82727.m00037

Species: T.vaginalis
Alias: 82727.m00037, TvagK0988
External Links:
Annotation:

Classification

Group: Other
Family: PEK
Subfamily: GCN2

Sequence

Name Sequence Type Origin Length Description Download
82727.m00037.AA Protein None 1209 None Fasta, JSON
82727.m00037.kin_dom Protein Kinase Domain None 507 None Fasta, JSON

Protein domain

Protein domains of 82727.m00037.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 82727.m00037.AA PEK 226-736 17 1.5e-70 240.69 In-house 1-655 (655) Show / Hide
Range on Protein: 226-736
Range on HMM: 1-655/655
Sequence Identity: 17% (124 aa)

FVKINNLGKGGY-GSVIEARKKADDDRHYAVKCIPLASLA----------------EVKE-MKREVAFLSKFQHRYIVNFYSSWVE--------------
| .|  |||||. |.|.... |. |...||.| |.| .                  .. | . ||| .|....|..||  ...| |              
FEEIQCLGKGGFGGQVYKVQNKL-DGCYYAIKRIKLNWKQRKQPCITQECMIHKCKKHCEKVLREVKTLARLNHPNIVRYHNAWIEKPEEKWQQQQDEMW

---SVTEDAAKE-------------------------------IKKTFDLADEEEEETDDSGDTTTVSRSRSFN--------------------TTPRSP
   |.|.. ...                               ......  ...|..  .|..   .| . |..                    |  .. 
QLDSSTDWPNGKHKSKDYNFHPFEKEWDDEEAQESNVMSECEDREQKGKKKCWSESNSHSSKNNYEESMEWSCSEHSDSSSFPNIENQFSINFGTENENE

RSVRRNDDSGSTTSIT----------------GEIVEKINELMNNHADFSSDSETQQTDKFHTFIKSDNESDSKSEYEEEDIPIEDASNSSNDG-EAGLI
...  ...|.. .|                  ..  | ............|.. .. .|..  . ..  .... .||...|  .|.  ..|..  ... .
SHISYWSSSVYMSSSWDNPFDSSFSNSCDSTNFNKDEDHSFFSCSSYSSCSTDCDDSKDSSPFNWDGGCDNWEQYEYSDQDDEHEQNDCQSKQCDSKNQS

GSSPPNADNQQIQMIFD--------------HSTDLNDEKEKEEEEEEEEETIYMEEDLPDDFFEQGDDSDFCNGAIDEQEEPPLIDLLTDSPCARSKSD
. .. .... | |   .              ...  |... |... ..   ..                                               
HKKCMEMTWIQDQEDNKNNCSHHIGSSSQSQEEMENNTNNNKNKFKQMHNTKQ-----------------------------------------------

SSGRILLPKTFPSLSDSKSKKSKKSKKQHFLFIQMELCSQSTLKDLMSDKS--------------------------------------FFETAPKLEES
                         ...| |.||||.|...||.|.... .                                      . ........ 
-------------------------YQCHYLYIQMEYCEKKTLRDWIDNNGCPVQFNYWRRNSCKNHYNNYIMNQCCFQSTWSMNMRQWDENNCMFWDKD

KQWRICREILEALSYIHQSKVIHRDLKPQNIFIDDKND-----VKLGDFGLSR-----------------------LIEAKKSLKLGDVDELA---KEAT
  ||| |.|||.| |||.  .|||||||.|||.|....     || |||||.                        .........   .   .   .. .
QCWRIFRQILEGLNYIHSQGMIHRDLKPSNIFLDCDGQHHQMQVKIGDFGLATNHEMLSQSQKNYNQQDQSYWKYVANDNCQWWNTNQQNSPTGQDTHMW

GTAQ--------------------GSFPYTAPEITKGK-----KYDKKSDMYSFGIIFFEIWCYFPTQM-ERRKILFDLID-NKQFPPQMM----TDDFK
 ...                    |   | .||  .|.     .|..|.|||| |||||| | .| |.| || |.| || | . ||| ..     .....
-SNNYHIQPTSMFYCEHCHHTGGVGTCLYMSPEQLSGQHYQKSHYNHKVDMYSLGIIFFEMWYPFFTTMMERVKTLTDLRDESIQFPGDFPPKWFDNKYP

LQREIILNLLD-EPEKRQTCEQLLEKMPL
 |...|. .|.  |..| . .|.|.   .
KQADFIQWMLSHDPQQRPSAQQILQHEFF

Kinase 82727.m00037.AA GCN2 518-736 31 8.9e-54 184.98 In-house 261-511 (511) Show / Hide
Range on Protein: 518-736
Range on HMM: 261-511/511
Sequence Identity: 31% (82 aa)

TFPSLSDSKSKKSKKSKKQHFLFIQMELCSQSTLKDLMSDKSFFETAPKLEESKQWRICREILEALSYIHQSKVIHRDLKPQNIFIDDKNDVKLGDFGLS
...... .|....||.|. | |.|||| |. .||... .. ....          ||. |.|||.|.|||.  .|||||||.|||.|  ..|| |||||.
QHKNKVHYKCMNCKKPKEVHYLYIQMEYCEGKTLRQYIDNHGWCMDHD-----ELWRYFRQILEGLNYIHSQGMIHRDLKPSNIFLDCCGNVKIGDFGLA

RL-------------------------IEAKKSLKLGDVDELAKEA------------TGTAQGSFPYTAPEITKGKKYDKKSDMYSF-GIIFFEIWCY-
                           .|....   .. .  . .             .||.     |..||..  ..|..| ||||  ||||||.| . 
TNNKMESQINRKQQKQQQQASSHWAIQNEICQDDQFNQQQSQFSQWDQQDEQVHHTGKVGTPF----YMCPEQQ-KSHYNQKVDMYSLGGIIFFEMWYPP

FPTQMERRKILFDLIDNKQFPPQMM---TDDFKLQREIILNLLD-EPEKRQTCEQLLEKMPL
|.||||| .|| .|  . .||...      . | |...|  .|.  | ||.. .|||.   |
FCTQMERVQILKQLR-SCEFPQDFDKKVDNHHKDQQDMIRWCLNHDPQKRPSAQQLLQHEFL

Kinase 82727.m00037.AA STE 226-737 12 2.4e-47 163.61 In-house 1-359 (359) Show / Hide
Range on Protein: 226-737
Range on HMM: 1-359/359
Sequence Identity: 12% (79 aa)

FVKINNLGKGGYGSVIEARKKADDDRH--------------YAVKCIPLASL-----------------AEVKEMKREVAFLSKFQ--HRYIVNFYSSWV
. .|  .|||..|.|  |... ... |              .|.| ..| .                   |... ..|. ...|..  | .||..| . .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

ESVTEDAAKEIKKTFDLADEEEEETDDSGDTTTVSRSRSFNTTPRSPRSVRRNDDSGSTTSITGEIVEKINELMNNHADFSSDSETQQTDKFHTFIKSDN
   ..                                                                                               
KEGHN-----------------------------------------------------------------------------------------------

ESDSKSEYEEEDIPIEDASNSSNDGEAGLIGSSPPNADNQQIQMIFDHSTDLNDEKEKEEEEEEEEETIYMEEDLPDDFFEQGDDSDFCNGAIDEQEEPP
                                                                                                    
----------------------------------------------------------------------------------------------------

LIDLLTDSPCARSKSDSSGRILLPKTFPSLSDSKSKKSKKSKKQ-HFLFIQMELCSQSTLKDLMSDK-SFFETAP-------KLEESKQWRICREILEA-
                                         .|. . |.| ||...  .| |..  | . ... .       ...||   .|||.||.. 
-----------------------------------------HKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGL

LSYIHQSKVIHRDLKPQNIFIDDKNDVKLGDFGLSRLIEAKKS----------LKLGDVDELAKEATG----TAQGSFPYTAPEITKG------KKYDKK
|.|.|. ..||||.||.||..     ||| |||..  .. . .                     | ..    |  |.  . |||. ..      |.|| |
LYYLHSHHIIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCI----------ETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTK

SDMYSFGIIFFEIWCYFPTQMERRKI--LFDLIDNK-------------QFPPQMMTDDF-------------------KLQREIILNLLD-EPEKRQTC
.|..|.|.   |  .  |  ..      .|  ..|.             . ||.  ..                     .  .. | . |. .|.|| | 
CDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTA

EQLLEK-MPLY
.|||.   |  
SQLLKSEHPFI

Kinase 82727.m00037.AA Ciliate-E2-Unclassified 226-736 11 5.7e-38 129.31 In-house 1-352 (352) Show / Hide
Range on Protein: 226-736
Range on HMM: 1-352/352
Sequence Identity: 11% (71 aa)

FVKINNLGKGGYGSVIEARKKADDDRHYAVKCIP-------LASLAEVKEMKREVAFLSKFQHRYIVNFYSSWVESVTEDAAKEIKKTFDLADEEEEETD
. .|  .|.||.|.| ....| ..   || | .        .  . .  |...|   . . .. |...                                
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKK-YHQR-K------------------------------

DSGDTTTVSRSRSFNTTPRSPRSVRRNDDSGSTTSITGEIVEKINELMNNHADFSSDSETQQTDKFHTFIKSDNESDSKSEYEEEDIPIEDASNSSNDGE
                                                                                                    
----------------------------------------------------------------------------------------------------

AGLIGSSPPNADNQQIQMIFDHSTDLNDEKEKEEEEEEEEETIYMEEDLPDDFFEQGDDSDFCNGAIDEQEEPPLIDLLTDSPCARSKSDSSGRILLPKT
                                                                                                    
----------------------------------------------------------------------------------------------------

FPSLSDSK---------------SKKSKKSKKQHFLFIQMELCSQSTLKDLMSDKSF--------FETAPK---LEESKQW-----RICREILEALSYIH
       .                |.    ...  ..| ||.| . .|.. ......        |..  .   ..| .       .....||..|.|.|
-----Y-NKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLH

QSK-VIHRDLKPQNIFIDDKN---DVKLGDFGLSRLIEAKKSLKLGDV--------DELAKEATGTAQ--GSFPYTAPEITKGKKYD----KKSDMYSFG
... .||||.||.||..|...    .|. |||.|. ..     . ..         .....  .|| .    . |||||. .|..||    .|.|..|.|
HKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMP-Q-YTAPEVLQGQNYDHSKAYKCDIWSLG

IIFFEI----WCYFPTQMER-------------RKILFDLI-DNKQFPPQMMT----DDFKLQREIILN------LLDEPEKRQTCEQLLEKMPL
.|..|.    .... .. |              ||.|.. | ..... | .      ..   . . ..|      |   |.|| | ||.|.   .
VILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF

Kinase 82727.m00037.AA S_TKc 226-737 13 3.5e-35 124.14 SMART 1-231 (231) Show / Hide
Range on Protein: 226-737
Range on HMM: 1-231/231
Sequence Identity: 13% (69 aa)

FVKINNLGKGGYGSVIEARKKADDDRHYAVKCIPLASLAEVKEMKREVAFLSKFQHRYIVNFYSSWVESVTEDAAKEIKKTFDLADEEEEETDDSGDTTT
. ... .|||..|.|  .|.|  ..|..|.|.|.                                                                  
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK------------------------------------------------------------------

VSRSRSFNTTPRSPRSVRRNDDSGSTTSITGEIVEKINELMNNHADFSSDSETQQTDKFHTFIKSDNESDSKSEYEEEDIPIEDASNSSNDGEAGLIGSS
                                                                                                    
----------------------------------------------------------------------------------------------------

PPNADNQQIQMIFDHSTDLNDEKEKEEEEEEEEETIYMEEDLPDDFFEQGDDSDFCNGAIDEQEEPPLIDLLTDSPCARSKSDSSGRILLPKTFPSLSDS
                                                                    ....    . ..     .   . | . .  | 
--------------------------------------------------------------------EHIRREIQILKK-----HHPNIVKLYDVFQD-

KSKKSKKSKKQHFLFIQMELCSQ--STLKDLMSDKSFFETAPKLEESKQWRICREILEALSYIHQSKVIHRDLKPQNIFIDDKNDVKLGDFGLSRLIEAK
           ..|.. ||.|..   .|.|.. ..    .  .. |   ......|..|| |.|. ..|||||||.||..|.   .|..||||.|..   
-----------DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---

KSLKLGDVDELAKEATGTAQGSFPYTAPEITKGKKYDK-KSDMYSFGIIFFEIWC-YFPTQMERRKILFDLIDNKQFPPQMMTDDFKLQREIILNLLD-E
                 |  |.  | |||.    .|.| |.|..|.|.|..|  | | | .    . .|..|              .  ...| ..|. .
----------------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKD

PEKRQTCEQLLE------KMPLY
|||| |. ..|.      ..|  
PEKRPTA-EALQDEWDIKCHPWF

Kinase 82727.m00037.AA TKL 543-675 23 3.9e-34 119.73 In-house 117-282 (364) Show / Hide
Range on Protein: 543-675
Range on HMM: 117-282/364
Sequence Identity: 23% (42 aa)

MELCSQST-LKDLMSDKSFFETAPKLEESKQWRICREILEALSYIHQSK--------VIHRDLKPQNIFIDDKND--------------VKLGDFGLSRL
||.|.  . | .|               ..  |....|  ...| |...        .||||||..||..|...               .|..|||||| 
MEYCPGGSLLHYLH-------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRF

IEAKKSLKLGDVDEL-------AKEATGTAQGSFPYTAPEITKGK----------------KYDKKSDMYSFGIIFFEI
.. ... . .  ..         ...|.|  |.. . |||. .|.                .|..|.|.|||||...||
MSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEI

Kinase 82727.m00037.AA Pkinase 539-674 29 1.2e-32 116.52 Pfam 75-204 (293) Show / Hide
Range on Protein: 539-674
Range on HMM: 75-204/293
Sequence Identity: 29% (43 aa)

LFIQMELCSQS----TLKDLMSDKSFFETAPKL--EESKQWRICREILEALSYIHQSKVIHRDLKPQNIFIDDKNDV----KLGDFGLSRLIEAKKSLKL
. . ||.|        |.|..|     .   ..  .|    .....||..| |.|. ..|||||||.||.||.....    |..||||.....       
IYMVMEYCEGGLYVMDLFDYIST----WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-------

GDVDELAKEATGTAQGSFPYTAPEITK-GKKYDKKSDMYSFGIIFFE
    .  .. . |  |. .| |||. . |..|..|.||.|.|.|..|
----Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYE

Kinase 82727.m00037.AA Ciliate-E2 526-736 22 9.8e-31 102.72 In-house 96-365 (365) Show / Hide
Range on Protein: 526-736
Range on HMM: 96-365/365
Sequence Identity: 22% (65 aa)

KSKKSKKSKKQHFLFIQMELCSQSTLKDLMS--DKSFFET-----APKLEESK--QWRICR-----------EILEALSYIHQSK-VIHRDLKPQNIFID
| . . ..|... ... ||.|.. .|.|..   .|....       ....| |   . |..           .|..|| |.|. . .||||.||.||.. 
KMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-

DKNDVKLGDFGLSR-----------LIEAKKSLKLG--------DVDELAKEATGTAQ-----------GSFPYTAPEITKGKK---------YDKKSDM
    .|. |||||.           . ..|. .  .        . |          |           |. .| |||| .|||         ||.|.|.
----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMD----------QIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDI

YSFGIIFFEIWCYFPTQMERRKILFDLIDNKQFPPQMMT-----------DDFKLQRE----IIL----NLLDEPEKRQT-CEQLLEKMPL
.|.|.|..|  .  |       .   .  . .||.. ..           . .|.  |    |       |  .|||| |  ||.|.   .
WSLGVILYEMLFGKPPF-----QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF

Kinase 82727.m00037.AA ULK 543-675 25 3.8e-29 98.94 In-house 99-249 (329) Show / Hide
Range on Protein: 543-675
Range on HMM: 99-249/329
Sequence Identity: 25% (40 aa)

MELCSQSTLKDLMSDK-SFFETA---PKLEESKQWRICREILEALSYIHQSKVIHRDLKPQNIFIDDKND------------VKLGDFGLSRLIEAK---
||.| . .|..... .  . |.     .|.|..   ... ||... ..|. ..||||.||||| |....             .|..|||... ..     
MEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNME

KSLKLGDVDELAKEATGTAQ---GSFPYTAPEITK----GKKYD-KKSDMYSFGIIFFEI
. . .  | |         .   |.  | ||.| .    .|.|. .|.|..|.|.||.|.
QQMMMTCVNE---------KRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEM

Kinase 82727.m00037.AA ULK 543-675 23 1.1e-27 95.34 In-house 96-245 (324) Show / Hide
Range on Protein: 543-675
Range on HMM: 96-245/324
Sequence Identity: 23% (38 aa)

MELCSQSTLKDLMS-DKSFFETA---PKLEESKQWRICREILEALSYIHQSKVIHRDLKPQNIFIDDKND------------VKLGDFGLSRLIE-----
||.| . .|....  .| . |      .|.|..   ... |.... ..|. ..||||.||||| | ...             .|..|||... ..     
MEYCNGGDLEQYIKKNKKLPE-TEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNME

--AKKSLK-LGDVDELAKEATGTAQ---GSFPYTAPEITK----GKKYD-KKSDMYSFGIIFFEI
    ....                .   |.  | ||.| .    .|.|. .|.|..|.|.||.|.
QQMCQTCVNE--------------KRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEM

Kinase 82727.m00037.AA HRI 529-689 34 3e-27 92.76 In-house 383-567 (613) Show / Hide
Range on Protein: 529-689
Range on HMM: 383-567/613
Sequence Identity: 34% (65 aa)

KSKKSKKQHF-LFIQMELCSQSTLKDLMSDKSFF------ETA-PKLEES--KQWRICREILEALSYIHQSKVIHRDLKPQNIFIDDKND----VKLGDF
... . | |. |.|||.||. ..|.| .|           ||. |    .     .|  .|.| . |||   ..|||.||.|||  |. .    || |||
RGQTEFKYHYMLHIQMQLCE-LSLWDWISERNKRSREYVDETECPYVMANEKVIQKIFQQIVEGMFYIHNMFIVHRDVKPRNIFLHDPDQGHPQVKIGDF

GLSR---LIEAKKSLKL---GDVDELAKEATGTAQ-----GSFPYTAPEITKGKKYDKKSDMYSFGIIFFEIWCYFPTQMERRKIL
|| .   | | |  ..     | |.  ..  .|       |   | .||   | .|| |||||| |.| || .  | | ||| ..|
GLACEDILQEPKTPMRFRRDQDFDWTNRNPCVTQTHTSRVGTCTYASPEQLDGSQYDNKSDMYSMGVILFELFQPFGTEMERAEVL

Kinase 82727.m00037.AA STE-Unique 522-617 33 1.4e-22 76.66 In-house 353-457 (616) Show / Hide
Range on Protein: 522-617
Range on HMM: 353-457/616
Sequence Identity: 33% (36 aa)

LSDSKSKKSKKSKKQHFLFIQMELCSQSTLKDLMSDKSF---FETAPKLEESKQWRICREILEALSYIHQSK--VIHRDLKPQNIFIDDKN-----DVKL
|| | |.| |  | |. . |.||.|. .||...    .          ..|.   .. ..|||.| |.|  .  .||||||| |||.. .       ||.
LSTSSSRK-KPPKEQNWVWIFMEYCEHGTLQQIIKRCGCPGNPNNLQLFPETEVIWYTYQILEGLEYLHSQHNPIIHRDLKPHNIFCMQDGKGRVCKVKI

GDFGLS
.|||..
CDFGHA

Kinase 82727.m00037.AA STE-Unique 648-736 22 1.1e-17 58.88 In-house 514-616 (616) Show / Hide
Range on Protein: 648-736
Range on HMM: 514-616/616
Sequence Identity: 22% (23 aa)

YTAPEITKGK-----KYDKKSDMYSFGIIFFEIWCYFPTQMERRKI--LFDLIDNKQFPPQ------MMTDDFKLQREIILNLLD-EPEKRQTCEQLLEK
|..||.. ..      || |.|..|.|...|.. | .|....|  .  .......  ..|          .  ..|...|  .|. .| .| . .|||..
YMCPEVINCRNQINNPYDTKVDIWSLGCMCFHMCCGCPPWHQRYHMQAYIEMCIHIHCQPPQCPIENIPPKCQPEQQQFIEKCLERNPHHRPSAHQLLHH

MPL
  |
FWL

Kinase 82727.m00037.AA GCN2 226-348 20 9.5e-16 51.25 In-house 1-148 (511) Show / Hide
Range on Protein: 226-348
Range on HMM: 1-148/511
Sequence Identity: 20% (30 aa)

FVKINNLGKGGYGSVIE-ARKKADDDRHYAVKCIPL--ASLAEVKE--MKREVAFLSKFQHRYIVNFYSSWVE------------SVTEDAAKEIKKTFD
|. |  ||||| |.|.  .| .. | | ||.| .|.  ..    ..  ..|||..|.. .|...|  | .|.|            . .......  .. .
FEEICCLGKGGFGQVVKNVRNMH-DGRYYAIKKWPINWKQRKLPCKHKIMREVKLLCRLHHQHVVRYYQAWIEKCDEPMVTDTNNDDDTNNNYHSDDESE

---------LADEEEEETDDSGDTTTVSRSRSFNTTPRSPRSVRRNDDS
          .....|| .....  . | | ..|.  ... ..   ...
CFSGQYEMPKSVNQSEEMCNKEESMEWSMSNERNNSNWHDNGNFFSEWD

Kinase 82727.m00037.AA TyrKc 226-734 11 1.1e-13 -1.42 SMART 1-280 (280) Show / Hide
Range on Protein: 226-734
Range on HMM: 1-280/280
Sequence Identity: 11% (64 aa)

FVKINNLGKGGYGSVIEARKKADDDRHYAVKCIPLASLAEVKEMKREVAFLSKF--QHRYIVNFYSSWVES------------VTEDAA--------KEI
 ...  || | .| | ... |    .  |||..   .   .... ||   ..|.  .|  ||..|   ...            |.| ..        .. 
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

KKTFDLADEEEEETDDSGDTTTVSRSRSFNTTPRSPRSVRRNDDSGSTTSITGEIVEKINELMNNHADFSSDSETQQTDKFHTFIKSDNESDSKSEYEEE
...                                                                                                 
RPK-------------------------------------------------------------------------------------------------

DIPIEDASNSSNDGEAGLIGSSPPNADNQQIQMIFDHSTDLNDEKEKEEEEEEEEETIYMEEDLPDDFFEQGDDSDFCNGAIDEQEEPPLIDLLTDSPCA
                                                                                                    
----------------------------------------------------------------------------------------------------

RSKSDSSGRILLPKTFPSLSDSKSKKSKKSKKQHFLFIQMELCSQSTLKDLMSDKSFFETAPKLEESKQWRICREILEALSYIHQSKVIHRDLKPQNIFI
                                                               |  ..   .|  | .  .|.|. ..|||||   |. .
---------------------------------------------------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLV

DDKNDVKLGDFGLSRLIEAK-KSLKLGDVDELAKEATGTAQGS--FPY--TAPEITKGKKYDKKSDMYSFGIIFFEIW----CYFPTQ----MERRKILF
.... || .|||||| |. . ..   | . .  . .... .|   .|.  .|||  . .|.  ||| .|||.  .||        | .    |. . .. 
GENHTVKISDFGLSRDIYDDDQQ---G-ESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVI-

DLIDNKQFPPQMMT--------DDFKLQREIILNLLDE-PEKRQTCEQLLEKM
 ....   .||.             .. . |..   .| ||.| | ... |..
EYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEIHECF

Kinase 82727.m00037.AA ULK 226-288 23 4e-12 39.36 In-house 1-81 (324) Show / Hide
Range on Protein: 226-288
Range on HMM: 1-81/324
Sequence Identity: 23% (19 aa)

FVKINNLGKGGYG-SVIEARKKADD--DRHYAVKCIPLASLAEVKEM----------KREVAFLSKFQ------HRYIVNFY
..... |||| .|  | ..|.| ..  . ..|.|.|.. .. . | .          |.|.  . |.       | .|| .|
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNH-HIVKLY

Kinase 82727.m00037.AA HRI 226-295 38 2.3e-11 35.53 In-house 1-71 (613) Show / Hide
Range on Protein: 226-295
Range on HMM: 1-71/613
Sequence Identity: 38% (28 aa)

FVKINNLGKGGYGSVIEARKKADDDRHYAVKCIPL--ASLAEVKEMKREVAFLSKFQHRYIVNFYSSWVESV
| .   .|||||| |   | | | . |||.| |    .   ..  | |||  |   ||  || .  .|.| |
FEQKEIIGKGGYGRVYKVRHKLDKQ-HYAIKKIKIKKRTKCSCMKMQREVKVLACLQHHNIVRYHQAWIEHV

Kinase 82727.m00037.AA Pkinase_Tyr 543-678 28 4.9e-11 37.99 Pfam 86-210 (270) Show / Hide
Range on Protein: 543-678
Range on HMM: 86-210/270
Sequence Identity: 28% (39 aa)

MELCSQSTLKDLMSDKSFFETAPKLEESKQWRICREILEALSYIHQSKVIHRDLKPQNIFIDDKNDVKLGDFGLSRLIEAKKSLKLGDVDELAKEATGTA
||..    |.|   ...  |  ..|  .    .|..| ....| .. . |||||   |. ....| || .||||.|.|         . |.    ..| .
MEYMPHGDLLDYLRKHR--EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI--------YNDDYY-YRKRGGG

QGSFPYTAPEITKGKKYDKKSDMYSFGIIFFEIWCY
    . .|||  . .|.  ||| .|||.  .||  |
KLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTY

Kinase 82727.m00037.AA ULK 226-288 21 6.6e-10 30.85 In-house 1-84 (329) Show / Hide
Range on Protein: 226-288
Range on HMM: 1-84/329
Sequence Identity: 21% (18 aa)

FVKINNLGKGGYGSVIEARKKADD---DRHYAVKCIPLASLAEVKEM----------KREVAFLSKF--------QHRYIVNFY
..... |||| .| | ..|.| ..   .  .|.| |.. .. . . .          |.|.  . |         .| .|| .|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLY

Kinase 82727.m00037.AA Pkinase 226-294 20 8e-10 35.82 Pfam 1-72 (293) Show / Hide
Range on Protein: 226-294
Range on HMM: 1-72/293
Sequence Identity: 20% (15 aa)

FVKINNLGKGGYGSVIEARKKADDDRHYAVKCIPLASLAEVKEMK----REVAFLSKFQHRYIVNFYSSWVES
....  .|.|..|.| ....| . .  .|||.|.. .  . |..     .|.. . ...| .|| .| .. ..
YHIGRKIGSGSFGCVYKCHHKGTGK-IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDK

Kinase 82727.m00037.AA STE-Unique 227-293 24 8.1e-09 26.86 In-house 1-72 (616) Show / Hide
Range on Protein: 227-293
Range on HMM: 1-72/616
Sequence Identity: 24% (18 aa)

VKINNLGKGGYGSVIEARKKADDDRHYAVKCIPLASLAE------VKEMKREVAFLSKFQHRYIVNFYSSWVE
. ....|.|. | |  .. | | .| .|.| |.|  .        |. . .|.  .... | .||. | .| .
NCQQMIGRGSFGNVHNCQNKKDCFR-CAIKVIHLKQFKDFNQEPLVNMIISEIEIMKCLHHQNIVKYYGHWLW

Kinase 82727.m00037.AA Ciliate-E2 226-291 13 1.6e-08 25.34 In-house 1-101 (365) Show / Hide
Range on Protein: 226-291
Range on HMM: 1-101/365
Sequence Identity: 13% (14 aa)

FVKINNLGKGGYGSVIEARKKADDD----------------------RHYAVKCIPLASLAEVKEMKREV-------------AFLSKFQHRYIVNFYSS
. .|. .|.|..||| ..... ..                         ||.|..    . ..| ....                |.. .| .|...| .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

W
.
F

Kinase 82727.m00037.AA Pkinase_Tyr 226-288 22 5.5e-07 24.28 Pfam 1-70 (270) Show / Hide
Range on Protein: 226-288
Range on HMM: 1-70/270
Sequence Identity: 22% (16 aa)

FVKINNLGKGGYGSVIEARKK---ADDDRHYAVKCI-PLASLAE--VKEMKREVAFLSKF-QHRYIVNFY
 ...  ||.| .|.| ... |    ... . |||.. . |.  .   ... ||.. .... .|  ||..|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLY

Kinase 82727.m00037.AA TKL 232-288 16 7.2e-05 13.48 In-house 1-91 (364) Show / Hide
Range on Protein: 232-288
Range on HMM: 1-91/364
Sequence Identity: 16% (15 aa)

LGKGGYGSVIEARKKADD-------DRHYAVKCIPLASLAE--------------------------VKEMKREVA-FLSKFQHRYIVNFY
.|.||.| |  .. .  .       ..  ||| ..  .  |                           .. ..|..  .|...|  || |.
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFM