82578.m00512

Species: T.vaginalis
Alias: TvagK0869, 82578.m00512
External Links:
Annotation:

Classification

Group: TKL
Family: TKL-Tvag2

Sequence

Name Sequence Type Origin Length Description Download
82578.m00512.AA Protein None 905 None Fasta, JSON
82578.m00512.kin_dom Protein Kinase Domain None 225 None Fasta, JSON

Protein domain

Protein domains of 82578.m00512.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 82578.m00512.AA TKL 189-277 19 2.5e-14 48.0 In-house 241-364 (364) Show / Hide
Range on Protein: 189-277
Range on HMM: 241-364/364
Sequence Identity: 19% (24 aa)

PPELLSGN--------------FKKITPESDIYAFGILTFRFICKKIVFNQVDVS---------LSFSQNIIQGKRFMIP----------QFSYT--FLR
.||.| |.              ... .. .|.|.|||. .  .. .... . . .         . |....  |.|  ||          . ...   ..
APEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMK

EIVENCWVQDPNKRPSMADVYKKL
.. . || .||.||||. .. |.|
KLMQDCWDHDPEKRPSFQEILKRL

Kinase 82578.m00512.AA Fer 234-278 31 2.4e-11 35.03 In-house 237-283 (283) Show / Hide
Range on Protein: 234-278
Range on HMM: 237-283/283
Sequence Identity: 31% (15 aa)

QNIIQ-GKRFMIPQFSYTFLREIVE-NCWVQDPNKRPSMADVYKKLK
..||. |..  .|.   .....|.. .||..||..||.|.....|||
KWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK

S_TKc 82578.m00512.AA S_TKc 25-285 16 3.7e-11 -13.23 SMART 1-231 (231) Show / Hide
Range on Protein: 25-285
Range on HMM: 1-231/231
Sequence Identity: 16% (47 aa)

LRMIDVLKE-------KSTNNEFIAITHTKFGIKDSRKKSFFERVNAMACLHHPAVCTLYGYFLPDNAEKKCPTLLFKNAKR--GCLGYYIDKSRLRSTK
 ...... .       | ....    |. .. ||  . ...   .. .   ||| ...||..|       ..  . .  .    | |  ||.| . . ..
YEILRKIGKGAFGKVYKCRHKK----TGRIVAIKIIK-EHIRREIQILKK-HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

SYLEPPKILKILLGVASALKYLHSQGFVCGDLQPTSIFLNENYEPLLYPI------LSTHNAYRKLNVATFDMATDLISPPELLSGNFKKITP-ESDIYA
... .  . ...  ...||.|.||.|..  || |  |.|.|        |      |...         |    |    .||.|     . .. ..|...
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------HIKICDFGLARQL--------TTFCGTPWYMAPEVL-----GYGKCKCDWWS

FGILTFRFICKKIVFNQVDVSLSFSQNIIQGKRFMIPQFSYTFLREIVENCWVQDPNKRPSMADVYK-KLKQDCPIFL
.|.. . ..| .  |      .    ..|          |  ..  ....|.. ||.|||.  .. .  ..  |  ..
CGCILYEMLCGYPPFP----QMQMMFKKIG---------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase 82578.m00512.AA TKL 51-159 17 1.8e-10 33.9 In-house 63-178 (364) Show / Hide
Range on Protein: 51-159
Range on HMM: 63-178/364
Sequence Identity: 17% (22 aa)

KDSRKKSFFERVNAMACLH--HPAVCTLYG-YFLPDNAE--------KKCPTLLFKNAKRGC-LGYYIDKSRLRSTKSYLEPPKILKILLGVASALKYLH
.....  |||.. .| ..   || .. ..|  . |.. .        .. . .    ...|. | |..             ....... |..|... |||
PEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------------WHQRCRWALDIARGMNYLH

SQG--------FVCGDLQPTSIFLNENYE
|..         .  || .  |...||..
SMNPKWCTKPPIIHRDLKSKNILVDENWT

Kinase 82578.m00512.AA Pkinase 189-277 13 5.3e-09 32.91 Pfam 179-293 (293) Show / Hide
Range on Protein: 189-277
Range on HMM: 179-293/293
Sequence Identity: 13% (16 aa)

PPELLSGNFKKITPESDIYAFGILTFRFICKKIVFNQV------DVSLSFSQNIIQGKRFMIPQFSY-------------------TFLREIVENCWVQD
.||..    ....|..|....|.. . ..|..  | .       |    . ..     .| .|. .                      .......|. .|
APEVIR-GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKD

PNKRPSMADVYKK--L
|.|||. ... .   .
PKKRPTAEQILQHPWF

Kinase 82578.m00512.AA RIPK 189-277 23 1.5e-08 25.2 In-house 190-290 (290) Show / Hide
Range on Protein: 189-277
Range on HMM: 190-290/290
Sequence Identity: 23% (24 aa)

PPELLSGNFKKI----TPESDIYAFGILTFRFICKKIVFNQVDVSLSFSQNIIQGKRFMIPQFSYTFLR--------EIVENCWVQDPNKRPSMADVYKK
|||..  . ||     ||..|.| |.|...    .| ..  .  .. .   . ||.|  ..  .  . .        |  . || ||||.||.  ..  .
PPEHFRTDNKKPIKVVTPKYDVYSFAIVMWEVLTQKHPYEDRKCMMMIMMCCKQGHRPCLQPVPEYWPEPPHCEQMIELMQRCWQQDPNDRPCFQECEEW

L
 
T

TyrKc 82578.m00512.AA TyrKc 22-277 16 2.1e-08 -86.69 SMART 1-280 (280) Show / Hide
Range on Protein: 22-277
Range on HMM: 1-280/280
Sequence Identity: 16% (50 aa)

LSELRMID----------VLKEKSTNNEFIAITHTKFGIKDSRKKSFFERVNAMACL--HHPAVCTLYGYFLPD-----NAEKKCPTLLFKNAKRGCLGY
.. ....           ..|      .  |.   | .     .. | .  . |  |  ||| .  |||. . .      .|  .  ...  .. |.|  
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLM--IVMEYMPHGDLKD

YIDKSRLRSTKSYLEPPKILKILLGVASALKYLHSQGFVCGDLQPTSIFLNENYEPLLYPILSTHNAY---------RKLNVA--------TFDMAT--D
|. |.| .     | ... |.. . .|.   ||||....  ||    . ..||.                       |..           . ....  .
YLRKHRPK-----LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-------------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKG

LI-------SPPELLSGNFKKITPESDIYAFGILTFRFICKKIVFNQV-----DVSLSFSQNIIQGKRFMIPQF--------SYTFLREIVENCWVQDPN
          .|| .  |..| |..||...||.. .                        ... ||.| ..|.           . . .| . ||  ||.
GKTMLPIRWMAPECI--NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPE

KRPSMADVYKKL
.||.........
DRPTFSEIHECF

Kinase 82578.m00512.AA LRRK 203-279 25 3.5e-08 25.01 In-house 262-351 (351) Show / Hide
Range on Protein: 203-279
Range on HMM: 262-351/351
Sequence Identity: 25% (23 aa)

ESDIYAFGILTFRFICKK-IVFNQVD-V-----SLSFSQNIIQGKRFMIPQF-SYT-----FLREIVENCWVQDPNKRPSMADVYKKLKQ
..|.|.||.. .  .  . . | . | .        ....|| | |  |||   .       . .  . || .||.|||.. .. |.|.|
KVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ

Kinase 82578.m00512.AA Dicty4-Unclassified 251-277 40 6.4e-08 23.18 In-house 237-263 (263) Show / Hide
Range on Protein: 251-277
Range on HMM: 237-263/263
Sequence Identity: 40% (11 aa)

FLREIVENCWVQDPNKRPSMADVYKKL
|..  .  ||  ||||||.| .. ..|
FWKKLIKWCWHNDPNKRPTMNQIIQYL

Kinase 82578.m00512.AA TKL-Unique 239-277 30 8.9e-08 23.69 In-house 252-290 (290) Show / Hide
Range on Protein: 239-277
Range on HMM: 252-290/290
Sequence Identity: 30% (12 aa)

GKRFMIPQFSYTFLREIVENCWVQDPNKRPSMADVYKKL
..| .||.     .|.. . || .|| .|||  .....|
NYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL

Kinase 82578.m00512.AA TK 250-277 25 8.5e-07 17.99 In-house 459-486 (486) Show / Hide
Range on Protein: 250-277
Range on HMM: 459-486/486
Sequence Identity: 25% (7 aa)

TFLREIVENCWVQDPNKRPSMADVYKKL
... ..   ||  ||..||........|
EEYYDLMQQCWHYDPEDRPTFSQLHEQL

Kinase 82578.m00512.AA UTK 254-277 29 2e-06 18.18 In-house 273-296 (296) Show / Hide
Range on Protein: 254-277
Range on HMM: 273-296/296
Sequence Identity: 29% (7 aa)

EIVENCWVQDPNKRPSMADVYKKL
...  || .|| .||.. |.....
RLMHRCWHYDPQERPDFEDLVQQM

Kinase 82578.m00512.AA TKL-Unique 188-211 45 7e-06 16.87 In-house 193-216 (290) Show / Hide
Range on Protein: 188-211
Range on HMM: 193-216/290
Sequence Identity: 45% (11 aa)

SPPELLSGNFKKITPESDIYAFGI
..||.|..||....  ||.|.|||
MAPEVLRMNFCQYSEKSDVYSFGI

Kinase 82578.m00512.AA Dicty5 205-281 24 2.3e-05 14.43 In-house 185-260 (260) Show / Hide
Range on Protein: 205-281
Range on HMM: 185-260/260
Sequence Identity: 24% (19 aa)

DIYAFGILTFRFICKKIVFNQVDVSLSFSQNIIQGKRFMIPQFSYTFLREIVENCWVQDPNKRPSMADVYKKLKQDC
|.|.|||  .  . .|  .  .  . .    .  | |  ||    |    ... ||.| | .|||   . | ...  
DVYSFGIVLWEMFTRKEPYDNI-NNWNIPVMVMKGERPTIPKDCPTEISNLIKKCWQQKPHNRPSFKEICKYFESII

Kinase 82578.m00512.AA TK-Unique 232-277 23 6e-05 13.13 In-house 248-294 (294) Show / Hide
Range on Protein: 232-277
Range on HMM: 248-294/294
Sequence Identity: 23% (11 aa)

FSQNIIQGKRFMIPQFS-YTFLREIVENCWVQDPNKRPSMADVYKKL
. ..| .|.|   |. . .  .... ..||  .| .||| ... ..|
IMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL

Kinase 82578.m00512.AA TK 108-147 10 6.6e-05 11.55 In-house 147-266 (486) Show / Hide
Range on Protein: 108-147
Range on HMM: 147-266/486
Sequence Identity: 10% (13 aa)

KSRLRSTKSY---------------------------------------------------------------------------LEPPKILKILLGVAS
.. ||. . .                                                                           | ..  | . . .|.
RDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIAC

ALKYLHSQ------GFVCGDL
.. ||||.      .|| .||
GMEYLHSKNCEFIQNFVHRDL

Kinase 82578.m00512.AA Pkinase_Tyr 232-277 23 0.00064 13.9 Pfam 224-270 (270) Show / Hide
Range on Protein: 232-277
Range on HMM: 224-270/270
Sequence Identity: 23% (11 aa)

FSQNI-IQGKRFMIPQFSYTFLREIVENCWVQDPNKRPSMADVYKKL
. . |  .| |  .|.     . ..   || .||..||...... .|
VYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL

Kinase 82578.m00512.AA Dicty5 121-159 23 0.000985 8.72 In-house 104-142 (260) Show / Hide
Range on Protein: 121-159
Range on HMM: 104-142/260
Sequence Identity: 23% (9 aa)

PKILKILLGVASALKYLHSQGFVCGDLQPTSIFLNENYE
. .| . ...| ....||| . .  ||    . ..||..
FQQLHMAIDIAQSMRHLHSMNIIHRDLKSMNFLITENWK

Kinase 82578.m00512.AA TK 189-212 32 0.001728 6.71 In-house 353-383 (486) Show / Hide
Range on Protein: 189-212
Range on HMM: 353-383/486
Sequence Identity: 32% (10 aa)

PPELLSGN-------FKKITPESDIYAFGIL
.|| | ..       ..| |..||...||.|
APECLNDRVFSEAEKYGKFTTKSDVWSFGVL

Kinase 82578.m00512.AA UTK 130-148 52 0.003278 6.84 In-house 127-145 (296) Show / Hide
Range on Protein: 130-148
Range on HMM: 127-145/296
Sequence Identity: 52% (10 aa)

VASALKYLHSQGFVCGDLQ
.|... ||||.||| .||.
IARGMQYLHSCGFVHRDLA

Kinase 82578.m00512.AA TK-Unique 115-147 22 0.003705 6.88 In-house 125-159 (294) Show / Hide
Range on Protein: 115-147
Range on HMM: 125-159/294
Sequence Identity: 22% (8 aa)

KSYLEPPKILKILLGVASALKYLHS--QGFVCGDL
.... |   . .. ..|....||.|  ...| .||
TEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDL

Kinase 82578.m00512.AA LRRK 123-140 50 0.006736 6.07 In-house 166-183 (351) Show / Hide
Range on Protein: 123-140
Range on HMM: 166-183/351
Sequence Identity: 50% (9 aa)

ILKILLGVASALKYLHSQ
.||| | .|....||||.
KLKIALQIAKGMEYLHSH

Kinase 82578.m00512.AA TK-Unique 189-212 36 0.015275 4.73 In-house 204-228 (294) Show / Hide
Range on Protein: 189-212
Range on HMM: 204-228/294
Sequence Identity: 36% (9 aa)

PPELLSGNFKKI-TPESDIYAFGIL
.|| |.   . . |..||...||.|
APESLKCYHGMYHTTKSDVWSFGVL

Kinase 82578.m00512.AA Fer 201-212 33 0.018362 4.33 In-house 196-207 (283) Show / Hide
Range on Protein: 201-212
Range on HMM: 196-207/283
Sequence Identity: 33% (4 aa)

TPESDIYAFGIL
.|..|...||..
SPKTDVWSFGVM

Kinase 82578.m00512.AA TKL-Unique 122-158 18 0.018908 4.67 In-house 111-154 (290) Show / Hide
Range on Protein: 122-158
Range on HMM: 111-154/290
Sequence Identity: 18% (8 aa)

KILKILLGVASALKYLHSQG--FVCGDLQPTSIFLNEN-----Y
...|. . .|... |||. .     .|| .... ...|     .
QRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEW

Kinase 82578.m00512.AA Pkinase_Tyr 108-143 23 0.025164 8.5 Pfam 95-133 (270) Show / Hide
Range on Protein: 108-143
Range on HMM: 95-133/270
Sequence Identity: 23% (9 aa)

KSRLRST---KSYLEPPKILKILLGVASALKYLHSQGFV
.. ||.    |  | .. .|.. . .|... ||.|....
LDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCI

Kinase 82578.m00512.AA Pkinase 118-143 17 0.025741 9.27 Pfam 103-130 (293) Show / Hide
Range on Protein: 118-143
Range on HMM: 103-130/293
Sequence Identity: 17% (5 aa)

L--EPPKILKILLGVASALKYLHSQGFV
.  ..  . .... ....|.|.||.|..
FYFSEWECKFYMYQILRGLEYCHSMGII

Kinase 82578.m00512.AA Fer 108-141 22 0.037227 3.27 In-house 97-131 (283) Show / Hide
Range on Protein: 108-141
Range on HMM: 97-131/283
Sequence Identity: 22% (8 aa)

KSRLRSTKS-YLEPPKILKILLGVASALKYLHSQG
.|.|. .|.  .   .........|. ..||||..
DSYLKKNKNKTVSDNEKIRMCYQAACGMEYLHSKN

Kinase 82578.m00512.AA Dicty4-Unclassified 123-147 28 0.069301 2.2 In-house 111-135 (263) Show / Hide
Range on Protein: 123-147
Range on HMM: 111-135/263
Sequence Identity: 28% (7 aa)

ILKILLGVASALKYLHSQGFVCGDL
|.|. . .|  . .||.  |.  |.
IIKYAFDIAQGMQHLHTRNFIHRDI

Ank 82578.m00512.AA Ank 733-754 40 0.044874 11.74 Pfam 1-22 (33) Show / Hide
Range on Protein: 733-754
Range on HMM: 1-22/33
Sequence Identity: 40% (9 aa)

FEKTALHSACENGCLEVLAVLI
   |.|| ||..|..||.  |.
DGFTPLHLACRCGHTEVVKMLL

Ank 82578.m00512.AA Ank 767-800 38 8.3e-08 32.41 Pfam 1-33 (33) Show / Hide
Range on Protein: 767-800
Range on HMM: 1-33/33
Sequence Identity: 38% (13 aa)

FGQTPLHIAIEHGRNDCAKKLIRSQNIDLNSKDD
 |.||||.|...|. ...| |.  .. |.| .||
DGFTPLHLACRCGHTEVVKMLLQ-HGADVNAQDD

Ank 82578.m00512.AA Ank 801-834 38 4.9e-05 22.43 Pfam 1-33 (33) Show / Hide
Range on Protein: 801-834
Range on HMM: 1-33/33
Sequence Identity: 38% (13 aa)

DGFSPLFYAINQKNIETVDLLLNDERCDINLQSN
|||.|| .|.   ..| | .||.   .|.|.| .
DGFTPLHLACRCGHTEVVKMLLQ-HGADVNAQDD

Ank 82578.m00512.AA Ank 835-868 26 0.000708 18.24 Pfam 1-33 (33) Show / Hide
Range on Protein: 835-868
Range on HMM: 1-33/33
Sequence Identity: 26% (9 aa)

KGYTALHWSAKHGNDEITIKLLSRKDINTEIADN
 |.|.||. ...|. |.   ||. .  .  . |.
DGFTPLHLACRCGHTEVVKMLLQ-HGADVNAQDD