95912.m00243

Species: T.vaginalis
Alias: TvagK0122, 95912.m00243
External Links:
Annotation:

Classification

Group: CAMK
Family: CAMKL
Subfamily: CAMKL-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
95912.m00243.AA Protein None 404 None Fasta, JSON
95912.m00243.kin_dom Protein Kinase Domain None 247 None Fasta, JSON

Protein domain

Protein domains of 95912.m00243.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 95912.m00243.AA AGC 41-261 20 3.3e-64 163.92 In-house 45-395 (395) Show / Hide
Range on Protein: 41-261
Range on HMM: 45-395/395
Sequence Identity: 20% (73 aa)

VCLKIDEKRKAETE----------NEFRMMKLLN----------HPLTCQ-FYGEFKSGDN--VGAVLEFIE---------GS-TILDFIN---KNGVIK
|..| .. ... ||          .| ......|          ||  ..  .  |.. |.  .  |.|...         |    .  .    |.|.  
VIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSFQDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFD

ENYARYLFAE-------LVSIIQHLHCELGMIHQD-LKCENIIIDTHNNLHLIDFGFAHLDSDNL-----------------------------------
|. ||. .||       .|. ...|| ..| || | || ||| .| . ...| |||..    ..                                    
EERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQ

---------------PLSYSGFG--TPGYIPPEVIKGNRYTFSSDIFS--IGVLLYSMLVGRLPFSGTNSA----------EIFHHTV------TDPVNY
                . ..  |  || |..||..    |... |. |   |.|.| ||.|. ||.| |            |.|.         ...| .
RNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKF

P----------ETISDDVIDLLDSLLDKDPIKRPN----------ISQILLHNWL
|          . .|..  ||.  || ||| ||.           ...|  | | 
PFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF

S_TKc 95912.m00243.AA S_TKc 15-261 26 8.8e-63 215.81 SMART 1-231 (231) Show / Hide
Range on Protein: 15-261
Range on HMM: 1-231/231
Sequence Identity: 26% (70 aa)

IVVLGKIARGGYASIWNAYCVEMKTHVCLKIDEKRKAETENEFRMMKLLNHPLTCQFYGEFKSGDNVGAVLEFIEG--STILDFINKNGV------IKEN
  .| || .|.... . .. .. . .| .||       ...| ...|  .||  ...|. | . |..  |.|...|   . .|.| |.|       . | 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-

YARYLFAELVSIIQHLHCELGMIHQDLKCENIIIDTHNNLHLIDFGFAHLDSDNLPLSYSGFGTPGYIPPEVIKGNRYTF-SSDIFSIGVLLYSMLVGRL
 ||........ ....|   | || ||| ||| .|.  .. ..|||.| .        ..  ||| |..|||.    |.. ..|. |.|..|| ||.|. 
HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYP

PFSGTNSAEIFHHTVTDPVNYPETISDDVIDLLDSLLDKDPIKRPNISQILL-------HNWL
||.  . ...|.. .          |....|... .|.||| ||| . ..|        | |.
PFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase 95912.m00243.AA CAMK 20-261 19 1.7e-59 190.04 In-house 1-425 (425) Show / Hide
Range on Protein: 20-261
Range on HMM: 1-425/425
Sequence Identity: 19% (82 aa)

KIARGGYASIWNAYCVEMK------------THVCLKI--------------------------------DEKRKAETENEFRMMKL-------LNHPLT
.. ||...    ..  . .            ..|  ||                                ..| ... ..| ..||.       |.||  
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

CQFYGEFK------------SGDN--------VGAVL---EFIEGS----TILDFINKN---------------GVIKENYARYLFAELVSIIQHLHCEL
...|  .             . ..        .  |.   |...|      ..|.| ..               | ..|  ||..|  ..| ....|   
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

GMIHQDLKCENIIIDTH-----------------NNLHLIDFGFA--HLDSDNLP---------------------LSYSGFGTPGYIP-PEVIKGNR--
  .| |||.||| .|..                 ||. .||||||    ...|.                      . .  .|||.|.. |||..|..  
-IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC

------------YTFSSDIFSIGVLLYSMLVGRLPFSGT-------------NSAEIFHHTVTDPVN-YPET---------------ISDD--------V
            |....|. |.||.|| ||.|..|| |              |  |.|.   .   . .|.                |||.        .
NMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQEC

IDLLDSLLDKDPIKRPNISQILLHNWL
.||. ..| .|| ||..|.|.| | |.
KDLIRKMLQVDPEKRMTIEQCLNHPWM

Kinase 95912.m00243.AA Ciliate-E2 15-261 19 7.8e-57 193.62 In-house 1-365 (365) Show / Hide
Range on Protein: 15-261
Range on HMM: 1-365/365
Sequence Identity: 19% (73 aa)

IVVLGKIARGGYASIWNAYC------------------------VEMKTHVCLKIDEKRKAETENEFRMMK----------------LLNHPLTCQFYGE
. .. || .|...|.. .                          | .|      . .. . ....| ..|.                .||||  ...|  
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FK--SGDNVGAVLEFIEGSTILDFINKN-----------GVIKENYARYLFAELVS---------------IIQHLHCELGMIHQDLKCENIIIDTHNNL
|.  . .|.  |.|...| . .|.|..|           . ..|. ..|.......                ...|| .   || |.| |||..     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

HLIDFGFA-HLDSD---------NLPLSYSG----------------------FGTPGYIPPEVIK---------GNRYTFSSDIFSIGVLLYSMLVGRL
 .||||..  .| |         .  . . .                       ||||| .||...         ...|....||.|.||.|| || |..
KIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PFSGTNSAEIFHHTVTD-PVNYP------------------ETISDDVIDLLDS----LLDKDPIKRPN-ISQILLHNWL
||              . ....|                  . .|....||.      .|.||| ||.. ..||| | |.
PF---------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF

Pkinase 95912.m00243.AA Pkinase 15-261 26 1.1e-56 199.47 Pfam 1-293 (293) Show / Hide
Range on Protein: 15-261
Range on HMM: 1-293/293
Sequence Identity: 26% (79 aa)

IVVLGKIARGGYASIWNAYCVEMKTHVCLKIDEKRKAETEN--------EFRMMKLLNHPLTCQFYGEFKSGDNVGAVLEFIEGS----TILDFIN--KN
.....|| .|.... . .. .     |..|| .||... .         | ..|| ||||  ...|. | ..|..  |.|. ||        |.|   ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GVI--KENYARYLFAELVSIIQHLHCELGMIHQDLKCENIIIDTHNNL----HLIDFGFAHLD-SDNLPLSYSGFGTPGYIPPEVIK-GNRYTFSSDIFS
|..   |. ..  . .... ....|   | || ||| ||| || ....    ...|||.| .    | .  ..  |||.|..||||. |. |. ..|..|
GCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

IGVLLYSMLVGRLPFSGT------NSAEIFHHTVTDPVNYPETIS---------------------DDVIDLLDSLLDKDPIKRPNISQILLHNWL
.|..|| || ||.||.|       .  ...  .   |. ...  .                     .. .|.....|.||| |||.. ||| | |.
CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF

Kinase 95912.m00243.AA Ciliate-E2-Unclassified 15-261 20 1.7e-51 176.9 In-house 1-352 (352) Show / Hide
Range on Protein: 15-261
Range on HMM: 1-352/352
Sequence Identity: 20% (71 aa)

IVVLGKIARGGYASIWNAYCVE------MKTHVCLKIDEKRKAET----------ENEFR-------------MMKLLNHPLTCQFYGEFKSGDNVGAVL
  .. .| .||..... ... .      ||.    .|. ... ..          .|.                .. ..||.   .. .|.. .|.  |.
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

EFIEGSTILDFINKNGV-----------------IKENYAR-----YLFAELVSIIQHLHCELGMIHQDLKCENIIIDTHN---NLHLIDFGFA-HLDSD
|..|| . ...|.|..                  . |. |.     ..||.... ...|| ... || |.|.|||..|  .   .. .||||.. .....
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN

NL--------------PLSYSGFGTPGYI----PPEVIKGNRYT----FSSDIFSIGVLLYSMLVGRLPFSGTNSAE---------------IFHHTV-T
|                ....  |||.|.    .|||..|. |     ...||.| ||.|| || |..||...|. .               ...     
NNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQ

DPVNYPE--------TISDDVIDLLD----SLLDKDPIKRPNISQILLHNWL
 ....|.        ..|. ..|..     ..|.|.| ||....||| | |.
KNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF

Kinase 95912.m00243.AA CAMKL 47-261 28 8.2e-51 160.31 In-house 54-297 (297) Show / Hide
Range on Protein: 47-261
Range on HMM: 54-297/297
Sequence Identity: 28% (71 aa)

EKRKAETENEFRMMKLLN---HPLTCQFYGEFKSGDN------VGAVLEFIEGST--ILDFINKN----GVIKENYARYLFAELVSIIQHLHCELGMIHQ
|...   . | . ||.||   ||  ...|  .   ..      .  |.| ..|     .|.| |.    | ..|. || .|  .|| ....|     .| 
ESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHG-IVHR

DLKCENIIIDTHN--NLHLIDFGFA--HLD--SDNLPLSYSGFGTPGYIPPEVIKG--NRYT-FSSDIFSIGVLLYSMLVGRLPFSGT--------NSAE
|.| ||| .| ..  |. .|||||.  . .    .  .     |.| | .||...|   .|  .  || |.||.|| |..|.||| .         |  .
DIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-Y

IFHHTVTDPVNYP--ETISDDVIDLLDSLLDKDPIKRPNISQILLHNWL
 .. . ..  ..|    .| |..||. ..| ..| |||.| ||. | |.
LYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM

Kinase 95912.m00243.AA RSK 44-261 27 2.2e-44 153.76 In-house 36-278 (278) Show / Hide
Range on Protein: 44-261
Range on HMM: 36-278/278
Sequence Identity: 27% (67 aa)

KIDEKRK--AETENEFRMMKLLN-HPLTCQFYGEFKSGDNVGAVLEFIEGSTILDFINKNGV---IKENYARYLFAELVSIIQHLHCELGMIHQDLKCEN
||. . |  . |  | . ... . ||  .. .  |. .. .  ..|...|   .. . | .    . |. |.. .||.|. ..||| ..| || ||| ||
KIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGCFSEDEACFYMAEIVLAVEHLH-QQGIIHRDLKPEN

IIIDT---HNNLHLIDFGFAHL-DSDNLPLSYSGFGTPGYIPPEVIK---GNR-YTFSSDIFSIGVLLYSMLVGRLPFSG---TNSAEIFHHTVTDP--V
|. |    .  . |.||||. . . |.  . ..  .|  |..||..|   ... .. . |..| |||.| ||.|..|| |    |..||.    .    .
ILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSL

NYP--ETISDDVIDLLDSLLDKDPIKRPN-----ISQILLHNWL
. |  ...|..  ||.  .| .|| ||..     ...|. | |.
TMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF

Kinase 95912.m00243.AA Ciliate-E2b 55-261 26 5.8e-43 128.47 In-house 49-272 (272) Show / Hide
Range on Protein: 55-261
Range on HMM: 49-272/272
Sequence Identity: 26% (60 aa)

NEFRMMKLLNHPLTCQFYGEFKSGDNVGAVLEFIEGSTILDFINKNG--VIKENYARYLFAELVSIIQHLHCELGMIHQDLKCENIIIDTHNNLHLIDFG
.|   .. .|||   .|.  ||. ...  ..||. |  ..| |   |   . .. ..  .|... ... || ... |. |.| |||..|    . |||.|
QEKNVLEKCNHPFIMKFIRSFKDDQHMYFMMEFCNGMELFDVIREIGRLLLSTYDSQFYIASICLCLEYLH-NQNIIYRDIKPENIMVDHKGYMKLIDMG

FA-HLDSDNLPL--SYSGFGTPGYIPPEVIK-----GNRYTFSSDIFSIGVLLYSMLVGRLPFS--GTNSAEIFHHTVTD--PVNYPETISDDVI--DLL
 | |... |  .   ..  ||| |  ||.|.     |  ||...||.|.|. || ...|..|.     .  ||    .    ....|  ..| .   .| 
TAKHMYKKNEQMTRTFTIIGTPHYMAPEIIQSLQPGGKGYTYKVDIWSVGICLYEFMCGYVPWAEDVQDPYEIYQEIIKKYDEIQFPSYCKDKMADKKLM

DSLLDKDPIKRP--NISQILLHNWL
...| | |  |.   .|.  .| | 
LQCLQKMPEVRLGGSYSWLKSHPWF

Kinase 95912.m00243.AA MARK 84-261 31 3.5e-41 132.48 In-house 80-262 (262) Show / Hide
Range on Protein: 84-261
Range on HMM: 80-262/262
Sequence Identity: 31% (59 aa)

VLEFIEGSTILDFINKN--GVIKENYARYLFAELVSIIQHLHCELGMIHQDLKCENIIIDTHN--NLHLIDFGFAHLD-SDNLPLSYSGF-GTPGYIPPE
..| ..|   .|.| .   | ..|. || .|  .|| .. .|     .| |.|.||| || ..  |  .|||||.    ....    . | ||| | .||
IMEYASGGELYDYIKAHPNGRLHEEEARRIFRQIVSAVNYCHSKN-IVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQK---LNTFCGTPPYMAPE

VIKGNRYT-FSSDIFSIGVLLYSMLVGRLPFSGTN--SAEIFHHTVTDPVNYPETISDDVIDLLDSLLDKDPIKRPNISQILLHNWL
.... .|. .  || | ||.|| |..|..|| |..    |..   ..    .|  .|..  .|. .||  .| .|| |..|. | |.
IFLKKPYDGPKVDIWSLGVVLYFMVCGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM

Kinase 95912.m00243.AA MELK 16-261 29 2.8e-38 128.25 In-house 2-254 (254) Show / Hide
Range on Protein: 16-261
Range on HMM: 2-254/254
Sequence Identity: 29% (76 aa)

VVLGKIARGGYASIWNAYCVEMKTHVCLKIDEKRK-----AETENEFRMMKLLNHPLTCQFYGEFKSGDNVGAVLEFIEGSTILDFINKNGVIKENYARY
 |  .|  ||.| .  |  .    .| .|| .|..        . |   .| | |   ||.|      | .  |.|.  |  ..|.| ..  ..|. .| 
EVHDEIGTGGFAKVKLACHILTNQMVAIKIMDKNQLGHDLPRVKTEMDALKNLRHQHICQLYHYIETEDKIFMVMEYCPGGEMFDYIIRQDRLEEEETRH

LFAELVSIIQHLHCELGMIHQDLKCENIIIDTHNNLHLIDFGFAHLDSDNLPLS--YSGFGTPGYIPPEVIKGNRYTFS-SDIFSIGVLLYSMLVGRLPF
.| ..|| | ..| . |  |.||| ||...| . .| |||||.      .          | | |  ||.|.| .|  |  |..|.|.||| ...| |||
FFRQIVSAIAYVHSQ-GYAHRDLKPENLLFDEDHHLKLIDFGLCAKTKGRKDYHNLQTCCGSPAYAAPELIQGKQYIGSEADVWSMGILLYVLMCGFLPF

SGTNSAEIFHHTVTDPVNYPETISDDVIDLLDSLLDKDPIKRPNISQILLHNWL
   |   ...  .    . |. .|   ..||  .|  || ||  . ..| |.|.
DDDNMMIMYKKIMSGCYEEPKWLSPESKQLLRHMLQVDPKKRISMKNLLNHPWV

Kinase 95912.m00243.AA Delta 64-261 31 7.9e-38 131.99 In-house 58-259 (259) Show / Hide
Range on Protein: 64-261
Range on HMM: 58-259/259
Sequence Identity: 31% (64 aa)

NHPLTCQFYGEFKSGDNVGAVLEFIEGSTILDFINKNGVIKENYARYLFAELVSIIQHLHCELGMIHQDLKCENIIIDTHNNLHLIDFGFAHLDSDNLPL
.||  |...  |.. ...  |.|.. |  ..  | . .  .|. ||.  .|... .| || . |.|  ||| .|...|    ... ||| .  .      
EHPFLCHLFCTFQTKEHLFFVMEYLNGGDLMYHIQQCHRFDEKRARFYACEIICGLQFLHKK-GIIYRDLKLDNVLLDCDGHIKIADFGMCKENMYGEKK

SYSGFGTPGYIPPEVIKGNRYTFSSDIFSIGVLLYSMLVGRLPFSGTNSAEIFHHTVTDPVNYPETISDDVIDLLDSLLDKDPIKRPNI-----SQILLH
. .  ||| || ||.|||..|..| | .| |||.| ||.|  ||.| .  |.|.  . |   || .|. .  |.|  |...|| ||  .      .|  |
ASTFCGTPDYIAPEIIKGQKYNHSVDWWSFGVLMYEMLIGQSPFHGEDEDELFWSICNDRPWYPRWITKEAKDCLKKLFERDPEKRLGVQYCPKGDIRQH

NWL
 . 
CFF

Kinase 95912.m00243.AA TyrKc 15-261 18 2.6e-10 -56.02 SMART 1-280 (280) Show / Hide
Range on Protein: 15-261
Range on HMM: 1-280/280
Sequence Identity: 18% (55 aa)

IVVLGKIARGGYASIWNAYCVEMKTHV---CLKIDEKRKAETENEFRMMKLL--NHPLTCQFYGEFKSG-------DNVGAVLEFIEGSTILDFINKNGV
|. . |. .| .  .. .      . |   .|| |   ...  .| |.|. |  .||   ..||   ..       . .  |.|. ..   .|.. |.. 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

IKENYARYLFAELVSII-------QHLHCELGMIHQDLKCENIIIDTHNNLHLIDFGFAHLDSDN-----LPLSYSG-F--GTPG-----YIPPEVIKGN
          ..|.|.        ..||   . || || . |. ..  .     ||| .    |          |.     |. .       .||.|. .
K------LCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

RYTFSSDIFSIGVLLYSML-VGRLPFSG-----TNSAEIFHHTVTDPVNYPETI---------SDDVIDLLDSLLDKDPIKRPNISQILLHNWL
..|. ||..| ||... ..  |  | .|      . .|....  .     .            .|.. ..  .  . || .||. |.|  |  .
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF