Gene 81997.m00115 (T.vaginalis)

81997.m00115

Species: T.vaginalis
Alias: 81997.m00115, TvagK0446
External Links:
Annotation:

Classification

Group: CK1
Family: TTBK

Sequence

Name Sequence Type Origin Length Description Download
81997.m00115.AA Protein None 332 None Fasta, JSON
81997.m00115.kin_dom Protein Kinase Domain None 173 None Fasta, JSON

Protein domain

Protein domains of 81997.m00115.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 81997.m00115.AA CK1 19-273 26 2.4e-75 256.65 In-house 1-339 (339) Show / Hide 
Range on Protein: 19-273
Range on HMM: 1-339/339
Sequence Identity: 26% (90 aa)

FTIGKQIGHGGYG-DVYIVT----HNKSN------KMFAFKAEIL-QKKR-PTLQHEVKVLRKLS---------------------SPEYPTVLATGGTD
....|.|| ||.| ..| |.     ...|      . .| |.|   .... |.|..|.....||                      .|  ...   |..|
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED

Q-FKWFVMDLYGKSLSQLRR--LLPGRKFPMMFVVPIAHETFRLLKKLHQKGYIHRDVKPSNFVYRR------IKNTQ--------PIVLIDFGFAK-KH
. ... ||.|.|..|..||.   ...||| |  .. ||  .   |. .| .|.||||.||.||.  |       |. .         ...||||.|. | 
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKH-HHEWNNEHRQVYMIDFGMARRKY

IDP-----------STGKPFPVNN---GIGFVG-TTMYASDNALKGCDLGRCDDLMSWFYMIVEFVQGK--LPWACGGQRSD-----VVRLRQRVTQSEI
.|.           .|... |  .     ||.| |. |.| |. .|...|| ||| |||||..|.. |.  |||    . .      |..  .  .    
RDKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKK

LLN------------MPSQLKNIYNYLQELKYEDDPDYDRI
...            .|...  |..|. .|||.| |||. |
MSTPFFLCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI
Kinase 81997.m00115.AA Worm6 19-273 32 5.7e-65 222.15 In-house 1-279 (279) Show / Hide 
Range on Protein: 19-273
Range on HMM: 1-279/279
Sequence Identity: 32% (90 aa)

FTIGKQIGHGGYGDVYIVTHNKSNK--MFAFKAEI--LQKKRPTLQHEVKVLRKL---SSPEYPTVLATGGTDQ--FKWFVMDLYGKSLSQLRRLLPGRK
....| || ||.|.|| |.. . .|  .|| |.|    . ||. |..|. || ..    ..  ...   | .|.  |.. || |.||.|. ||. .|.||
WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK

FPMMFVVPIAHETFRLLKKLHQKGYIHRDVKPSNFVYRR-----IKNTQPIVLIDFGFAK--KHIDPSTGKPFPVNNGIGFVGTTMYASDNALKGCDLGR
| |     || .. . .  ||. |.|||||||.||   |      ..   | ..|||...  | ..  .    |  . .||.||. ||. .. ||....|
FSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQEQCR

CDDLMSWFYMIVEFVQGKLPWACGGQRSDVV--RLRQRVTQS----EILLN-MPS-QLKNIYNYLQELKYEDDPDYDRI
 ||. |||||.||.. |.|||.    ...|   . ..| . .    . ...  |  ... |  |. ...|.|.|||. |
KDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI
Kinase 81997.m00115.AA TTBKL 19-277 29 4.6e-57 191.21 In-house 1-288 (288) Show / Hide 
Range on Protein: 19-277
Range on HMM: 1-288/288
Sequence Identity: 29% (86 aa)

FTIGKQIGHGGYGDVYIVTHNKS-NKMFAFKAEILQ-KK-RPTLQHEVKVLRKLS---SPEYPTVLATGGTDQFKWFVMDLYGKSLSQLRRLLPGRK-FP
..| |.|| ||.| || |   |. ....| |.|  .  .   ... ||.|| ||.   || .|.... | .... ..|| | |..|. ||. .| .| | 
WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS

MMFVVPIAHETFRLLKKLHQKGYIHRDVKPSNFVYRRIKNT----QPIVLIDFGFAKKHIDPSTGKP----------FPVNN---GIGFVGTTMYASDNA
   .. |.. ..  || .| .|.|||||||.|..    ...    . . |||||.|.. .... . .           .  |     .| ||| |.| |.
DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNM

LKGCDLGRCDDLMSWFYMIVEFVQGKLPWACGGQRSDVVRLRQRVTQSEILLN------MPSQLKNIYNYLQELKYEDDPDYDRIERQL
  ....||.||| ||.|||.|.. | |||    .. ... . .  .   .  .      .||..  .. .| .|.| | |||. |   .
HDRKEQGRHDDLWSWMYMIIELHCG-LPWTNMEDKMEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF
Kinase 81997.m00115.AA TTBK 19-273 34 2.5e-50 173.51 In-house 1-257 (257) Show / Hide 
Range on Protein: 19-273
Range on HMM: 1-257/257
Sequence Identity: 34% (88 aa)

FTIGKQIGHGGYGDVYIVTHNKSN-KMFAFKAEILQKKRPTLQHEVKVLRKLSSPEYPTVLATGG-TDQFKWFVMDLYGKSLSQLRRLLPGRKFPMMFVV
 .. | || ||.| .|  .    .    | | |  |...  |. || ||.||   ..     . |  |.| . ||.| ||.|. |||  |  .| .   .
WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQPKQVLKMEVAVLKKLQGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLSTTL

PIAHETFRLLKKLHQKGYIHRDVKPSNFVYRRIKNTQPIV-LIDFGFAKKHIDPSTGKPFPVNNGIGFVGTTMYASDNALKGCDLGRCDDLMSWFYMIVE
 .       ..  |. |. |||.|||||   |   |  .. ..||| | . .  ..|   |  .  || ||  ||| || .  ..|| ||| | ||| ||
RLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTN-ACGEVRPPREVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVE

FVQGKLPWACGGQRSDVVRLRQRVTQSEILLNMPSQLKNIYNYLQELKYEDDPDYDRI
|||| |||     . .| .....     .| ..|....   . .. |.||| |||  |
FVQGQLPWRKIKDKDQVGEMKEKYDHRMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI
Kinase 81997.m00115.AA CK1-D 19-273 32 1.2e-38 133.86 In-house 1-261 (261) Show / Hide 
Range on Protein: 19-273
Range on HMM: 1-261/261
Sequence Identity: 32% (84 aa)

FTIGKQIGHGGYGDVYIVTHNKSNKMFAFKAEILQKKRPTLQHEVKVLRKLSSP-EYPTVLATGGTDQFKWFVMDLYGKSLSQLRRLLPGRKFPMMFVVP
. ||..|| | .||.|  |  ..|   | | | .. | | |. | |. . ..     |..   |   ..   |||| | ||  |     .||| .  |. 
YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTKHPQLHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFNYC-HRKFSLKTVLM

IAHETFRLLKKLHQKGYIHRDVKPSNFVYRRIKNTQPIVLIDFGFAKKHIDPSTGKPFPVNNGIGFVGTTMYASDNALKGCDLGRCDDLMSWFYMIVEFV
.|   .. .. .| . .||||.|| ||.    |  . . .|||| ||.. |. | .  |        ||  ||| |  .| .  | ||| |  |... | 
LADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVLMYFN

QGKLPW-----ACGGQRSDVVRLRQRVTQSEILLN-MPSQLKNIYNYLQELKYEDDPDYDRI
.| |||     |   |. . .  ..  |. . | . .||. ..  || ..||..| |||  .
RGSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL
Kinase 81997.m00115.AA CK1-A 19-273 31 2.8e-36 125.66 In-house 1-261 (261) Show / Hide 
Range on Protein: 19-273
Range on HMM: 1-261/261
Sequence Identity: 31% (83 aa)

FTIGKQIGHGGYGDVYIVTHNKSNKMFAFKAEILQKKRPTLQHEVKVLRKLS-SPEYPTVLATGGTDQFKWFVMDLYGKSLSQLRRLLPGRKFPMMFVVP
. . ..|| | .||.|.    .. .  | | |  . . | |  | || | |.  .  |...  |   ..  .|||| | || .|  .   |.| |  |. 
YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKARHPQLIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFNFC-KRRFTMKTVLM

IAHETFRLLKKLHQKGYIHRDVKPSNFVYRRIKNTQPIVLIDFGFAKKHIDPSTGKPFPVNNGIGFVGTTMYASDNALKGCDLGRCDDLMSWFYMIVEFV
.|      .  .|.|..||||.|| ||.    .    . ||||| |||. |. | .  |  .    .||  ||| ||  | .  | ||. |  |... | 
LADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVMMYFN

QGKLPW-----ACGGQRSDVVRLRQRVTQSEILLN-MPSQLKNIYNYLQELKYEDDPDYDRI
.|||||     .   |. . .  ..  |  | |   .|...  . || ..|..|. |||  .
RGKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL
Kinase 81997.m00115.AA CK1 19-223 33 5.5e-31 104.02 In-house 1-216 (271) Show / Hide 
Range on Protein: 19-223
Range on HMM: 1-216/271
Sequence Identity: 33% (72 aa)

FTIGKQIGHGGYGDVYIVTHNKSNKMF---AFKAEILQKKRPTLQHEVKVLRKLSS-------PEYPTVLATGGTDQ--FKWFVMDLYGKSLSQLRRLLP
. .|. || |  ||.| ...  .|. .   | | |   .| | |. |.|... |         . .|..   |  .|  .   |||| |.|| .|  .  
YRVGRKIGQGSFGDIYLGINM-TNGEENHVAIKLEKNKSKHPQLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDLFNFC-

GRKFPMMFVVPIAHETFRLLKKLHQKGYIHRDVKPSNFVYRR-IKNTQPIVLIDFGFAKKHIDPSTGKPFPVNNGIGFVGTTMYASDNALKGCDLGRCDD
.||| .  |. ||    . .  .| |..||||.|| ||.  |  |. . . .||||.||. .|..|..  |  .. ...||. ||| |.  |   .| ||
NRKFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDD

LMSWFYMIVEFVQGKLPW
. |  |... |  |.|||
MESLGYVLMYFLRGSLPW
Kinase 81997.m00115.AA CK1-G 19-273 30 3.6e-27 89.08 In-house 1-266 (266) Show / Hide 
Range on Protein: 19-273
Range on HMM: 1-266/266
Sequence Identity: 30% (83 aa)

FTIGKQIGHGGYGDVYIVTHNKSNKMFAFKAEILQKKRPTLQHEVKVLRKLSSPE--YPTVLATGGTDQFKWFVMDLYGKSLSQLRRLLPGRKFPMMFVV
. .|| || | .| ..  .    |   | | |  . . | |. | .  . |..     | |   |    .   |||| | ||  |  .  .||| .  |.
YRVGKKIGCGNFGELFEGKNMYNNEHVAIKFEPMKSRAPQLHDEYRFYKILNGCPEGIPQVYYFGQCGKYNIMVMDLLGPSLEDLFDWC-DRKFSVKTVC

PIAHETFRLLKKLHQKGYIHRDVKPSNFVYRRI--KNTQPIVLIDFGFAKKHIDPSTGKPFPVNNGIGFVGTTMYASDNALKGCDLGRCDDLMSWFYMIV
 .|    .... .|..  | ||||| ||   |   |. . | .|||| ||. ||| |..  |        ||  | | |   |    | ||. .   |  
MVAIQMIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQHVIHIIDFGMAKQYIDPETKQHIPYREHKSLTGTARYMSINTHLGREQSRRDDMEALGHMFM

EFVQGKLPWACGGQRSDVVRLR-------QRVTQSEILLNM---PSQLKNIYNYLQELKYEDDPDYDRI
 |  |.|||   | . |  ..|        | |  | |..    | |.     |  .|.....|||| .
YFLRGSLPWQ--GLKADNNKERYQKIGDTKRKTNIEDLCQNNAFPEQFATYLRYVRRLDFFECPDYDYL
Kinase 81997.m00115.AA CK1-Unclassified 129-223 44 3.4e-25 71.32 In-house 120-216 (244) Show / Hide 
Range on Protein: 129-223
Range on HMM: 120-216/244
Sequence Identity: 44% (43 aa)

LHQKGYIHRDVKPSNFVYR-RIKNTQPIVLIDFGFAKKHIDP-STGKPFPVNNGIGFVGTTMYASDNALKGCDLGRCDDLMSWFYMIVEFVQGKLPW
|| |..|||| || ||.   . || . . .||||..|. ||. .|||  |  .. ...||. ||| || .|   .| ||| |  | .. |  |.|||
LHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINAHLGIEQSRRDDLESLGYVLIYFLKGSLPW
Kinase 81997.m00115.AA CK1-Unique 19-223 19 3.6e-20 66.64 In-house 1-232 (337) Show / Hide 
Range on Protein: 19-223
Range on HMM: 1-232/337
Sequence Identity: 19% (46 aa)

FTIGKQIGHGGYGDVYIVTHNKSN------KMFAFKAEILQKKRP-----TLQHEVKVLRKLS-----SPEYPTVLATGGTDQFKWFVMDLYGKSLSQLR
. . | || ||||.|. |   .        .|.. | |    ...      .. . | . |..     .   . | . . ... .| || . |.|.  ..
WCVIKHIGYGGYGCVHRVIFVNNGTFRIDDDMYCMKTEQHFMQKHDQRLHIERNVMKFICKCEYQCKYWRHFCEVHDFHQHRDWWWIVMTMHGPSMEECC

RLLPGRKFPMM------FVVPIAHETFRLLKKLHQKGYIHRDVKPSNFVYRRIK--NTQPIVLIDFGFAKK--HIDPSTGKPFPVNNGIGFVGTTMYASD
... . .|.         ..  .  .  ..   |. |..||. || |..|   .    . .  .|.|  ..   .... .   .    . | |.  |.. 
MMMKNFQFTLNEKKNQLCAIQCGYQCLNVIECMHWHGFHHRHMKPNNYCYMAPSQQHQHCYYMLDYGICRRVFFVSNN-HQIRQPRPITPFRGCKDYCPC

NALKGCDLGRCDDLMSWFYMIVEFVQGK--LPW
   .  ..|| ||. |||||..  | .   | |
SCHQCREHGRRDDMESWFYMLYHLVHNTRGLSW
Kinase 81997.m00115.AA Pkinase 19-177 20 7.3e-18 64.25 Pfam 1-172 (293) Show / Hide 
Range on Protein: 19-177
Range on HMM: 1-172/293
Sequence Identity: 20% (37 aa)

FTIGKQIGHGGYGDVYIVTHNKSNKMFAFKAEILQKKRPTLQH------EVKVLRKLSSPEYPTVLATGGTDQFKWFVMDLYGKSLSQLRRLL------P
..||..|| |..| ||. .| ...|..| |   ......  .       |......|..|   . . .  ...  ..||.. .. |. .  |        
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLY-VMDLFDYISTWR

GRKF--PMMFVVPIAHETFRLLKKLHQKGYIHRDVKPSNFVYRRIKNTQP---IVLIDFGFAKKH-IDPSTGKPFPV
...|  ..  .  .. ...| |. .|..| ||||.||.|. .   .| ..   . ..|||.||.. . ...    ..
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID--NNGHIDACVKICDFGLAKQFDY-NNS-MTTFC
Kinase 81997.m00115.AA S_TKc 19-285 16 7.3e-15 41.02 SMART 1-231 (231) Show / Hide 
Range on Protein: 19-285
Range on HMM: 1-231/231
Sequence Identity: 16% (46 aa)

FTIGKQIGHGGYGDVYIVTHNKSNKMFAFKAEILQKKRPTLQHEVKVLRKLSSPEYPTVLATGGTDQFKWFVMDLYGK---SLSQLRRLLPGRK----FP
..|...||.|..| || ..|.|... .| |         ... |...|.|   |   . . .  . .. ..||.. .    .| .. .  ....    ||
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFP

MMFVVPIAHETFRLLKKLHQKGYIHRDVKPSNFVYRRIKNTQPIVLIDFGFAKKHIDPSTGKPFPVNNGIGFVGTTMYASDNALKGCDLGRCDDLMSWFY
   .  ....... |. .|..| ||||.||.|    .      | ..|||.|..                 |.||  | .   |            .. .
E-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL--------------TTFCGTPWYMAPEVL------------GYGK

----------MIVEFVQGKLPWACGGQRSDVVRLRQRVTQSEILLNMPSQLKNIYNYLQELKYEDDPDYDRIER-QLRDAADKYN
          .. |.. |. |.       .. .. ...         ....|.. . . .   |. |    . . ..  ... . 
CKCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 81997.m00115.AA CK1-Unclassified 19-101 27 1.4e-11 30.5 In-house 1-93 (244) Show / Hide 
Range on Protein: 19-101
Range on HMM: 1-93/244
Sequence Identity: 27% (26 aa)

FTIGKQIGHGGYGDVYIVTHNKSNKMFAFKAEILQKKRPTLQHEVKVLRKLSSPE--------YPTVLATGGTDQ--FKWFVMDLYGKSLSQL
. ... || |  |..| ... ..|. .| | |   .| |.|. |.|... |   .        .| .   |  .|  .   |||| |.|| .|
YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSKHPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDL
Kinase 81997.m00115.AA CK1-Unique 248-283 50 2.2e-05 14.69 In-house 238-273 (337) Show / Hide 
Range on Protein: 248-283
Range on HMM: 238-273/337
Sequence Identity: 50% (18 aa)

MPSQLKNIYNYLQELKYEDDPDYDRIERQLRDAADK
.|| . ||  ||  ||.||  ||  ||  || |  |
IPSGIDNIIVYLRGLKFEDPVDYRQIENELRTAGKK
Kinase 81997.m00115.AA CK1 247-271 30 0.000792 9.29 In-house 246-271 (271) Show / Hide 
Range on Protein: 247-271
Range on HMM: 246-271/271
Sequence Identity: 30% (8 aa)

N-MPSQLKNIYNYLQELKYEDDPDYD
.  |... .  ||   |..|..|||.
GNFPNEFAMYLNYCRQLHFEEKPDYM