Gene 82761.m00512 (T.vaginalis)

82761.m00512

Species: T.vaginalis
Alias: TvagK0620, 82761.m00512
External Links:
Annotation:

Classification

Group: PKL
Family: PIK
Subfamily: FRAP

Sequence

Name Sequence Type Origin Length Description Download
82761.m00512.AA Protein None 2207 None Fasta, JSON
82761.m00512.kin_dom Protein Kinase Domain None 107 None Fasta, JSON

Protein domain

Protein domains of 82761.m00512.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
FAT 82761.m00512.AA FAT 1445-1624 14 7.4e-05 16.5 Pfam 228-408 (408) Show / Hide 
Range on Protein: 1445-1624
Range on HMM: 228-408/408
Sequence Identity: 14% (29 aa)

IDSPDVQVSFVKILWHRGKANEAIEAIHLLNAIHS-ITEKSTFIEAFNNVNKSSLESLAKVISTKDFKVESTADSFYEYAVKSRKF-NLFDDKQKA-RML
.  | ....  |..|..|   . .||.  |.   |   .. .  .  |. |  ...                     .. |....  . |  |..| |  
RAPPQWTYAYLKYMWATG---QQQEAFQHLREFTSCHMQHDLGVHNNNEIN-GLTY---------------------NLEVINNTNLEYFYTKLLAMRCY

RLEATWIGQE---------YSTVDNALEMFQKSANLYANDYR-TWSNWAYTASKNVDDSD------------KDDKYVQMAINGFLRASILHTS-NTLEY
 . . |  .          . ..| .|. ...   .  . |.  | |||.   . ..               ..  .|  |. .|...  |  . | ...
HKQGMWQWKLYEEQYMNWNQEQKDEILQCYMTATHFDPQWYKKAWHNWALYNFEVFQHYQCQPQREEQNYTHMIIQHVVPAVKCFFHSIALSQGSNSRQD

LCQLFS
.  | .
TLRLLW
Kinase 82761.m00512.AA FRAP 1893-2144 46 1e-91 311.01 In-house 1-251 (251) Show / Hide 
Range on Protein: 1893-2144
Range on HMM: 1-251/251
Sequence Identity: 46% (119 aa)

KWKFLLKGNEDLRLDQRIMQFFDLINSLVKSNKVTQKTGITIINYSITPLAVNAGLISWVTGADTMHQLVTDYRKMQNIPVNAENDITASYVGSCAQY--
 . ||||| ||.| | |.|| | ||| | . |  ||| .. |  ||| || .|.||| ||   ||.| |. ||||  .|  |.|  |   .  .|  |  
EYHFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVHHCDTLHILIRDYRKKYHIRYNIEYNI---MDRMCNDYDH

LHSIQKLEMWDKISKECPATELRDYFWMKSPNPVAWLRCVDTFSLSTALMSMSGYVVGLGDRHPSNIMIQRKKGHVVHIDFGDSFEVTQTRPKMPEKVPF
|  ..| |..  | .     .|.   |.||||   |.     .  | | ||| ||. |||||||||||.||  | .||||||| |||  .| |.|||.||
LPLMNKVEIFRYIMNNTKGEDLKKLLWLKSPNSEIWFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPF

RLTRMIVNALGVSQTAGQFATMCENVLYILRKNKSSIFAQLEIFVHEPIFASRD
|||||.|||. . .  |..   || |. ..| .| |. | || ||  |.|  | 
RLTRMLVNAMEACGIEGNYRNTCELVMKVIREHKESVMAVLEAFVYDPLFYWRL
Kinase 82761.m00512.AA PIKK 1864-2134 32 7.7e-86 291.48 In-house 1-290 (290) Show / Hide 
Range on Protein: 1864-2134
Range on HMM: 1-290/290
Sequence Identity: 32% (95 aa)

SIISIDSTLPVLNTQQHPRILYMYGSDGAKWKFLLKGNEDLRLDQRIMQFFDLINSLVKSNKVTQKTGITIINYSITPLAVNAGLISWVTGADTMHQLVT
 | ..|  . |. . | |. .|. |.||    .|.|| ||||.|||.||.| |.| .   .. .||   .|  ||..|.  . ||| ||....| . . .
RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYK

DYRK----MQNIPVNA-----------------ENDITASYVGSCAQYLHSIQKLEMWDKISKECPATELRDYFWMKSPNPVAWLRCVDTFSLSTALMSM
....     .....                    .. ..  ..   | ... .|.|   ...   |.  ... || |.|.| .|..    .  |.|.|.|
QWCQKKHIRHEQEAQMNYQTCMYRDWLKQMSYYKHQMQQQCMM--YQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCM

SGYVVGLGDRHPSNIMIQRKKGHVVHIDFGDSFEVTQTRPKMPEKVPFRLTRMIVNALGVSQTAGQFATMCENVLYILRKNKSSIFAQLEIF
.||. |||||||.||||..  | .||||||..||.  .| . ||||||||||..|||.|. .. | |   || |. ..|... .. . .| |
VGYILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF
Kinase 82761.m00512.AA PI3Kc 1895-2196 25 6.6e-71 242.8 SMART 1-336 (336) Show / Hide 
Range on Protein: 1895-2196
Range on HMM: 1-336/336
Sequence Identity: 25% (87 aa)

KFLLKGNEDLRLDQRIMQFFDLINSLVKSNKVTQKTGITIINYSITPLAVNAGLISWVTGADTMHQLVTDYRKMQNIPVNAENDI-----TASYVGSCAQ
 ...|...||| |.|.||.| |.| . ...| ...   ..  |.. |.  . |.| ||. ..|.||.   |.|....| . . ..     .. .  . ..
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQ-K-NM

Y-----------------LHSIQKLEMWDKISKECPATELRDYFWMKSPNP-VAWLRCVDTFSLSTALMSMSGYVVGLGDRHPSNIMIQRKKGHVVHIDF
|                 ......|.  ..  .  .   |.|.|| ..|.|  .|  ..|.| .|.| ..| .|. |.||||..|||. .| ||..||||
YMMIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDF

GDSFEVTQTRPKMP----EKVPFRLTRMIVNALG----VSQTAGQFATMCENVLYILRKNKSSIFAQLEIFVHEPI-FASRDSQNNGTAIMNRVSMKLN-
|. |.  ...|. .    |.||||||...|.. |    .|.  |.| |.|. .. ..||.. .| . .|..|. || .  | .    . .. | .. |. 
GHIFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMM--EKDIKYLRQRFRLDH

-GLDPSIESGSD----VSEELSVEEQTSRLISIASDYHRY
   . ...   .       | |.|..|.|.. .. ..  |
LSDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
Kinase 82761.m00512.AA PI3_PI4_kinase 1893-2144 23 1.1e-65 229.31 Pfam 1-300 (300) Show / Hide 
Range on Protein: 1893-2144
Range on HMM: 1-300/300
Sequence Identity: 23% (73 aa)

KWKFLLKGNEDLR--LDQRIMQFF-----------------------DLINSLVKSNKVTQKTGITIINYSITPLAVNAGLISWVTGADTMHQLVTDYRK
  .|..||..|||   |.|.||..                        |.| . |..... .  ...  |.. |.. . |.| ||  ..|.|..   |..
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV

MQNIPV----------------NAENDITASYVGSCAQYLHSIQKLEMWDKISKECPATELRDYFWMKSPNP-VAWLRCVDTFSLSTALMSMSGYVVGLG
. ...                 ...                 .||.|  .. ..  |   |...||...|..  .|... |.| .| | |.. .|. |.|
KCKHKHFNKEHKMWMKMWPDWWHLM----------------RMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNG

DRHPSNIMI--QRKKGHVVHIDFGDSFE-VTQTRPKMPEKVPFRLTR------MIVNAL------GVSQTAGQFATMCENVLYILRKNKSSIFAQL----
|||..|||.   ...||..|||||..|. . . ... ||.||||.|.      ..|.|.      ..|. .| | ..|. .. .||... .. . |    
DRHNDNIMVKDDKTTGHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAV

---EIFVHEPIFASRD
   |..|| ...  |.
MRGECMVHDGLPMWRS
Kinase 82761.m00512.AA ATR 1864-2134 26 3.5e-41 137.84 In-house 2-267 (267) Show / Hide 
Range on Protein: 1864-2134
Range on HMM: 2-267/267
Sequence Identity: 26% (73 aa)

SIISIDSTLPVLNTQQHPRILYMYGSDGAKWKFLLKGNEDLRLDQRIMQFFDLINSLVKSNKVTQKTGITIINYSITPLAVNAGLISWVTGADTMHQLVT
 |  .|  . .| . |.|. . . ||||  .  . |  .||| | | |.| .||| . .     ..  . .  |.. ||  ....| ||    |.. ...
YIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATLRPILD

DYRKMQNIPVNAENDITASYVGSCAQYLHSIQKLEMW-DKISKECPATELRDYFWMKSPNPVAWLRCVDTFSLSTALMSMSGYVVGLGDRHPSNIMIQRK
   | . .     .    .   | ...    .|.    . .    |.   .|.|  . | |  |    . .  |.| ..| ||..||||||  ||.|.. 
KLWKEKKQYMQFYQLRQCMDKKSREEW----EKQKVFREFLLPRHPPI-FHDWFNRRFPDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKI

KGHVVHIDFGDSFEVTQTRPKMPEKVPFRLTRMIVNALGVSQTAGQFATMCENVLYILRKNKSSIFAQLEIF
 | .||.|.   |   ..  ..|| ||||||. .|...|  .| | |   || .. ..|...  | . .. |
NGECVHVDYNCIFNSGEQF-EVPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRDHRDDIMSVWDCF
Kinase 82761.m00512.AA ATM 2015-2140 37 4.5e-24 73.47 In-house 121-246 (304) Show / Hide 
Range on Protein: 2015-2140
Range on HMM: 121-246/304
Sequence Identity: 37% (48 aa)

YFWM-KSPNPVAWLRCVDTFSLSTALMSMSGYVVGLGDRHPSNIMIQRKKGHVVHIDFGDSFEVTQTRPKMPEKVPFRLTRMIVNALGVSQTAGQFATMC
|| | |   |  |      .  | |  |. ||..||||||  ||.|  .   .|||| |  ||  .  |  || ||||||| ||  .|.    | |   |
YFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILP-TPETVPFRLTRDIVDGMGITGVEGVFRRCC

ENVLYILRKNKSSIFAQLEIFVHEPIF
|  . ..|  .  .    |. . .|.|
EKTMEVMRNSQETLLTIVEVLLYDPLF
Kinase 82761.m00512.AA SMG1 1872-1955 40 8.3e-19 58.79 In-house 1-84 (242) Show / Hide 
Range on Protein: 1872-1955
Range on HMM: 1-84/242
Sequence Identity: 40% (34 aa)

LPVLNTQQHPRILYMYGSDGAKWKFLLKGNEDLRLDQRIMQFFDLINSLVKSNKVTQKTGITIINYSITPLAVNAGLISWVTGA
. .| |.  |. |   ||||  . .| || ||| || |||||  ..| .                ||.|||   .||| || ||
ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWVDGA
Kinase 82761.m00512.AA SMG1 2017-2071 47 9.1e-15 45.2 In-house 174-228 (242) Show / Hide 
Range on Protein: 2017-2071
Range on HMM: 174-228/242
Sequence Identity: 47% (26 aa)

WMKSPNPVAWLRCVDTFSLSTALMSMSGYVVGLGDRHPSNIMIQRKKGHVVHIDF
|     |  | |    .  ||| ||| ||..||||||  |..|    | |||||.
WSSCTTPDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDY
Kinase 82761.m00512.AA FATC 2175-2207 51 1e-14 50.14 Pfam 1-33 (33) Show / Hide 
Range on Protein: 2175-2207
Range on HMM: 1-33/33
Sequence Identity: 51% (17 aa)

EELSVEEQTSRLISIASDYHRYVTHYDGWCPYW
|.||||.| .|||. |.|  ..  .| ||||.|
EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW
Kinase 82761.m00512.AA DNAPK 2038-2144 31 4.1e-14 47.61 In-house 195-301 (301) Show / Hide 
Range on Protein: 2038-2144
Range on HMM: 195-301/301
Sequence Identity: 31% (34 aa)

ALMSMSGYVVGLGDRHPSNIMIQRKKGHVVHIDFGDSFE-VTQTRPKMPEKVPFRLTRMIVNALGVSQTAGQFATMCENVLYILRKNKSSIFAQLEIFVH
|.   |... | ||||  | |.    | .. |||| ||   ||  |  ||  ||||||  .| .      | .       .  .|| .       ..|. 
AVICISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLP-VPELMPFRLTRCFINLMSPMKINGIMYQIMIHSMMAFRKDRNILTNFCDVFIN

EPIFASRD
.| |    
DPSFDWKN
Kinase 82761.m00512.AA ATM 1895-1954 38 7.1e-12 33.81 In-house 1-60 (304) Show / Hide 
Range on Protein: 1895-1954
Range on HMM: 1-60/304
Sequence Identity: 38% (23 aa)

KFLLKGNEDLRLDQRIMQFFDLINSLVKSNKVTQKTGITIINYSITPLAVNAGLISWVTG
. | || .||| |  . | | . | |.. |  | |  .||  | . ||.  .| . | ||
RQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTG
Kinase 82761.m00512.AA DNAPK 1864-1952 32 4.3e-10 32.74 In-house 3-91 (301) Show / Hide 
Range on Protein: 1864-1952
Range on HMM: 3-91/301
Sequence Identity: 32% (29 aa)

SIISIDSTLPVLNTQQHPRILYMYGSDGAKWKFLLKGNEDLRLDQRIMQFFDLINSLVKSNKVTQKTGITIINYSITPLAVNAGLISWV
 |   |    |.     |. . . | |     |. || ||||.|||| | |   |         |        |.| |.    ||| ||
RIAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYKGIEDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWV