Gene 82048.m00078 (T.vaginalis)

82048.m00078

Species: T.vaginalis
Alias: 82048.m00078, TvagK0616
External Links:
Annotation:

Classification

Group: PKL
Family: PIK
Subfamily: FRAP

Sequence

Name Sequence Type Origin Length Description Download
82048.m00078.AA Protein None 2165 None Fasta, JSON
82048.m00078.kin_dom Protein Kinase Domain None 260 None Fasta, JSON

Protein domain

Protein domains of 82048.m00078.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
FAT 82048.m00078.AA FAT 1363-1578 17 1.2e-21 72.75 Pfam 96-403 (408) Show / Hide 
Range on Protein: 1363-1578
Range on HMM: 96-403/408
Sequence Identity: 17% (53 aa)

NRAAHNLSTAQLLIEISEAIKYK-ILR----------NSNQKEV---WSRRLKGF-KRDGDTWIKLIQIRSLISL--------------PDSDFGVYLKI
||.   .   | |.|. |.|.||  .            ..||..   | .||.|   |. . |  ... |...                |  |.   .| 
NRHYPVMVRVQMLAELEEIIQYKSQCNQNNAQNLDNSPEKQKHMRQTWWKRLPGCKQRNVEVWQRILTWRQHVFSKINQRYMNSFCYRGPHEDMWMWIKF

LSVLRREQRWDIIDSYIDKLA----MKGA-----PPEIVLARAKIEWSRGQREEAIDSLRSILNRDMSPN------------------------------
 .. |.  | .     . .|     . .      ||... |..|. |..||..||.  ||  ..  |. .                              
ANLCRKHGRMQLCEKTLKMLYTYDPSEEDWHPRAPPQWTYAYLKYMWATGQQQEAFQHLREFTSCHMQHDLGVHNNNEINGLTYNLEVINNTNLEYFYTK

VSA-HVHRKLAAYLSQA--------HPEEMHSVADLYKEATEICANDAR-GWIGWAYSNNAIAQRE-------------MSEDYGINSVSAFLRAVSLSQ
  |  .. |.. .. ..         .|.   . . |..||... . ..  |  ||. | .. | .             |  .. ...|. |.....|||
LLAMRCYHKQGMWQWKLYEEQYMNWNQEQKDEILQCYMTATHFDPQWYKKAWHNWALYNFEVFQHYQCQPQREEQNYTHMIIQHVVPAVKCFFHSIALSQ

T-GNLEYL
   .....
GSNSRQDT
Kinase 82048.m00078.AA FRAP 1855-2100 42 2.7e-86 293.0 In-house 3-246 (251) Show / Hide 
Range on Protein: 1855-2100
Range on HMM: 3-246/251
Sequence Identity: 42% (105 aa)

KFLLKGSEDLRLDQRVMQFFNLVNSLLRHDVTMRDHPDAAIVEYAIVPLAPSAGLIRWVENADTLHQMICDMRYAYNTSQVPEFDVLNQYTGGLFGQLTT
 ||||| ||.| | |||| | |.| ||. . . .   .  |  |.|.||   .||| ||.. |||| .| | | .|.    .|. ....     . .|. 
HFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKK-NLSIQRYSIIPLSMNTGLIGWVHHCDTLHILIRDYRKKYHIRYNIEYNIMDRMCND-YDHLPL

VQKLEAFQNIVRECPANEVRDFLWYRATNAEEWLRMQDNFTLTTALMSMIGYVIGLGDRHPSNIMVQRDTGRVIHIDFGDTFETTINRASYPEKVPFRLT
..| | |. |.     .. .  || .  | | |.    |.|   | |||.||..||||||||||| || ||...|||||| ||  . | ..|||.|||||
MNKVEIFRYIMNNTKGEDLKKLLWLKSPNSEIWFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRLT

RMIVNALDGGNVQGMFTELCISTMNVLRQNKSSLVALLEIFIHEPL
||.|||..   ..| .   |   |.|.| .| |..| || |.  ||
RMLVNAMEACGIEGNYRNTCELVMKVIREHKESVMAVLEAFVYDPL
Kinase 82048.m00078.AA PIKK 1824-2095 32 7.4e-82 278.26 In-house 1-290 (290) Show / Hide 
Range on Protein: 1824-2095
Range on HMM: 1-290/290
Sequence Identity: 32% (95 aa)

KIKYIDPGLQVLGTQQHPRVCKLISESGKTVKFLLKGSEDLRLDQRVMQFFNLVNSLLRHDVTMRDHPDAAIVEYAIVPLAPSAGLIRWVENADTLHQMI
 |. .|. ..|. . | |.   .    ||   .|.|| ||||.||||||.| |.| .|. | . .  ..  |  |...|. .  ||| ||.|..||.  .
RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQ-KRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIY

CDMRYAYNTSQVPE-------------------FDVLNQYTGGLFGQLTTVQKLEAFQNIVRECPANEVRDFLWYRATNAEEWLRMQDNFTLTTALMSMI
 . . ... .. .|                    . . |        .. ..|.|.|  ..   |..  ....| .....|.|..   |.| ..|.|.| 
KQWCQKKHIRHEQEAQMNYQTCMYRDWLKQMSYYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCMV

GYVIGLGDRHPSNIMVQRDTGRVIHIDFGDTFETTINRASYPEKVPFRLTRMIVNALDGGNVQGMFTELCISTMNVLRQNKSSLVALLEIF
||..|||||||.|||....|| ..|||||. ||    | . ||||||||||..|||.    | | |.  |...| ..||.. .| ...| |
GYILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF
Kinase 82048.m00078.AA PI3_PI4_kinase 1853-2105 23 2e-58 205.23 Pfam 1-300 (300) Show / Hide 
Range on Protein: 1853-2105
Range on HMM: 1-300/300
Sequence Identity: 23% (77 aa)

TVKFLLKGSEDLR--LDQRVMQFF-----------------------NLVNSLLRHDVTMRDHPDAAIVEYAIVPLAPSAGLIRWVENADTLHQMICDMR
...|..|| .|||   |.|.||..                       .|.| ... |   | .    .  | ..|..|  |.| ||.|..|.|. ..  .
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRN-MQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYM

---------------------YAYNTSQVPEFDVLNQYTGGLFGQLTTVQKLEAFQNIVRECPANEVRDFLWYRATNA-EEWLRMQDNFTLTTALMSMIG
                     .  ..                      .||.| | .     | .  ....|   ..| |||..  |||..  | |....
VKCKHKHFNKEHKMWMKMWPDWWHLM---------------------RMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVD

YVIGLGDRHPSNIMV--QRDTGRVIHIDFGDTFE-TTINRASYPEKVPFRLTR------MIVNAL------DGGNVQGMFTELCISTMNVLRQNKSSLVA
|..|.||||..||||   ..|| ..|||||. |. .  ..   ||.||||.|.      ..|.|.      |     |.| ..| .....||... ....
YILGNGDRHNDNIMVKDDKTTGHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMN

LL-------EIFIHEPLEESSN
||       |...| .| . . 
LLKKAVMRGECMVHDGLPMWRS
Kinase 82048.m00078.AA PI3Kc 1855-2158 22 8.8e-57 195.88 SMART 1-336 (336) Show / Hide 
Range on Protein: 1855-2158
Range on HMM: 1-336/336
Sequence Identity: 22% (78 aa)

KFLLKGSEDLRLDQRVMQFFNLVNSLLRHDVTMRDHPDAAIVEYAIVPLAPSAGLIRWVENADTLHQMICDMRYAYN-----------------------
 ...|. .||| |.|.||.|.|.| ... |   |   |  .  |...|. |  |.| || |..||||. .  ..  .                       
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRR-DLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMY

---TSQVPEFDVLNQYTGGLFGQLTTVQKLEAFQNIVRECPANEVRDFLWYRATNA-EEWLRMQDNFTLTTALMSMIGYVIGLGDRHPSNIMVQRDTGRV
   ..|. ... .         ..|  ..|. |   .   . .  .|..| . ... |.|  ..||||. .| ..|..|. |.||||..|||. ..|| .
MMIWHQQACHWMM------MYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHC

IHIDFGDTFETTINRASYP----EKVPFRLTRMIVNALDGG----NVQGMFTELCISTMNVLRQNKSSLVALLEIFIHEPL-EESSNERSGHLPPTETIA
.|||||. |.    .  ..    |.||||||...|..  ||     . | | ..| ......|... ....|.|.... |.  . . .        ..|.
FHIDFGHIFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMM-------EKDIK

RVTDKLQGTDMNPNKSLGVAEQ----------VEILIKEASDYTLYVSHY
 . ....  ... ....  ..|          .| ..... .   .. .|
YLRQRFRLDHLSDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
Kinase 82048.m00078.AA ATR 1824-2095 27 3.7e-41 137.72 In-house 2-267 (267) Show / Hide 
Range on Protein: 1824-2095
Range on HMM: 2-267/267
Sequence Identity: 27% (75 aa)

KIKYIDPGLQVLGTQQHPRVCKLISESGKTVKFLLKGSEDLRLDQRVMQFFNLVNSLLRHDVTMRDHPDAAIVEYAIVPLAPSAGLIRWVENADTLHQMI
 |  .|  ...| . |.|.   |    ||    . |  .||| | | |.| .|.| ..| |   |      .  ||..||   ...| ||.|  || . |
YIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRR-FYHMRTYAVIPLNDQCCIIEWVNNTATL-RPI

CDMRYAYNTSQVPEFDVLNQYTGGLFGQLTTVQKLEAFQNIVRECPANEVRDFLWYRATNAEEWLRMQDNFTLTTALMSMIGYVIGLGDRHPSNIMVQRD
 |  .     |  .|  | |    .  ..   .|. .|....        .|.   |   ...|   ..|.  ..| ..|.||.|||||||  ||.... 
LDKLWK-EKKQYMQFYQLRQCMDKKSREE--WEKQKVFREFLLPRHPPIFHDWFNRRFPDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKI

TGRVIHIDFGDTFET--TINRASYPEKVPFRLTRMIVNALDGGNVQGMFTELCISTMNVLRQNKSSLVALLEIF
.| ..|.|.   |    ...    || ||||||. .|...     .|.|   |. .| ..|...  ...... |
NGECVHVDYNCIFNSGEQFE---VPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRDHRDDIMSVWDCF
Kinase 82048.m00078.AA ATM 1994-2100 39 3.6e-23 70.54 In-house 140-245 (304) Show / Hide 
Range on Protein: 1994-2100
Range on HMM: 140-245/304
Sequence Identity: 39% (42 aa)

FTLTTALMSMIGYVIGLGDRHPSNIMVQRDTGRVIHIDFGDTFETTINRASYPEKVPFRLTRMIVNALDGGNVQGMFTELCISTMNVLRQNKSSLVALLE
.|   |  |..||..||||||  ||..      ..||| |  ||        || ||||||| ||  .    | |.|   |  || |.|  .  |. . |
YTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQG-KILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQETLLTIVE

IFIHEPL
. . .||
VLLYDPL
Kinase 82048.m00078.AA DNAPK 1981-2105 30 4e-19 66.09 In-house 177-301 (301) Show / Hide 
Range on Protein: 1981-2105
Range on HMM: 177-301/301
Sequence Identity: 30% (38 aa)

ATNAEEWLRMQDNFTLTTALMSMIGYVIGLGDRHPSNIMVQRDTGRVIHIDFGDTFETTINRASYPEKVPFRLTRMIVNALDGGNVQGMFTELCISTMNV
.|  | .| ... |  . |.    ... | ||||  | ||  ..| .| ||||  |         ||  ||||||  .| .    . |..    |. |  
STTCETYLYLREHFIRNYAVICISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMYQIMIHSMMA

LRQNKSSLVALLEIFIHEPLEESSN
.|. .  |.   ..|| .|.    |
FRKDRNILTNFCDVFINDPSFDWKN
Kinase 82048.m00078.AA SMG1 1977-2032 48 1.6e-17 54.49 In-house 173-228 (242) Show / Hide 
Range on Protein: 1977-2032
Range on HMM: 173-228/242
Sequence Identity: 48% (27 aa)

LWYRATNAEEWLRMQDNFTLTTALMSMIGYVIGLGDRHPSNIMVQRDTGRVIHIDF
||   |  .|| |.   .   || |||.||.|||||||  |...   || |.|||.
LWSSCTTPDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDY
Kinase 82048.m00078.AA FATC 2133-2165 45 1.6e-13 46.38 Pfam 1-33 (33) Show / Hide 
Range on Protein: 2133-2165
Range on HMM: 1-33/33
Sequence Identity: 45% (15 aa)

KSLGVAEQVEILIKEASDYTLYVSHYAGWCPYW
..| | .||. ||.||.|   .  .| ||||.|
EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW
Kinase 82048.m00078.AA SMG1 1832-1919 34 3.2e-13 40.02 In-house 1-87 (242) Show / Hide 
Range on Protein: 1832-1919
Range on HMM: 1-87/242
Sequence Identity: 34% (30 aa)

LQVLGTQQHPRVCKLISESGKTVKFLLKGSEDLRLDQRVMQFFNLVNSLLRHDVTMRDHPDAAIVEYAIVPLAPSAGLIRWVENADTL
. .| |.  |.    .   ||   .| || ||| || |.|||  .|| .    .   . |      |.. ||   .||| ||. |  |
ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFAT-INRQETPRFHARHYSVTPLGTRSGLIQWVDGATPL
Kinase 82048.m00078.AA DNAPK 1856-1919 37 2e-10 33.94 In-house 35-97 (301) Show / Hide 
Range on Protein: 1856-1919
Range on HMM: 35-97/301
Sequence Identity: 37% (24 aa)

FLLKGSEDLRLDQRVMQFFNLVNSLLRHDVTMRDHPDAAIVEYAIVPLAPSAGLIRWVENADTL
|. || ||||.|||. | |   |  .  |       .     | |.|.    ||| ||.|  .|
FCYKGIEDLRQDQRIEQLFQVMNNIFEYDPQCQQR-ELQLRTYNIIPMTNRLGLIEWVDNTVVL
Kinase 82048.m00078.AA ATM 1855-1912 34 7.4e-07 17.51 In-house 1-57 (304) Show / Hide 
Range on Protein: 1855-1912
Range on HMM: 1-57/304
Sequence Identity: 34% (20 aa)

KFLLKGSEDLRLDQRVMQFFNLVNSLLRHDVTMRDHPDAAIVEYAIVPLAPSAGLIRW
. | || .||| |  . | | . | ||      |      |  | .|||.  .| . |
RQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKR-KLTICTYKVVPLSQRSGVLEW