Gene 82174.m00129 (T.vaginalis)

82174.m00129

Species: T.vaginalis
Alias: 82174.m00129, TvagK0271
External Links:
Annotation:

Classification

Group: TKL
Family: TKL-Tvag1

Sequence

Name Sequence Type Origin Length Description Download
82174.m00129.AA Protein None 823 None Fasta, JSON
82174.m00129.kin_dom Protein Kinase Domain None 260 None Fasta, JSON

Protein domain

Protein domains of 82174.m00129.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 82174.m00129.AA TKL 28-280 24 4.3e-77 262.44 In-house 1-364 (364) Show / Hide 
Range on Protein: 28-280
Range on HMM: 1-364/364
Sequence Identity: 24% (93 aa)

IGEGGFGEVNYAIHIATK--------KKCAIKKLFLKELKGS-------------------------DFDLFIREVENLAICDNMFCLAFLGCTFKYP--
||.||||||  ...  .         |  |.||.  .. . .                          .. ...|.  .  ..    . |.|. .  |  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------FSIITQYIPNGSLFNALKHRDGSPDLDGTDKTLIAMGIAHGMTYLHKHG--------IIHRDLKSLNILLDEKKL-------------
            . |...|.|.|||.. |             .  .|..|| || ||| ..        |||||||| |||.||.               
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADW

-PIICDFGLSRRQGESDIDSPENMMTK--------------DVGTPHWMAPELFESN----------------NYTNKVDVYAFGMIMWEMLTEMSPFKN
 . ||||||||.  .|  ..   ....               .||| |||||... .                 |. |.|||.||...||.||   |...
CCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYD

MNGMQIA---------YAVCKKGERPQIP------------NITAEPMRAFINRCWNQDPNQRPTFEEIYKDF
.. |..          . ||.||.|| ||            . . ..|.  . .||..||..||.|.|| | .
YPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase 82174.m00129.AA MLK 22-280 31 3.2e-69 236.27 In-house 1-291 (291) Show / Hide 
Range on Protein: 22-280
Range on HMM: 1-291/291
Sequence Identity: 31% (92 aa)

FKFGDKIGEGGFGEVNYAIHIATK---KKCAIKKLF-------LKELKGSDFDLFIREVENLAICD-NMFCLAFLGCTFKY-P-FSIITQYIPNGSLFNA
..|  .||.|.||.|  .   ..    |  |.|. .        ..    ||. ..|..  |     .    .|.|.  .. . | |...|...|||.| 
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LKHRDGSPD-----------LDGTDKTLIAMGIAHGMTYLHKHG---IIHRDLKSLNILLDE-----KKLPI-ICDFGLSRRQGESDIDSPENMMTKDVG
|. ... ..            |   .  .|. .|.|| |||..    |||||||| |||.||     ...   |||||.||   ... .     |..  |
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TN----MMSNAG

TPHWMAPELF---ESNNYTNKVDVYAFGMIMWEMLTEMSPFK-NMNGMQIAYAVCKKGERPQIPNITAEPMRAFINRCWNQDPNQRPTFEEIYKDF
|. ||||| .   ... |. |.||. .|...|||||   |.|  ...|.||. |  .|.|| ||.   |..  ....||||||..||.| .| . .
TYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase 82174.m00129.AA TKL-Unique 24-280 31 2.1e-61 210.34 In-house 1-290 (290) Show / Hide 
Range on Protein: 24-280
Range on HMM: 1-290/290
Sequence Identity: 31% (92 aa)

FGDKIGEGGFGEVNYAIHIATKKKCAIKKLFLKELKGSDFDL-FIREVENLAICD-NMFCLAFLGCTFK---YPF--SIITQYIPNGSLFNALKH-----
|. ||||||.|.|  ...   ... |||.....|.. ...   |..||  .   .   . . . | ...   ||   .|.. |.| ||| . |       
FWNKIGEGGYGQVYKGKW--RGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNN

---RDGSPDLDGTDKTLIAMGIAHGMTYLHKHG--IIHRDLKSLNILLDEK----KLPI-ICDFGLSRRQGESDIDSPENMM-----TKDVGTPHWMAPE
   .. .. |.   .  .|  || || |||  .  ||||||||.|.|.|..    .. | |||||||. .  ...... |.      .  .|.. |||||
NNNNNNCK-LNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFN-SKINKMTNNEHKGTRNQTRCGSFRWMAPE

LFES--NNYTNKVDVYAFGMIMWEMLTEMS------PFKNMNGMQIAYAVCK--KGERPQIPNITAEPMRAFINRCWNQDPNQRPTFEEIYKDF
....  . |..|.|||.||...||..| .       |...|.  |.. .| .  .. || |||   .  |  |..||..|| |||.|.||..  
VLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase 82174.m00129.AA HH498 22-280 32 1.4e-58 184.2 In-house 1-284 (284) Show / Hide 
Range on Protein: 22-280
Range on HMM: 1-284/284
Sequence Identity: 32% (95 aa)

FKFGDKIGEGGFGEVNYAIHIATKKKCAIKKL-FLKELKGSD-----FDLFIREVENLAICDNMFCLAFLGCTFKYP--FSIITQYIPNGSLFNAL----
..|  ||| | ||.| |       |  |.|     . .  ||      | |.|||  .   ..    .|.. .   |  | |.|||. |||||  |    
IEFHEKIGSGSFGKV-YKGEWRN-KIVAVKRYRAMAFCCKSDSYQWIVDMFCREVSIMCRLNHPCVVQFVYACCDDPSQFAIVTQYCDNGSLFSILNTIP

-----------KHRDGSPDLDGTDKTLIAMGIAHGMTYLHK---HGIIHRDLKSLNILLDEKKLPIICDFGLSRRQGESDIDSPENMMTKDVGTPHWMAP
             .     .|   |  |.. .|||| |||    | |||||| | |||..|     . ||| ||     |..  .  |||  | . ||||
IGGAGANNNNHNQKNNYRIMDLQSKMTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIHEDGHAVVADFGESRFV--CDMH--DDNMTKQPGNLRWMAP

ELFE-SNNYTNKVDVYAFGMIMWEMLTEMSPFKNMNGMQIAYAVCKKGERPQIPNI----TAEPMRAFINRCWNQDPNQRPTFEEIYKDF
| |  .  |. ||||. ..|..|||.|   ||        |  .  .  || ||.        .    | .||.. |. ||.| .|    
EVFSQCQKYSIKVDVFSYAMCIWEMHTREVPFHHYKPAAAAAEMAYHHIRPPIPQTPTAQIPHHWSNLIQMCWHPCPENRPDFDQIVTIL
Kinase 82174.m00129.AA Dicty5 90-286 43 6.2e-57 194.5 In-house 72-260 (260) Show / Hide 
Range on Protein: 90-286
Range on HMM: 72-260/260
Sequence Identity: 43% (87 aa)

KYPFSIITQYIPNGSLFNALK-HRD--GSPDLDGTDKTLIAMGIAHGMTYLHKHGIIHRDLKSLNILLDEKKLPIICDFGLSRRQGESDIDSPENMMTKD
|||| ..| |. ||||||.|.  |   | | . .. .  .|..|| .| .||  .||||||||.|.|. |     | ||| ||      .|   . || .
KYPF-HVTEYCHNGSLFNYLNDQRKTTGQPIAYFQ-QLHMAIDIAQSMRHLHSMNIIHRDLKSMNFLITENWKIKIIDFGTSR-----FVDNRYH-MTMH

VGTPHWMAPELFESNNYTNKVDVYAFGMIMWEMLTEMSPFKNMNGMQIAYAVCKKGERPQIPNITAEPMRAFINRCWNQDPNQRPTFEEIYKDFKTGKIA
|||. |||.||| .. |..|.|||.|| . |||.|  .|..|.|   |.  |  ||||| ||          |  || | | .||.| || | |.  .| 
VGTQCWMACELFNGQPYHQKCDVYSFGIVLWEMFTRKEPYDNINNWNIPVMV-MKGERPTIPKDCPTEISNLIKKCWQQKPHNRPSFKEICKYFE--SII
Kinase 82174.m00129.AA S_TKc 22-281 27 1.9e-56 194.79 SMART 1-231 (231) Show / Hide 
Range on Protein: 22-281
Range on HMM: 1-231/231
Sequence Identity: 27% (75 aa)

FKFGDKIGEGGFGEVNYAIHIATKKKCAIKKLFLKELKGSDFDLFIREVENLAICDNMFCLAFLGCTFKYPFSIITQYIPN--GSLFNALKHRDGSPD--
.....|||.|.||.|  ..|. |....|||..          . ..||.. |   .  .   ....     . ... |...  |.||  .|.| . .   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-LDGTDKTLIAMGIAHGMTYLHKHGIIHRDLKSLNILLDEKKLPIICDFGLSRRQGESDIDSPENMMTKDVGTPHWMAPELFESNNYTN-KVDVYAFGMI
 ..  .   ..  |. .. |.|.|||||||||  ||||||     ||||||.|.             |  .|||..||||..    |.  |.|....| |
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI

MWEMLTEMSPFKNMNGMQIAYAVCKKGERPQIPNITAEPMRAFINRCWNQDPNQRPTFEEIYK--------DFK
..|||.   ||     ||  . ...            .... ||..|.. ||..|||  |. .         . 
LYEMLCGYPPFP---QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 82174.m00129.AA Dicty4 93-282 38 2.8e-55 182.88 In-house 77-277 (277) Show / Hide 
Range on Protein: 93-282
Range on HMM: 77-277/277
Sequence Identity: 38% (78 aa)

FSIITQYIPNGSLFNALKH------RDGSPDLDGTDK-TLIAMGIAHGMTYLHK--HGIIHRDLKSLNILLDEKKLPIICDFGLSR--RQGESDIDSPEN
..| | | | |.|.. |           ..|.    .  ..|  .| ||..||     |||||||| |.| |. .   .||||||.  . .|.  |   |
MCIVTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKD---N

MMTKDVGTPHWMAPELFESNNYTNKVDVYAFGMIMWEMLTEMSPFK--NMNGMQIAYAVCKKGERPQIPNITAEPMRAFINRCWNQDPNQRPTFEEIYKD
.||  .||| |||||   .. |. |.||| ||.. ||.||   |.    |. ||.. ||| |..|| ||. .  . .. |..||. ||..||.|||| . 
QMTA-CGTPCWMAPEVMMHQPYNEKADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQR

--FKT
    .
RILEH
Kinase 82174.m00129.AA Pkinase_Tyr 22-280 29 3.3e-55 187.59 Pfam 1-270 (270) Show / Hide 
Range on Protein: 22-280
Range on HMM: 1-270/270
Sequence Identity: 29% (82 aa)

FKFGDKIGEGGFGEVNYAIHI----ATKKKCAIKKLFLKELKGSD---FDLFIREVENLAIC-DNMFCLAFLGCTF--KYP--FSIITQYIPNGSLFNAL
 .|| |.||| ||||  ..       || ..|.|.|  ||   ..    . |.||.. .    ..   . ..|.    . |    |.. | |.|.| . |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML--KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

KHR-DGSPDLDGTDKTLIAMGIAHGMTYLHKHGIIHRDLKSLNILLDEKKLPIICDFGLSRRQGESDIDSPE-NMMTKDVGTPHWMAPELFESNNYTNKV
. . .. . |.  |.  ... || || ||. ...|||||   |.|..|..   ||||||.|       |.    . ..      ||||| .  . .| | 
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI---YNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKS

DVYAFGMIMWEMLT-EMSP-FKNMNGMQIAYAVCKKGERPQIPNITAEPMRAFINRCWNQDPNQRPTFEEIYKDF
||..||  |||..|  ..| ...|   ..  .. ..|.|  .|  . ...   . .||..||..||||.||. ..
DVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase 82174.m00129.AA STE 22-281 23 2.9e-54 186.58 In-house 1-359 (359) Show / Hide 
Range on Protein: 22-281
Range on HMM: 1-359/359
Sequence Identity: 23% (85 aa)

FKFGDKIGEGGFGEVNYAIHI------ATKKK---------CAIKKLFLKELK---------------GSDFDLFIREVENLAICD--NMFCLAFLGCTF
... .|||.|.||.| .|...       |...         .|||.. |.. .                .... ...|.. .  |.    .   ..|| |
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

KYP--------FSIITQYIPNGSLFNALKHRDGSPD-LDGT--------DKTL--IAMGIAHG-MTYLHKHGIIHRDLKSLNILLDEKKLPIICDFGLSR
|            |.  |...|||   .||. | .. |.           . .  |.  | .| . |||.|.|||||.|. ||||       .||||.. 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

RQGES--DIDSPE-----------NMMTKDVGTPHWMAPELFES------NNYTNKVDVYAFGMIMWEMLTEMSPFKNMNGMQIAYAVCKK---------
.  .|  .| . .            . . .|||| |||||  .       . |. |.|.. .|  ..||.|   |. .|. |.  ..  ..         
QLTDSMANI-Q-SNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQ

-----GERPQIPNITA-------------------EPMRAFINRCWNQDPNQRPTFEEIYK---DFK
     |. |..|. .                    .... |||.| . |||.||| ..  |    | 
LCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 82174.m00129.AA TK 22-280 15 1.4e-51 170.8 In-house 1-486 (486) Show / Hide 
Range on Protein: 22-280
Range on HMM: 1-486/486
Sequence Identity: 15% (78 aa)

FKFGDKIGEGGFG---EVNYAIHIATKK-------------------------KCAIKKLFLK-ELKGSDFDL--------------FIREVENLA--IC
 ..|.|.||| ||   ||  .. .  ..                         ..|.| | .. .    .| .              . .| . .   ..
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

DNMFCLAFLG-CTFK------------YPFSIITQYIPNGS----LFNALK-HRDGSPD-----------------------------------------
.    . ..| || .             |. |.. | |.|.    | . |. .|..  .                                         
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LDGTDKTLIAMGIAHGMTYLHKH------GIIHRDLKSLNILLDEKKL-----------PIICDFG---
                               |.  ..  ... || || |||..      ...||||   |.|..|..              |.|||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LSRRQGESDIDSPENMMTKDVGTPH----------------------WMAPELFE---------SNNYTNKVDVYAFGMIMWEMLT--EMSPFKN
     |.|. ...|     .  .....                         ||||| ..          . .| | ||..||  |||..|  .. .  .
QGSGVLARDIYSDDDYYRKSSYGTGRPM-WPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGG

MNG--------MQIAYAVCKKGER---------------PQIPNITA-------------EPMRAFINRCWNQDPNQRPTFEEIYKDF
|.         .|  .   ..| |               || |. .              | .  .. .||. ||..||||..... .
MSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase 82174.m00129.AA TyrKc 22-280 29 7.4e-51 176.2 SMART 1-280 (280) Show / Hide 
Range on Protein: 22-280
Range on HMM: 1-280/280
Sequence Identity: 29% (86 aa)

FKFGDKIGEGGFGEVNYAIHIATKKKCAIKKLFLKELKGSDFDLFIREVENLAIC--DNMFCLAFLGCTFK--------YPFSIITQYIPNGSLFNAL-K
 ..|.|.||| ||||  .. .    ..|.|.|            |.|| . .     ..   ....|.  .         |  |.. | |.|.| . | |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

HRDGSPDLDGTDKTLIAMGIAHGMTYLHKHGIIHRDLKSLNILLDEKKLPIICDFGLSRRQGES-------DIDSPEN-MMTKDVGTPHWMAPELFESNN
||.    |   |.  ..  || || |||....|||||   |.|..|..   |.||||||  ..        |  ..     .|..    ||||| .  . 
HRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

YTNKVDVYAFGMIMWEMLTE-MSPFKNM----NGMQIAYAVCKKGERPQIPNI--------TAEPMRAFINRCWNQDPNQRPTFEEIYKDF
.| | ||..||  |||..|  ..|  .|       | ...  |.|.|. .|            . |   . .||. ||..||||.||...|
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 82174.m00129.AA Pkinase 22-280 25 2.4e-50 178.38 Pfam 1-293 (293) Show / Hide 
Range on Protein: 22-280
Range on HMM: 1-293/293
Sequence Identity: 25% (79 aa)

FKFGDKIGEGGFGEVNYAIHIATKKKCAIKKLFLKELKGSDFDLFIR--EVENLAICDNMFCLAFLGCT--FKYPFSIITQYIPNG----SLFNALK-HR
...| |||.|.||.|  ..|. | |. |.|.. ... | .     .|  |.. .. ..  . . ....    ...  ... | ..|    .||  .. .|
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIY-MVMEYCEGGLYVMDLFDYISTWR

DGSP--DLDGTDKTLIAMGIAHGMTYLHKHGIIHRDLKSLNILLDEKKLP----IICDFGLSRR-QGESDIDSPENMMTKDVGTPHWMAPELFE-SNNYT
.|.   . .   .  ..  |. |. |.|..||||||||. |||.|..  .     ||||||..  .    . . .  ||  .|||..||||.   .. |.
HGCFYFSEWECKF--YMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD----Y-NNS--MTTFCGTPWYMAPEVIRGGQYYG

NKVDVYAFGMIMWEMLTEMSPFKNM----NGMQIAYAVCKKGE---RPQIPNITA-------------------EPMRAFINRCWNQDPNQRPTFEEIYK
 |||....| |..|||.   ||..     | .   . .|....   . ..|.                      |... ||..|...||..|||.|.| .
PKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQ

D--F
.  |
HPWF
Kinase 82174.m00129.AA DRK 95-282 37 3e-47 158.11 In-house 74-258 (258) Show / Hide 
Range on Protein: 95-282
Range on HMM: 74-258/258
Sequence Identity: 37% (71 aa)

IITQYIPNGSLFNALKHRDGSPDLDGTDKTLIAMGIAHGMTYLHKHG--IIHRDLKSLNILLDEKKLPIICDFGLSRRQGESDIDSPENMMTKDVGTPHW
|.. |.| ||| | |   | |  .|      ... .| ||.|||     |||||||| | | ||     . ||||| |     . .    ||  .||| |
ICMEYMPRGSLYNIL--HDESIEMDWPLMKQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLVDEHWQVKVADFGLSTRF--KKHKQHKFAMTM-CGTPCW

MAPELFESNNYTNKVDVYAFGMIMWEMLTEMSPFKNMNGMQIAYAVCKKGERPQIPNITAEPMRAFINRCWNQDPNQRPTFEEIYKDFKT
 |||   .  || | ||| |. . ||..|   |.  |. .|.  .| . |.|| .|     .  . .|.||| || .||...|. .    
TAPEVLRNQRYTEKADVYSFAIVLWECVTRQDPYFGMPTFQVVFSVGRHGMRPPMPQWCPPKYIQLMNDCWNEDPQHRPSMQECLERLEA
Kinase 82174.m00129.AA LRRK 92-282 33 5.1e-46 159.2 In-house 129-351 (351) Show / Hide 
Range on Protein: 92-282
Range on HMM: 129-351/351
Sequence Identity: 33% (76 aa)

PFSIITQYIPNGSLFNALKHRDGSP------DLDGTDKTLIAMGIAHGMTYLHKHG--IIHRDLKSLNILLDEKK---------LPI---ICDFGLSRRQ
|. ... |.|.|.|   |...  ..      ... . |  ||. || || |||.|   |||||||| |||| . .          ..   |.|||.||  
PLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISR-M

GESDIDSPENMMTKDVGTPHWMAPELFESN---NYTNKVDVYAFGMIMWEMLTEM-SPFKNMN----G--MQIAYAVCKKGERPQIPNI-TAE-----PM
    .. ..  ... ||.| |||||    |   .|| |||.|.||||.|| ||    || ...    .  | .     ..| || ||.    .      .
F--QCFHMGVAKGC-VGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIEDKIIEGLRPTIPQHYCPPCQPWHMY

RAFINRCWNQDPNQRPTFEEIYKDFKT
 . |. ||..||..||.|..| |  ..
QDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase 82174.m00129.AA Dicty4 22-36 46 0.001934 7.53 In-house 1-15 (277) Show / Hide 
Range on Protein: 22-36
Range on HMM: 1-15/277
Sequence Identity: 46% (7 aa)

FKFGDKIGEGGFGEV
 .....||.|.||||
INIEQRIGKGSFGEV
Kinase 82174.m00129.AA LRRK 22-36 50 0.003368 7.15 In-house 1-16 (351) Show / Hide 
Range on Protein: 22-36
Range on HMM: 1-16/351
Sequence Identity: 50% (8 aa)

FKFGDKIGEGGFG-EV
.|.. .||.|||| .|
LKIEEQIGRGGFGTFV
Kinase 82174.m00129.AA DRK 22-36 53 0.092701 1.78 In-house 1-15 (258) Show / Hide 
Range on Protein: 22-36
Range on HMM: 1-15/258
Sequence Identity: 53% (8 aa)

FKFGDKIGEGGFGEV
 | |  || |..|||
IKIGNRIGRGNYGEV