Gene 86673.m00318 (T.vaginalis)
86673.m00318
Species: T.vaginalis
Alias: TvagK0055, 86673.m00318
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| 86673.m00318.AA | Protein | None | 286 | None | Fasta, JSON |
| 86673.m00318.kin_dom | Protein Kinase Domain | None | 171 | None | Fasta, JSON |
Protein domains of 86673.m00318.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 86673.m00318.AA | CAMKL | 7-177 | 39 | 3.5e-75 | 239.35 | In-house | 106-297 (297) | Show / Hide |
Range on Protein: 7-177 Range on HMM: 106-297/297 Sequence Identity: 39% (77 aa) GS--LLSYANKN----GPMKEEDAAVIFSELIIALRYLHDECNIAHRDIKAENILLDENH--NIRLIDFGISRI---H-DIETEYMKTNCGSILYAAPEI |. |. | |. |.|.|..| .| .. |. |.|. . |.|||||.||||||||. || .|||| | . . ... . .|| ||| |.|||| GEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHG-IVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEI ISE--KGYT-KSVDIWSAGVLLYAIVVGHFPFEENNY-------KNLTHKIVYSNVEYPP---CLSILLTDLLQKMLVKDPTQRITIKEILDHPWL .. | | . |||||.||.|||.|.|..||.. .| . . .... . .||| .| . ||..|||...|..|.||..|. |||. FQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM |
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| Kinase | 86673.m00318.AA | CAMK | 7-177 | 25 | 5.8e-75 | 240.79 | In-house | 145-425 (425) | Show / Hide |
Range on Protein: 7-177
Range on HMM: 145-425/425
Sequence Identity: 25% (71 aa)
G----SLLSYANKNGP---------------MKEEDAAVIFSELIIALRYLHDECNIAHRDIKAENILLDENH-----------------NIRLIDFGIS
| |..| ..|. ..|..|. .| .. |..|.|. |.|||.| ||||||.|. || .|||| .
GELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN-IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFA
RIHDI-----------------------ETEYMKTNCGSILYAA-PEIIS--------------EKGYTKSVDIWSAGVLLYAIVVGHFPFEEN------
.. | |.. ||| ||. |.| ||... ...|....|.||.||.||. ..|..||..
NKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEIC
-------NYKNLTHKIVYSNVE-YPPCLSI-----------------------LLTDLLQKMLVKDPTQRITIKEILDHPWL
|...| .|| . . .|| .|. ||..|||..||..|.||...|.|||.
EDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
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| Kinase | 86673.m00318.AA | AGC | 6-177 | 24 | 2.6e-72 | 185.35 | In-house | 127-395 (395) | Show / Hide |
Range on Protein: 6-177
Range on HMM: 127-395/395
Sequence Identity: 24% (67 aa)
DGSLLSYAN---KNGPMKEEDAAVIFSE-------LIIALRYLHDECNIAHRD-IKAENILLDENHNIRLIDFGISRIHDIE------------------
.. |... |.| . || | ...| .. || |||.. .| ||| .| |||||||. .|.| ||| . . .
GCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNK
--------------------------------TEYMKTNCG--SILYAAPEIISEKGYTKSVDIWS--AGVLLYAIVVGHFPFEENN----------YKN
.. .| || . | ||||. |.|..|.|| |.|.| ..|. || .| .
KYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPME
LTHKIV------YSNVEYP----------PCLSILLTDLLQKMLVKDPTQRIT----------IKEILDHPWL
. .|| .|..| . .| . ||..|.|.|||..|.. ..|| .|||
MFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
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| Kinase | 86673.m00318.AA | MARK | 7-177 | 42 | 2.2e-68 | 222.7 | In-house | 87-262 (262) | Show / Hide |
Range on Protein: 7-177 Range on HMM: 87-262/262 Sequence Identity: 42% (76 aa) GSLLSYANKN--GPMKEEDAAVIFSELIIALRYLHDECNIAHRDIKAENILLDENH--NIRLIDFGISRIHDIETEYMKTNCGSILYAAPEIISEKGYT- |.|..| . |...||.| .||. .. |. |.|. |.|||||.||||.||| || .|||| | |. .. . .| ||. |.||||.. | |. GELYDYIKAHPNGRLHEEEARRIFRQIVSAVNYCHSKN-IVHRDIKPENILIDENGNHNIKIIDFGFS-ICIPPGQKLNTFCGTPPYMAPEIFLKKPYDG KSVDIWSAGVLLYAIVVGHFPFEENN--YKNLTHKIVYSNVEYPPCLSILLTDLLQKMLVKDPTQRITIKEILDHPWL . ||||| ||.||..|.|.|||.. . ||.| ||. . ..|. .| . .|.|..|. .| .|.||.||. |||. PKVDIWSLGVVLYFMVCGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM |
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| Kinase | 86673.m00318.AA | AMPK | 1-177 | 44 | 4.2e-62 | 183.2 | In-house | 79-254 (254) | Show / Hide |
Range on Protein: 1-177
Range on HMM: 79-254/254
Sequence Identity: 44% (79 aa)
MENLFDGSLLSYANKNGPMKEEDAAVIFSELIIALRYLHDECNIAHRDIKAENILLDENHNIRLIDFGISRIHDIETEYMKTNCGSILYAAPEIISEKGY
|| | | .| |.| ..|..|. | | .. |.|. .|.||| | ||.|||.|.|| . ||| | . |. || ||| |||||.|| | |
MEYVSGGELFDYIVKHGRLQEREACRFFQQIISGVEYCHR-HMIVHRDLKPENLLLDHNKNIKIVDFGLSNMMKDG-EFLKTACGSPCYAAPEMISGKLY
T-KSVDIWSAGVLLYAIVVGHFPFEENNYKNLTHKIVYSNVEYPPCLSILLTDLLQKMLVKDPTQRITIKEILDHPWL
||||| || ||| . | ||.. | .| ||. .. | || ||...|| .||..||||..| |||.
CGPEVDIWSCGVILYAMLCGYLPFDDENTPTLYKKIKNGEYYIPKFLSPEAKDLIKHMLQVDPMKRITIHDIRNHPWF
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| Kinase | 86673.m00318.AA | Pkinase | 7-177 | 26 | 6.2e-58 | 203.59 | Pfam | 85-293 (293) | Show / Hide |
Range on Protein: 7-177 Range on HMM: 85-293/293 Sequence Identity: 26% (56 aa) G----SLLSYAN--KNGPM--KEEDAAVIFSELIIALRYLHDECNIAHRDIKAENILLDENHNI----RLIDFGISRIH-DIETEYMKTNCGSILYAAPE | .| .| ..|.. |... .. ... .| |.|. ..| |||.| ||||.|.| .| ...|||... . . |.| ||.. |.||| GLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPE IIS-EKGYTKSVDIWSAGVLLYAIVVGHFPFEEN----------NYKNLTHKIVYSNVEYPPCLS-----------------ILLTDLLQKMLVKDPTQR .| ..|...||.||.|..|| . |..|| . ... .... .. ... . | . |.. ..| |||..| VIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKR ITIKEILDHPWL .|...|| |||. PTAEQILQHPWF |
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| Kinase | 86673.m00318.AA | Ciliate-E2-Unclassified | 1-177 | 28 | 1.4e-57 | 197.57 | In-house | 100-352 (352) | Show / Hide |
Range on Protein: 1-177
Range on HMM: 100-352/352
Sequence Identity: 28% (73 aa)
MENLFDGSLLSYANKNGP-----------------MKEEDAA-----VIFSELIIALRYLHDECNIAHRDIKAENILLDENH---NIRLIDFGISR----
|| . .|.|. | .|.. |. |. .| ... .| ||| . || ||||| ||||.|.|. .|..||||||.
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ
-----------IHDIETEYMKTNCGSILYA----APEIISEKGYT----KSVDIWSAGVLLYAIVVGHFPFEENNYKN---------------LTHKIVY
. . . |.|.||.. | |||.. ...| ...|||| ||.||... | .||. ||.. ... .
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIK
SN-------------VEYPPCLSILLTDLLQKMLVKDPTQRITIKEILDHPWL
. .|. ...|||||||.|.| .|||...|| |||.
QKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
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| Kinase | 86673.m00318.AA | Ciliate-E2 | 1-177 | 26 | 1.5e-55 | 189.14 | In-house | 113-365 (365) | Show / Hide |
Range on Protein: 1-177 Range on HMM: 113-365/365 Sequence Identity: 26% (72 aa) MENLFDGSLLSYANKN-----------GPMKEEDAAVIFSELI---------------IALRYLHDECNIAHRDIKAENILLDENHNIRLIDFGISRIHD || . |.|..| ..| ....|. .. |. ... ||.||| . || ||||| ||||. | .||||.|.. | MEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYD IE----------TEYMKTN----------------------CGSILYAAPEIIS---------EKGYTKSVDIWSAGVLLYAIVVGHFPFEENNYKNLTH .. .|| . ||. | ||||.. .|||....||||.||.|| . | .|| DDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF---------Q KIVYS-NVEYPPC------------------LSILLTDLLQK----MLVKDPTQRIT-IKEILDHPWL .. ....|. .| ||..| ||.||| .||| ...||.|||. QQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF |
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| Kinase | 86673.m00318.AA | AktR | 7-177 | 37 | 7.4e-55 | 188.56 | In-house | 86-268 (268) | Show / Hide |
Range on Protein: 7-177 Range on HMM: 86-268/268 Sequence Identity: 37% (68 aa) GSLLSYANKNGPMKEEDAAVIFSELIIALRYLHDECNIAHRDIKAENILLDENHNIRLIDFGISR--IHDIETEYMKTNCGSILYAAPEIISE-KGYTKS | |... .|.. ..||.| .|.. ..|| |||.. || ||.| |||||||. .....||| |. . . ..| .. ||. | |||.| . ||..|| GELFQHLKKKKKFSEEQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKS VDIWSAGVLLYAIVVGHFPFEENNYKNLTHKIVYSN---VEYPPCLSILLTDLLQ-KMLVKDPTQRIT-----IKEILDHPWL ||.|. |...| .|.|. ||. .| . . .|| ... ..||...| . ||.| | | |.|..|.. ..|| .||| VDWWAFGIFIYEMVTGCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF |
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| Kinase | 86673.m00318.AA | RSK | 17-177 | 33 | 2e-54 | 187.14 | In-house | 99-278 (278) | Show / Hide |
Range on Protein: 17-177 Range on HMM: 99-278/278 Sequence Identity: 33% (61 aa) GPMKEEDAAVIFSELIIALRYLHDECNIAHRDIKAENILLDE---NHNIRLIDFGISRIHDIE-TEYMKTNCGSILYAAPEIIS----EKGYTKSVDIWS | . |..|.....|.. |...||. | |||.| ||||.|. . |.|.||| ... ... .. ..| |..| |.|||.. ..|..|..|.|| GCFSEDEACFYMAEIVLAVEHLHQQG-IIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWS AGVLLYAIVVGHFPFEE---NNYKNLTHKIVYSN--VEYP--PCLSILLTDLLQKMLVKDPTQRIT-----IKEILDHPWL |||.| .|. || || | . .| . .. | . || ||..||| .|| .|.. ..||..|||. LGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF |
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| Kinase | 86673.m00318.AA | QIK | 18-177 | 42 | 1.7e-53 | 184.02 | In-house | 114-272 (272) | Show / Hide |
Range on Protein: 18-177 Range on HMM: 114-272/272 Sequence Identity: 42% (68 aa) PMKEEDAAVIFSELIIALRYLHDECNIAHRDIKAENILLDENHNIRLIDFGISRIHDIETEYMKTNCGSILYAAPEIISEKGYT-KSVDIWSAGVLLYAI ||.|..|. .|.... | |.|. ||.|||.||||||||.| || ..||| | . . . ..| ||| |||||. | |. ||||| ||.||. PMAENEARRWFWQICSAVHYCHKR-NIVHRDLKAENILLDNNMNIKIADFGFSN-WFKQGQLLMTWCGSPPYAAPEMFEGKEYDGPKVDIWSMGVVLYVL VVGHFPFEENNYKNLTHKIVYSNVEYPPCLSILLTDLLQKMLVKDPTQRITIKEILDHPWL | | .|| . .|| .... . |. .| . .| .||| ||..|.||. |. |.|. VCGALPFDGKTLQNLRQRVLSGKFRIPFFMSQDCEHLIRHMLVVDPEHRYTIMQICQHRWM |
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| Kinase | 86673.m00318.AA | S_TKc | 1-177 | 26 | 2.9e-31 | 111.12 | SMART | 18-231 (231) | Show / Hide |
Range on Protein: 1-177 Range on HMM: 18-231/231 Sequence Identity: 26% (64 aa) MENLF-----------------------------------------------DG---SLLSYANKNGP------MKEEDAAVIFSELIIALRYLHDECNI . || .|..| |.|. . | .|. .. ... || |.|. .| CRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSH-GI AHRDIKAENILLDENHNIRLIDFGISRIHDIETEYMKTNCGSILYAAPEIISEKGYTK-SVDIWSAGVLLYAIVVGHFPFEENNYKNLTHKIVYSNVEYP |||.| ||||||| .| ..|||..|. .| ||. | |||.. ||.| ..|.|| |..|| ..| ||. ... . .||. IHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG------- PCLSILLTDLLQKMLVKDPTQRITIKEILD-------HPWL | . |...|.|.|||..|.|. |.| |||. ---SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | 86673.m00318.AA | TyrKc | 1-177 | 16 | 4e-06 | -122.72 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 1-177 Range on HMM: 1-280/280 Sequence Identity: 16% (48 aa) ME-------------------------------------------NL---------------FD-------------------GSLLSYANKNGP-MKEE . .| . |.|..| |..| . . ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMK DAAVIFSELIIALRYLHDECNIAHRDIKAENILLDENHNIRLIDFGISRIHDIE------TEYMKT----NC---GSILYAAPEIISEKGYTKSVDIWSA | . .|||. |. |||. | |.|..||| .. ||| || .. . ..| .. .. | ||| | .. .| |.|| DLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSF GVLLYAIV-VGHFPFEE-----NNYKNLTHKIVYSNVEYPPCL---------SILLTDLLQKMLVKDPTQRITIKEILDHPWL ||... | | | .. . . . ... . .| . . .. .. || .| | .|| | . GVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF |
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| Kinase | 86673.m00318.AA | Pkinase_Tyr | 46-114 | 35 | 2.9e-05 | 18.43 | Pfam | 134-205 (270) | Show / Hide |
Range on Protein: 46-114 Range on HMM: 134-205/270 Sequence Identity: 35% (26 aa) HRDIKAENILLDENHNIRLIDFGISRIHDIETEYM-KTNCGSIL---YAAPEIISEKGYTKSVDIWSAGVLLY |||. | |.|..||. .. ||| .| . ...| .. |. | ||| |... .| |.|| |||.. HRDLAARNCLVTENNVVKICDFGLARDI-YNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMW |
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