Gene 83138.m00062 (T.vaginalis)

83138.m00062

Species: T.vaginalis
Alias: TvagK0452, 83138.m00062
External Links:
Annotation:

Classification

Group: CK1
Family: CK1
Subfamily: CK1-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
83138.m00062.AA Protein None 335 None Fasta, JSON
83138.m00062.kin_dom Protein Kinase Domain None 135 None Fasta, JSON

Protein domain

Protein domains of 83138.m00062.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 83138.m00062.AA CK1 45-296 25 4e-72 245.93 In-house 10-339 (339) Show / Hide 
Range on Protein: 45-296
Range on HMM: 10-339/339
Sequence Identity: 25% (83 aa)

GSFG-TVYCA-----YNNVTK-----TFVALKVEREDLK--QSQVYNEARVYQYLKDT-------------------PGFAVQHAFLAQQN--QRILVLE
|.|| ..| .     ..  ..     ...|.|||... .  ..|   |...|..|..                     .. ... .   ..   ...|..
GGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEEDDYYNYMVMT

LLGANLLELFK---ECGHKFSLKTVTMIALQMIDRLETFHSRGFIHRDIKPQNILIGR-------------GDKSKILYLADFGLTS-PFLPARRDG---
||| || .|.|    |..|||.||. |||.||...||  |..|||||||||.|...||             .......|. |||.    ... . ..   
LLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYRDKDGHNRWN

-------ILPPLVT----AQVTG-NQLFSSTGNHMNYQQGPKDDLESLAYMLVYLLTGA--LPWSNIQTTDP-------NKRANILTNTKMTSSVTEICK
       .. |  .    .. .|    . |   | .  ||..|||.|..|||...| |   |||.|.   .         .  .. ...||  ..   |.
GPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKMSTPFF-LCC

D-----CPDMFGDFLRTIKSLKSDDTPDYNAL
      ||. | ...  |.||| .|.||| ..
PKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI
Kinase 83138.m00062.AA CK1-Unclassified 45-179 42 3.2e-68 200.43 In-house 10-154 (244) Show / Hide 
Range on Protein: 45-179
Range on HMM: 10-154/244
Sequence Identity: 42% (61 aa)

GSFGTVYCAYNNVTKTFVALKVEREDLKQSQVYNEARVYQYLKDTP-------GFAVQHAFLAQ--QNQRILVLELLGANLLELFKECGHKFSLKTVTMI
|||| .| ..|  |...||.|.|... |..|   ||...|||..         |..  . .  .  ..  |.|..||| .| .||. |. ||||||| ||
GSFGEIYKCINMQTNEEVAIKLEKKNSKHPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDLFNMCNRKFSLKTVLMI

ALQMIDRLETFHSRGFIHRDIKPQNILIG-RGDKSKILYLADFGL
| |||.|.| .|...|||||||| |.|.| .| .....|. ||||
ADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGL
Kinase 83138.m00062.AA CK1-A 45-296 32 5.7e-58 198.91 In-house 10-261 (261) Show / Hide 
Range on Protein: 45-296
Range on HMM: 10-261/261
Sequence Identity: 32% (83 aa)

GSFGTVYCAYNNVTKTFVALKVEREDLKQSQVYNEARVYQYLKDTPGFAVQHAFLAQQNQRILVLELLGANLLELFKECGHKFSLKTVTMIALQMIDRLE
|||| .| . |      ||.|.|... .  |.  ||.||. |.  .|.   . .  ...  ..|..|||  | .||  |  .|..||| |.| ||| |.|
GSFGDIYLGINITNGEEVAIKMESNKARHPQLIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFNFCKRRFTMKTVLMLADQMIMRIE

TFHSRGFIHRDIKPQNILIGRGDKSKILYLADFGLTSPFLPARRDGILPPLVTAQVTGNQLFSSTGNHMNYQQGPKDDLESLAYMLVYLLTGALPWSNIQ
  | ..|||||||| | |.| |     |.| ||||.  .  .|    .|     ..||   . |   |.   |  .||.||..|...|   | |||  ..
YVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVMMYFNRGKLPWQGMK

TTDPNKRANILTNTKMTSSVTEICKDCPDMFGDFLRTIKSLKSDDTPDYNAL
     ..   .   ||. .. ..||  |  |  ..  ...|. ...|||  |
AMTKKQKYEKISEKKMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL
Kinase 83138.m00062.AA CK1-D 45-296 36 1.9e-57 197.16 In-house 10-261 (261) Show / Hide 
Range on Protein: 45-296
Range on HMM: 10-261/261
Sequence Identity: 36% (92 aa)

GSFGTVYCAYNNVTKTFVALKVEREDLKQSQVYNEARVYQYLKDTPGFAVQHAFLAQQNQRILVLELLGANLLELFKECGHKFSLKTVTMIALQMIDRLE
|||| .|   |  |   ||.|.|    |  |.  |...|....   |    . . .. .  ..|..|||  | .||  |. ||||||| |.|.||| |.|
GSFGDIYHGTNIQTNEEVAIKLECIKTKHPQLHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFNYCHRKFSLKTVLMLADQMICRIE

TFHSRGFIHRDIKPQNILIGRGDKSKILYLADFGLTSPFLPARRDGILPPLVTAQVTGNQLFSSTGNHMNYQQGPKDDLESLAYMLVYLLTGALPWSNIQ
  |.| |||||||| | |.| | . .. |. ||||.  .  ||    .|     ..||   . |   |.   |  .|||||| |.|.|   |.|||  ..
YIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVLMYFNRGSLPWQGLK

TTDPNKRANILTNTKMTSSVTEICKDCPDMFGDFLRTIKSLKSDDTPDYNAL
 .   .. . ... ||  .. ..||  |  | ...   ..|| || |||  |
AATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL
Kinase 83138.m00062.AA CK1 45-179 41 6e-55 187.58 In-house 10-155 (271) Show / Hide 
Range on Protein: 45-179
Range on HMM: 10-155/271
Sequence Identity: 41% (61 aa)

GSFGTVYCAYNNVTKTF---VALKVEREDLKQSQVYNEARVYQYLKD------TPGFAVQHAFLAQ--QNQRILVLELLGANLLELFKECGHKFSLKTVT
|||| .| ..|  |..    || |.|... |..|   ||..|..|..       .|..  . .  .  ..  |.|..||| .| .||. |. ||||||| 
GSFGDIYLGINM-TNGEENHVAIKLEKNKSKHPQLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDLFNFCNRKFSLKTVL

MIALQMIDRLETFHSRGFIHRDIKPQNILIGR-GDKSKILYLADFGL
||| |||.|.| .|...|||||||| |.|.|| | .....|. ||||
MIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGL
Kinase 83138.m00062.AA CK1-G 45-179 38 8.3e-32 105.03 In-house 10-147 (266) Show / Hide 
Range on Protein: 45-179
Range on HMM: 10-147/266
Sequence Identity: 38% (53 aa)

GSFGTVYCAYNNVTKTFVALKVEREDLKQSQVYNEARVYQYLKDTP-GFAVQHAFLAQQNQRILVLELLGANLLELFKECGHKFSLKTVTMIALQMIDRL
|.|| ..   | ..  .|| | |    .  |   | | |. |  .| |    . |       |.|..|||  |  ||  |. |||.||| |.| |||.|.
GNFGELFEGKNMYNNEHVAIKFEPMKSRAPQLHDEYRFYKILNGCPEGIPQVYYFGQCGKYNIMVMDLLGPSLEDLFDWCDRKFSVKTVCMVAIQMIHRM

ETFHSRGFIHRDIKPQNILIGR--GDKSKILYLADFGL
|  ||.  | ||.|| | ||||    . ..... |||.
EYVHSHHLIYRDVKPDNFLIGRPSNKDQHVIHIIDFGM
Kinase 83138.m00062.AA TTBK 107-296 35 5.2e-28 96.1 In-house 73-257 (257) Show / Hide 
Range on Protein: 107-296
Range on HMM: 73-257/257
Sequence Identity: 35% (68 aa)

LVLELLGANLLELFKECGH-KFSLKTVTMIALQMIDRLETFHSRGFIHRDIKPQNILIGR-GDKSKILYLADFGLTSPFLPARRDGILPPLVTAQVTGNQ
.|..|.| || .|  .    .||| |   . .|... .|  || || |||||| |  .||   . .. |. ||||   .. |  . . ||   |   |  
MVMQLQGKNLADLRRKQPRGCFSLSTTLRLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTNACGE-VRPPREVAGFRGTV

LFSSTGNHMNYQQGPKDDLESLAYMLVYLLTGALPWSNIQTTDPNKRANILTNTKMTSSVTEICKDCPDMFGDFLRTIKSLKSDDTPDYNAL
 . |   | |   | .||| || ||||  . | |||  |      |  .   ..|       . |.||  |  |.  ||||.  |.|||  .
RYASINAHRNREMGRHDDLWSLFYMLVEFVQGQLPWRKI------KDKDQVGEMKEKYDHRMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI
Kinase 83138.m00062.AA Worm6 107-180 40 1.5e-21 74.29 In-house 80-159 (279) Show / Hide 
Range on Protein: 107-180
Range on HMM: 80-159/279
Sequence Identity: 40% (32 aa)

LVLELLGANLLELFKEC-GHKFSLKTVTMIALQMIDRLETFHSRGFIHRDIKPQNILIGR-----GDKSKILYLADFGLT
.|..|.| || .| |.. . |||. |   ||.|.....|  |. ||||||.||.|  |||      ......|. |||..
IVMTLVGKNLWDLRKNRPDRKFSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMC
Kinase 83138.m00062.AA CK1 220-294 32 1.6e-21 70.98 In-house 196-271 (271) Show / Hide 
Range on Protein: 220-294
Range on HMM: 196-271/271
Sequence Identity: 32% (25 aa)

KDDLESLAYMLVYLLTGALPWSNIQTTDPNKRANILTNTKMTSSVTEICKD-CPDMFGDFLRTIKSLKSDDTPDYN
.||.|||.|.|.|.| | ||| ...      . .   ..||. .| . ||. .|  | ..|. ...|. ...||| 
RDDMESLGYVLMYFLRGSLPWQGLKANTKKQKYEKIMEKKMSTPVEQLCKGNFPNEFAMYLNYCRQLHFEEKPDYM
Kinase 83138.m00062.AA VRK 105-185 37 1.1e-18 56.82 In-house 104-185 (284) Show / Hide 
Range on Protein: 105-185
Range on HMM: 104-185/284
Sequence Identity: 37% (31 aa)

RILVLELLGANLLELFK-ECGHKFSLKTVTMIALQMIDRLETFHSRGFIHRDIKPQNILIGR-GDKSKILYLADFGLTSPFLP
| .|.. .|  |  . .  .||.|| |||   |..|.| ||  |. .  | ||| .||| |  .....  ||.|.||.. . |
RFMVMPRFGRDLQKIYEDQNGHRFSMKTVLQLACRMLDVLEYLHENEYVHGDIKAANILLGFEKNPDQV-YLVDYGLAYRYCP
Kinase 83138.m00062.AA TTBKL 45-184 31 1.5e-18 59.35 In-house 10-160 (288) Show / Hide 
Range on Protein: 45-184
Range on HMM: 10-160/288
Sequence Identity: 31% (48 aa)

GSFGTVYCAYNNVT-KTFVALKVEREDLK--QSQVYNEARVYQYLK--DTPGFAVQHAFLAQQNQRILVLELLGANLLELFKECGHK--FSLKTVTMIAL
| ||.|| . . .. |.. |.|.|   |    |    |. |   |   . | |.  |.   ... . .|..|.| ||  | |   .|  ||  |.  |. 
GGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFSDGTWSRIGI

QMIDRLETFHSRGFIHRDIKPQNILIGRGDK----SKILYLADFGLTSPFL
| .. |   |. ||||||.||.|. .|  |.    ....|| |||..  ..
QCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYA
Kinase 83138.m00062.AA TTBKL 212-300 30 8.4e-18 56.74 In-house 201-288 (288) Show / Hide 
Range on Protein: 212-300
Range on HMM: 201-288/288
Sequence Identity: 30% (29 aa)

HMNYQQGPKDDLESLAYMLVYLLTGALPWSNIQTTDPNKRANILTNTKMTSSVTEICKD------CPDMFGDFLRTIKSLKSDDTPDYNALKQMF
|. . ||..||| |. ||...|. | |||.|.  ..      ..  .|. .. . ..||      ||. |..| ....||.  |.|||  . . |
HDRKEQGRHDDLWSWMYMIIELHCG-LPWTNMEDKM------EIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF
Kinase 83138.m00062.AA Pkinase 45-179 27 8.1e-16 57.01 Pfam 10-158 (293) Show / Hide 
Range on Protein: 45-179
Range on HMM: 10-158/293
Sequence Identity: 27% (41 aa)

GSFGTVYCAYNNVTKTFVALKVEREDLKQSQV-YN-----EARVYQYLKDTPGFAVQHAFLAQQNQRILVLELLGAN--LLELF----KECGHKF--SLK
||||.|| ...  |   ||.|. . . . |.. ..     |... . | . |     . .    .   .|.|...    ...||     . . .|  | .
GSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEW

TVTMIALQMIDRLETFHSRGFIHRDIKPQNILIG-RGDKSKILYLADFGL
.. ....|..  ||  ||.|.||||.||.||||  .|. . .. ..||||
ECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGL
Kinase 83138.m00062.AA CK1-Unclassified 217-268 40 1.6e-13 36.3 In-house 193-244 (244) Show / Hide 
Range on Protein: 217-268
Range on HMM: 193-244/244
Sequence Identity: 40% (21 aa)

QGPKDDLESLAYMLVYLLTGALPWSNIQTTDPNKRANILTNTKMTSSVTEIC
|. .||||||.| |.|.| | ||| ||.. .   . .   . ||. .| . |
QSRRDDLESLGYVLIYFLKGSLPWQNIKANNKKEKYEKIMEMKMSTPVEQLC
Kinase 83138.m00062.AA CK1-G 212-296 29 2e-13 41.76 In-house 180-266 (266) Show / Hide 
Range on Protein: 212-296
Range on HMM: 180-266/266
Sequence Identity: 29% (26 aa)

HMNYQQGPKDDLESLAYMLVYLLTGALPWSNIQTTDPNKRANILTNTKMTSSVTEICKD--CPDMFGDFLRTIKSLKSDDTPDYNAL
|.   |   ||.|.|  |  | | | |||         .| .   .||    .  .|.    |. |. .|| . .|. ...|||. |
HLGREQSRRDDMEALGHMFMYFLRGSLPWQGLKADNNKERYQKIGDTKRKTNIEDLCQNNAFPEQFATYLRYVRRLDFFECPDYDYL
Kinase 83138.m00062.AA S_TKc 45-315 16 7.9e-13 11.24 SMART 10-231 (231) Show / Hide 
Range on Protein: 45-315
Range on HMM: 10-231/231
Sequence Identity: 16% (50 aa)

GSFGTVYCAYNNVTKTFVALKVEREDLKQSQVYNEARVYQYLKDTPGFAVQHAFLAQQNQRILVLELLGA---NLLELFKECGHK-----FSLKTVTMIA
|.||.||..... |.  ||.|. .      ....| .. .   . |     . .    .   .|.|...    .|... |..|..     |.  ..  ..
GAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYM

LQMIDRLETFHSRGFIHRDIKPQNILIGRGDKSKILYLADFGLTSPFLPARRDGILPPLVTAQVTGN-----QLFSSTGNHMNYQQGP-KDDLESLAYML
 |... ||  ||.|.||||.||.|||. .      . ..||||   .             |  .| .      |          . |. | |  |.  .|
YQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL------------TTFCGTPWYMAPEVL----------GYGKCKCDWWSCGCIL

VYLLTGALPWSNIQTTDPNKRANILTNTKMTSSVTEICKDCPDMFGDFLRTIKSLKSDDTPDYNALKQMFIDFMEEN-------EIQN-------DLMF
  .|.|  |..     ....  ...                                        .|..    .. .       |. .       .  |
YEMLCGYPPFP-----QMQMMFKKIG------------------------------------SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase 83138.m00062.AA Worm6 217-296 28 8.4e-10 31.68 In-house 198-279 (279) Show / Hide 
Range on Protein: 217-296
Range on HMM: 198-279/279
Sequence Identity: 28% (23 aa)

QGPKDDLESLAYMLVYLLTGALPWSNIQTTDPNK-RANILTNTKMTSSVTEICKDCPD-MFGDFLRTIKSLKSDDTPDYNAL
|..|||.||  ||.| ...| ||| ..  .|  . ..    ...     ..  . ||   | | .  | ...  |.|||. .
QCRKDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI
Kinase 83138.m00062.AA TyrKc 45-300 17 1e-05 -130.22 SMART 10-280 (280) Show / Hide 
Range on Protein: 45-300
Range on HMM: 10-280/280
Sequence Identity: 17% (53 aa)

GSFGTVYCAYNNVTKTFVALKVEREDLKQSQVYNEARVYQYL-KDTPGFAVQHAFLAQQ-------NQRILVLELLGA-NLLELFKECGHKFSLKTVTMI
| ||.|| .  .   . || |. .||  .   ..|||.   | .. |     ..   ||        .  .|.|.    .|..  .....|...|.   .
GAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMKDLLSF

ALQMIDRLETFHSRGFIHRDIKPQNILIGRGDKSKILYLADFGLTSPFLPARRDGILPPLVTAQVTGNQLFSSTGNHMNYQQ--GPKDD---------LE
..|  .  |  ||...||||.   |.|.|..    .   .||||.       . |                    ..  | .  .   .         .|
CWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQG-------------------ESKDYYRKKEHKGGKTMLPIRWMAPE

SLAYM-------------LVY-LLT-GALPWSN-IQ--TTDPNKRANILTNTKMTSSVTEICKD-----CPDMFGDFLRTIKSLKSDDTPDYNALKQMF
.. |              . . ..| |. |... ||   ..   .... .   |               |||   .  ..    . .| |  ..... |
CINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY--PMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 83138.m00062.AA VRK 222-250 43 0.000246 10.28 In-house 222-251 (284) Show / Hide 
Range on Protein: 222-250
Range on HMM: 222-251/284
Sequence Identity: 43% (13 aa)

DLESLAYMLVYLLTGALPWSNIQT-TDPNK
|||.|.| . . |.| ||| .     ||.|
DLEILGYCMMMWLYGYLPWMDCLQQQDPEK
Kinase 83138.m00062.AA Worm6 45-69 34 0.001402 9.11 In-house 10-38 (279) Show / Hide 
Range on Protein: 45-69
Range on HMM: 10-38/279
Sequence Identity: 34% (10 aa)

GSFGTVYCAYNNVTKT--FVALKVER--E
|.||.|| . .  .|.  ..|.|.|.  |
GGFGAVYKVEDKSDKKKKQFAMKCEKQME
Kinase 83138.m00062.AA TTBK 45-67 41 0.096001 1.98 In-house 10-33 (257) Show / Hide 
Range on Protein: 45-67
Range on HMM: 10-33/257
Sequence Identity: 41% (10 aa)

GSFGTVYCAYNNVTK-TFVALKVE
| || .| | . ...   ||.|||
GGFGEIYEAKDMINHHEQVAIKVE
Kinase 83138.m00062.AA Pkinase 218-251 29 0.097816 7.22 Pfam 190-221 (293) Show / Hide 
Range on Protein: 218-251
Range on HMM: 190-221/293
Sequence Identity: 29% (10 aa)

GPKDDLESLAYMLVYLLTGALPWSNIQTTDPNKR
||| |  |.  .| ..|.| .|...   ...| .
GPKVDMWSCGCILYEMLCGRPPFPGHC-WHDN-H