACEIICGLQFLHKKGIIYRDLKLDNVLLDCDGHIKIADFGMCKENMYGE--KKASTFCGTPDYIAPEIIKGQKYNHSVDWWSFGVLMYEMLIGQS

PFEGNSTPELMSNIVARKICSDIEKLPKASQNIITSLLEIDPKKRLGYNENSKGYPSIRNHPFF
||.|.   ||   |.   .      . | .....  |.| ||.|||| ..  ||   ||.|.||
PFHGEDEDELFWSICN-DRPWYPRWITKEAKDCLKKLFERDPEKRLGVQYCPKG--DIRQHCFF
Kinase 86393.m00081.AA MAST 10-153 30 2.2e-32 101.43 In-house 1-144 (334) Show / Hide 
Range on Protein: 10-153
Range on HMM: 1-144/334
Sequence Identity: 30% (44 aa)

FIVESPIGQGAFGQIYKAIEIKSGKTFALKALNRRFLIKMKKQSLATQEKDALTKAASPFVVKLYGTFKDASNLYFVLDYAEHGDLAEAVNDLGSLNTKA
|    ||. ||.|. |... .|....||.| .. . .|. . ..    |...|. . .|||||.. .|  ...|..|..| | ||.|   ...|..    
FEFIKPISKGAYGKVYLVKHKKTNDRFAMKVIKKSDMINKNMVDQVQVERNILAMYQNPFVVKMFYSFQTKNYLCMVMEYMEGGDCASLLHMYGYFDEWM

TTYVCAQLLEAISTLHAKNIIHRDIKIENILLNYKNYIMLTDFG
.    |..  ..  || . |.|||.| .|.|.  .  | |||||
AKMYIAETVLCLEYLHSHGIVHRDLKPDNMLIDSNGHIKLTDFG
Kinase 86393.m00081.AA MAST 169-272 29 1.9e-21 65.58 In-house 223-334 (334) Show / Hide 
Range on Protein: 169-272
Range on HMM: 223-334/334
Sequence Identity: 29% (34 aa)

SVVGTPDFVAPELLNDGH-ICYGSDMWAFGCVIFNLLTGKAPFEGNSTPELMSNIVARK----ICSDI------EKLPKASQNIITSLLEIDPKKRLGYN
...||||. |||....       .| |. | ... .|.|  || . .. |. .||. |.     . .       |.... .| .|  ||. ||.||||  
QCCGTPDYIAPEVILGQGTHGKPVDWWSMGIIMYEFLVGCPPFNDDTPEEIFQNILNRNCNEIEWPEGGDINDDEAMSPEAQDLIEKLLQPDPRKRLG--

ENSK-GYPSIRNHPFF
  .. |  .. .||||
--ANNGADEVKQHPFF
Kinase 86393.m00081.AA TyrKc 10-263 22 9.4e-13 -16.46 SMART 1-280 (280) Show / Hide 
Range on Protein: 10-263
Range on HMM: 1-280/280
Sequence Identity: 22% (66 aa)

FIVESPIGQGAFGQIYKAIEIKSGKTFALKALNRRFLIKMKK---QSLATQEKDALTKA--ASPFVVKLYGTFKDA-------SNLYFVLDYAEHGDLAE
   .  .| ||||..||.. .            .   .|| |   .    .|   ..|     | .|.|||   .          |. |. |..|||| .
ITLGKKLGEGAFGEVYKGTWK------------IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

AVNDLGS-LNTKATTYVCAQLLEAISTLHAKNIIHRDIKIENILLNYKNYIMLTDFGTAMMTDND------DSGFRPSSVVGTPDFV-----APELLNDG
   . .  |..|   . | |  .  . || ||.||||.   |.|.. .. .  .||| .   ..|      ..  |...  |. . .     ||| .|.|
YLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

HICYGSDMWAFGCVIFNLLT-GKAPFEG-----NSTPELMSNIVARKICSDIEK--------LPKASQNIITSLLEIDPKKRLGYNENSKGY
     || |.|| ... ..| |. | .|      |  |.. .. ...     .          |..  .|...  . ||..|   .|  .  
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 86393.m00081.AA PDK1 232-272 32 1e-10 28.51 In-house 265-307 (307) Show / Hide 
Range on Protein: 232-272
Range on HMM: 265-307/307
Sequence Identity: 32% (14 aa)

EK--LPKASQNIITSLLEIDPKKRLGYNENSKGYPSIRNHPFF
..   |.   ...  || .||..||.  .   ||..|..||||
DNFRFPPCAKDLVKKLLVRDPNDRLTSCDECGGYQQIKAHPFF
Kinase 86393.m00081.AA Pkinase_Tyr 10-134 24 2e-06 22.09 Pfam 1-137 (270) Show / Hide 
Range on Protein: 10-134
Range on HMM: 1-137/270
Sequence Identity: 24% (34 aa)

FIVESPIGQGAFGQIYKAIEI----KSGKTFALKALNRRFLIKMK--KQSLATQEKDALTKA-ASPFVVKLYGTFK-DASN--LYFVLDYAEHGDLAEAV
 .    .|.||||..||..      . . . | | | .    .    ....   |   ...    | .|.|||    .     .| |. |..|||| .  
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

ND----LGSLNTKATTYVCAQLLEAISTLHAKNIIHRDI
 .     ..|..|     |.|  .. . |..||.||||.
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL
Kinase 86393.m00081.AA Pkinase_Tyr 178-222 36 0.041902 7.75 Pfam 182-228 (270) Show / Hide 
Range on Protein: 178-222
Range on HMM: 182-228/270
Sequence Identity: 36% (17 aa)

APELLNDGHICYGSDMWAFGCVIFNLLT-GKAP-FEGNSTPELMSNI
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APECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYI
PDK1_PH 86393.m00081.AA PDK1_PH 297-333 31 0.000942 10.78 In-house 1-41 (112) Show / Hide 
Range on Protein: 297-333
Range on HMM: 1-41/112
Sequence Identity: 31% (13 aa)

TSFAEDMLAPGETIMLEGVVERKRGLMW----KGRLLIITN
|...  ....||.|  .| |. ..||      | |.||.|.
TPWHQFLMPEGEHILKCGWVYKRKGLFAKPKKKRRQLILTD