87388.m00127

Species: T.vaginalis
Alias: TvagK1000, 87388.m00127
External Links:
Annotation:

Classification

Group: STE
Family: STE20
Subfamily: YSK

Sequence

Name Sequence Type Origin Length Description Download
87388.m00127.AA Protein None 296 None Fasta, JSON
87388.m00127.kin_dom Protein Kinase Domain None 252 None Fasta, JSON

Protein domain

Protein domains of 87388.m00127.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
S_TKc 87388.m00127.AA S_TKc 22-276 25 1.5e-41 145.32 SMART 1-231 (231) Show / Hide
Range on Protein: 22-276
Range on HMM: 1-231/231
Sequence Identity: 25% (69 aa)

FTEVFDIGSGSFGKVIKAIDNECKKMIAIKVILQQGSYESTYKCVQNEITMMNKFKMKEICNLSDYFHINSSFYLILEFCSL--GNISKYKTK-------
.. .  ||.|.|||| |..... ..  |||.|          . ...|| .. | . . |..| |.|.  ...|...|.|.   |.  .|  |       
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--MTSPILLAIIRDISKPLEKFHKEGFVHYDIKPQNILLTLSGDIKVCDFGIMGRELESVKNTTNAISSLKKGTEMYMAPEVKEMNQLST-AADIYSLGV
  ..      ... | . ||  |. |..| |.||.||||.    ||.||||.  .             .   ||  ||||||    . .. ..|..|.|.
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGC

TIFEMISGIPLCLTNCTSSQQWFDENQHKISNGKPIAPIIEKIVNSCLISDPSSRISAINILK-------MIPS
...||..| |.        |. |.             |    ... ||  ||. |..|  .|.       .   
ILYEMLCGYPPFP----QMQMMFKKIG---------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase 87388.m00127.AA Ciliate-E2 22-276 18 1.8e-35 119.23 In-house 1-365 (365) Show / Hide
Range on Protein: 22-276
Range on HMM: 1-365/365
Sequence Identity: 18% (73 aa)

FTEVFDIGSGSFGKVIKAIDNECKKMIAIKVILQQG-----------------SYESTY--KCVQNEITMMNKFKMKE-----------------ICNLS
.  .  ||.|.||.| |. . . .|..|||.|  |                   . . .  . . .|| .|.. .  .                 |... 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINC-FYKKINEKNILEQLNHPNIIKMY

DYFH--INSSFYLILEFCSLGNISKYKTKM-TS---------PILLAIIRDISKPLEK-------------------FHKEG-FVHYDIKPQNILLTLSG
..|    ....||..|.|. |.  .|  .. ..         .. .  |..|.| . .                    |...  .| ||||.|||.    
ECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----

DIKVCDFGI---------------MGRELESVKNTTNAISSLKK------------GTEMYMAPEVKEMNQ---------LSTAADIYSLGVTIFEMISG
 ||..|||.               .  ..   || |.  ..  .            || .|||||. .. .          ....||.||||...||..|
-IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFG

IPLCLTNCTSSQQWFDENQHKISNGKPIAPIIE-----------------------KIVNS----CLISDPSSRIS-AINILKMIPS
 |                | .| ..|   |  |                        . .     .|  ||. ||. .  ||.    
KPPF--------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF

Pkinase 87388.m00127.AA Pkinase 22-274 22 6.1e-34 121.1 Pfam 1-293 (293) Show / Hide
Range on Protein: 22-274
Range on HMM: 1-293/293
Sequence Identity: 22% (69 aa)

FTEVFDIGSGSFGKVIKAIDNECKKMIAIKVILQQGSYESTYKCVQN--EITMMNKFKMKEICNLSDYFHINSSFYLILEFCSLG----NIS-----KYK
.. .  |||||||.| |...    |. |.|.|  ..  ..  .   .  || .|.... . |. | |.|. ... |...|.|  |      .     ...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

TKM--TSPILLAIIRDISKPLEKFHKEGFVHYDIKPQNILLTLSGDI----KVCDFGIMGR--ELESVKNTTNAISSLKKGTEMYMAPEV-KEMNQLSTA
...  .   .  ... | . ||  |..|..| |.||.|||.   |.|    |.||||.     .  .. .|| .      ||  |||||| .. .  ...
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFC------GTPWYMAPEVIRGGQYYGPK

ADIYSLGVTIFEMISGIPLCLTNC-----TSSQQWFDENQH---KISNGKPIA-------------------PIIEKIVNSCLISDPSSRISAINILKM-
.|..|.|....||..| |..  ..      . .| .... .   . .  ...                    .   .....||  ||..|..|  ||.  
VDMWSCGCILYEMLCGRPPFP-GHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHP

-I
 .
WF

Kinase 87388.m00127.AA Ciliate-E2-Unclassified 22-272 20 2e-32 109.77 In-house 1-348 (352) Show / Hide
Range on Protein: 22-272
Range on HMM: 1-348/352
Sequence Identity: 20% (71 aa)

FTEVFDIGSGSFGKVIKAIDNECKKMIAIKVILQQGSYESTYKCV-----QNEITMMNK---------FKMKE---------ICNLSDYFHINSSFYLIL
.. .  ||.|.|||| |..... |.  |.| . .. .| . ..       .....|.||         . |..         | .. ..|     .|...
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

EFCSLGNISKYKTKMTS-------------------PILLA------IIRDISKPLEKFHKEG-FVHYDIKPQNILLTLSG---DIKVCDFGIMGRELES
|.|  |. ..| .|. .                       .      ... | . ||. |... ..|.||||.|||.. .|    ||..||||  .  ..
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN

VKNTTN-----------AISSLKKGTEMYM----APEVKEMNQLS----TAADIYSLGVTIFEMISGIPLCL-TNCTS----------------SQQWFD
.... .            ... . || .||    |||| . .. .     ..||.|||| ..||. | .    .||..                 .|.. 
NNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIK

ENQHKISNGKP------IAPIIEKIVN----SCLISDPSSRISAINILK
... .... ..      . |  . ..|    ..|  .|..||..  ||.
QKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILN

Kinase 87388.m00127.AA ULK 28-266 22 1.2e-31 107.74 In-house 7-319 (329) Show / Hide
Range on Protein: 28-266
Range on HMM: 7-319/329
Sequence Identity: 22% (71 aa)

IGSGSFGKVIKAIDNECK----KMIAIKVIL----QQGSYEST----YKCVQNEITMMNKFKMKE--------ICNLSDYFHIN--SSFYLILEFCSLGN
.|.|||||| |..... |    ...|.|.|.    .| ..|..     ....|||  | | | .         |. | |.|       .|.|.|.|  |.
LGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIMEYCNGGD

ISKYKTKMTS-------------PILLAIIRDISKPLEKFHKEGFVHYDIKPQNILLTLS------------GDIKVCDFGIMGRELESVKNTTNAISSL
 ..|  |                .. . ....|   .   ||.. .| ||||||||..              | .|..|||  .. ... ..  . . . 
LEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGF-AKHVDNDNMEQQMMMTC

K-----KGTEMYMAPEVKE----MNQLSTA-ADIYSLGVTIFEMISGI-P----LCLTN---CTSSQQW-------FDENQHKIS---NGKPIAPIIEKI
.     .|| .||||.. .      . ... .||.|||. ..||. |  |     . ..   ...  ..        . .. ..    |...| | .. .
VNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDL

VNSCLISDPSSRIS
   .|. |.. |||
IRRMLQYDEKDRIS

Kinase 87388.m00127.AA TKL 28-274 16 2.6e-31 109.97 In-house 1-364 (364) Show / Hide
Range on Protein: 28-274
Range on HMM: 1-364/364
Sequence Identity: 16% (59 aa)

IGSGSFGKVIKAIDNECK--------KMIAIKVILQQG-------------------------SYESTYKCVQNEITMMNKFKMKEICNLSDYFHINSS-
||||.||.| |.. .           | .|.|.. ..                           ..   ..  .|| ||....   |. .  |   ... 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------FYLILEFCSLGN-ISKYKTKMTSPILLAIIRDISKPLEKFHKEG--------FVHYDIKPQNILLTLSGD--------------IKVC
            .... |.|. |.  . .      . .. ...||.. ..  | ..         .| |.|..|||.   .               .|.|
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKIC

DFGIMGRELESVKNTTNA--------------ISSLKKGTEMYMAPEVKEMN----------------QLSTAADIYSLGVTIFEMISGIPLCLTNCTSS
|||.  .  .| ... ..               .. . ||  .||||| ...                . |...|.|| |. ..|.... .    .  ..
DFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMP

QQWF----DENQHKISNG------------------KPIAPIIEKIVNSCLISDPSSRISAINILKMI
....    ..    ...|                  ... | . |.   |  .||..| |.  ||| .
MIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL

Kinase 87388.m00127.AA STE 22-217 22 5.1e-30 103.25 In-house 1-264 (359) Show / Hide
Range on Protein: 22-217
Range on HMM: 1-264/359
Sequence Identity: 22% (62 aa)

FTEVFDIGSGSFGKVIKAIDNE-----CKK----------MIAIKVIL--QQGSYEST--------------YKCVQNEITMMNKFK--MKEICNLSDYF
.. .  ||.|.||.| ||....     ...          ..|||..   .. ... .               . ...|| .|.|..   . | .  ...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

HIN-------SSFYLILEFCSLGNIS-----KYKTKMT------------SPILLAIIRDISKP-LEKFHKEGFVHYDIKPQNILLTLSGDIKVCDFGIM
  .       .. ....|... | ..     ||.....             ... .|.|.| |  |.  |. . .| ||||.||||     .| ||||. 
FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVC

GRELESVKNTTNAI--------SSLKK-----GTEMYMAPEVKEM------NQLSTAADIYSLGVTIFEMISG
|.  .|. |  . .        .. .|     ||  .||||| .       .. .| .||.||| || ||. |
GQLTDSMANI-Q-SNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATG

Kinase 87388.m00127.AA ULK 28-219 24 2.1e-29 101.54 In-house 7-250 (324) Show / Hide
Range on Protein: 28-219
Range on HMM: 7-250/324
Sequence Identity: 24% (60 aa)

IGSGSFG-KVIKAIDNEC---KKMIAIKVILQQGSYESTYK--------CVQNEITMMNKFK------MKEICNLSDYFHIN--SSFYLILEFCSLGNIS
.|.|||| || |.....    .. .|.|.| ...  .. ..          .|||  | |.|         |. | |.|       .|.|.|.|  |. .
LGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNH-HIVKLYDWFETSNHNNIYIIMEYCNGGDLE

KYKTKMTS------------PILLAIIRDISKPLEKFHKEGFVHYDIKPQNILLTL------------SGDIKVCDFGIMGRELESVKNTTNAISSLK--
.|  |               .. . ....|   .   ||.. .| ||||||||..             .| .|..|||  .. ...     . . ...  
QYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGF-AKHVDNNNMEQQMCQTCVNE

---KGTEMYMAPEVKE----MNQLSTA-ADIYSLGVTIFEMISGIP
   ||| .||||.. .      . ... .||.|||. ..||. | .
KRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKY

Kinase 87388.m00127.AA SLK 22-219 27 6.3e-23 74.09 In-house 1-200 (259) Show / Hide
Range on Protein: 22-219
Range on HMM: 1-200/259
Sequence Identity: 27% (57 aa)

FTEVFDIGSGSFGKVIKAIDNECKKMIAIKVILQQGSYESTYKCVQNEITMMNKFKMKEICNLSDYFHINSSFYLILEFCSLGNISK----YKTKMTSPI
.  . ..| | |||| || . | |.. | |.|  .   |     |  || .. . |   | .| . ....   ....|||  | .       .  .| . 
WEIIGELGDGAFGKVYKAQHKEQKVFAAAKMIEIKDEEELEDYMV--EIDILSECKHPNIVKLYEAYYYDNKLWMMIEFCDGGAVDNIMVELEHPLTEDQ

LLAIIRDISKPLEKFHKEGFVHYDIKPQNILLTLSGDIKVCDFGIMGRELESVKNTTNAISSLKKGTEMYMAPEV-----KEMNQLSTAADIYSLGVTIF
.  . . .   |.  |..  .| |.|  |||.|. ||... |||.  .  . ..     |     ||  .|||||        .     |||.|||.|. 
IQYVCKHMCEALNWLHSNKVIHRDLKAGNILMTMDGDVRLADFGVSAKNKHTMQKRDTFI-----GTPYWMAPEVVMCETFKDQPYDYKADIWSLGITLI

EMISGIP
||  . |
EMAQMEP

Kinase 87388.m00127.AA YSK 121-219 41 6.9e-19 53.16 In-house 104-199 (257) Show / Hide
Range on Protein: 121-219
Range on HMM: 104-199/257
Sequence Identity: 41% (42 aa)

IIRDISKPLEKFHKEGFVHYDIKPQNILLTLSGDIKVCDFGIMGREL-ESVKNTTNAISSLKKGTEMYMAPEVKEM--NQLSTAADIYSLGVTIFEMISG
|.| | | |.  |.|  .| |||  |.||. .||.|.||||. |.    . |  | .      ||  .|||||      .  . ||| |||.|  ||  |
ILREILKGLDYLHSERKIHRDIKAANVLLSEHGDVKLCDFGVAGQITDTQIKRNTFV------GTPYWMAPEVICQEVSYYDFKADIWSLGITAYEMAKG

IP
 |
EP

Kinase 87388.m00127.AA STE-Unique 138-220 25 1.7e-18 61.87 In-house 427-552 (616) Show / Hide
Range on Protein: 138-220
Range on HMM: 427-552/616
Sequence Identity: 25% (32 aa)

VHYDIKPQNILLTLSG-----DIKVCDFGIMGRELESV---K-------------------------------NTTNAISSLKKGTEMYMAPEVKEMN--
.| |.|| ||... .|      .|.||||. . ..  .   |                               |  | .     ||. ||.||| ...  
IHRDLKPHNIFCMQDGKGRVCKVKICDFGH-ATCCQPDHFEKDNNSKNSNTWININNNSSTNSTAQQTPMWDLNINNYTMKYCCGTPCYMCPEVINCRNQ

---QLSTAADIYSLGVTIFEMISGIPL
     .| .||.||| ..|.|..| |.
INNPYDTKVDIWSLGCMCFHMCCGCPP

Kinase 87388.m00127.AA CAMK 133-219 22 3.8e-14 41.28 In-house 196-332 (425) Show / Hide
Range on Protein: 133-219
Range on HMM: 196-332/425
Sequence Identity: 22% (31 aa)

HKEGFVHYDIKPQNILLTLS-----------------GDIKVCDFGIMGRELESVKNTT-------------------NAISSLKKGTEMYMA-PEVKEM
|. . || |.|| ||||. .                 ..||..||| . ..... .| .                   .   .   ||  ||| ||| . 
HSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFG-FANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNG

NQ--------------LSTAADIYSLGVTIFEMISGIP
..               . ..|. |.||  . | .| |
KGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYP

Kinase 87388.m00127.AA TyrKc 22-274 18 2.6e-12 -23.67 SMART 1-280 (280) Show / Hide
Range on Protein: 22-274
Range on HMM: 1-280/280
Sequence Identity: 18% (54 aa)

FTEVFDIGSGSFGKVIKAIDNECKKMIAIKVILQQGSYESTYKCVQNEITMMNKF--KMKEICNLSDYFHIN-------SSFYLILEFCSLGNISKY--K
 |    .|.| ||.| |.. .    . |.|..          .   .|. .| |.  . . | .|  .              ....|....|.  .|  |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

TK--MTSPILLAIIRDISKPLEKFHKEGFVHYDIKPQNILLTLSGDIKVCDFGIMGRELESV------KNTTNAIS-SLKK--GTEMYMAPEVKEMNQLS
..   . . || .  .|..  |  |. ...| |.   |.|..  . .|..||| . |....       | .  . . . .|       ||||.   .  .
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLS-RDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

TAADIYSLGVTIFEMISGIPLCLTNCTSSQQW----FDENQ---HKISNG------KP--------IAPIIEKIVNSCLISDPSSRISAINILKMI
|. |..| ||...|.       .|.. .        . .||   ... .|      .           . . .|  .|   ||..| .  .| . .
TKSDVWSFGVCMWEI-------FTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF

Kinase 87388.m00127.AA CAMK 27-102 17 4.4e-12 34.51 In-house 1-143 (425) Show / Hide
Range on Protein: 27-102
Range on HMM: 1-143/425
Sequence Identity: 17% (25 aa)

DIGSGSFGKVIKAIDNECK------------KMIAIKVIL---QQGSY-----------------------ESTYKCVQNEITMMNK-------FKMKEI
 .|.|||||| ..|. . .            .  |||.|     ...                        ... | |..|| .|.|        . . |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

CNLSDYFH------------INSS--------FYLIL---EFCS
..| ...               |         .|...   |.||
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCS

Kinase 87388.m00127.AA YSK 22-53 53 1.5e-10 27.6 In-house 1-32 (257) Show / Hide
Range on Protein: 22-53
Range on HMM: 1-32/257
Sequence Identity: 53% (17 aa)

FTEVFDIGSGSFGKVIKAIDNECKKMIAIKVI
||    || |||| | |.|||  .. .|||.|
FTKQECIGRGSFGEVYKGIDNRTQRVVAIKII

Kinase 87388.m00127.AA STE-Unique 23-77 25 0.000183 11.12 In-house 1-59 (616) Show / Hide
Range on Protein: 23-77
Range on HMM: 1-59/616
Sequence Identity: 25% (15 aa)

TEVFDIGSGSFGKVIKAIDNECKKMIAIKVILQQGSYEST----YKCVQNEITMMNKFK
..   || ||||.| .....  ..  ||||| . .   .      .  ..||. | ...
NCQQMIGRGSFGNVHNCQNKKDCFRCAIKVIHLKQFKDFNQEPLVNMIISEIEIMKCLH

Kinase 87388.m00127.AA YSK 253-282 40 0.006145 4.28 In-house 234-257 (257) Show / Hide
Range on Protein: 253-282
Range on HMM: 234-257/257
Sequence Identity: 40% (12 aa)

VNSCLISDPSSRISAINILKMIPSLPPSFI
|. ||  ||. | || . ||       .||
VECCLNKDPEQRPSAKELLKH------KFI