TVAG_166980

Species: T.vaginalis
Alias: TVAG_166980, TvagK1052
External Links:
Annotation:

Classification

Group: Other
Family: PEK
Subfamily: GCN2

Sequence

Name Sequence Type Origin Length Description Download
TVAG_166980.AA Protein None 850 None Fasta, JSON
TVAG_166980.kin_dom Protein Kinase Domain None 282 None Fasta, JSON

Protein domain

Protein domains of TVAG_166980.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase TVAG_166980.AA GCN2 362-446 36 2.3e-11 35.63 In-house 281-367 (511) Show / Hide
Range on Protein: 362-446
Range on HMM: 281-367/511
Sequence Identity: 36% (32 aa)

YFFIQTEYCHNRSLTDILQDM-SYPDIN-KSEITRQILEILHYIHSNGIVHNNLSTDCIYVDDNYIIKLGGFGLNTIVNPDSAVNTK
| .|| ||| ...| ... .   ..|   . ...||||| | ||||.|..|  |.   |..| .  .| | ||| |   . | .|.|
YLYIQMEYCEGKTLRQYIDNHGWCMDHDELWRYFRQILEGLNYIHSQGMIHRDLKPSNIFLDCCGNVKIGDFGLATNNKMESQINRK

Kinase TVAG_166980.AA Ciliate-E6 362-439 25 4.6e-11 31.78 In-house 24-105 (154) Show / Hide
Range on Protein: 362-439
Range on HMM: 24-105/154
Sequence Identity: 25% (21 aa)

YFFIQTEYCHNRSLTDILQDMSYPDINKSE-----ITRQILEILHYIHSNGIVHNNLSTDCIYVDDNYIIKLGGFGLNTIVNP
|.||. | |  ..| | ..  .. .. ..      .. |..... |.||...|. |..   |..| |. ||.  ||.   ..|
YYFIVMERC-EMNLQDWIHQHKNKKQINQNDQFFKFCCQLFHAVEYLHSKNYVLQNITLKNIFLDKNMNIKICDFGFQQCIIP

Kinase TVAG_166980.AA PEK 348-433 23 1.7e-10 32.01 In-house 331-478 (655) Show / Hide
Range on Protein: 348-433
Range on HMM: 331-478/655
Sequence Identity: 23% (35 aa)

EEEEENPENPELT------------TYFFIQTEYCHNRSLTDILQD---------------------------------------------MSYPDINKS
||.|.| .| . .             |..||.|||.  .| |....                                             |. .     
EEMENNTNNNKNKFKQMHNTKQYQCHYLYIQMEYCEKKTLRDWIDNNGCPVQFNYWRRNSCKNHYNNYIMNQCCFQSTWSMNMRQWDENNCMFWDKDQCW

EITRQILEILHYIHSNGIVHNNLSTDCIYVDDNYI-----IKLGGFGL
.|.||||| | ||||.|..|  |    |..|..       .| | |||
RIFRQILEGLNYIHSQGMIHRDLKPSNIFLDCDGQHHQMQVKIGDFGL

Kinase TVAG_166980.AA PEK-Unclassified 391-435 42 1.4e-09 28.58 In-house 617-663 (835) Show / Hide
Range on Protein: 391-435
Range on HMM: 617-663/835
Sequence Identity: 42% (20 aa)

EITRQILEILHYIHSNG-IVHNNLSTDCIYVDDN-YIIKLGGFGLNT
||||||.  | .||. . .||  .  . |.| .| . || | ||| .
EITRQIIKALYHIHHQCKMVHRDIKPHNIFVCQNPMQIKIGDFGLVK

Kinase TVAG_166980.AA Ciliate-E2 360-440 20 3.5e-09 27.64 In-house 106-209 (365) Show / Hide
Range on Protein: 360-440
Range on HMM: 106-209/365
Sequence Identity: 20% (22 aa)

TTYFFIQTEYCHNRSLTDILQDM------------SYPDINKSEITRQILE---------------ILHYIHSNG-IVHNNLSTDCIYVDDNYIIKLGGF
...... .|||   .| |.....            .. .   ..|..|||.                |.|.||.. |.| ..  . | .     ||.  |
DNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDF

GLNTIVNPD
|| .....|
GLSKKYDDD

Kinase TVAG_166980.AA STE 271-410 17 5.5e-09 28.0 In-house 66-175 (359) Show / Hide
Range on Protein: 271-410
Range on HMM: 66-175/359
Sequence Identity: 17% (28 aa)

IKKPEEEKKIKEVVKALTSLQ--HRNLVRYYNSWVETCDGALAKLINDDFKLVKKNQKRSLTREEAIDFSTITQDYGELEEEEENPENPELTTYFFIQTE
.| .||...|.. .| .  ..  | | |.|| . .  ..                                                  .  .. .|  |
NKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHN------------------------------------------------HKNDDELWICME

YCHNRSLTDILQ-DMSYPDINK--------------SEITRQILEI-LHYIHSNGIVH
|. . ||.||..  .. .. ..              . |.||||.  |.|.||..|.|
YMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIH

S_TKc TVAG_166980.AA S_TKc 242-513 15 9.1e-09 -48.33 SMART 1-231 (231) Show / Hide
Range on Protein: 242-513
Range on HMM: 1-231/231
Sequence Identity: 15% (48 aa)

FSIIYPFGVGY----IKASNIVDNRVYTVQCMIIKKPEEEKKIKEVVKALTSLQHRNLVRYYNSWVETCDGALAKLINDDFKLVKKNQKRSLTREEAIDF
. |. . | |      |. .. ..|.. . ..                                                    .  . ... ..   . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------------------------------------------------EHIRREIQILKK---HH

STITQDYGELEEEEENPENPELTTYFFIQTEYCHN--RSLTDILQDMS-------YPDINKSEITRQILEILHYIHSNGIVHNNLSTDCIYVDDNYIIKL
  | . |.  ..           ..... .||| .   .| |.....        .|      ...||.. | |.||.||.|  |  . | .|.   ||.
PNIVKLYDVFQD-----------DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKI

GGFGLNTIVNPDSAV-------------NT-KSDMESF---AYILFK---LFYTRSTETTLEDIRLGKLPTDWSFAFPIEAK--IVSLLV-QPNKRPSAL
. ||| ...  .. .             .. |.|. |.    |...    .|.    ..... |.            . |||  |  .|.  |.|||.| 
CDFGLARQL--TTFCGTPWYMAPEVLGYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-

DLLQ-------WKII
..||          .
EALQDEWDIKCHPWF

Kinase TVAG_166980.AA Ciliate-E2-Unclassified 360-433 19 9.6e-09 26.48 In-house 93-193 (352) Show / Hide
Range on Protein: 360-433
Range on HMM: 93-193/352
Sequence Identity: 19% (20 aa)

TTYFFIQTEYCHNRSLTDILQDMS------------------YPDINKS-----EITRQILEILHYIHSNG-IVHNNLSTDCIYVDDNY---IIKLGGFG
. ...| .||| . .| .......                   .. . .      ...|||. | |.|... |.| ..  . | .|.|     ||. .||
KQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFG

L
.
I

Kinase TVAG_166980.AA HRI 446-513 37 1.6e-08 25.3 In-house 540-613 (613) Show / Hide
Range on Protein: 446-513
Range on HMM: 540-613/613
Sequence Identity: 37% (28 aa)

KSDMESFAYILFKLFYTRSTE----TTLEDIRLGKLPTDWSFAFPIEAKIVSLLVQPN--KRPSALDLLQWKII
|||| |   ||| ||    ||    . |  .| |..|   .   |. || . .| . |  .||||. |||  . 
KSDMYSMGVILFELFQPFGTEMERAEVLTGVRTGQIPESLRKRCPVQAKYIQHLTRRNASQRPSAIQLLQSELF

Kinase TVAG_166980.AA GCN2 253-307 36 3.1e-08 24.51 In-house 16-75 (511) Show / Hide
Range on Protein: 253-307
Range on HMM: 16-75/511
Sequence Identity: 36% (22 aa)

IK-ASNIVDNRVYTVQCMII--KKPEEEKK--IKEVVKALTSLQHRNLVRYYNSWVETCD
.| . | .|.| |..    |  |. . ..|  |.. || | .|.|.. ||||..|.| ||
VKNVRNMHDGRYYAIKKWPINWKQRKLPCKHKIMREVKLLCRLHHQHVVRYYQAWIEKCD

Kinase TVAG_166980.AA PEK 284-307 50 4.8e-08 23.32 In-house 65-88 (655) Show / Hide
Range on Protein: 284-307
Range on HMM: 65-88/655
Sequence Identity: 50% (12 aa)

VKALTSLQHRNLVRYYNSWVETCD
||.| .|.|.| |||.|.| |...
VKTLARLNHPNIVRYHNAWIEKPE

Kinase TVAG_166980.AA PEK 284-305 54 6.8e-07 17.74 In-house 56-77 (758) Show / Hide
Range on Protein: 284-305
Range on HMM: 56-77/758
Sequence Identity: 54% (12 aa)

VKALTSLQHRNLVRYYNSWVET
|..| .| |.| |||.|.| ||
VRTLAMLDHHNIVRYFNAWLET

Kinase TVAG_166980.AA WEE 364-411 34 2e-06 17.42 In-house 81-136 (297) Show / Hide
Range on Protein: 364-411
Range on HMM: 81-136/297
Sequence Identity: 34% (20 aa)

FIQTEYCHNRS--LTDILQD-------MSYPDINKSEITRQILEILHYIHSN-GIVHN
.||.||| . |  | ...|.       .... | .  | ..|.. ||.|||| |.||.
YIQMEYCNGGSNLLQFWIQQCHNWNHWLPEWMIWQ--ILVDICQGLHHIHSNCGMVHM

Kinase TVAG_166980.AA PEK 455-513 26 1.7e-05 14.3 In-house 583-655 (655) Show / Hide
Range on Protein: 455-513
Range on HMM: 583-655/655
Sequence Identity: 26% (19 aa)

ILFKLFY-TRSTE----TTLEDIRL------GKLP-TDWSFAFPIEAKIVSLLVQ--PNKRPSALDLLQWKII
|.| ..| . .|.    .|| |.|       |..|  ..   .| .|........  | .|||| ..|| . .
IFFEMWYPFFTTMMERVKTLTDLRDESIQFPGDFPPKWFDNKYPKQADFIQWMLSHDPQQRPSAQQILQHEFF

Kinase TVAG_166980.AA PEK 467-513 22 2.4e-05 12.48 In-house 710-758 (758) Show / Hide
Range on Protein: 467-513
Range on HMM: 710-758/758
Sequence Identity: 22% (11 aa)

TTLEDIRLGKLPTDWSFAFPIEAKIVSLL--VQPNKRPSALDLLQWKII
.|. |.| |..| ..    | |.. ....   .|  ||.| ...   . 
RTMCDLRNGQWPKWFTQKYPQEYEFIQQMMSMNPDERPTADQISMHDFF

Kinase TVAG_166980.AA Pkinase 254-410 14 8.1e-05 18.11 Pfam 17-131 (293) Show / Hide
Range on Protein: 254-410
Range on HMM: 17-131/293
Sequence Identity: 14% (24 aa)

KASNIVDNRVYTVQCMIIKKPEEEKKIKEV----VKALTSLQHRNLVRYYNSWVETCDGALAKLINDDFKLVKKNQKRSLTREEAIDFSTITQDYGELEE
|. .. ..... | ..  .. ...|..  .    .. . .|.| | ||.| .. .                                             
KCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED---------------------------------------------

EEENPENPELTTYFFIQTEYCHNR----SLTDILQ---DMSY--PDINKSEITRQILEILHYIHSNGIVH
           ..  . .||| .     .| |...   . ..  ..     . .|||. | |.||.||.|
----------KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIH

Kinase TVAG_166980.AA PEK-Unclassified 277-304 46 0.000158 10.4 In-house 48-74 (835) Show / Hide
Range on Protein: 277-304
Range on HMM: 48-74/835
Sequence Identity: 46% (13 aa)

EKKIKEVVKALTSLQHRNLVRYYNSWVE
|| |.| | ..  . | | .||| ||.|
EKEIME-VRYMAQVNHPNIIRYYHSWIE

Kinase TVAG_166980.AA TyrKc 274-512 14 0.000159 -149.46 SMART 1-280 (280) Show / Hide
Range on Protein: 274-512
Range on HMM: 1-280/280
Sequence Identity: 14% (47 aa)

PEEEKKI-----KEVVKALTSLQHRNLVRYYNSWVETCDGALAKLINDDFKLVKKNQKRSLTRE----EAI--DFSTITQDYGELEEEEENPENPELT--
 . .||.      ||.|.  .                      | ...|        .. . ||      .  .   | . ||   ....|         
ITLGKKLGEGAFGEVYKGTWK-----------------IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN------FMY

-TYFFIQTEYCHNRSLTDILQDMS--YPDINKSEITRQILEILHYIHSNGIVHNNLSTDCIYVDDNYIIKLGGFGLNTIVNPD------SAVNTK----S
    .| .||. . .| | |..     .   . ..  || .   |.||....|  | .  . |..|...| . |||   .  |      . . .|    .
IEPLMIVMEYMPHGDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKG

DM----------ESFAYILF---------------------KLFYT-----RSTETTLEDIRLG----KLPTDWSFAFP-----IEAKIVSLLVQ-----
            |.. |  |                     .  .       | .  .|... |    . | |     |       ... ..  |     
GKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY----PMSFVCCPDEMYQIMKQCWHED

PNKRPSALDLLQWKI
|..||.  ..   ..
PEDRPTFSEI-HECF

Kinase TVAG_166980.AA HRI 284-304 57 0.000164 10.81 In-house 49-69 (613) Show / Hide
Range on Protein: 284-304
Range on HMM: 49-69/613
Sequence Identity: 57% (12 aa)

VKALTSLQHRNLVRYYNSWVE
|| |  ||| | |||  .|.|
VKVLACLQHHNIVRYHQAWIE

Kinase TVAG_166980.AA PEK 362-410 28 0.001531 6.33 In-house 413-465 (758) Show / Hide
Range on Protein: 362-410
Range on HMM: 413-465/758
Sequence Identity: 28% (15 aa)

YFFIQTEYCHNRSLTDILQDM-SYPDINKSEIT---RQILEILHYIHSNGIVH
| .||...|   .| | . .  .  . .....     ||.| . |||| |. |
YMYIQMQLCRKETLKDWMRNRCTMESRPWMHMLHWFHQICEGVNYIHSKGMIH

Kinase TVAG_166980.AA Ciliate-E2 494-513 23 0.001922 7.66 In-house 345-365 (365) Show / Hide
Range on Protein: 494-513
Range on HMM: 345-365/365
Sequence Identity: 23% (5 aa)

LLVQPNKRPS-ALDLLQWKII
| ..|.||.. . ..|.....
LQKDPEKRITGWEQILNHPWF

Kinase TVAG_166980.AA WEE 275-305 31 0.004971 6.09 In-house 41-77 (297) Show / Hide
Range on Protein: 275-305
Range on HMM: 41-77/297
Sequence Identity: 31% (12 aa)

EEEKKIKEVVKALTSLQ-------HRNLVRYYNSWVET
|.. ...| |.|. .|        | . ||||..| |.
ERKRALRE-VYAHMVLGQIMDCDHHPHIVRYYSAWEED

Kinase TVAG_166980.AA STE 498-513 50 0.020198 4.51 In-house 342-359 (359) Show / Hide
Range on Protein: 498-513
Range on HMM: 342-359/359
Sequence Identity: 50% (9 aa)

PNKRPSALDLLQ--WKII
|||||.| .||.   . |
PNKRPTASQLLKSEHPFI

Kinase TVAG_166980.AA HRI 395-433 37 0.036229 2.36 In-house 441-483 (613) Show / Hide
Range on Protein: 395-433
Range on HMM: 441-483/613
Sequence Identity: 37% (16 aa)

QILEILHYIHSNGIVHNNLSTDCIYVDDNYI----IKLGGFGL
||.| . |||  .|||  .    |.  |       .| | |||
QIVEGMFYIHNMFIVHRDVKPRNIFLHDPDQGHPQVKIGDFGL

Kinase TVAG_166980.AA GCN2 498-513 56 0.042481 2.64 In-house 496-511 (511) Show / Hide
Range on Protein: 498-513
Range on HMM: 496-511/511
Sequence Identity: 56% (9 aa)

PNKRPSALDLLQWKII
|.||||| .||| . .
PQKRPSAQQLLQHEFL

Kinase TVAG_166980.AA WEE 498-513 37 0.057178 2.48 In-house 282-297 (297) Show / Hide
Range on Protein: 498-513
Range on HMM: 282-297/297
Sequence Identity: 37% (6 aa)

PNKRPSALDLLQWKII
| .||.. .|||  ..
PEQRPTCQQLLQHPVL

Kinase TVAG_166980.AA Ciliate-E2-Unclassified 494-513 30 0.231428 0.51 In-house 333-352 (352) Show / Hide
Range on Protein: 494-513
Range on HMM: 333-352/352
Sequence Identity: 30% (6 aa)

LLVQPNKRPSALDLLQWKII
| ..||||... ..|.  ..
LKKNPNKRITFEQILNHPWF