Gene 85337.m00291 (T.vaginalis)

85337.m00291

Species: T.vaginalis
Alias: TvagK0288, 85337.m00291
External Links:
Annotation:

Classification

Group: TKL
Family: TKL-Tvag1

Sequence

Name Sequence Type Origin Length Description Download
85337.m00291.AA Protein None 796 None Fasta, JSON
85337.m00291.kin_dom Protein Kinase Domain None 251 None Fasta, JSON

Protein domain

Protein domains of 85337.m00291.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 85337.m00291.AA TKL 28-273 27 1.4e-81 277.37 In-house 1-364 (364) Show / Hide 
Range on Protein: 28-273
Range on HMM: 1-364/364
Sequence Identity: 27% (102 aa)

IGGGSFGDVYLAKYIP--------TGQMTAVKELKHETLEEP-------------------------FLQYFLREIRILAKCDNYFLLHFTGYTATHP--
|| |.|| || .|.          ||.  ||| .| .   |                          | . . .||... ...   ...| ||    |  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------FLIVTEYIQNGSLFDSLHDQTKSLDGTQKTIIALGIACGMARLHSFN--------IMHRDLKSLNILLDES--------------YFP
            . ||.||...|||.. ||         |.  .||.||.||. ||| |        | |||||| |||.||               ...
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

RICDFGASRIKSAESE-------------------LVTQNIGTVHWMAPEMFDST----------------NYTLAVDVYAYAILLWELLAEEIPYNGYS
 ||||| || .| ...                        .||  |||||... .                 |. ..|||...|.|||.|. ..|| .| 
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYP

VP---------QIMRTVCMNDQRLTIP------------QGTPPNLAKLIQLCWNRDPEKRPPFDRIFKIF
 .         ...  || . .|..||              .|| ..||.| ||. |||||| |..| |..
YMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase 85337.m00291.AA MLK 22-273 32 5e-68 232.31 In-house 1-291 (291) Show / Hide 
Range on Protein: 22-273
Range on HMM: 1-291/291
Sequence Identity: 32% (94 aa)

FQYEKKIGGGSFGDVYLAKYIPTG---QMTAVKELKHETLEEPFLQY-----FLREIRILAKCDNYF----LLHFTGYTATH-P-FLIVTEYIQNGSLFD
.| ...|| ||||.|.....  .       |||. ....  .    |     | .|.|.|.. .          | |  . . . |.||.||...|||..
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

SLHDQTK-------------SLDGTQKTIIALGIACGMARLHSFN---IMHRDLKSLNILLDE------SYFPRICDFGASRIKSAESELVTQNIGTVHW
 ||....               |  ..  .|| .| ||. |||     | |||||| |||.||          .|||||.|| ..   .  . |.||. |
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYAW

MAPEMF---DSTNYTLAVDVYAYAILLWELLAEEIPYN-GYSVPQIMRTVCMNDQRLTIPQGTPPNLAKLIQLCWNRDPEKRPPFDRIFKIF
||||..    .. |. ..||. ....|||.|. |.||  .|.  .|   | .| .|..||.. |. ..||.. ||| ||.||| |. | ...
MAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase 85337.m00291.AA TKL-Unique 26-273 31 1.3e-65 224.26 In-house 3-290 (290) Show / Hide 
Range on Protein: 26-273
Range on HMM: 3-290/290
Sequence Identity: 31% (92 aa)

KKIGGGSFGDVYLAKYIPTGQMTAVKELK-HETLEEPFLQYFLREIRILAKCD-NYFLLHFTGYTA----THP-FLIVTEYIQNGSLFDSLH--------
.|||.|..| || .|.   |  .|.| ..  | ..  ..| | .|.... | .   ...|. ||..    . | . ||.||.. ||| | ||        
NKIGEGGYGQVYKGKW--RGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

-DQTKSLDGTQKTIIALGIACGMARLHSFN--IMHRDLKSLNILLDES-----YFPRICDFGASRIKSAESELVTQNI---------GTVHWMAPEMFDS
  . . |.  |.  .|. || || .||. .  |.||||||.|.|.|.      .  .||||| |...| ...  . ..         |.  |||||.. .
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRM

--TNYTLAVDVYAYAILLWELLAEEI------PYNGYSVPQIMRTVCM--NDQRLTIPQGTPPNLAKLIQLCWNRDPEKRPPFDRIFKIF
  . |.  .|||...| |||..  .|      || |..  |.  .|      .|..||.  |... .||| ||..||..|| || | .  
NFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase 85337.m00291.AA Dicty4 22-275 35 3.5e-64 212.98 In-house 1-277 (277) Show / Hide 
Range on Protein: 22-275
Range on HMM: 1-277/277
Sequence Identity: 35% (98 aa)

FQYEKKIGGGSFGDVYLAKYIPTGQMTAVKEL--KHETLEEPFLQYFLREIRILAKCDNYFLLHFTGYTAT---HP--FLIVTEYIQNGSLFDSLHD---
 . |..||.|||| ||...    |.  ||| |  . ....| .|. |..|. |..|  .  .. | |.      ||  ..|||||   |.|.  |||   
INIEQRIGKGSFGEVYKGTW--RGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPS

---QTKSLD-GTQKT--IIALGIACGMARLHS--FNIMHRDLKSLNILLDESYFPRICDFGASR----IKSAESELVTQNIGTVHWMAPEMFDSTNYTLA
   | ..|| .. |    .|. .| ||. ||.   .| |||||| |.| |...   .|||| |.    ...    . |. .||. |||||.  .  |. .
EQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTA-CGTPCWMAPEVMMHQPYNEK

VDVYAYAILLWELLAEEIPYN--GYSVPQIMRTVCMNDQRLTIPQGTPPNLAKLIQLCWNRDPEKRPPFDRIFKI--FKS
.||| ..|.|||.|  ..||.  . . .|. | ||    |. ||. .||....||| ||. ||..|| |  | ..    .
ADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase 85337.m00291.AA HH498 22-273 31 1.3e-58 184.32 In-house 1-284 (284) Show / Hide 
Range on Protein: 22-273
Range on HMM: 1-284/284
Sequence Identity: 31% (92 aa)

FQYEKKIGGGSFGDVYLAKYIPTGQMTAVKELKHETLEEPFL------QYFLREIRILAKCDNYFLLHFTGYTATHP--FLIVTEYIQNGSLFDSL----
. . .||| ||||.||. ..   . . |||  . ..  .           | ||. |. . ..     | . .   |  |.|||.|..|||||  |    
IEFHEKIGSGSFGKVYKGEW--RNKIVAVKRYRAMAFCCKSDSYQWIVDMFCREVSIMCRLNHPCVVQFVYACCDDPSQFAIVTQYCDNGSLFSILNTIP

----------HDQT---KSLDGTQKTIIALGIACGMARLHS---FNIMHRDLKSLNILLDESYFPRICDFGASR-IKSAESELVTQNIGTVHWMAPEMFD
          | |      .|   | .|.. .| ||  ||.     | |||| | |||..|     . ||| || ... . .  |  .|   ||||| | 
IGGAGANNNNHNQKNNYRIMDLQSKMTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIHEDGHAVVADFGESRFVCDMHDDNMTKQPGNLRWMAPEVFS

-STNYTLAVDVYAYAILLWELLAEEIPYNGYSVPQIMRTVCM-NDQ-RLTIPQG----TPPNLAKLIQLCWNRDPEKRPPFDRIFKIF
 .. |.  |||. ||. .||..  |.|.  |   ..     | . . | .|||      |     ||| ||.  || || || |  | 
QCQKYSIKVDVFSYAMCIWEMHTREVPFHHYK--PAAAAAEMAYHHIRPPIPQTPTAQIPHHWSNLIQMCWHPCPENRPDFDQIVTIL
Kinase 85337.m00291.AA Pkinase_Tyr 22-273 29 5e-54 183.59 Pfam 1-270 (270) Show / Hide 
Range on Protein: 22-273
Range on HMM: 1-270/270
Sequence Identity: 29% (79 aa)

FQYEKKIGGGSFGDVYLAKYI----PTGQMTAVKELKHETLEEP-FLQYFLREIRILAKC-DNYFLLHFTGYTA--THP--FLIVTEYIQNGSLFDSLHD
 .  ||.| |.||.||....      |..  ||| ||. . .|  ... |.||..|. .  ..  .. . |       |   .||.|| ..|.| | |..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

Q---TKSLDGTQKTIIALGIACGMARLHSFNIMHRDLKSLNILLDESYFPRICDFGASRIKSAESEL-VTQN--IGTVHWMAPE-MFDSTNYTLAVDVYA
.    ..|.  ..  ... ||.||. |.| |. ||||   |.|..|. . .||||| .|    ...  ...      . ||||| ....  .| . ||..
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGK-FTTKSDVWS

YAILLWELLA-EEIP-YNGYSVPQIMRTVCMNDQRLTIPQGTPPNLAKLIQLCWNRDPEKRPPFDRIFKIF
. .|.||..   |.| | | |  .... .  . .|. .|...|. . .|...||. |||.|| |  |  ..
FGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase 85337.m00291.AA S_TKc 22-279 26 1.7e-53 184.93 SMART 1-231 (231) Show / Hide 
Range on Protein: 22-279
Range on HMM: 1-231/231
Sequence Identity: 26% (72 aa)

FQYEKKIGGGSFGDVYLAKYIPTGQMTAVKELKHETLEEPFLQYFLREIRILAKCDNYFLLHFTGYTATHPFLIVTEYIQN--GSLFDSLHDQTKS----
..  .||| |.|| ||... . ||.  |.|..|         . ..|||.|| | .  .. .. ..  .. . .|.||. .  |.||| .... .     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-LDGTQKTIIALGIACGMARLHSFNIMHRDLKSLNILLDESYFPRICDFGASRIKSAESELVTQNIGTVHWMAPEMFDSTNYTL-AVDVYAYAILLWELL
 ..  .   ..  |.|... .|| .|.|||||  ||||||     ||||| .|.        |  .|| ..||||..    |.  ..|...  ..|.|.|
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML

AEEIPYNGYSVPQIMRTVCMNDQRLTIPQGTPPNLAKLIQLCWNRDPEKRPPFDRIFK---IFKSHKVS
. . |.    . .... ..            .| .  .|. |...||||||    ...     |.|   
CGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 85337.m00291.AA Dicty5 95-277 40 1.4e-52 179.28 In-house 76-260 (260) Show / Hide 
Range on Protein: 95-277
Range on HMM: 76-260/260
Sequence Identity: 40% (76 aa)

IVTEYIQNGSLFDSLHDQTK----SLDGTQKTIIALGIACGMARLHSFNIMHRDLKSLNILLDESYFPRICDFGASR-IKSAESELVTQNIGTVHWMAPE
.||||..|||||. | || |     .   |.  .|..|| .|  ||| || ||||||.|.|. | .   | ||| || .  .     | ..||  |||.|
HVTEYCHNGSLFNYLNDQRKTTGQPIAYFQQLHMAIDIAQSMRHLHSMNIIHRDLKSMNFLITENWKIKIIDFGTSRFVDNRYH--MTMHVGTQCWMACE

MFDSTNYTLAVDVYAYAILLWELLAEEIPYNGYSVPQIMRTVCMNDQRLTIPQGTPPNLAKLIQLCWNRDPEKRPPFDRIFKIFKSHK
.| .  |.  .|||...| |||...   ||       |   | |   | |||   |   ..||  ||   | .|| |  | |.|.|  
LFNGQPYHQKCDVYSFGIVLWEMFTRKEPYDNINNWNIPVMV-MKGERPTIPKDCPTEISNLIKKCWQQKPHNRPSFKEICKYFESII
Kinase 85337.m00291.AA TyrKc 22-273 26 9.6e-52 179.14 SMART 1-280 (280) Show / Hide 
Range on Protein: 22-273
Range on HMM: 1-280/280
Sequence Identity: 26% (76 aa)

FQYEKKIGGGSFGDVYLAKYIPTGQMTAVKELKHETLEEPFLQYFLREIRILAKC--DNYFLLHFTGYTAT--------HPFLIVTEYIQNGSLFDSLHD
 . .||.| | || ||.....   .. ||| ||...     .. |.||.||. |   ..  .. . |.  .        .| .||.||  .|.| | |..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

QTKSLDGTQKTIIALGIACGMARLHSFNIMHRDLKSLNILLDESYFPRICDFGASRIKSAE------SELVT-----QNI--GTVHWMAPEMFDSTNYTL
  . |   ..  ... |||||. ||| |. ||||   |.|..| .  .|.||| ||    .      ..  .     .      . ||||| ..   .| 
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT

AVDVYAYAILLWELLAEEIPYNGY-----SVPQIMRTVCMNDQRLTIPQG--------TPPNLAKLIQLCWNRDPEKRPPFDRIFKIF
. ||... ...||..    .           .| ..   ..  |. .|.          |. . .... ||..|||.|| |  | ..|
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 85337.m00291.AA TK 22-273 16 1e-51 171.23 In-house 1-486 (486) Show / Hide 
Range on Protein: 22-273
Range on HMM: 1-486/486
Sequence Identity: 16% (80 aa)

FQYEKKIGGGSFG---DVYLAKYIPTG-------------------------QMTAVKELK--HETLEEPFLQ----------YFLREIRILAKCD----
 ...||.| | ||   .||...... .                         . .||| ||  ... .| |..           ||.| ..... .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-NYFLLHFTGYTATH-------------PFLIVTEYIQNGS----LFDSLHDQTKS--------------------------------------------
    .... |.   .             |..||.|| ..|.    | | |..  .                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LDGTQKTIIALGIACGMARLHSF------NIMHRDLKSLNILLDESYF-----------PRICDFG---
                               |.  |.  ... |||||. |||       |. ||||   |.|..|..             .|.|||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----ASRIKSAESELVTQNIGTVH--------------------------WMAPEMFD---------STNYTLAVDVYAYAILLWELLA--EEIPYNGY
      .|    ... .... ...                           ||||| ..            .| . ||... .|.||..   .| .| | 
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

SV---------PQIMRTVCMN-----------DQRLTIP--QGTP--------------PNLAKLIQLCWNRDPEKRPPFDRIFKIF
|           ..|. ...             .|.  |  .. |              . .. |.| ||..|||.|| |. . . .
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase 85337.m00291.AA Pkinase 22-273 24 1.7e-51 182.22 Pfam 1-293 (293) Show / Hide 
Range on Protein: 22-273
Range on HMM: 1-293/293
Sequence Identity: 24% (72 aa)

FQYEKKIGGGSFGDVYLAKYIPTGQMTAVKELKHETLEEPFLQYFLR--EIRILAKCDNYFLLHFTGYTATHPFLI-VTEYIQNG----SLFDSLH-DQT
.. ..||| |||| ||... . ||.. |||..| .. .. ..|. .|  ||.|.....  . . . ..  ... .  |.|| ..|    .||| .. .. 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

KSL--DGTQKTIIALGIACGMARLHSFNIMHRDLKSLNILLDESYFP----RICDFGASRIK-SAESELVTQNIGTVHWMAPEMFD-STNYTLAVDVYAY
...  .  .   ... |..|.. .|| .|.|||||. |||.|. . .    .||||| .. .    ..  |   || ..||||    .. |. .||....
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

AILLWELLAEEIPYNGY------SVPQIMRTVCMNDQRLTIPQGTP-------------------PNLAKLIQLCWNRDPEKRPPFDRIFKI--F
 ..|.|.|  . |. |       .  |... . . . .  .|.  .                   ... ..|  |...||.||| .. |..   |
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 85337.m00291.AA UTK 22-273 26 8.3e-49 165.1 In-house 1-296 (296) Show / Hide 
Range on Protein: 22-273
Range on HMM: 1-296/296
Sequence Identity: 26% (78 aa)

FQYEKKIGGGSFGDVYLAKYIPTG-----QMTAVKELKHETLEEPFLQ---YFLREIR---ILAKCD-NYFLLHFTGY-TATHPFLIVTEYIQNGSLFDS
 |  ...| | ||.|..|.. .       .  |||...|.   . .     .|..| |   ......  . .| . |. |.  |..||||| .||.| . 
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LHDQTKSLD-------GTQKTIIALGIACGMARLHSFNIMHRDLKSLNILLDES-------YFPRICDFG---ASRIKSA--------ESELVTQN---I
| .......        .|..  |. ||.||. ||| .. ||||   |.|....       .. .|.|||    ||  ..        ||......   .
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

GTVHWMAPEMFDST-NYTLAVDVYAYAILLWELLAE-EIPYNGYSVPQIMRTVCMND-QRLTIPQGTPPNLAKLIQLCWNRDPEKRPPFDRIFKIF
 .. ||||| ...   .|.. ||... ...||...    || |.| .|.   ||  . .|.  |.. | .. .| . ||. ||..|| |... . .
WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase 85337.m00291.AA Dicty4-Unclassified 22-273 32 1.8e-48 164.13 In-house 1-263 (263) Show / Hide 
Range on Protein: 22-273
Range on HMM: 1-263/263
Sequence Identity: 32% (88 aa)

FQYEKKIGGGSFGDVYLAKYIPTGQMTAVKELKHETLEEP--FLQYFLREIRILAKCDNYFLLHFTGYTATHP------FLIVTEYIQNGSLFDSLH---
 |  . || | |  |.  | .  |   ||| .           .| |..|. ||       |.   || .  |      . ||.| .  | ||   |   
IQIDQFIGKGHFSKVH--KGNWKGKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGY-CINPRSHKSTMCIVMEFMHKGNLFEVIHSKP

---DQTKSLDGTQKTIIALGIACGMARLHSFNIMHRDLKSLNILLDESYFPRICDFGASRIKSAESELVTQNIG-TVHWMAPEMFDSTNYTLAVDVYAYA
   .|  .|| |    .|. || ||. ||. |. |||.|| |||.|  .  .| ||| ||  .    . |  |. |. | .||      |. . ||| ||
SEQQQPIKLDDTLIIKYAFDIAQGMQHLHTRNFIHRDIKSSNILMDKHFNIKIADFGISRVIDFNFNMTT--IAGTPKWESPECLMHESYNQKSDVYSYA

ILLWELLAEEIPYNGYS-VPQIMRTVCMNDQRLTIPQGTPPNLAKLIQLCWNRDPEKRPPFDRIFKIF
..|.||.  . || .   .  . | ||    |  ||   .... |||  ||  || ||| .. | .  
MMLYELATGDEPYQEIQSIMNAARSVCDKKLRPKIPDNCDNFWKKLIKWCWHNDPNKRPTMNQIIQYL
Kinase 85337.m00291.AA LRRK 91-275 34 1.2e-43 151.34 In-house 128-351 (351) Show / Hide 
Range on Protein: 91-275
Range on HMM: 128-351/351
Sequence Identity: 34% (77 aa)

HPFLIVTEYIQNGSLFDSLHDQTKS--------LDGTQKTIIALGIACGMARLHSFN--IMHRDLKSLNILLDESYFP------------RICDFGASR-
||. .|.||...|.| . ||.  ..        .. . |  ||| || ||. |||.|  | |||||| |||| .|  .             |.||| || 
HPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISRM

IKSAESELVTQNIGTVHWMAPEMFDST---NYTLAVDVYAYAILLWELLAEE-IPYNGYS-VPQI--MRTVCM---NDQRLTIPQG-TPP-----NLAKL
 ..  ....    |.  |||||    .   .||  ||.|.....|||||  . .|. ... . ..  | ..     . .| ||||   ||      . .|
FQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIEDKIIEGLRPTIPQHYCPPCQPWHMYQDL

IQLCWNRDPEKRPPFDRIFKIFKS
||.||. ||.||| |  |.|. ..
IQHCWQHDPKKRPHFSQIVKRLSQ
Kinase 85337.m00291.AA LRRK 22-54 21 7.9e-05 12.99 In-house 1-60 (351) Show / Hide 
Range on Protein: 22-54
Range on HMM: 1-60/351
Sequence Identity: 21% (13 aa)

FQYEKKIGGGSFG-DVYLAKYI--------------------------PTGQMTAVKELK
. .|..|| |.||  || ||..                            .|..|.| ..
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWN