Gene 80378.m00220 (T.vaginalis)

80378.m00220

Species: T.vaginalis
Alias: TvagK0849, 80378.m00220
External Links:
Annotation:

Classification

Group: Other
Family: Other-Tvag1

Sequence

Name Sequence Type Origin Length Description Download
80378.m00220.AA Protein None 714 None Fasta, JSON
80378.m00220.kin_dom Protein Kinase Domain None 292 None Fasta, JSON

Protein domain

Protein domains of 80378.m00220.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 80378.m00220.AA STE 220-313 35 2.5e-21 72.15 In-house 168-274 (359) Show / Hide 
Range on Protein: 220-313
Range on HMM: 168-274/359
Sequence Identity: 35% (41 aa)

IHNHHIILRDIKPDNILLDEFDKPHYADFDVSVFDTD-------------------KAYDFTGTEFYMAPEVDQNLSKSKY-VGYGVKSDIFSLGCVLNY
.|.|||| |||||.||||        .|| |.   ||                   | . |.||  .||||| |. ... .  ||..|.|| ||||..  
LHSHHIIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQG-RDKGYDTKCDIWSLGCTIIE

MFNHNYPYSIYTPL
| . ..|.. ..|.
MATGKPPWHDMHPM
Pkinase 80378.m00220.AA Pkinase 184-308 28 1e-20 74.32 Pfam 80-213 (293) Show / Hide 
Range on Protein: 184-308
Range on HMM: 80-213/293
Sequence Identity: 28% (40 aa)

PLYRKG----TLKAYIQ--NNPNL--TNLELLEKFYQICLDVRNIHNHHIILRDIKPDNILLDEFDKP----HYADFDVS----VFDTDKAYDFTGTEFY
.. ..|     |..||.  .. ..  .  |.   .|||.  .  .|.. || ||.||.|||.|. . .    . .|| ..          ...|.|| .|
EYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWY

MAPEVDQNLSKSKYVGYGVKSDIFSLGCVLNYMFNHNYPYS
|||||   .   .. .|| |.|..|.||.| .|.. . |..
MAPEV---IR--GGQYYGPKVDMWSCGCILYEMLCGRPPFP
Kinase 80378.m00220.AA AGC 220-297 22 8.9e-20 46.39 In-house 169-295 (395) Show / Hide 
Range on Protein: 220-297
Range on HMM: 169-295/395
Sequence Identity: 22% (31 aa)

IHN-HHIILRD-IKPDNILLDEFDKPHYADFDVSVF-----------------------------------------------------DTDKAYDFTG-
.|. ..|| || .||.||||||    . .||  .                                                       ..|... | | 
LHSHMGIIHRDYLKPENILLDEDGHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGP

-TEFYMAPEVDQNLSKSKYVGYGVKSDIFS--LGCVL
 |  |||||.           ||   |. |  |||..
CTPEYMAPEIL----------YGKACDWWSFGLGCLM
Kinase 80378.m00220.AA CAMK 210-297 25 2e-17 52.02 In-house 185-324 (425) Show / Hide 
Range on Protein: 210-297
Range on HMM: 185-324/425
Sequence Identity: 25% (36 aa)

FYQICLDVRNIHNHHIILRDIKPDNILLDEFD-----------------KPHYADFDVS--VFD------------------------TDKAYDFTGTEF
| |||  |. .|.|.|. ||.||.|||||. .                 .   .||  .  ...                        ..| ..| ||  
FRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPE

YMA-PEVDQNLSKSKY--------VGYGVKSDIFSLGCVL
||| ||| .  ... .         .|| |.|. |.|..|
YMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVIL
Kinase 80378.m00220.AA Ciliate-E2b 212-307 33 5.5e-17 48.3 In-house 110-210 (272) Show / Hide 
Range on Protein: 212-307
Range on HMM: 110-210/272
Sequence Identity: 33% (34 aa)

QICLDVRNIHNHHIILRDIKPDNILLDEFDKPHYADFDVS-VFDTDKA-----YDFTGTEFYMAPEVDQNLSKSKYVGYGVKSDIFSLGCVLNYMFNHNY
.|||  .  ||  || ||||| ||..|.   .  .|. .. .... .      .   || .|||||. | | .    ||..|.||.|.| .|  .     
SICLCLEYLHNQNIIYRDIKPENIMVDHKGYMKLIDMGTAKHMYKKNEQMTRTFTIIGTPHYMAPEIIQSL-QPGGKGYTYKVDIWSVGICLYEFMCGYV

PY
|.
PW
Kinase 80378.m00220.AA Ciliate-E2-Unclassified 189-308 25 2.7e-16 53.05 In-house 106-271 (352) Show / Hide 
Range on Protein: 189-308
Range on HMM: 106-271/352
Sequence Identity: 25% (43 aa)

GTLKAYIQNNPN-----------------LTNLELL-----EKFYQICLDVRNIHNHH-IILRDIKPDNILLDEFD---KPHYADFDVS-----------
|.|. ||.....                 .|  . .       |.||..    .|  . || |||||.|||.|.     ..  .||  |           
GDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDT

-------VFDTDKAYDFTGTEFYM----APEVDQNLSKSKYVGYG----VKSDIFSLGCVLNYMFNHNYPYS
       ... .....|.||  ||    ||||       .  .|.     |.||.|||..| .|   .||..
NQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEV------LQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFY
Kinase 80378.m00220.AA Ciliate-E2 189-472 13 1.1e-14 46.75 In-house 119-337 (365) Show / Hide 
Range on Protein: 189-472
Range on HMM: 119-337/365
Sequence Identity: 13% (48 aa)

GTLKAYIQNN-----------PNLTNLELLEKFYQICL---------------DVRNIHNHH-IILRDIKPDNILLDEFDKPHYADFDVSVFDTDK----
|.|. ||.||            ..|  | .. ..||.                 .. .|. . || |||||.|||.     .  .||  | . .|.    
GDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNR

------------------------------AYDFTGTEFYMAPEVDQNLSKS---KYVGYGVKSDIFSLGCVLNYMFNHNYPYSIYTPLIPKTVIYLIDF
                              .. . ||  |||||. .. . .   |  ||. |.||.|||..| .|   ..|.                 
THKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF-----------------

MRNPNPDFRPTIDELISLTLGTMKYYRSNPVNEGHFGLMNYVPRPDDKINPKQNSDYGENRFKKHADNRKNAHNPENNQNSNKRPPPQNINPSQDSSESD
                                                                                                    
----------------------------------------------------------------------------------------------------

TEKITKSDTKTSSNNLKRGSNISRKKDPKYPGTFRQ------------KQIFSDSLNELL
                    ..  ... ..|  . |            ..  |..   |.
-------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLI
Kinase 80378.m00220.AA C8 217-297 30 5.7e-14 44.97 In-house 136-226 (226) Show / Hide 
Range on Protein: 217-297
Range on HMM: 136-226/226
Sequence Identity: 30% (28 aa)

VRNIHNHHIILRDIKPDNILLDEFDKPH----YADFDVSVF---DTDKAYDFT----GTEFYMAPEVDQNLSKSKYVGYGVKSDIFSLGCVL
| .|| . |. |||||.|.|. .  .       .||... .   . .. ..      ||  |.|||. .  .. .|  |  .||.||.| ||
VNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFAPEIEKK-QDNQYKQYRIQSDLFSVGLVL
Kinase 80378.m00220.AA Ciliate-E1 190-291 24 7.7e-14 41.82 In-house 82-202 (202) Show / Hide 
Range on Protein: 190-291
Range on HMM: 82-202/202
Sequence Identity: 24% (30 aa)

TLKAYIQ-------------NNPNLTNLELLEKFYQICLDVRNIHNHHIILRDIKPDNILLDEFDKPHYADFDVSV---FDTDKAYDFTGTEFYMAPEVD
.|| |.|             |. ..| ..... ..|.   .  .|.. || |||||.||| . ...  |.|| .|      ... ....|   |..|.  
SLKDYLQNHNRLEYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQ

QN---LSKSKYV-GYGVKSDIF
 |   . . ..   .. ||||.
YNCPEQ-EHNKNQKINYKSDIY
Kinase 80378.m00220.AA Ciliate-C8 217-297 28 8.2e-14 46.15 In-house 132-238 (238) Show / Hide 
Range on Protein: 217-297
Range on HMM: 132-238/238
Sequence Identity: 28% (30 aa)

VRNIHNHHIILRDIKPDNIL--LDEFDKPH--YAD------FDVSVFDTDKAY-----DFTGTEFY-----------MAPEVDQNLSKSKYVGYGVKSDI
| ..| ..|. |||||.|.|  .|. . |    .|      |. . . ..         | ||. |           .|||| .. |. ..  .  |||.
VNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEMYFCGNWGYFAPEVEKKQSRIQSDIFSKKSDS

FSLGCVL
.|.| ||
YSVGLVL
S_TKc 80378.m00220.AA S_TKc 121-493 13 3.5e-13 16.37 SMART 1-231 (231) Show / Hide 
Range on Protein: 121-493
Range on HMM: 1-231/231
Sequence Identity: 13% (53 aa)

PRGFKVLGYGAHSVVLHSDEFFSSHIF------KFSKLDLSVENKIKEILGIPIYYPNLAVPNKYFTSSPLYRK--GTLKAYIQNNPN------LTNLEL
 .  ...| || ..|    .  . .|.      .  .  ...  | .    . .|.      ....    .     |.|. ||....       ..  . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HA

LEKFYQICLDVRNIHNHHIILRDIKPDNILLDEFDKPHYADFDVSVFDTDKAYDFTGTEFYMAPEVDQNLSKSKYVGYGV-KSDIFSLGCVLNYMFNHNY
   .||||. .  .|.|.|| ||.||.||||||      .|| .. .     . | || .||||||          |||  |.|. |.||.|  |.    
RFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----TTFCGTPWYMAPEVL---------GYGKCKCDWWSCGCILYEMLCGYP

PYSIYTPLIPKTVIYLIDFMRNPNPDFRPTIDELISLTLGTMKYYRSNPVNEGHFGLMNYVPRPDDKINPKQNSDYGENRFKKHADNRKNAHNPENNQNS
|..        ..  ... ..                                                                               
PFP--------QMQMMFKKIG-------------------------------------------------------------------------------

NKRPPPQNINPSQDSSESDTEKITKSDTKTSSNNLKRGSNISRKKDPKYPGTFRQKQIFSDSLNELLYLLNMRNSN--ISLPDEEL-------MPMI
                                                           |... ...  .  .. .  ..  .          .| .
-----------------------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 80378.m00220.AA TKL 221-297 22 1.2e-12 41.82 In-house 149-279 (364) Show / Hide 
Range on Protein: 221-297
Range on HMM: 149-279/364
Sequence Identity: 22% (30 aa)

HNHH--------IILRDIKPDNILLDEFDK--------------PHYADFDVSVFDTD----------------------KAYDFTGTEFYMAPEV-DQN
|...        || ||.|..|||.||  .              .  .||  | | .                       . .   ||  .||||| ...
HSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQ

LSKSKYV---------GYGVKSDIFSLGCVL
.  ...|          |  |.|..| | ||
MNYTEKVGIDEFCKGFEYSEKCDVYSFGIVL
TyrKc 80378.m00220.AA TyrKc 125-343 18 4.3e-05 -140.23 SMART 5-280 (280) Show / Hide 
Range on Protein: 125-343
Range on HMM: 5-280/280
Sequence Identity: 18% (55 aa)

KVLGYGAHSVV-------------LHSDEFFSSHIFKFSKLDLSVENKIKEILG------IPIYYPNLAVP--------NKYFTSSPLYRKGTLKAYIQN
|.|| ||  .|             |..|           . |.  | .|   ||      . .|    ..           ..    .  .| || |...
KKLGEGAFGEVYKGTWKIQVAVKMLKEDA----------REDFMREARIMCKLGGHHPNIVRLYG--VCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

NPN-LTNLELLEKFYQICLDVRNIHNHHIILRDIKPDNILLDEFDKPHYADFDVSVFDTDK-------AYDFT----GTE-----FYMAPEVDQNLSKSK
. . |.. .||.  .||.   . .| ...| ||.   |.|..|      .||  | . .|.        |  .    |.        ||||.       .
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI------N

YVGYGVKSDIFSLGCVL--------NYMFN-----------HNYPYSIYTPLIPKT---------VIYLIDFMR---NPNPDFRPTIDELISLT
|  .  |||..| | ..            .           ..|  . | . .|.             . . |.   . .|. |||  |.... 
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 80378.m00220.AA TKL 312-343 21 0.069273 2.59 In-house 333-364 (364) Show / Hide 
Range on Protein: 312-343
Range on HMM: 333-364/364
Sequence Identity: 21% (7 aa)

PLIPKTVIYLIDFMRNPNPDFRPTIDELISLT
| .|. .. |.    ...|. ||. .|...  
PDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL