Gene 80572.m00040 (T.vaginalis)
80572.m00040
Species: T.vaginalis
Alias: TvagK0778, 80572.m00040
External Links:
Annotation:
Group:
CAMK
Family:
CAMK-Tvag1
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| 80572.m00040.AA | Protein | None | 492 | None | Fasta, JSON |
| 80572.m00040.kin_dom | Protein Kinase Domain | None | 151 | None | Fasta, JSON |
Protein domains of 80572.m00040.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 80572.m00040.AA | Ciliate-E2-Unclassified | 85-256 | 17 | 5.3e-17 | 55.53 | In-house | 100-331 (352) | Show / Hide |
Range on Protein: 85-256
Range on HMM: 100-331/352
Sequence Identity: 17% (44 aa)
MDYIPGVTLERLLRD---------------HKRIRL-----------LYIIEIITALNLQLKKMGKKGIKHRDLKPGNIVIDAN---FIPHILDWDDMT-
|.|..| .|. ... ..| .. |. .|. .|. .| ..| |||.|| ||..| | . . | |.
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHK---NNIIHRDIKPENILFDNNGKNYYIKIIDFGISKK
------------TRISMTQSPYH----GTIRFA----APEIFEM-KRE----CASDIFSFGSIIFNMLTGKAPFDD---------------------VYN
........ ||... |||... . . ..||.|.| |.. ||.|. ||.| .|.
YQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQ
NL-DGIFQFIPKEYHVEEVDEQEDDEDEQEDDENKQKDKEKKLKRLIQK
| ....|| . . .. . .. . ...|.||
NIKQKNIQFPKFPWQQ--------------IPKHWSPEAKDFINDLLQK
|
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| Kinase | 80572.m00040.AA | Ciliate-E2 | 85-251 | 17 | 3.8e-13 | 41.46 | In-house | 113-306 (365) | Show / Hide |
Range on Protein: 85-251
Range on HMM: 113-306/365
Sequence Identity: 17% (42 aa)
MDYIPGVTLERLLRDHKRIRL------LYIIEIITA-LNLQLKK-------------------MGKKG-IKHRDLKPGNIVIDANFIPHILDWD------
|.|. | .|. .....| |. .|. | . . |. . . .|. | |||.|| ||.. . | |.
MEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYD
-------------DMTTRISMTQSPYH---------------GTIRFAAPEIFEMK----------RECASDIFSFGSIIFNMLTGKAPFDDVYNNLDGI
.. ..| . || . ||||...| ..||.|.| |.. ||.|| ||
DDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF----------
FQFIPKEYHVEEVDEQEDDEDEQEDDENKQKDKEKKLK
|. |..|..
----------------------------QQQIKQCKID
|
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| S_TKc | 80572.m00040.AA | S_TKc | 21-413 | 12 | 4.2e-13 | 15.17 | SMART | 9-231 (231) | Show / Hide |
Range on Protein: 21-413
Range on HMM: 9-231/231
Sequence Identity: 12% (51 aa)
SGAYGKCF-VLKIGDKFQVLKKYFNSSGQKIEKVFEEMEGFQIPLAPKYFDTSVKHPGEPFDWVLMDYIPG--VTLERLLRDHKR------IRLLYIIEI
.||.||.. . ..... .| | . . | .. . | |..|. . . .. |.|..| .| .......| . . .
KGAFGKVYKCRHKKTGRIVAIKIIK-EHIRREIQILKK---HHPNIVKLYDVFQD----DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFY
ITALNLQLKKMGKKGIKHRDLKPGNIVIDANFIPHILDWDDMTTRISMTQSPYHGTIRFAAPEIFEMKRECASDIFSFGSIIFNMLTGKAPFDDVYNNLD
. . . |. . ..|| |||||| || .| | | . ... . . || . |||.. |..|. |.| |.. ||.|. ||. ...
MYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDF-GLARQL----TTFCGTPWYMAPEVL-GYGKCKCDWWSCGCILYEMLCGYPPFP----QMQ
GIFQFIPKEYHVEEVDEQEDDEDEQEDDENKQKDKEKKLKRLIQKTKRGVNYYLKRNEELEDLISEHPNKGHLALNIFNTYNDDTKASMHLYVMNLAEQH
.|. |
MMFKKIG---------------------------------------------------------------------------------------------
TKEKIRQQIEEYRSLDETTQKILSMKIDLDQCYGELIRNNIEPILIELIKIGVRDEDLIYDKEFLEHEHDKALANIISNCWKQEPKDRWTPKQIQKEI--
.. . ..|..|.. .|..|.| .. ..
---------------------------------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWD
---DNIV
. .
IKCHPWF
|
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| Kinase | 80572.m00040.AA | CAMK | 124-220 | 17 | 9.8e-13 | 36.64 | In-house | 197-370 (425) | Show / Hide |
Range on Protein: 124-220
Range on HMM: 197-370/425
Sequence Identity: 17% (31 aa)
KKGIKHRDLKPGNIVIDAN-----------------FIPHILDWDDMTTRIS-------------------------MTQSPYHGTIRFAA-PEIFEMK-
...| |||||| || .| | . | |. . .. . . || ..| ||... |
SHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKG
--------------RECASDIFSFGSIIFNMLTGKAPFDDVY-------------------NNLDGIFQFIPKE
..|. | | | . ||.|. ||.. . . . | ..|.|..
HCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPY
|
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| Kinase | 80572.m00040.AA | Pkinase | 125-205 | 32 | 2.8e-09 | 33.91 | Pfam | 127-214 (293) | Show / Hide |
Range on Protein: 125-205 Range on HMM: 127-214/293 Sequence Identity: 32% (29 aa) KGIKHRDLKPGNIVIDANFIP----HILDWDDMT---TRISMTQSPYHGTIRFAAPEI--FEMKRECASDIFSFGSIIFNMLTGKAPFDD .|| |||||| || || | . .| |. . . . . ||....|||. . . ..|..|.| |.. ||.|. ||.. MGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPG |
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| Kinase | 80572.m00040.AA | TKL-Unique | 123-206 | 22 | 4.8e-09 | 28.23 | In-house | 130-237 (290) | Show / Hide |
Range on Protein: 123-206
Range on HMM: 130-237/290
Sequence Identity: 22% (25 aa)
GKKGIKHRDLKPGNIVIDAN-----FIPHILDWDDMTTRISMTQSPYH-----------GTIRFAAPEIFEM---KRECASDIFSFGSIIFNMLTGKA--
... | |||||. |. .| | . | | ... ....... |..| .|||...| .. . ||..||| . ..|.|
EPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEIATRKITK
----PFDDV
|....
TYKKPYQGM
|
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| Kinase | 80572.m00040.AA | TKL | 124-205 | 23 | 2e-08 | 26.43 | In-house | 158-291 (364) | Show / Hide |
Range on Protein: 124-205
Range on HMM: 158-291/364
Sequence Identity: 23% (31 aa)
KKGIKHRDLKPGNIVIDANFI-------PHILDWD----DMTTRISMTQSPY------------------------HGTIRFAAPEIFEMKRE-------
|..| |||||. || .| |. ... ||. |. . .|.|| ||.|. |||..... .
KPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGI
----------CASDIFSFGSIIFNMLTGKAPFDD
..|..||| ... .||.. |..|
DEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYD
|
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| Kinase | 80572.m00040.AA | AGC | 166-217 | 31 | 5.6e-08 | 15.18 | In-house | 267-327 (395) | Show / Hide |
Range on Protein: 166-217 Range on HMM: 267-327/395 Sequence Identity: 31% (20 aa) G--TIRFAAPEIFEMKRECASDIFS--FGSIIFNMLTGKAPFDDV--------YNNLDGIFQFI | | . ||||. | |. | .| ... ||||. || . ..| . .|| | GPCTPEYMAPEIL---YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKI |
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| Kinase | 80572.m00040.AA | Ciliate-E9 | 122-143 | 52 | 1.9e-07 | 19.43 | In-house | 127-149 (298) | Show / Hide |
Range on Protein: 122-143 Range on HMM: 127-149/298 Sequence Identity: 52% (12 aa) MGKKG-IKHRDLKPGNIVIDANF | ... | |||||| |..||.|. MHQYQNICHRDLKPENMLIDKNY |
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| Kinase | 80572.m00040.AA | MLK | 129-207 | 27 | 1.9e-07 | 22.06 | In-house | 150-241 (291) | Show / Hide |
Range on Protein: 129-207 Range on HMM: 150-241/291 Sequence Identity: 27% (26 aa) HRDLKPGNIVIDA------NFIPHILDWDDMTTRISMTQS-----PYHGTIRFAAPEIF----EMKRECASDIFSFGSIIFNMLTGKAPFD-DVY |||||. ||.||. . . | | . | ...|. || .. |||.. . | ..|..|.| .. |||.. |.. ... HRDLKSHNILIDEICHDMHHGTLKICDFG---TSRDWHQMCTNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYD |
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| Kinase | 80572.m00040.AA | ZAK | 384-408 | 40 | 8.5e-07 | 20.4 | In-house | 233-257 (257) | Show / Hide |
Range on Protein: 384-408 Range on HMM: 233-257/257 Sequence Identity: 40% (10 aa) LANIISNCWKQEPKDRWTPKQIQKE .. ...||| .|||| .||| . FKQLMHQCWKMDPKDRPNMRQIQSI |
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| Kinase | 80572.m00040.AA | RIPK | 166-210 | 26 | 1e-06 | 18.72 | In-house | 184-235 (290) | Show / Hide |
Range on Protein: 166-210 Range on HMM: 184-235/290 Sequence Identity: 26% (14 aa) GTIRFAAPEIFE---MKR----ECASDIFSFGSIIFNMLTGKAPFDDVYNNL ||. . .|| |. |. ..|. ||. ... ||.| |. |. . . GTLSYMPPEHFRTDNKKPIKVVTPKYDVYSFAIVMWEVLTQKHPYEDRKCMM |
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| Kinase | 80572.m00040.AA | AGC | 124-142 | 52 | 9.2e-05 | 6.67 | In-house | 171-191 (395) | Show / Hide |
Range on Protein: 124-142 Range on HMM: 171-191/395 Sequence Identity: 52% (11 aa) K-KGIKHRD-LKPGNIVIDAN . .|| ||| ||| ||..|.. SHMGIIHRDYLKPENILLDED |
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| Kinase | 80572.m00040.AA | TKL | 373-409 | 16 | 9.6e-05 | 13.02 | In-house | 329-364 (364) | Show / Hide |
Range on Protein: 373-409 Range on HMM: 329-364/364 Sequence Identity: 16% (6 aa) KEFLEHEHDKALANIISNCWKQEPKDRWTPKQIQKEI . .. .. ..... ||...|..| . ..| |.. M-CPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL |
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| Kinase | 80572.m00040.AA | ZAK | 129-205 | 32 | 9.9e-05 | 12.95 | In-house | 127-206 (257) | Show / Hide |
Range on Protein: 129-205 Range on HMM: 127-206/257 Sequence Identity: 32% (26 aa) HRDLKPGNIVIDANFIPHILDWDDMT-TRISMTQSPYHGTIRFAAPEIF--EMKRECASDIFSFGSIIFNMLTGKAPFDD ||||| |.|||.| . | | . | . || |||. . |..|.| . ||| |. | HRDLKSRNVVIDKNGVCKICDFGTSRDFHHHCTHMSWVGTFPWMAPEMILQSEPVTETCDVWSYGVVLWEMLTREVPYKD |
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| TyrKc | 80572.m00040.AA | TyrKc | 21-409 | 11 | 0.00024 | -152.35 | SMART | 9-280 (280) | Show / Hide |
Range on Protein: 21-409
Range on HMM: 9-280/280
Sequence Identity: 11% (52 aa)
SGAYGKCFVLKIGDKFQVLKKYFNSSGQKIEKVFEEMEGFQIPLAPKYFDTSV--KHPG------------------EPFDWVLMDYIPGVTLERLLRDH
.||.|. . . || | ... .| .|.. ... .|| || ...| | |. | ||.|
EGAFGEVYKGTWK--IQVAVKMLKEDA--REDFMREARIM----------CKLGGHHPNIVRLYGVCTQQGRNFMYIEPL-MIVMEYMPHGDLKDYLRKH
KR-IRLLYIIEIITALNLQLKKMGKKGIKHRDLKPGNIVIDANFIPHILD------WDDM------TTRISMT---QSPYHGTIRFAAPEIFEMKREC--
.. . . ... . .|.. |||| |. ...|.. | | ..| . .... .. . || ||| . .....
RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKFTT
ASDIFSFGSIIFNMLT-GKAPFDD-VY--NNLDGIFQFIPKEYHVEEVDE----QEDDEDEQEDDENKQKDKEKKLKRLIQKTKRGVNYYLKRNEELEDL
.||..||| .. ..| |. | . . . . ..... . | . ..
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS---------------------------------------------
ISEHPNKGHLALNIFNTYNDDTKASMHLYVMNLAEQHTKEKIRQQIEEYRSLDETTQKILSMKIDLDQCYGELIRNNIEPILIELIKIGVRDEDLIYDKE
----------------------------------------------------------------------------------------------------
FLEHEHDKALANIISNCWKQEPKDRWTPKQIQKEI
| . ... .|.. ||. .|.|| | ..| ...
F--VCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
|
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| Kinase | 80572.m00040.AA | RIPK | 129-143 | 73 | 0.000322 | 10.24 | In-house | 132-146 (290) | Show / Hide |
Range on Protein: 129-143 Range on HMM: 132-146/290 Sequence Identity: 73% (11 aa) HRDLKPGNIVIDANF ||||||.|| .|.|| HRDLKPENILVDNNF |
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| Kinase | 80572.m00040.AA | MLK | 381-409 | 24 | 0.000428 | 10.25 | In-house | 263-291 (291) | Show / Hide |
Range on Protein: 381-409 Range on HMM: 263-291/291 Sequence Identity: 24% (7 aa) DKALANIISNCWKQEPKDRWTPKQIQKEI .. ... ...||.|.|..| . .||... PEHWKKLMKQCWNQDPHKRPSFRQIVQHL |
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| Kinase | 80572.m00040.AA | Ciliate-E9 | 185-203 | 52 | 0.000826 | 7.62 | In-house | 207-225 (298) | Show / Hide |
Range on Protein: 185-203 Range on HMM: 207-225/298 Sequence Identity: 52% (10 aa) DIFSFGSIIFNMLTGKAPF |||| | | | |... .|| DIFSAGCILFMMVMNQYPF |
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| Kinase | 80572.m00040.AA | TKL-Unique | 384-409 | 23 | 0.003998 | 7.08 | In-house | 265-290 (290) | Show / Hide |
Range on Protein: 384-409 Range on HMM: 265-290/290 Sequence Identity: 23% (6 aa) LANIISNCWKQEPKDRWTPKQIQKEI . ..| ||...| .| . .| ... YRDLIQQCWHHDPSQRPSFDEIIHRL |
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| Kinase | 80572.m00040.AA | Pkinase | 374-409 | 23 | 0.012094 | 10.43 | Pfam | 257-293 (293) | Show / Hide |
Range on Protein: 374-409 Range on HMM: 257-293/293 Sequence Identity: 23% (9 aa) EFLEHEHDKALANIISNCWKQEPKDRWTPKQIQKE--I ... |. .... .|..|... ||.|.|..|| . . WTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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| Kinase | 80572.m00040.AA | RIPK | 384-409 | 23 | 0.014234 | 4.55 | In-house | 265-290 (290) | Show / Hide |
Range on Protein: 384-409 Range on HMM: 265-290/290 Sequence Identity: 23% (6 aa) LANIISNCWKQEPKDRWTPKQIQKEI . . . ||.|.|.|| . .. .. MIELMQRCWQQDPNDRPCFQECEEWT |
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