Gene 84221.m00095 (T.vaginalis)

84221.m00095

Species: T.vaginalis
Alias: 84221.m00095, TvagK0954
External Links:
Annotation:

Classification

Group: TKL
Family: TKL-Tvag3

Sequence

Name Sequence Type Origin Length Description Download
84221.m00095.AA Protein None 493 None Fasta, JSON
84221.m00095.kin_dom Protein Kinase Domain None 145 None Fasta, JSON

Protein domain

Protein domains of 84221.m00095.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 84221.m00095.AA TKL 65-240 20 1.7e-38 134.18 In-house 115-364 (364) Show / Hide 
Range on Protein: 65-240
Range on HMM: 115-364/364
Sequence Identity: 20% (52 aa)

IISSYQPRGC-VNLHTIRTLNPTLKWVTAIGISSAINYLHRNH--------VYNLNLKPSNILLSDDFR--------------PKLSDYGLTSKLQTHM-
|.  | |.|.  ....     . ..   |..|....|||| ..        .   .||..|||. ....              .|..|.||   ..... 
IVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGN

-------------------RPNQNIGTIIYMAPELLTKQ---------------FSITPKADIYSFGLILYLIFAERCAYNDSDNPLTQ---------IM
                   . .  .||. .||||.| .|               |. ..|.|.||||..|. |.. .  | | ...  .         .|
MNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMM

AFSKGVRPHIF------------EGVPPVVVDLIKQMWQTNPDYRPTAAAVYDML
. .|| || |             . .|| . .|... |...|. ||..  . . |
VCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase 84221.m00095.AA RIPK 95-240 25 1.5e-25 84.0 In-house 116-290 (290) Show / Hide 
Range on Protein: 95-240
Range on HMM: 116-290/290
Sequence Identity: 25% (44 aa)

ISSAINYLHRNH--VYNLNLKPSNILLSDDFRPKLSDYGLTSKLQTHMRPN--------------QNIGTIIYMAPELLT--KQFSI---TPKADIYSFG
||.. .||| .   .  . |||.|||.  .|  |..| || . ...  . .              .. ||..||.||..      .|   ||| |.|||.
ISCGMCYLHSMNPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTDNKKPIKVVTPKYDVYSFA

LILYLIFAERCAYNDSDNPLTQIMAFSKGVRPH---IFEGVPPV-----VVDLIKQMWQTNPDYRPTAAAVYDML
 ... ... . .| |  .... .|  ..| ||    . |  |        ..|... || .|. ||.   . .  
IVMWEVLTQKHPYEDRKCMMMIMMCCKQGHRPCLQPVPEYWPEPPHCEQMIELMQRCWQQDPNDRPCFQECEEWT
Kinase 84221.m00095.AA TKL-Unique 82-240 26 3.2e-23 78.87 In-house 106-290 (290) Show / Hide 
Range on Protein: 82-240
Range on HMM: 106-290/290
Sequence Identity: 26% (49 aa)

TLNPTLKWVTAIGISSAINYLHRNH--VYNLNLKPSNILLSDD-----FRPKLSDYGLTSKLQTHMRPNQN----------IGTIIYMAPELLTKQ-FSI
.||. ..   || |... .|||..   .. ..||.||.|.. .     .. |..| ||   . . .. . |          .|....||||.|.   . .
KLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQY

TPKADIYSFGLILYLIFAERCA-------YNDSDNP-LTQIMAFS-KGVRPHIFEGVPPVVVDLIKQMWQTNPDYRPTAAAVYDML
. |.|.|||| .|. | |.|.        | . |   . .. ..  .. || | .  |.   |||.| |  .|. ||.   ..  |
SEKSDVYSFGIVLWEI-ATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase 84221.m00095.AA Ciliate-E2-Unclassified 97-233 21 6.8e-23 76.27 In-house 154-343 (352) Show / Hide 
Range on Protein: 97-233
Range on HMM: 154-343/352
Sequence Identity: 21% (40 aa)

SAINYLHRNH-VYNLNLKPSNILLSDD---FRPKLSDYGLTSKLQT----------------HMRPNQNIGTIIYM----APELLTKQFSITP---KADI
....|||... .   ..||.|||....   ...|..|.|. .|.|.                ... ....||..||    |||.| .|   ..   |.||
QGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDI

YSFGLILYLIFAERCAYNDSD------------------NPLTQIMAFSKGVRPHIF----EGVPPVVVDLIK----QMWQTNPDYRPTA
.|.| ||| .   .. ..| .                  . . .|..    .... .     ...| . |.|.    .| . ||..|.|.
WSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITF
Kinase 84221.m00095.AA Ciliate-E2 95-233 20 7.4e-23 75.28 In-house 154-356 (365) Show / Hide 
Range on Protein: 95-233
Range on HMM: 154-356/365
Sequence Identity: 20% (44 aa)

ISS---------------AINYLHRNH-VYNLNLKPSNILLSDDFRPKLSDYGLTSKLQ------THMRPNQN---------------------------
| .               |..||| .. .   ..||.|||.     .|..| ||  |..      ||  . ..                           
ILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTI

IGTIIYMAPELLTKQFS--------ITPKADIYSFGLILYLIFAERCAYNDSDNPLTQIMAFSKGVRPH--------------IFEGVPPVVVDLIKQ--
.||  ||||| | ..           . |.||.|.| |||     .  .      . ||.      ..               ... ... . ||||.  
CGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFG

--MWQTNPDYRPT-A
  | | .|. |.| .
KRMLQKDPEKRITGW
Kinase 84221.m00095.AA Pkinase 95-240 23 3.8e-22 79.38 Pfam 117-293 (293) Show / Hide 
Range on Protein: 95-240
Range on HMM: 117-293/293
Sequence Identity: 23% (42 aa)

ISSAINYLHRNHVYNLNLKPSNILLSDDFRP----KLSDYGLTSK--LQTHMRPNQNIGTIIYMAPELLTKQFSITPKADIYSFGLILYLIFAERCAYND
| ....|.|.. .    |||.|||....  .    |..| ||  .  .     ..   ||. |||||.. ..  ..||.|..|.|.|||  .  |  . .
ILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPG

S---DNPLTQIMAFSKGVRPHIFEGVP-----------------------PVVVDLIKQMWQTNPDYRPTAAAVYDM--L
.   || ..|.  . .  .| . .  |                       .   |.|| ... .|  ||||. .     .
HCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 84221.m00095.AA TAK1 95-239 24 7.9e-19 60.15 In-house 111-284 (284) Show / Hide 
Range on Protein: 95-239
Range on HMM: 111-284/284
Sequence Identity: 24% (43 aa)

ISSAINYLHRNH---VYNLNLKPSNILLSDDFRP-KLSDYGLTSKLQTHMRPNQNIGTIIYMAPEL---------------------LTKQFSITPKADI
......||| .    .    .|| | ||..  |  |. | |.   ....|  |.  || ..||||                        .    . |.||
CAQGVAYLHSMQPKPQIHRDIKPQNMLLCNKHRTLKICDFGTFCDMHQMMTCNR--GTCRWMAPEVRELFDFKSNRIIINQPTGFQKVFRCEKYNMKCDI

YSFGLILYLIFAERCAYNDSDNP--LTQIM-AFSKGVR-PHIFE--GVPPVVVDLIKQMWQTNPDYRPTAAAVYDM
||.| |.  . . .  | . .||  ...|| | ..| | |.. .   .|.   .. |  |..||. ||. . .   
YSWGIIMWEVISRKHPYDHIMNPNSAYRIMWAIHNGNRPPMETNRSDCPKRIEQFMKCCWDDNPEKRPSMQECVKY
Kinase 84221.m00095.AA LRRK 92-242 25 1.6e-18 62.09 In-house 170-351 (351) Show / Hide 
Range on Protein: 92-242
Range on HMM: 170-351/351
Sequence Identity: 25% (47 aa)

AIGISSAINYLHRNH---VYNLNLKPSNILL-SD-----------DFRPKLSDYGLTS--KLQTHMRPNQNIGTIIYMAPELLTKQ--FSITPKADIYSF
|. |.....|||...   ..  .||. |||| |            .   |..|.|...  .  ..   .   |....|||| . .    . | |.|.|||
ALQIAKGMEYLHSHNPPIIHR-DLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSF

GLILYLIFAER-CAYNDSDNP-----LTQIMA-FSKGVRPHIFEG-VPP-----VVVDLIKQMWQTNPDYRPTAAAVYDMLIN
|.||. .   . ... . | .      .||    ..| || | .   ||      . |||.. ||..|. ||..  . . |  
GMILWELLTRQHHPFDEHDFFDHMQWMEQIEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase 84221.m00095.AA CAMKL 95-236 27 2.3e-18 55.06 In-house 136-291 (297) Show / Hide 
Range on Protein: 95-236
Range on HMM: 136-291/297
Sequence Identity: 27% (44 aa)

ISSAINYLHRNHVYNLNLKPSNILLSDDF--RPKLSDYGLTSKLQT-----HMRPNQNIGTIIYMAPELLTK--QFSITPKADIYSFGLILYLIFAERCA
| ||.||.|....    .|| ||||...     |..| |.  . .          .   |.  |||||.. .  .  . ||.|| | | ||| .   .  
IVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLP

YNDS--------DNPLTQIMAFSKGVRPHIFEGVPPVVVDLIKQMWQTNPDYRPTAAAV
 .|         .. .   .  .   .| |.  |.  . |||..| |.||..|||.  .
FDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQI
Kinase 84221.m00095.AA MLK 92-240 24 3.8e-17 56.13 In-house 130-291 (291) Show / Hide 
Range on Protein: 92-240
Range on HMM: 130-291/291
Sequence Identity: 24% (40 aa)

AIGISSAINYLHRNH---VYNLNLKPSNILLSD------DFRPKLSDYGLTSKLQTH---MRPNQNIGTIIYMAPELL--TKQFSITPKADIYSFGLILY
|  ......||| .    .    ||..|||...      .   | .| |.  .....   |    |.|| ..|||| .   .    . |.|..|.|..|.
ALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNM--MSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLW

LIFAERCAYNDSDNPLTQIM-AFSKGVRPHIFEGVPPVVVDLIKQMWQTNPDYRPTAAAVYDML
 ... .  | . ..|.. .. .  .| ||.|  . |.    |.||.|...|  ||. . .   |
EMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase 84221.m00095.AA IRAK 92-176 32 1.8e-16 55.04 In-house 115-214 (317) Show / Hide 
Range on Protein: 92-176
Range on HMM: 115-214/317
Sequence Identity: 32% (33 aa)

AIGISSAINYLHRNH----VYNLNLKPSNILLSDDFRPKLSDYGLTS-------KLQTHM---RPNQNIGTIIYMAPELLT---KQFSITPKADIYSFGL
..|.. .|..|| ||    .   . |..|||| ..| ||..| ||         |...     . .  .|| .||.|| ..   .|  .|.| |.||||.
CWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQ--LTKKTDVYSFGI

IL
 |
VL
S_TKc 84221.m00095.AA S_TKc 1-240 20 2.1e-13 19.51 SMART 18-231 (231) Show / Hide 
Range on Protein: 1-240
Range on HMM: 18-231/231
Sequence Identity: 20% (54 aa)

MENKNTHRKVVFKYNELLSNASCNNDGAAINEFYEYLSDVSQNMHPAINPIEGWCVPNEKRIPIIISSYQPR--GCVNLHTIRT--------LNPTLKWV
  .|.|.|.|  |               ...|  . |.      || |  . ....        ..  | .   | .  .  .         ...   . 
CRHKKTGRIVAIKIIK----------EHIRREI-QILKK----HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARF

TAIGISSAINYLHRNHVYNLNLKPSNILLSDDFRPKLSDYGLTSKLQTHMRPNQNIGTIIYMAPELLTKQFSITP-KADIYSFGLILYLIFAERCAYNDS
 .  | .|..|.|....    |||.||||..  . |..| ||  .|      .  .||  |||||.|    . .. |.|..|.| |||  .. .  .   
YMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEMLCGYPPFP--

DNPLTQIMAFSKGVRPHIFEGVPPVVVDLIKQMWQTNPDYRPTAAAVYD---------ML
     |...  | ..       .| . |.|....| .|. ||||  .            .
-----QMQMMFKKIG-------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
TyrKc 84221.m00095.AA TyrKc 12-240 18 1.5e-08 -84.45 SMART 1-280 (280) Show / Hide 
Range on Protein: 12-240
Range on HMM: 1-280/280
Sequence Identity: 18% (51 aa)

FKYNELLSNAS----------------CNNDGAAINEFYEYLSDVSQN--MHPAINPIEGWCVPNEK-----RIPIIISSYQPRGCVNLHTIRTLNPTLK
 . .. | .                  . ...| . .|.. ..  ..    || |  . | |.  .        . |.  | | |.  .. .|   |.|.
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDL-KDYLRKHRPKLC

WVT----AIGISSAINYLHRNHVYNLNLKPSNILLSDDFRPKLSDYGLTSKLQTH---------MRPN---QNI--GTIIYMAPELLTKQFSITPKADIY
. .    .. |..  .|||....    |   |.|...... | || ||. ..  .          |.    .      |  |||| . .    |.| |..
MKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKFTTKSDVW

SFGLILYLIFAERCAYNDSD----NPLTQIMAFSKGV-RPHIFEG--------VPPVVVDLIKQMWQTNPDYRPTAAAVYDML
|||  .. ||         .     . ...... |   |. . .          |. . ...|| |. .|. ||| ..... .
SFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Ank 84221.m00095.AA Ank 389-422 38 2.9e-07 30.48 Pfam 1-33 (33) Show / Hide 
Range on Protein: 389-422
Range on HMM: 1-33/33
Sequence Identity: 38% (13 aa)

DGDTALHVACKKNDLTLAQLLLSIEKIDVNYQNK
||.|.||.||.....  ...||.    ||| |..
DGFTPLHLACRCGHTEVVKMLLQ-HGADVNAQDD
Ank 84221.m00095.AA Ank 423-456 41 5e-06 26.08 Pfam 1-33 (33) Show / Hide 
Range on Protein: 423-456
Range on HMM: 1-33/33
Sequence Identity: 41% (14 aa)

KGYTPLHEASRMGASEIVNALLLVKGIKLTVPDK
 |.|||| |.|.|  |.|  ||  .|  . . |.
DGFTPLHLACRCGHTEVVKMLLQ-HGADVNAQDD
Ank 84221.m00095.AA Ank 364-388 36 26.051839 1.77 Pfam 9-33 (33) Show / Hide 
Range on Protein: 364-388
Range on HMM: 9-33/33
Sequence Identity: 36% (9 aa)

AANSGDREKIRNLLNDDVDVNSIDK
|. .|. | .. ||.   |||  |.
ACRCGHTEVVKMLLQHGADVNAQDD