Gene 86587.m00091 (T.vaginalis)

86587.m00091

Species: T.vaginalis
Alias: TvagK0389, 86587.m00091
External Links:
Annotation:

Classification

Group: AGC
Family: Akt

Sequence

Name Sequence Type Origin Length Description Download
86587.m00091.AA Protein None 417 None Fasta, JSON
86587.m00091.kin_dom Protein Kinase Domain None 251 None Fasta, JSON

Protein domain

Protein domains of 86587.m00091.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PH 86587.m00091.AA PH 3-98 19 2.5e-12 48.22 SMART 1-82 (82) Show / Hide 
Range on Protein: 3-98
Range on HMM: 1-82/82
Sequence Identity: 19% (19 aa)

TTIEGWLHKKDPENSLWHRRYCILTENKLMIQKSQGEDYENFVSLTGDVKVEIDDKKPPPRIHIITDKNEVITLSSPDEPVLNKWAFLIIGATMNR
...||||.||   .  |..|...|... |.. |.   ..  ...|..  .|.  .      . |.. .. ..... ..|  ...|   |  |. | 
VIKEGWLYKKS--K-RWKKRWFVLFNDCLYYYKDK--KPKGSIPLSDC-TVRE-P-----CFEIHH-DR-TYYFQCESEEEMQEWMQAIQKAIHNN
PH 86587.m00091.AA PH 3-87 23 3.6e-10 39.31 Pfam 1-83 (92) Show / Hide 
Range on Protein: 3-87
Range on HMM: 1-83/92
Sequence Identity: 23% (20 aa)

TTIEGWLHKKDPENSLWHRRYCILTENKLMIQKSQGEDYENFVSLTGDVKVEIDDKKPPPRIHIITDKNE-VITLSSPDEPVLNKW
 ..|||||||   .. |..|...|..|.|.. |. ....   ..| .  .|..... . | .  |.  .. ..... ..|  .| |
VIKEGWLHKKG-KRKSWKKRWFVLFNNCLYYYKDDKYRPKGSIPLSDC-QVTKVPDNKRPHCFQIRT-DRRTYYFQAESEEEMNDW
Kinase 86587.m00091.AA AGC 106-356 32 2.3e-174 455.35 In-house 1-395 (395) Show / Hide 
Range on Protein: 106-356
Range on HMM: 1-395/395
Sequence Identity: 32% (129 aa)

FRIISVLGRGYYGKVMLCEEN------TTKELYAIKTIHKKM-LVNSD--KVQNALTE------------RNVLVRVH----------HPFIVS-LKTTF
|... |.|.| .|||.|....      .|...||.| . ||   |  .  .|....||            ||.|....          |||||. |. .|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTPTK--LYFAMEYAP---------GG-ELFFHLE---RKGAFHIHDVRIYVAE-------LALAIEYLHD-NNIIYRD-IKPENILLDSEGHVKITDFG
|....  ||| |||.|         || |||.||    ..| |    .|.| ||       ..||.||||. ..||.|| .||||||||..||.|.||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LSKEME----------------------------------------------------EDTTSTLCG--SPNYMAPEIITHTRYGPAVDWWS--LGILMY
|.||.                                                     .|.|.|.||  .|.||||||.    ||.|.||||  ||.|||
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMLFGVQPFVNEN----------KSVLLMMIA------TCRVSFP----------RNANPDAQSLILGLLQKNPSERFG----------FEQIKSHPFF
|||.|  || ..|          .  .   |       ...| ||          |.  |.|..|| .||.|.|..| |          .|.||.||.|
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 86587.m00091.AA Akt 106-356 46 1.9e-142 458.19 In-house 1-264 (264) Show / Hide 
Range on Protein: 106-356
Range on HMM: 1-264/264
Sequence Identity: 46% (122 aa)

FRIISVLGRGYYGKVMLCEENTTKELY-AIKTIHKKMLVNSDKVQNALTERNVLVRVHHPFIVSLKTTFQTPTKLYFAMEYAPGGELFFHLERKGAFHIH
|... |||.| .|||.|.... |...| |.| . |..... ..|....||||.|... |||||.|.  |||..|||| |.|..|||||.|| ||. |   
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

DVRIYVAELALAIEYLHDNNIIYRD-IKPENILLDSEGHVKITDFGLSKEM---EEDTTSTLCGSPNYMAPEIITHTRYGPAVDWWS-LGILMYEMLFGV
  | |.||. ||||.|| .||||||  ||||||.|..||...|||||.||.   . |.| |.||.| |.||||.  . .. |||||. ||..||||..| 
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGR

QPFVNENKSVLLMMIATCRVSFP--RNANPDAQSLILGLLQKNPSERFG-----FEQIKSHPFF
 || |... ..   | .. | ||  ..  |....|| |||.|.|..| |      ..||.||.|
PPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase 86587.m00091.AA SGK 106-356 39 1.8e-132 411.64 In-house 1-283 (283) Show / Hide 
Range on Protein: 106-356
Range on HMM: 1-283/283
Sequence Identity: 39% (112 aa)

FRIISVLGRGYYGKVMLCEENTT------------------KELYAIKTIHKKMLV-------NSDKVQNALTER-NVLVRVHHPFIVSLKTTFQTPTKL
|....|.| | .|||.. .   .                  . .||.| . |.  .       .  .. . ..|| ..|. . |||||.|.  |||..||
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

YFAMEYAPGGELFFHLERKGAFHIHDVRIYVAELALAIEYLHDNNIIYRDIKPENILLDSEGHVKITDFGLSK-EMEE-DTTSTLCGSPNYMAPEIITHT
|| |.|. |||.|.|| | . |  . .|.|.||...|.||||. .||||| ||||||||..||...|||||.| .... |||.| ||.| |.|||.. . 
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRKQ

RYGPAVDWWSLGILMYEMLFGVQPFVNENKSVLLMMIATCRVSFPRNANPDAQSLILGLLQKNPSERFGFE----QIKSHPFF
 .. .||||.||...|||..|  || . ||. .   |      .|..  .|| .|| |||||.|..| |      .||.||||
PHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPFF
Kinase 86587.m00091.AA AktR 106-356 45 4e-124 418.65 In-house 1-268 (268) Show / Hide 
Range on Protein: 106-356
Range on HMM: 1-268/268
Sequence Identity: 45% (121 aa)

FRIISVLGRGYYGKVMLCEEN-TTKELYAIKTIHKKMLVNSDKVQNALTERNVLV-RVHHPFIVSLKTTFQTPTKLYFAMEYAPGGELFFHLERKGAFHI
|... .||.| .|||.|.... .....||.| |.|| ...  . . ..||||..   . ||||| |. .||| .||.|.||| ||||||.|| .|. |  
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

HDVRIYVAELALAIEYLHDN-NIIYRDIKPENILLDSEGHVKITDFGLSK---EM-EEDTTSTLCGSPNYMAPEIITH-TRYGPAVDWWSLGILMYEMLF
 ..|.| |.  ||.||||.. ||||||.||||||||..||||||||||||    | ..... ..||.| |||||.||    .. .||||..||. |||..
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVT

GVQPFVNENKSVLLMMIATCR-VSFPRNANP--DAQSLIL-GLLQKNPSERFG-----FEQIKSHPFF
|  || ..|.  .. .| ... ..|| ....   ...||  .||.||| .| |     .|.|||||.|
GCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase 86587.m00091.AA RSK 109-356 41 2.3e-115 389.57 In-house 1-278 (278) Show / Hide 
Range on Protein: 109-356
Range on HMM: 1-278/278
Sequence Identity: 41% (114 aa)

ISVLGRGYYGKVMLCEEN---TTKELYAIKTIHKKMLVNSDK-VQNALTERNVLVRVH-HPFIVSLKTTFQTPTKLYFAMEYAPGGELFFHLERKGA---
..|||.| |||| || .     |. .|| | ..|...|...| .  ..||||.| |.  |||||.|. .|||..|||  ||| .||||| ||....    
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FHIHDVRIYVAELALAIEYLHDNNIIYRDIKPENILLDS---EGHVKITDFGLSKEM---EEDTTSTLCGSPNYMAPEIIT---HTR-YGPAVDWWSLGI
|  .....| ||..||.|.||.  ||.||.||||||.|.   |||.|.||||..|..   ..  | | |.. .|||||...   . . .. |.||||||.
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LMYEMLFGVQPFVN---ENKSVLLMMIATCR--VSFP--RNANPDAQSLILGLLQKNPSERFG-----FEQIKSHPFF
||||||.|  || .   .|.....  | ...  ...|   .  ..|..|| ..|...|. | |      |.||.||.|
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 86587.m00091.AA PKA 106-356 43 8.3e-112 377.75 In-house 1-263 (263) Show / Hide 
Range on Protein: 106-356
Range on HMM: 1-263/263
Sequence Identity: 43% (116 aa)

FRIISVLGRGYYGKVMLCEENTTKELYAIKTIHKKMLVNSDKVQNALTERNVLVRVHHPFIV-SLKTTFQTPTKLYFAMEYAPGGELFFHLERKGAFHIH
| || .||.| .|.|||| . .... ||.|.. |   |    |.  ..|.|.|  ..||||| ... |||....||. |||.||||.| .| ..| |   
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP

DVRIYVA-ELALAIEYLHDNNIIYRDIKPENILLDSEGHVKITDFGLSKEMEEDTTSTLCGSPNYMAPEIITHT-RYGPAVDWWSLGILMYEMLFGVQPF
. ..|.| .  ||.||||  |||||| ||||||.|..||.|||||| .|....  |.|||| | |.|||||. .  .| .||||.|||| ||||.|. ||
HAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAKKVDD-RTWTLCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGYPPF

VNE--NKSVLLMMIATCRVSFPRNANPDA---QSLILGLLQKNPSERF-----GFEQIKSHPFF
 ..  ..  .   |. ... |||. ..||    .||  |||.....|.     | ..|| |..|
YDHNRDPMQIYEKICNGKIKFPRHFDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF
Kinase 86587.m00091.AA PKC 106-356 43 9.20000000001e-108 350.4 In-house 1-262 (262) Show / Hide 
Range on Protein: 106-356
Range on HMM: 1-262/262
Sequence Identity: 43% (115 aa)

FRIISVLGRGYYGKVMLCEENTTKELYAIKTIHKKMLVNSDKVQNALTERNVLVRVH-HPFIVSLKTTFQTPTKLYFAMEYAPGGELFFHLERKGAFHIH
|. . |||.| .||||| |   |.|.|||| . | . .  | |  ..||. ||     ||| ..|  .|||. .|.|.|||  || | ||  . . |   
FNFLKVLGKGSFGKVMLAERKGTDEYYAIKVLKKDVIIQDDDVECTMTEKRVLALAWKHPFLTHLHCCFQTMDRLFFVMEYVNGGDLMFHIQQQRRFKEE

DVRIYVAELALAIEYLHDNNIIYRDIKPENILLDSEGHVKITDFGLSKE--MEEDTTSTLCGSPNYMAPEIITHTRYGPAVDWWSLGILMYEMLFGVQPF
  | | || ..|  .||...||||| | .|.|||.|||.||.|||..||  ...||||| || |.|.||||.    ||..||||..|.|||||. |  ||
HARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNGDTTSTFCGTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMMAGQSPF

VNENKSVLLMMIATCRVSFPRNANPDAQSLILGLLQKNPSERFGF--------EQIKSHPFF
  |.   |   | . ....||    .| |.. |...|||..| |         . |..||||
HGEDEDELFQSIMHDNPHYPRWLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIREHPFF
Kinase 86587.m00091.AA S_TKc 106-356 34 3e-107 363.52 SMART 1-231 (231) Show / Hide 
Range on Protein: 106-356
Range on HMM: 1-231/231
Sequence Identity: 34% (93 aa)

FRIISVLGRGYYGKVMLCEENTTKELYAIKTIHKKMLVNSDKVQNALTERNVLVRVHHPFIVSLKTTFQTPTKLYFAMEYAPG--GELFFHLERKGA---
..|. ..|.| .|||..| .. |....||| |.          .... |...| . |||.|| |. .||. ..||. |||..|  |.|| .....|    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FHIHDVRIYVAELALAIEYLHDNNIIYRDIKPENILLDSEGHVKITDFGLSKEMEEDTTSTLCGSPNYMAPEIITHTRYGP-AVDWWSLGILMYEML
   |.  ..| |......|.||.|...||.||.||||||||.  |.||.||||....     .|.||.|.|||||..    ||. ..||||.|...||||
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML

FGVQPFVNENKSVLLMMIATCRVSFPRNANPDAQSLILGLLQKNPSERFGFEQIKS-------HPFF
 |  ||   .  ... .|            |.| ..| ..|||.|..| .  ..         ||.|
CGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 86587.m00091.AA RSK-Unclassified 106-356 38 1.8e-99 313.11 In-house 1-283 (283) Show / Hide 
Range on Protein: 106-356
Range on HMM: 1-283/283
Sequence Identity: 38% (110 aa)

FRIISVLGRGYYGKVMLCEENTTKELYAIKTIHKKMLVNSDKVQNALTERNVLVRVHHPFIVSLKTTFQTPTKLYFAMEYAPGGELFFHLE--RKGAFHI
|  .  .|.|  ||| | ..  |. .||.|  ||. ..   |.. ..||.|..    ||||| |   |||  .||  ||| .||..| ||   ..  |  
FIKHRLIGQGDFGKVYLVRKKDTQQIYAMKVLHKHKMIRHNKIKYVMTEQNIMATTNHPFIVTLYHSFQTQDYLYLCMEYCMGGDFFRHLQTRKEKCFCE

HDVRIYVAELALAIEYLHDNNIIYRDIKPENILLDSEGHVKITDFGLSKEM-----------------------EEDTTSTLCGSPNYMAPEIITHTRYG
 |||.|..|  .| ||||   .|||| ||.||.|. ||||. |||.||..                        .   |   ||.  |.|||.|     .
DDVRFYASEVTAALEYLHKRDFIYRDLKPDNIVLHQEGHVMLTDFDLSIQAKDSKKPVMKGSAQSTYVDTKICDHGFRTNSFCGTEEYLAPEMIRRCGHT

PAVDWWSLGILMYEMLFGVQPFVNENKSVLLMMIATCRVSFP--RNANPDAQSLILGLLQKNPSERFG-----FEQIKSHPFF
 ||||| |||.|||||||. |.  .||  .   | .  |.||       ....||  |||.||. | |      . || ||||
KAVDWWTLGIVMYEMLFGCPPYYGNNKNETFYNIEKNHVKFPHDSYISNNCRDLIKKLLQRNPAKRLGCKMGDADDIKRHPFF
Kinase 86587.m00091.AA Pkinase 106-356 31 3.7e-97 333.87 Pfam 1-293 (293) Show / Hide 
Range on Protein: 106-356
Range on HMM: 1-293/293
Sequence Identity: 31% (93 aa)

FRIISVLGRGYYGKVMLCEENTTKELYAIKTIHKKMLVNSDKVQNAL-TERNVLVRVHHPFIVSLKTTFQTPTKLYFAMEYAPGG----ELFFHLE--RK
..|....|.| .|.| .| .  | ...|.|.| |.    . ...... .|  .. |..||.|| |. .|......|. |||..||    .|| ...  |.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GAF--HIHDVRIYVAELALAIEYLHDNNIIYRDIKPENILLDSEGHV----KITDFGLSK---EMEEDTTSTLCGSPNYMAPEIIT-HTRYGPAVDWWSL
|.|    .... |. ... ..||.|...||.||.||||||.|..||.    ||.||||.|   .     ..|.||.|.|||||.|  .. |||.||.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GILMYEMLFGVQPFVNE------NKSVLLMMIATCRVSFPR---------------------NANPDAQSLILGLLQKNPSERFGFEQIKSHPFF
|...||||.|  || ..      .. ... .|  ....|..                     |........| ..|.|.|..| ..|||. ||.|
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 86587.m00091.AA p70 106-356 37 3.9e-93 315.73 In-house 1-299 (299) Show / Hide 
Range on Protein: 106-356
Range on HMM: 1-299/299
Sequence Identity: 37% (113 aa)

FRIISVLGRGYYGKVMLCEENT---TKELYAIKTIHKKMLVNSDKVQNALT--------------------------ERNVLVRVHHPFIVSLKTTFQTP
|  . |||.| ||||..    |   |  .|| | . | . | . |                                |||.|  | ||||. |   ||| 
FELLKVLGKGGYGKVFQVRKVTGEDTGKIYAMKVLRKAKIVRNQKDTAHTREDEDKNDGNNNDNDDGLSKRLERTFAERNILEEVKHPFICDLHYAFQTN

TKLYFAMEYAPGGELFFHLERKGAFHIHDVRIYVAELALAIEYLHDNNIIYRDIKPENILLDSEGHVKITDFGLSKEMEEDTTS------------TLCG
 |||   || .||||| ||||.| .    .. | .|  .|.|.||   ||||| ||||..|.. |||. |||||.||  .| .             |.||
GKLYLILEYLHGGELFMHLERHGIWMEDTACFYLSEIICALEHLHQHGIIYRDLKPENCMLNQQGHVVLTDFGLCKESIHDGAVDEEDPENVNATHTFCG

SPNYMAPEIITHTRYGPAVDWWSLGILMYEMLFGVQPFVNENKSVLLMMIATCR--VSFPRNANPDAQSLILGLLQKNPSERFG-----FEQIKSHPFF
 . ||||||.. . .. ||||||||.||| || |. ||  ||. .    |  ..  .. |    ...  ||  || ..|..| |      ..|..||||
TIEYMAPEILMRCGHNHAVDWWSLGCLMYDMLTGGPPFTGENRKKTIDKILKGKQGLKLPPYLTHEMRDLIKKLLKRHPTQRWGAGPEDAADIQEHPFF
Kinase 86587.m00091.AA RSK 106-356 37 7.2e-92 311.51 In-house 1-271 (271) Show / Hide 
Range on Protein: 106-356
Range on HMM: 1-271/271
Sequence Identity: 37% (102 aa)

FRIISVLGRGYYGKVMLCEEN---TTKELYAIKTIHKKMLVNSDKVQNALTERNVLVRVHHPFIVSLKTTFQTPTKLYFAMEYAPGGELFFHLERKGAFH
. .....|.| ..|| .|       |. .||.| | |. ....|. . . .||..|  .|||||| |.  ||. .|.|  |. . ||.|| .| ... | 
YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDR-VCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMFS

IHDVRIYVAELALAIEYLHDNNIIYRDIKPENILLDSE----GHVKITDFGLSKEM--EEDTTSTLCGSPNYMAPEIITHTRYGPAVDWWSLGILMYEML
  .|..| ||.||| ||||   |..|| ||||||.|.|    ||.||.|||..|..  |.  . | |.. ||||||..    .. |.||||.|.||||||
EREVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQLRDENGMLMTFCYTANYMAPEVLKRQGHDQACDWWSFGVLMYEML

FGVQPFVNENKSVLLMMIATCRVSF-------PRNANPDAQSLILGLLQKNPSERFGF-----EQIKSHPFF
 |  ||.| ..  .  .|.   .         . .  . |..|. ..|  .|  | |      ||||.||.|
TGCTPFQNKPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase 86587.m00091.AA Pkinase_Tyr 106-296 27 6.1e-19 64.78 Pfam 1-208 (270) Show / Hide 
Range on Protein: 106-296
Range on HMM: 1-208/270
Sequence Identity: 27% (57 aa)

FRIISVLGRGYYGKVMLCEEN----TTKELYAIKTIHKKMLVNSDK--VQNALTERNVLVRV-HHPFIVSLKTTFQ--TPT-KLYFAMEYAPGGELFFHL
 ... .||.| .|.|.... .     ||   |.|..  |    ..    .  . | ...    ||| ||.|           ..|  |||.|.| |  .|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML--KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

ER----KGAFHIHDVRIYVAELALAIEYLHDNNIIYRDIKPENILLDSEGHVKITDFGLSKEM-EEDTT-STLC---GSPNYMAPEIITHTRYGPAVDWW
 .    |... ..|   . .. | . |||...|.| ||.   |.|......|||.||||.. . ..|.   .          |||| | . ..  . | |
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVW

SLGILMYEML
| |.||.|..
SFGVLMWEIF
Kinase 86587.m00091.AA TyrKc 106-356 23 2.1e-18 68.37 SMART 1-280 (280) Show / Hide 
Range on Protein: 106-356
Range on HMM: 1-280/280
Sequence Identity: 23% (69 aa)

FRIISVLGRGYYGKVMLCEENTTKELYAIKTIHKKMLVNSDKVQNALTERNVLVRV--HHPFIVSLKTTFQTP-------TKLYFAMEYAPGGELFFHLE
 . . .||.| .|.|.... .   .  |.|....        ..  . | ... ..  ||| || |     ..         |.  |||.|.| |  .| 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

RKGA-FHIHDVRIYVAELALAIEYLHDNNIIYRDIKPENILLDSEGHVKITDFGLSKEMEED------TTSTLC----GSP-----NYMAPEIITHTRYG
...  .   |   .    |   ||||..|.| ||.   |.|......|||.|||||.. ..|      .         |.        |||| | . .. 
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

PAVDWWSLGILMYEML-FGVQPFVN------ENKSVLLMMIATCRVSFPRN--------ANPDAQSLILGLLQKNPSERFGFEQIKSHPFF
.. | || |..|.|.. .| ||  .      .|. |.    .  |   | |        . ..  ....   . .|..|  |..|  | .|
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 86587.m00091.AA S_TK_X 357-416 27 1e-05 25.96 SMART 1-79 (79) Show / Hide 
Range on Protein: 357-416
Range on HMM: 1-79/79
Sequence Identity: 27% (22 aa)

QGRDFDDYLQ--KKVKPIFVPISL----RRTDPVNFSTEFTQETPTDSVGSPLSCNK-------------EFEGFSFNG
 | |.|. ..  |...| |.|         ||  || .||| |||.... .| ..|              .|.||... 
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF