Gene 96726.m00108 (T.vaginalis)

96726.m00108

Species: T.vaginalis
Alias: 96726.m00108, TvagK0965
External Links:
Annotation:

Classification

Group: CAMK
Family: CAMKL
Subfamily: CAMKL-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
96726.m00108.AA Protein None 306 None Fasta, JSON
96726.m00108.kin_dom Protein Kinase Domain None 197 None Fasta, JSON

Protein domain

Protein domains of 96726.m00108.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 96726.m00108.AA Ciliate-E2 66-264 19 1.8e-27 91.31 In-house 86-365 (365) Show / Hide 
Range on Protein: 66-264
Range on HMM: 86-365/365
Sequence Identity: 19% (57 aa)

LKEINHKNIPKIYSVQA--YGDYIYLFCERVPNATLKEYVLSN-----------GKMPTQHVILIMNQLLS---------------ALHCAHSKG-VAHN
|...||.|| |.| .      ..|||  | .   .|..|  .|           ...  .... || |.|.               ||.  |||. . | 
LEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHR

HITLDNIMFDRDMVPVLYNFHL------------------GMKDFFSAVKTPKNDI----------------NFCSPEEIKEDSIDQ--------YATDI
 | ..||.|     . .  | |                   ... ..  ..   ..                .. .|| ..  ..|         |. ||
DIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDI

WHLGVVIYVLCTSKYPFSNTNHSKLCQNILSEEP--------------DYDSIDPKIVVKLKQ----MLEKDPAKRAT-AEQLMETEPI
| |||..| ... |.||      .. ..|   .|              ........    .|.    ||.||| || | .||... . .
WSLGVILYEMLFGKPPF---QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 96726.m00108.AA Ciliate-E2-Unclassified 46-264 17 1.1e-26 89.59 In-house 37-352 (352) Show / Hide 
Range on Protein: 46-264
Range on HMM: 37-352/352
Sequence Identity: 17% (55 aa)

SIKKLEENHIYPQFVEKLNKLKEIN-----------------HKNIPKIYSVQAYGDY--IYLFCERVPNATLKEYVLSNGK-----------------M
..|..  ..   ... ... .....                 |... ... . .  |.  ||.  | ... .|..|  ...|                  
IYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIF

PTQHVI-----LIMNQLLSAL-HCAHSKGVAHNHITLDNIMFDRDMVPVLYNFHLGMKDFFSA------------------------VKTPKNDINFC--
. |...      .. |.|..| .. |.... |  |...||.|| ..     |...   ||...                         .|    .|.   
TEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK----NYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQ

--SPEEIKEDSIDQ---YATDIWHLGVVIYVLCTSKYPFSNTNHSK----------------LCQNILSEEPDYDSIDP-----------KIVVK--LKQ
  .|| ...   |.   |. ||| |||..| ... .|||. .|  .                | |||.  ...... ..           |  ..  |..
YTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQK

MLEKDPAKRATAEQLMETEPI
||.|.| || |.||...   .
MLKKNPNKRITFEQILNHPWF
Kinase 96726.m00108.AA CAMK 63-260 14 1.1e-21 65.96 In-house 85-421 (425) Show / Hide 
Range on Protein: 63-260
Range on HMM: 85-421/425
Sequence Identity: 14% (49 aa)

LNKLKE----INHKNIPKIYSVQA-----------------YGD---YIYLFC---ERVPNA----TLKEYVLSN---------------GKMPTQHVIL
..||..    ..|.|| |.| |                   . .   ..|..    | ...      | .|. ..               |... . .  
MKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYETSKQVF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARR

IMNQLLSALHCAHSKGVAHNHITLDNIMFDRDM-----------------VPVLYNFHLGMKDFFSA-------------------------VKTPKNDI
.. |..||.|  ||....|  . ..||..| ..                    .  | .  | . .                           ||.    
YFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTP

NFCS-PEEIKE-------------DSIDQYATDIWHLGVVIYVLCTSKYPFSNT-------------NHSKLCQNILSEEPDYDSID-------------
 ... || ..                 . ...|.| .||. |.. . ..||                | ..|...|.. . |...               
EYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWW

------------PKIVVKLKQMLEKDPAKRATAEQLME
            .     ...||..|| ||.|.|| ..
DDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLN
Kinase 96726.m00108.AA MELK 57-264 26 3.6e-20 65.37 In-house 42-254 (254) Show / Hide 
Range on Protein: 57-264
Range on HMM: 42-254/254
Sequence Identity: 26% (57 aa)

PQFVEKLNKLKEINHKNIPKIYSVQAYGDYIYLFCERVPNATLKEYVLSNGKMPTQHVILIMNQLLSALHCAHSKGVAHNHITLDNIMFDRDMVPVLYNF
|.    .. ||.. |..| ..| .    | |..  |  |   . .|.... ..  .    .. |..||.   ||.| ||  .  .|..|| |.   | .|
PRVKTEMDALKNLRHQHICQLYHYIETEDKIFMVMEYCPGGEMFDYIIRQDRLEEEETRHFFRQIVSAIAYVHSQGYAHRDLKPENLLFDEDHHLKLIDF

HL-----GMKDFFSAVKTPKNDINFCSPEEIKEDSIDQYATDIWHLGVVIYVLCTSKYPFSNTNHSKLCQNILS---EEPDYDSIDPKIVVKLKQMLEKD
 |     | ||    ..|      .  || |.  .      |.| .|...|||     ||   | . . . |.|   |||.. |   | .  |..||  |
GLCAKTKGRKDYH-NLQTCCGSPAYAAPELIQGKQYIGSEADVWSMGILLYVLMCGFLPFDDDNMMIMYKKIMSGCYEEPKWLSPESKQL--LRHMLQVD

PAKRATAEQLMETEPI
| ||    .|.. . .
PKKRISMKNLLNHPWV
S_TKc 96726.m00108.AA S_TKc 24-264 20 4.5e-15 44.07 SMART 1-231 (231) Show / Hide 
Range on Protein: 24-264
Range on HMM: 1-231/231
Sequence Identity: 20% (53 aa)

SDDDITI---------LVRDQEGNNALCMAYSIKKLEENHIYPQFVEKLNKLKEINHKNIPKIYSVQAYGDYIYLFCERVPN--ATLKEYVLSNGK----
 .   .|         ..|. .        . ||..       ..   .. ||. .|.|| |.| |    |..|.. | ...   .|..|  ..|.    
YEILRKIGKGAFGKVYKCRHKK----TGRIVAIKIIK-----EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--MPTQHVILIMNQLLSALHCAHSKGVAHNHITLDNIMFDRDMVPVLYNFHLGMKDFFSAVKTPKNDINFCSPEEIKEDSIDQYATDIWHLGVVIYVLCT
  .|  |.  .| |...||   ||.|. |  .  .||..|.  .  .  | |  .   . . ||    ....|| .   . .  . |.| .|...| ...
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-TTFCGTP----WYMAPEVL---GYGKCKCDWWSCGCILYEMLC

SKYPFSNTNHSKLCQNILSEEPDYDSIDPKIVVKLKQMLEKDPAKRATAEQLME-------TEPI
 . ||.  .. .. ..|.         .|     ....|.|||.|| || ....        . .
GYPPFP--QMQMMFKKIG---------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 96726.m00108.AA MARK 190-260 27 4.7e-12 35.87 In-house 185-258 (262) Show / Hide 
Range on Protein: 190-260
Range on HMM: 185-258/262
Sequence Identity: 27% (20 aa)

YATDIWHLGVVIYVLCTSKYPFSNTN--HSKLCQNILSEEPD-YDSIDPKIVVKLKQMLEKDPAKRATAEQLME
...||| |||| |.. . ..|| ...    .| ..||....| .. . ...   ....|  .| .|.|.|..|.
PKVDIWSLGVVLYFMVCGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMK
Kinase 96726.m00108.AA SNRK 176-264 32 1.4e-11 33.91 In-house 165-254 (254) Show / Hide 
Range on Protein: 176-264
Range on HMM: 165-254/254
Sequence Identity: 32% (30 aa)

FCSPEEIKEDSIDQYATDIWHLGVVIYVLCTSKYPFSNTNHSKLCQNILSEE---PDYDSIDPKIVVKLKQMLEKDPAKRATAEQLMETEPI
.  || .  || |  | ||| |||..|.|   . || . | |     |.      ||  | . . ..  ..|| .|| |||. |.. ..  .
YSAPEILLGDSYDAPAVDIWSLGVILYMLVCGQAPFQEANDSETLTMIMDCKYTVPDHVSDECRDLI--QSMLVRDPKKRASLEEIVSHSWV
Kinase 96726.m00108.AA Pkinase 174-264 18 2.2e-11 41.36 Pfam 175-293 (293) Show / Hide 
Range on Protein: 174-264
Range on HMM: 175-293/293
Sequence Identity: 18% (22 aa)

INFCSPEEIKEDSIDQYATDIWHLGVVIYVLCTSKYPFSNT------NHSKLCQNILSEEPDYDSIDP---------------------KIVVKL-KQML
.....|| |.... . .. |.| .|...| ... . ||..       .. .. ..|.. ....|.  .                     .   .. | .|
PWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCL

EKDPAKRATAEQLMETEPI
.|||.|| ||||... . .
CKDPKKRPTAEQILQHPWF
Kinase 96726.m00108.AA CAMKL 175-260 21 2.1e-10 29.29 In-house 198-293 (297) Show / Hide 
Range on Protein: 175-260
Range on HMM: 198-293/297
Sequence Identity: 21% (21 aa)

NFCSPEEIKE--DSIDQYATDIWHLGVVIYVLCTSKYPFS----------NTNHSKLCQNILSEEP-DYDSIDPKIVVKLKQMLEKDPAKRATAEQLME
....|| ..   .. | ...||| .||. |.. . ..||           |.   .. .... ..|  . ...      ...||...| ||.|..|.|.
PYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMN
Kinase 96726.m00108.AA Pkinase 66-135 26 5.3e-10 36.46 Pfam 54-131 (293) Show / Hide 
Range on Protein: 66-135
Range on HMM: 54-131/293
Sequence Identity: 26% (21 aa)

LKEINHKNIPKIYSVQAYGDYIYLFCERVPNA----TLKEYVL--SNGKM--PTQHVILIMNQLLSALHCAHSKGVAH
.|..||.|| ..| .  ..|.||.  | ...      |..|.   ..|..  . .... .| |.|..|   ||.|. |
MKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIH
Kinase 96726.m00108.AA CAMK-Unique 66-145 19 8.8e-10 28.26 In-house 70-190 (363) Show / Hide 
Range on Protein: 66-145
Range on HMM: 70-190/363
Sequence Identity: 19% (24 aa)

LKEINHKNIPKIYSV----QAYGD---------------YIYLFCERVPNATLKEYVLS--------------------NGKMPT--QHVILIMNQLLSA
.|  .| || |.| .        .               |.|.. |...  .|......                    .|..     ....|| .||||
WKMVDHPNIIKLYDWNNPIFCDRKYPLCDLIIKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSA

LHCAHSKGVAHNHITLDNIMF
.  .||... |  . |.|||.
VAYMHSQDIVHRDLKLENIMV
Kinase 96726.m00108.AA AMPK 192-264 28 1.4e-09 24.71 In-house 181-254 (254) Show / Hide 
Range on Protein: 192-264
Range on HMM: 181-254/254
Sequence Identity: 28% (21 aa)

TDIWHLGVVIYVLCTSKYPFSNTNHSKLCQNILSEEPDY-DSIDPKIVVKLKQMLEKDPAKRATAEQLMETEPI
.|||  ||. |..   . ||   | ..| ..|.. |.   . . |..   .|.||..|| ||.| ..... .  
VDIWSCGVILYAMLCGYLPFDDENTPTLYKKIKNGEYYIPKFLSPEAKDLIKHMLQVDPMKRITIHDIRNHPWF
Kinase 96726.m00108.AA AMPK 66-149 21 1.1e-08 21.94 In-house 53-137 (254) Show / Hide 
Range on Protein: 66-149
Range on HMM: 53-137/254
Sequence Identity: 21% (18 aa)

LKEINHKNIPKIYSVQ-AYGDYIYLFCERVPNATLKEYVLSNGKMPTQHVILIMNQLLSALHCAHSKGVAHNHITLDNIMFDRDM
|| ..| .| . | |     . |... | |..  | .|. ..|... .     . | .|..   |  ...|    . |. .| ..
LKLFRHPHIIQLYEVIIETPTDIFMVMEYVSGGELFDYIVKHGRLQEREACRFFQQIISGVEYCHRHMIVHRDLKPENLLLDHNK
Kinase 96726.m00108.AA CAMK-Unique 176-264 19 4.6e-08 22.49 In-house 241-363 (363) Show / Hide 
Range on Protein: 176-264
Range on HMM: 241-363/363
Sequence Identity: 19% (24 aa)

FCSP--------------EEIKEDSIDQYAT---DIWHLGVVIYVLCTSKYPFSNTNHS--------KLCQNILSEEP------DYDS---IDPKIVVKL
...|              | |... .||      ||| |||. | . . . ||  ..          .. ..|.. ..       ...   | .   . .
YMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECEDRDYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFV

KQMLEKDPAKRATAEQLMETEPI
|. .. ||..| .|..| | . |
KCCMTVDPDHRWSAKELLEHQWI
Kinase 96726.m00108.AA ULK 178-264 17 5.9e-08 23.95 In-house 219-329 (329) Show / Hide 
Range on Protein: 178-264
Range on HMM: 219-329/329
Sequence Identity: 17% (20 aa)

SPEEIKED--SIDQY-A-TDIWHLGVVIYVLCTSKYPFSNTNHSKLC-----QN----------ILSEEPDYD------SIDPKIVVKLKQMLEKDPAKR
.|. ...    ...| . .||| ||...| . . |.||..   ...      ..          | .. ....       | |..   ...||..|. .|
APQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEKDR

ATAEQLMETEPI
 . |.| . . .
ISWEELFNHPWF
Kinase 96726.m00108.AA CAMKL 66-146 28 7e-06 14.52 In-house 66-161 (297) Show / Hide 
Range on Protein: 66-146
Range on HMM: 66-161/297
Sequence Identity: 28% (28 aa)

LKEIN---HKNIPKIYSVQ-------AYGDYIYLFCERVPNAT--LKEYVLSN----GKMPTQHVILIMNQLLSALHCAHSKGVAHNHITLDNIMFD
.| .|   |.|| |.| |           ..|||. | ...    | .|. ..    |.||      .  |..||..  ||.|..|  | ..||..|
MKMLNIGKHPNIIKLYEVIETPEHDIET-KKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLD
Kinase 96726.m00108.AA ULK 66-135 22 6.7e-05 13.13 In-house 64-153 (329) Show / Hide 
Range on Protein: 66-135
Range on HMM: 64-153/329
Sequence Identity: 22% (20 aa)

LKEIN----HKN----IPKIYSVQAYG--DYIYLFCERVPNATLKEYVLSNGKMPTQH----------VILIMNQLLSALHCAHSKGVAH
.|...    |||    | | | ..     ..||.. |  .  .|..|   |.|.| ..          .| .. |.|... . |.... |
MKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIH
TyrKc 96726.m00108.AA TyrKc 30-262 15 0.000239 -152.32 SMART 1-280 (280) Show / Hide 
Range on Protein: 30-262
Range on HMM: 1-280/280
Sequence Identity: 15% (45 aa)

ILVRDQEGNNALCMAYS--------IKKLEENHIYPQFVEKLNKLKEI--NHKNIPKIYSVQAYG-------DYIYLFCERVPNATLKEYVLSNGK-MPT
|   .. |. | .  |         .|.| |..    | . .. ....  .|.|| ..| |   .       . ...  | .|.  ||.|  ....  ..
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCM

QHVILIMNQLLSALHCAHSKGVAHNHITLDNIMFDRDMVPVLYNFHLGMKDFFSA--------VKTP-----KND---INFCSPEEIKEDSIDQYATDIW
.. . .. |  .     |||.. |  .   |.. ... .     | | ..|  .         ....     ...   |  ..|| |  ...   ..|.|
KDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGL-SRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKFTTKSDVW

HLGVVIYVLCTS-KYPFSN-----TNHSKLCQNILSE--EPDYDS--------IDPKIVVKLKQMLEKDPAKRATAEQLMETE
  ||... ..|  . | ..      . . . ... .    |  ..          ...    ||  . ||..| | ... |  
SFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 96726.m00108.AA MARK 120-149 36 0.001707 7.48 In-house 112-141 (262) Show / Hide 
Range on Protein: 120-149
Range on HMM: 112-141/262
Sequence Identity: 36% (11 aa)

QLLSALHCAHSKGVAHNHITLDNIMFDRDM
|..||..  |||...|  | ..||. | ..
QIVSAVNYCHSKNIVHRDIKPENILIDENG