92247.m00068

Species: T.vaginalis
Alias: TvagK0953, 92247.m00068
External Links:
Annotation:

Classification

Group: TKL
Family: TKL-Tvag2

Sequence

Name Sequence Type Origin Length Description Download
92247.m00068.AA Protein None 956 None Fasta, JSON
92247.m00068.kin_dom Protein Kinase Domain None 229 None Fasta, JSON

Protein domain

Protein domains of 92247.m00068.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 92247.m00068.AA TKL 239-279 24 2e-07 22.79 In-house 326-364 (364) Show / Hide
Range on Protein: 239-279
Range on HMM: 326-364/364
Sequence Identity: 24% (10 aa)

VYSRLMYNEKNFLKRLKNLYKECTSLDPSQRPKSPQVEKML
.. . |..........|.| ..| . ||..||   .. | |
HH-K-MCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL

S_TKc 92247.m00068.AA S_TKc 19-286 15 2.7e-07 -69.83 SMART 1-231 (231) Show / Hide
Range on Protein: 19-286
Range on HMM: 1-231/231
Sequence Identity: 15% (45 aa)

HKLRRYIIRGTHGNYFIAKDYEIKTDV-SKEVKKFLNVFFGGKTIDKDWTRKYPVTRINRVNIAEELKESFIIEFNVCAALKHTALNPVLDYVIDTRDNE
 .. | | .|. |  . ... . .  |  |..|                                   |... | ...   .|  .   .|.  |     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------------------------------EHIRREIQILKK-HHPNIVKLYDVFQD-----

KAGLFIV---YKN---SVRDYFDNYISNSVESAVNDIIMIKILLGVISALSYLHSNGIVAGDLRPGTIFLNSRMEPLLINYNLPQLYPCPLIPYEVKKSE
   |..|     .   ...|| ... ..   .  .     ...  ...|| |.||.||.  || |  |.|..  .  ..   |  ..        .   .
-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPW

YSAPELADEYKITE-KSDVFSFGVLLSKVYS--------RLMYNEKNFLKRLKNLYKECTSLDPSQRPKSPQVEK--MLFEINQQL
| |||.    . .  |.|. |.|..|   ..         .|..     . .|.. . |   ||..||   .. .  ..  . . .
YMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFPQMQMMFKKIG-SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase 92247.m00068.AA PLK2 154-186 39 5.4e-07 18.27 In-house 109-141 (257) Show / Hide
Range on Protein: 154-186
Range on HMM: 109-141/257
Sequence Identity: 39% (13 aa)

LLGVISALSYLHSNGIVAGDLRPGTIFLNSRME
.....| | |||. .|.  || .|  |.|  ||
MRQIVSGLRYLHQQCIIHRDLKLGNFFINDNME

Kinase 92247.m00068.AA Ciliate-A5 157-181 48 1e-06 18.94 In-house 108-132 (275) Show / Hide
Range on Protein: 157-181
Range on HMM: 108-132/275
Sequence Identity: 48% (12 aa)

VISALSYLHSNGIVAGDLRPGTIFL
.||...||..|.|. ||.|| .|.|
LISVCMYLQQNNICHGDIRPQNICL

Kinase 92247.m00068.AA SCY1 202-281 19 1e-06 19.09 In-house 216-337 (337) Show / Hide
Range on Protein: 202-281
Range on HMM: 216-337/337
Sequence Identity: 19% (24 aa)

LIPYEVKKSEYSAPELADE-------------YKITEKSDVFSFGVLLSKVYSRLM---YNEKNF----------------------LKRLKNL----YK
..|..  .....||| . |              | | .||.||.|.|  .||....    . .|                        |.|...    |.
YPPPCQPNPDWLAPEYIHEDQHTPASYNWGQEQKCTWASDMFSLGCLIWWVYNGKKPQITCNSNPYSTFHRYMEQWNAMSHCWWDHIPKELQEHLGHCYC

ECTSLDPSQRPKSPQVEKMLFE
.  . || .||.  |  .  ..
HLLHQDPTCRPDPQQFLQHCYF

Kinase 92247.m00068.AA NZAK 211-241 41 2e-06 16.72 In-house 237-267 (329) Show / Hide
Range on Protein: 211-241
Range on HMM: 237-267/329
Sequence Identity: 41% (13 aa)

EYSAPELADEYKITEKSDVFSFGVLLSKVYS
.| |||    ..|.|||||.|||..  .. .
HYMAPENKNNHRINEKSDVWSFGCTVWQMFG

Kinase 92247.m00068.AA TAK1 252-278 29 3e-06 17.14 In-house 258-284 (284) Show / Hide
Range on Protein: 252-278
Range on HMM: 258-284/284
Sequence Identity: 29% (8 aa)

KRLKNLYKECTSLDPSQRPKSPQVEKM
||.....| | . .|..|| .  ..| 
KRIEQFMKCCWDDNPEKRPSMQECVKY

Kinase 92247.m00068.AA Pkinase_Tyr 214-236 60 6e-06 20.66 Pfam 182-204 (270) Show / Hide
Range on Protein: 214-236
Range on HMM: 182-204/270
Sequence Identity: 60% (14 aa)

APELADEYKITEKSDVFSFGVLL
|||   ..| |.|||| |||||.
APECINYGKFTTKSDVWSFGVLM

Kinase 92247.m00068.AA MLK 252-279 35 1.4e-05 15.5 In-house 264-291 (291) Show / Hide
Range on Protein: 252-279
Range on HMM: 264-291/291
Sequence Identity: 35% (10 aa)

KRLKNLYKECTSLDPSQRPKSPQVEKML
...|.|.|.| . ||..||.. |. . |
EHWKKLMKQCWNQDPHKRPSFRQIVQHL

Kinase 92247.m00068.AA TKL-ciliate1 212-236 33 1.6e-05 14.9 In-house 180-209 (279) Show / Hide
Range on Protein: 212-236
Range on HMM: 180-209/279
Sequence Identity: 33% (10 aa)

YSAPELAD-----EYKITEKSDVFSFGVLL
. |||  |      | |.|| |....|...
WMAPEQMDPHIFPNYPINEKIDIYAYGIVM

Kinase 92247.m00068.AA TKL 212-236 26 1.8e-05 15.65 In-house 239-279 (364) Show / Hide
Range on Protein: 212-236
Range on HMM: 239-279/364
Sequence Identity: 26% (11 aa)

YSAPELAD----------------EYKITEKSDVFSFGVLL
. |||. .                ... .||.||.|||..|
WMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVL

Kinase 92247.m00068.AA TK 214-236 43 2e-05 13.3 In-house 353-384 (486) Show / Hide
Range on Protein: 214-236
Range on HMM: 353-384/486
Sequence Identity: 43% (14 aa)

APELAD---------EYKITEKSDVFSFGVLL
|||  .         . | |.||||.|||||.
APECLNDRVFSEAEKYGKFTTKSDVWSFGVLM

Kinase 92247.m00068.AA RAF 252-279 42 0.000145 11.57 In-house 248-275 (275) Show / Hide
Range on Protein: 252-279
Range on HMM: 248-275/275
Sequence Identity: 42% (12 aa)

KRLKNLYKECTSLDPSQRPKSPQVEKML
| .|.|. || | .|  ||  .|. ||.
KEMKELLMECWSYQPEERPSFQQIMKMI

Kinase 92247.m00068.AA MLK 214-236 46 0.000239 11.14 In-house 201-226 (291) Show / Hide
Range on Protein: 214-236
Range on HMM: 201-226/291
Sequence Identity: 46% (12 aa)

APEL---ADEYKITEKSDVFSFGVLL
|||    . . | .||.||.|.||.|
APEVIQQFRCEKYSEKCDVWSWGVVL

Kinase 92247.m00068.AA NZAK 151-192 26 0.000354 9.37 In-house 108-149 (329) Show / Hide
Range on Protein: 151-192
Range on HMM: 108-149/329
Sequence Identity: 26% (11 aa)

IKILLGVISALSYLHSNGIVAGDLRPGTIFLNSRMEPLLINY
||... .   .||||  .|.  |...  . |. . . .||..
IKMIADIAETMSYLHKHHIIHRDIKSNNVILDFNKNLKLIDF

Kinase 92247.m00068.AA TKL 150-186 20 0.002811 7.67 In-house 134-178 (364) Show / Hide
Range on Protein: 150-186
Range on HMM: 134-178/364
Sequence Identity: 20% (9 aa)

MIKILLGVISALSYLHSNG--------IVAGDLRPGTIFLNSRME
.... |.. ....||||..        |.  || .  |.... ..
RCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWT

Kinase 92247.m00068.AA TK 257-279 34 0.00315 5.82 In-house 464-486 (486) Show / Hide
Range on Protein: 257-279
Range on HMM: 464-486/486
Sequence Identity: 34% (8 aa)

LYKECTSLDPSQRPKSPQVEKML
| ..| ..||..||   |. ..|
LMQQCWHYDPEDRPTFSQLHEQL

Kinase 92247.m00068.AA RAF 151-183 33 0.004001 6.57 In-house 103-135 (275) Show / Hide
Range on Protein: 151-183
Range on HMM: 103-135/275
Sequence Identity: 33% (11 aa)

IKILLGVISALSYLHSNGIVAGDLRPGTIFLNS
|.|   .. . .|||. .|. .||.   ||| .
IQIAQQICQGMDYLHAKNIIHRDLKSKNIFLHN

Kinase 92247.m00068.AA TAK1 224-236 30 0.015375 4.28 In-house 203-215 (284) Show / Hide
Range on Protein: 224-236
Range on HMM: 203-215/284
Sequence Identity: 30% (4 aa)

TEKSDVFSFGVLL
..|.|..|.|. .
NMKCDIYSWGIIM

Kinase 92247.m00068.AA TKL-ciliate1 254-279 26 0.024073 3.83 In-house 254-279 (279) Show / Hide
Range on Protein: 254-279
Range on HMM: 254-279/279
Sequence Identity: 26% (7 aa)

LKNLYKECTSLDPSQRPKSPQVEKML
. || . | . .| .||.. ..   |
FHNLMMRCWCQNPNKRPNFNEIIQIL

Kinase 92247.m00068.AA RAF 214-236 22 0.064009 2.39 In-house 173-207 (275) Show / Hide
Range on Protein: 214-236
Range on HMM: 173-207/275
Sequence Identity: 22% (8 aa)

APELADEYKI------------TEKSDVFSFGVLL
|||.. . ..            ...|||..||. .
APEVIRMMRPDWDEYQCDCNPFSFQSDVYAFGTVW

Kinase 92247.m00068.AA NZAK 254-278 37 0.071707 1.49 In-house 303-329 (329) Show / Hide
Range on Protein: 254-278
Range on HMM: 303-329/329
Sequence Identity: 37% (10 aa)

LKNLYKECTSLDPSQRPK--SPQVEKM
.|.. . |   || .|||  |  .||.
MKDFITQCWDIDPKKRPKDFSHMIEKL

Ank 92247.m00068.AA Ank 694-727 23 0.385807 8.37 Pfam 1-33 (33) Show / Hide
Range on Protein: 694-727
Range on HMM: 1-33/33
Sequence Identity: 23% (8 aa)

FGKTLFHAAVENGDYLFLRLLLSISNIKPFKRDS
 | |  | |...|..  ...||.  .  .  .| 
DGFTPLHLACRCGHTEVVKMLLQ-HGADVNAQDD

Ank 92247.m00068.AA Ank 728-740 38 10.069502 3.26 Pfam 1-13 (33) Show / Hide
Range on Protein: 728-740
Range on HMM: 1-13/33
Sequence Identity: 38% (5 aa)

WGRNSLHWAAIYG
 |.  ||.|...|
DGFTPLHLACRCG

Ank 92247.m00068.AA Ank 858-891 41 6.2e-08 32.87 Pfam 1-33 (33) Show / Hide
Range on Protein: 858-891
Range on HMM: 1-33/33
Sequence Identity: 41% (14 aa)

YGMTPLHYAAENGGLNVMKVLFSKIGLDPNLKDE
.|.||||.|...|...|.| | .  | |.|..| 
DGFTPLHLACRCGHTEVVKMLLQ-HGADVNAQDD

Ank 92247.m00068.AA Ank 892-925 23 7.2e-05 21.82 Pfam 1-33 (33) Show / Hide
Range on Protein: 892-925
Range on HMM: 1-33/33
Sequence Identity: 23% (8 aa)

KGRTPLHICAKNDDADCFTFLLKSGKVKPEIEDN
 |.||||. ........ ..||.     . . |.
DGFTPLHLACRCGHTEVVKMLLQ-HGADVNAQDD