Gene 87082.m00003 (T.vaginalis)

87082.m00003

Species: T.vaginalis
Alias: TvagK0393, 87082.m00003
External Links:
Annotation:

Classification

Group: AGC
Family: Akt

Sequence

Name Sequence Type Origin Length Description Download
87082.m00003.AA Protein None 238 None Fasta, JSON
87082.m00003.kin_dom Protein Kinase Domain None 107 None Fasta, JSON

Protein domain

Protein domains of 87082.m00003.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PH 87082.m00003.AA PH 10-107 21 9.5e-11 42.96 SMART 1-82 (82) Show / Hide 
Range on Protein: 10-107
Range on HMM: 1-82/82
Sequence Identity: 21% (21 aa)

YGLKSWLKKKGTNQGLWHKRFVTLNEKKIVISKDEEQTHIEQVIDLGPDTTAEIVTGASTPRFQVIPSAGADPLLFTAGSPEEVARWVAAINQIKLPM
  .. ||.||.     |.||...| .. ... ||.       .|.|    | .  .      |...   .   ..| . |.||  .|..||..   . 
VIKEGWLYKKS--K-RWKKRWFVLFNDCLYYYKDK---KPKGSIPLSDC-TVRE-P-----CFEIHH-DR--TYYFQCESEEEMQEWMQAIQKAIHNN
PH 87082.m00003.AA PH 10-105 23 2.4e-08 32.72 Pfam 1-92 (92) Show / Hide 
Range on Protein: 10-105
Range on HMM: 1-92/92
Sequence Identity: 23% (23 aa)

YGLKSWLKKKGTNQGLWHKRFVTLNEKKIVISKDEEQTHIEQVIDLGPDTTAEIVTGAS---TPRFQVIPSAGADPLLFTAGSPEEVARWVAAINQIKL
  .. ||.|||   . |.||...| ...... ||.       .|.|    ......  .      ||..   . . ..| | |.||  .|..||...  
VIKEGWLHKKG-KRKSWKKRWFVLFNNCLYYYKDDK-YRPKGSIPL---SDCQVTKVPDNKRPHCFQIRT-DR-RTYYFQAESEEEMNDWMQAIQSACR
Kinase 87082.m00003.AA AGC 115-221 29 2.1e-50 127.42 In-house 1-154 (395) Show / Hide 
Range on Protein: 115-221
Range on HMM: 1-154/395
Sequence Identity: 29% (45 aa)

FRIISVIGRGFYGKVMLVQKL------DTGDLYAIKSIHKSR---INEPGKANSVLAE------------RNIMMRAH----------YPFLVN-LCFAF
|... |||.| .|||.||.|       |||..||.| . |..   |..  .   ...|            |||.....           ||.|. | ..|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTPAK--FYLGLEYAA---------GG-ELFYHM--D-KVGTIPLNDARLYIAE
|.. .   |. .||.          || |||.|.  . | |. . . || |.||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAE
Kinase 87082.m00003.AA Akt 115-221 40 3.3e-42 132.69 In-house 1-108 (264) Show / Hide 
Range on Protein: 115-221
Range on HMM: 1-108/264
Sequence Identity: 40% (44 aa)

FRIISVIGRGFYGKVMLVQKLDTGDLY-AIKSIHKSRINEPGKANSVLAERNIMMRAHYPFLVNLCFAFQTPAKFYLGLEYAAGGELFYHMDKVGTIPLN
|... |.|.| .|||.||.| ||...| |.|.. |..| . ..   ...||||  .   ||.||| ..|||. | |. ..|. |||||||. . .... .
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

DARLYIAE
 || |.||
RARFYCAE
Kinase 87082.m00003.AA SGK 115-221 32 6.7e-37 111.16 In-house 1-133 (283) Show / Hide 
Range on Protein: 115-221
Range on HMM: 1-133/283
Sequence Identity: 32% (43 aa)

FRIISVIGRGFYGKVMLVQKLDT------------------GDLYAIKSIHKSRIN-------EPGKANSVLAER-NIMMRAHYPFLVNLCFAFQTPAKF
|....||| | .|||..|.. |.                  ...||.| . |  |           ... ..||| .|.     ||.||| .||||. | 
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

YLGLEYAAGGELFYHMDKVGTIPLNDARLYIAE
|. ..|. |||.|||. . .  |   || | ||
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAE
Kinase 87082.m00003.AA AktR 115-221 40 8.2e-34 118.65 In-house 1-109 (268) Show / Hide 
Range on Protein: 115-221
Range on HMM: 1-109/268
Sequence Identity: 40% (44 aa)

FRIISVIGRGFYGKVMLVQKL-DTGDLYAIKSIHKSRINEPGKANSVLAERNIMM-RAHYPFLVNLCFAFQTPAKFYLGLEYAAGGELFYHMDKVGTIPL
|... ..|.| .|||.||||. |....||.|.|.|. | |  ..  .. |||||   .  ||.|.| ..|||  | .. .|| .|||||.|  | ...  
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

NDARLYIAE
..|| |.|.
EQARFYFAQ
Kinase 87082.m00003.AA RSK-Unclassified 115-221 39 2.7e-32 98.34 In-house 1-109 (283) Show / Hide 
Range on Protein: 115-221
Range on HMM: 1-109/283
Sequence Identity: 39% (43 aa)

FRIISVIGRGFYGKVMLVQKLDTGDLYAIKSIHKSRINEPGKANSVLAERNIMMRAHYPFLVNLCFAFQTPAKFYLGLEYAAGGELFYHMD--KVGTIPL
|  .  ||.|  ||| ||.| ||  .||.|  ||...    |   |. |.|||     || | | ..|||  . || .||  ||..| |.   |   .  
FIKHRLIGQGDFGKVYLVRKKDTQQIYAMKVLHKHKMIRHNKIKYVMTEQNIMATTNHPFIVTLYHSFQTQDYLYLCMEYCMGGDFFRHLQTRKEKCFCE

NDARLYIAE
.|.| |..|
DDVRFYASE
Kinase 87082.m00003.AA RSK 118-221 41 6.8e-27 95.52 In-house 1-112 (278) Show / Hide 
Range on Protein: 118-221
Range on HMM: 1-112/278
Sequence Identity: 41% (47 aa)

ISVIGRGFYGKVMLVQKL---DTGDLYAIKSIHKSRINEPGK-ANSVLAERNIMMRAH-YPFLVNLCFAFQTPAKFYLGLEYAAGGELFYHMDKVGT---
..| |.| |||| |..|    ||| .|| | ..|. |    | .  ...||||..|    ||.|.|  ||||. |.|| .||  |||||.|  | ..   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

IPLNDARLYIAE
.  ..|. |.||
FSEDEACFYMAE
Kinase 87082.m00003.AA Iota 115-224 37 3.8e-26 83.7 In-house 1-111 (271) Show / Hide 
Range on Protein: 115-224
Range on HMM: 1-111/271
Sequence Identity: 37% (42 aa)

FRIISVIGRGFYGKVMLVQKLDTGDLYAIKSIHKSRINEPGKANSVLAERNIMMRA-HYPFLVNLCFAFQTPAKFYLGLEYAAGGELFYHMDKVGTIPLN
|..| ||||| | ||..|.   |  .||.| | |  .|.      |  |. .   |  .|||| |   |||... .. .|.  ||.| .|| .   .|  
FELIRVIGRGSYAKVLMVEHKKTRRIYAMKVIKKEMVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEFVNGGDLMFHMQRQRKLPEE

DARLYIAESAL
 || | || .|
HARFYSAEICL
Kinase 87082.m00003.AA PKC 115-221 33 4.9e-26 81.24 In-house 1-108 (262) Show / Hide 
Range on Protein: 115-221
Range on HMM: 1-108/262
Sequence Identity: 33% (36 aa)

FRIISVIGRGFYGKVMLVQKLDTGDLYAIKSIHKSRINEPGKANSVLAERNIMMRAH-YPFLVNLCFAFQTPAKFYLGLEYAAGGELFYHMDKVGTIPLN
|. . |.|.| .|||||. . .|  .|||| . |  |..     ....|. ..  |  .|||..|   |||. . .  .||  || | .|. ...  .. 
FNFLKVLGKGSFGKVMLAERKGTDEYYAIKVLKKDVIIQDDDVECTMTEKRVLALAWKHPFLTHLHCCFQTMDRLFFVMEYVNGGDLMFHIQQQRRFKEE

DARLYIAE
 || | ||
HARFYAAE
Kinase 87082.m00003.AA p70 115-221 33 2.2e-25 88.93 In-house 1-136 (299) Show / Hide 
Range on Protein: 115-221
Range on HMM: 1-136/299
Sequence Identity: 33% (46 aa)

FRIISVIGRGFYGKVMLVQKLD---TGDLYAIKSIHKSRINEPGKA-NSVL-------------------------AERNIMMRAHYPFLVNLCFAFQTP
|  . |.|.| ||||..| |     || .|| | . |  |    |.  .                           |||||      ||.. | .|||| 
FELLKVLGKGGYGKVFQVRKVTGEDTGKIYAMKVLRKAKIVRNQKDTAHTREDEDKNDGNNNDNDDGLSKRLERTFAERNILEEVKHPFICDLHYAFQTN

AKFYLGLEYAAGGELFYHMDKVGTIPLNDARLYIAE
 | || |||  |||||.|  . |. . . |. | .|
GKLYLILEYLHGGELFMHLERHGIWMEDTACFYLSE
Kinase 87082.m00003.AA PKA 115-221 33 2e-24 87.46 In-house 1-109 (263) Show / Hide 
Range on Protein: 115-221
Range on HMM: 1-109/263
Sequence Identity: 33% (36 aa)

FRIISVIGRGFYGKVMLVQKLDTGDLYAIKSIHKSRINEPGKANSVLAERNIMMRAHYPFLVN-LCFAFQTPAKFYLGLEYAAGGELFYHMDKVGTIPLN
| || ..|.| .|.|||... ..|. ||.| . |..|        |. |.||..  . ||.|. . . ||.. . |. .||..|||.|... |.|  .  
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP

DARLYIA-E
.|..|.| .
HAKFYAASQ
Kinase 87082.m00003.AA Pkinase 115-221 25 5.5e-15 54.06 Pfam 1-116 (293) Show / Hide 
Range on Protein: 115-221
Range on HMM: 1-116/293
Sequence Identity: 25% (29 aa)

FRIISVIGRGFYGKVMLVQKLDTGDLYAIKSIHKSRINEPGKANSVL-AERNIMMRAHYPFLVNLCFAFQTPAKFYLGLEYAAGG----ELFYHMD--KV
..|...||.| .|.| . .. .||...|.| | |.....  . . .. .|  || | . |. | |  .|... . |. .||. ||    .|| ..   . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GTI--PLNDARLYIAE
|..  . .... |. .
GCFYFSEWECKFYMYQ
Kinase 87082.m00003.AA S_TKc 115-234 14 2.3e-07 -68.95 SMART 1-231 (231) Show / Hide 
Range on Protein: 115-234
Range on HMM: 1-231/231
Sequence Identity: 14% (36 aa)

FRIISVIGRGFYGKVMLVQKLDTGDLYAIKSIHKSRINEPGKANSVLAERNIMMRAHYPFLVNLCFAFQTPAKFYLGLEYAAG--GELFYHMDKVGT---
..|. .||.| .|||..... .|| ..||| |.          .... |..|... | |..|.|  .||.  ..|. .||. |  |.|| ...| |.   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---IPLNDARLYIAE---------------------------------------------------------SA--------------------------
   .|  .|| |...                                                         .                           
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDEHIKICDFGLARQLTTFCGTPWYMAPEVLGYGKCKCDWWSCGCILYEMLCGYPPFPQMQ

---------------------LPS-----HIST-------HWVL
                      |.      . .       |  .
MMFKKIGSPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF