Gene 81368.m00081 (T.vaginalis)

81368.m00081

Species: T.vaginalis
Alias: 81368.m00081, TvagK0942
External Links:
Annotation:

Classification

Group: CAMK
Family: CAMKL
Subfamily: CAMKL-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
81368.m00081.AA Protein None 315 None Fasta, JSON
81368.m00081.kin_dom Protein Kinase Domain None 209 None Fasta, JSON

Protein domain

Protein domains of 81368.m00081.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 81368.m00081.AA Ciliate-E2 37-265 17 2.8e-33 111.6 In-house 45-365 (365) Show / Hide 
Range on Protein: 37-265
Range on HMM: 45-365/365
Sequence Identity: 17% (59 aa)

FKGEKFHAFYFDVDAVIKIDKLDNLIADIN----------ILIQLRHPNIVRFVEFYH--DSKKMFLITEYFNNYSLEDLISST-TCG-----------E
.|. ..   ..  . .. | . ....  ||          || || ||||....|..   | ....|..||..  .|.|.| .  ..            |
VKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTE

YHYKTIVSGIIK---------------GIQALHHAG-ICHGNICPSNIMIYDRFHPKISNFQFLSQFSFKVDKHINPIQVN-------------------
.. |.|   |..               ... ||  . |.| .| |.||..     .||. | .  ... . ....   | .                   
KEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMFKNDTSRTPGYMDQI

--------------YYSPECLQYKCTDP--------FAADIWSFGVTCYVLLTRQMPFSQSNEIKLFNSIIECNYN------------------PTVIND
              | .|| |..|  |         ...||||.||. | .|. . ||        .. |..|...                   .   .
IQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWS

EAYRKMVTS----CIVLEPENRAS-IDEL--ENWF
.    .       ... .||.| . ....    ||
QECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 81368.m00081.AA Ciliate-E2-Unclassified 66-265 18 1.8e-31 106.42 In-house 73-352 (352) Show / Hide 
Range on Protein: 66-265
Range on HMM: 73-352/352
Sequence Identity: 18% (52 aa)

NILIQLRHPNIVRFVEFYHDSKKMFLITEYFNNYSLEDLISSTT------------------CGEYHYK-----TIVSGIIKGIQALHHAG-ICHGNICP
.||... ||.||....   | .......||... .|.. |..                      |.. |     ..   |..|.. ||| . |.| .| |
QILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKP

SNIMIYDR---FHPKISNFQFLS-----------------QFSFKVDKHI--NPIQVN-YYSPECLQYKCTDP---FAADIWSFGVTCYVLLTRQMPFSQ
.||.. .    ...||. |.. .                 .....  ...  .|.  . | .||.|| .  |    ...||||.|| .| .|. . ||..
ENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYD

SNEIK----------------LFNSIIECNYNPTV--------INDEAYRKMVT----SCIVLEPENRASIDEL--ENWF
 |...                |.. |...|..           . .. .  ...    ....  |..| .....    ||
NNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 81368.m00081.AA CAMK 65-265 17 3.3e-28 87.41 In-house 82-425 (425) Show / Hide 
Range on Protein: 65-265
Range on HMM: 82-425/425
Sequence Identity: 17% (60 aa)

INILIQ-------LRHPNIVRFVEFYHD-------------------SKKMFLIT---EYFNNY----SLEDLISSTTCG----------------EYHY
|.|. .       |.||||... |.| |                    |.|....   ||  .      | | | . .|.                |   
IEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREA

KTIVSGIIKGIQALHHAGICHGNICPSNIMIYDR-----------------FHPKISNFQFLSQFSFKV-------DKHINPIQVN--------------
....  |. ... .|  .|.|  . | ||.. |.                 .  ||. | |  .|  .         |. . .  |              
RRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-M-HNQWTTPTEGQKMKTF

-----YYS-PECLQY-------------KCTDPFAADIWSFGVTCYVLLTRQMPFSQS-------------NEIKLFNSIIECNY--NPTVIND------
     | . || |..             |  .....|.|| || .|..|.  .||  .             |. .||  |....|   |  . .      
CGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYG

----------------EAYRKMVTSCIVLEPENRASIDELEN--WF
                .  . .. .. . .||.|..|..  |  |.
PEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 81368.m00081.AA TKL 65-265 15 4.3e-22 76.34 In-house 76-364 (364) Show / Hide 
Range on Protein: 65-265
Range on HMM: 76-364/364
Sequence Identity: 15% (45 aa)

INILIQLRHPNIVRFVEFYHDSKK-------------MFLITEYFNNYSLEDLISSTTCGEYHYKTIVSGIIKGIQALHHAG--------ICHGNICPSN
|.....|||||||.|. .  ....             .....||  . ||....        .   .. .| .|.. ||  .        | | .. ..|
IMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKN

IMIYDRFH--------------PKISNFQFLSQFSFKVD-------------------KHINPI-QVNYYSPECLQYKCTDPFAA---------------
|.. . ..              .||. | .   .| . .                   ......   .. .||.|. .  .. ..               
ILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKC

DIWSFGVTCYVLLTRQMPFSQSNEI---------KLFNSIIECNYNPTVI-----------NDEA---YRKMVTSCIVLEPENRASIDELENWF
|..|||.  . .|||. |... ...           |  ... .. |..            .. .   ..|  . |   .||.| | .|.  ..
DVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
S_TKc 81368.m00081.AA S_TKc 17-265 22 1.6e-21 78.75 SMART 1-231 (231) Show / Hide 
Range on Protein: 17-265
Range on HMM: 1-231/231
Sequence Identity: 22% (61 aa)

YIVTKILEIGRFYSRVVVTDFKGEKFHAFYFDVDAVIKIDKLDNLIADINILIQLRHPNIVRFVEFYHDSKKMFLITEYFNN--YSLEDLISSTTC----
| . ...  | | ..|     |.        .    ||| | ....  |.|| . .|||||.. ....| .......|| ..   .| |.| .  .    
YEILRKIGKGAF-GKVYKCRHKK-------TGRIVAIKIIK-EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

---GEYHYKTIVSGIIKGIQALHHAGICHGNICPSNIMIYDRFHPKISNFQFLSQFSFKVDKHINPIQV--NYYSPECLQYKCTDPFAADIWSFGVTCYV
    | | . ..  |..... .|  ||.|  . |.||.. .  | ||. | .  |.        . . .  .| .|| |     .....|.||.|.. | 
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

LLTRQMPFSQSNEIKLFNSIIECNYNPTVINDEAYRKMVTSCIVLEPENRASIDELEN---------WF
.|... ||.  .. ..|. |           .||   ..  | . .||.| .. |. .         ||
MLCGYPPFP--QMQMMFKKIG---------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 81368.m00081.AA PLK1 52-265 26 2e-19 60.24 In-house 37-253 (253) Show / Hide 
Range on Protein: 52-265
Range on HMM: 37-253/253
Sequence Identity: 26% (58 aa)

VIKIDKLDNLIADINILIQLRHPNIVRFVEFYHDSKKMFLITEYFNNYSLEDLISS-TTCGEYHYKTIVSGIIKGIQALHHAGICHGNICPSNIMIYDRF
.||  . | .  .|.|  ||.|..||.| .|. |.. .... |  .  || .|     .  |.  .  .  |..|.| ||.  | |  .   |. . |..
LIKQHQRDKMTQEIQIHRQLHHRHIVKFHHFFEDKQNVYIVLELCRRRSLMELHKRRKAITEPECRYYMYQIVEGCQYLHNNKIIHRDLKLGNLFLNDHL

HPKISNFQFLSQFSFK-VDKHINPIQVNYYSPECLQYKCTDPFAADIWSFGVTCYVLLTRQMPFSQSNEIKLFNSIIECNYN-PTVINDEAYRKMVTSCI
. ||  |    .  ..   |.      ||  || |. |    |  |||| |   |.||  | ||  .     .  | ...|  |. |.  | .... . .
QVKIGDFGLATKCEYDGERKKTLCGTPNYIAPEVLN-KKGHSFEVDIWSIGCIMYILLFGQPPFETKCLKETYSRIKKNEYRIPSHISQPA-AQLIRKML

VLEPENRASIDEL--ENWF
  .|..|  |...  ...|
DPDPTRRPTIEQVLNDEFF
Kinase 81368.m00081.AA SNRK 73-265 29 1.5e-18 57.08 In-house 57-254 (254) Show / Hide 
Range on Protein: 73-265
Range on HMM: 57-254/254
Sequence Identity: 29% (59 aa)

HPNIVRFVEFYHDSKKMFLITEYFNNYSLEDLISSTTCG--EYHYKTIVSGIIKGIQALHHAGICHGNICPSNIMIYDRF-HPKISNFQFLSQFSFKVDK
||||||  |      |..|| |    | . | |     |  |   ..    |.. |.  |.  . |  . | |.. ...    |.  | |  .|      
HPNIVRLYEVIDTQTKLYLILELGDGYDMYDYIMKHEKGLCEDLARKYFCQIMHAIDYCHQLHVVHRDLKPENVVFFEKQGMVKLTDFGFSNKFMPGEKL

HINPIQVNYYSPECLQYKCTDPFAADIWSFGVTCYVLLTRQMPFSQSNEIKLFNSIIECNYN-PTVINDEAYRKMVTSCIVLEPENRASIDELEN--WF
.     . |  || |     |  | |||| ||  |.|.  |.|| . |.      |..| |  | .. ||  | ...| .| .|. |||..|...  | 
ETSCGSLAYSAPEILLGDSYDAPAVDIWSLGVILYMLVCGQAPFQEANDSETLTMIMDCKYTVPDHVSDEC-RDLIQSMLVRDPKKRASLEEIVSHSWV
Kinase 81368.m00081.AA Ciliate-E2b 59-154 24 3.9e-17 48.77 In-house 45-143 (272) Show / Hide 
Range on Protein: 59-154
Range on HMM: 45-143/272
Sequence Identity: 24% (24 aa)

DNLIADINILIQLRHPNIVRFVEFYHDSKKMFLITEYFNNYSLEDLISSTT---CGEYHYKTIVSGIIKGIQALHHAGICHGNICPSNIMIYDRFHPKI
. ..  .|.|  . ||.|..|.  . |...| .. |. |  .|.|.|.        .|  . ..  |..... ||. .| .. | |.|||.    ..|.
KHMLQEKNVLEKCNHPFIMKFIRSFKDDQHMYFMMEFCNGMELFDVIREIGRLLLSTYDSQFYIASICLCLEYLHNQNIIYRDIKPENIMVDHKGYMKL
Kinase 81368.m00081.AA ULK 65-263 19 6.9e-16 52.91 In-house 61-320 (324) Show / Hide 
Range on Protein: 65-263
Range on HMM: 61-320/324
Sequence Identity: 19% (51 aa)

INILIQLR---HPN--IVRFVEFYHDS--KKMFLITEYFNNYSLEDLISST-TCGEYH----------YKTIVSGIIKGIQALHHAGICHGNICPSNIMI
|.|. .|    |||  ||.. ... .|  .  ..|.|| |   ||..|    ...| .           . .   |. | ..||  .| |  | |.||.|
IQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPE-TEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILI

YDRF------------HPKISNFQFLSQFSFK--VDKHINPIQV---------NYYSPECLQYK--CTDPF-A-ADIWSFGVTCYVLLTRQMPFSQSNEI
 . .            . ||. |  .... ..   .. ..  .|          | .|. || .  . ..  . .||||.|.  | .|. . ||. .   
HNGQPKTDSKKVHPNGVLKIADF-GFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FN

KLF----NSIIE-------CNYNPTVIND--------EAYRKMVTSCIVLEPENRASIDELEN
...    . |          ...|  ...        .  .     ... ... | |..|. |
DQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKDRISWEEIFN
Kinase 81368.m00081.AA Pkinase 65-155 29 4.7e-14 50.78 Pfam 51-154 (293) Show / Hide 
Range on Protein: 65-155
Range on HMM: 51-154/293
Sequence Identity: 29% (31 aa)

INILIQLRHPNIVRFVEFYHDSKKMFLITEYFNNY----SLEDLIS---STTC--GEYHYKTIVSGIIKGIQALHHAGICHGNICPSNIMIYDRFHP---
| |.  |.||||||. ....|.... ...|| ..     .| |.||   ...    | . | ..  |..|.. .|  ||.|  . |.||.| .. |.   
IQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDAC

-KIS
 ||.
VKIC
Kinase 81368.m00081.AA CAMKL 177-265 26 2.4e-13 38.8 In-house 198-297 (297) Show / Hide 
Range on Protein: 177-265
Range on HMM: 198-297/297
Sequence Identity: 26% (27 aa)

NYYSPECLQY--KCTDPFAADIWSFGVTCYVLLTRQMPFSQS--------NEIKLFNSIIECNYNPT--VINDEAYRKMVTSCIVLEPENRASIDELEN-
.| .|| .|   |  | ...|||| ||. |.... ..|| .         |  .|.. |... |.|.  .  .   | .  .  .  || |..|....| 
PYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNH

-WF
 |.
PWM
Kinase 81368.m00081.AA Pkinase 177-265 14 2.7e-12 44.58 Pfam 176-293 (293) Show / Hide 
Range on Protein: 177-265
Range on HMM: 176-293/293
Sequence Identity: 14% (17 aa)

NYYSPECLQYKCTDPFAADIWSFGVTCYVLLTRQMPFSQS------NEIKLFNSIIECNYNPTVIND---------------------EAYRKMVTSCIV
.| .|| ..    .. ..|.||.|...| .|... ||...      ....... | .. .     ..                     |. .. ...|. 
WYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLC

LEPENRASIDELENW--F
. |. | ..... .   |
KDPKKRPTAEQILQHPWF
TyrKc 81368.m00081.AA TyrKc 19-265 17 1.7e-11 -36.91 SMART 1-280 (280) Show / Hide 
Range on Protein: 19-265
Range on HMM: 1-280/280
Sequence Identity: 17% (51 aa)

VTKILEIGR-FYSRVVVTDFKGEKFHAFYFDVDAVIKIDK---LDNLIADINILIQL--RHPNIVRFVEFYHDS-------KKMFLITEYFNNYSLEDLI
.|.. ..|. .. .|.    |          ..  .|  |   .  ..  ..|. .|  .||||||..    ..       . .....||  . .| | .
ITLGKKLGEGAFGEVYKGTWK----------IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

SSTT--CGEYHYKTIVSGIIKGIQALHHAGICHGNICPSNIMIYDRFHPKISNFQFLSQFSFKV--------DKHI-----NP--IQVNYYSPECLQYKC
 ..       .   .   | .| . ||. .. |  .   |... .... ||| |  || .             ..          . .  ..|||..|..
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFG-LSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

TDPFAADIWSFGVTCYVLLTR-QMPFSQ-----SNEIKLFNSIIECNYNPTVIN---------DEAYRKMVTSCIVLEPENRASIDELENWF
   .. |.|||||... ..|. |.| .       . . ... . . .. |   |          ..  .. ..|   .||.| .  |.   |
FT-TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 81368.m00081.AA CAMK-Unique 65-150 17 1e-10 31.41 In-house 67-194 (363) Show / Hide 
Range on Protein: 65-150
Range on HMM: 67-194/363
Sequence Identity: 17% (22 aa)

INILIQLRHPNIVRFVEF----YHDSK---------------KMFLITEYFNNYSLEDLISS---------------------TTCGE--YHYKTIVSGI
..|.. . ||||......    ..|.|               .|....|| .   | |.| .                     .   |  ..  .|.  .
HQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLIIKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCL

IKGIQALHHAGICHGNICPSNIMIYDRF
   .  .|  .| |... . |||.. .|
LSAVAYMHSQDIVHRDLKLENIMVCYSF
Kinase 81368.m00081.AA CAMKL 65-155 23 1.3e-08 23.5 In-house 63-171 (297) Show / Hide 
Range on Protein: 65-155
Range on HMM: 63-171/297
Sequence Identity: 23% (26 aa)

INILIQLR---HPNIVRFVEFYHDSKK------MFLITEYFNNYS--LEDLISSTTC-----GEYHYKTIVSGIIKGIQALHHAGICHGNICPSNIMIYD
|.|. .|.   ||||... | . ....      ..|..||  . .  | | | .  .      |   . .   |. ... .|  ||.|  | | ||.. .
IQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDE

RF--HPKIS
.     ||.
NGNNNIKII
Kinase 81368.m00081.AA CAMK-Unique 193-231 33 4.5e-07 19.16 In-house 273-320 (363) Show / Hide 
Range on Protein: 193-231
Range on HMM: 273-320/363
Sequence Identity: 33% (16 aa)

AADIWSFGVTCYVLLTRQMPFSQSNEI--------KLFNSIIECNY-N
|.|||| ||. | .|.  .||  ..|         ..| .|  ..| |
ASDIWSLGVIMYYMLCGCPPFDCECEDRDYENHDKEIFECICKGDYCN
Kinase 81368.m00081.AA Ciliate-E2b 192-265 23 0.00013 10.12 In-house 189-272 (272) Show / Hide 
Range on Protein: 192-265
Range on HMM: 189-272/272
Sequence Identity: 23% (20 aa)

FAADIWSFGVTCYVLLTRQMPFSQSNE--IKLFNSIIEC--NYN-PTVINDEAY-RKMVTSCIVLEPENRA--SIDELEN--WF
...||||.|.. | ..  . |.    .  . .   ||.   . . |  . |.    |.. .|    || |   |.. |..  ||
YKVDIWSVGICLYEFMCGYVPWAEDVQDPYEIYQEIIKKYDEIQFPSYCKDKMADKKLMLQCLQKMPEVRLGGSYSWLKSHPWF