Gene 92777.m00080 (T.vaginalis)

92777.m00080

Species: T.vaginalis
Alias: TvagK0322, 92777.m00080
External Links:
Annotation:

Classification

Group: TKL
Family: TKL-Tvag1

Sequence

Name Sequence Type Origin Length Description Download
92777.m00080.AA Protein None 790 None Fasta, JSON
92777.m00080.kin_dom Protein Kinase Domain None 257 None Fasta, JSON

Protein domain

Protein domains of 92777.m00080.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 92777.m00080.AA TKL 215-465 25 2.2e-85 289.94 In-house 1-364 (364) Show / Hide 
Range on Protein: 215-465
Range on HMM: 1-364/364
Sequence Identity: 25% (94 aa)

IGSGVSAVVYSGYYTPTN--------ELVAIKKLKYEKLTGPQL-------------------------QAFQRELSILATAVHPTILKFIG-ATDTHP-
|||| ...|| |..  ..        . ||.||.| .      .                         . . .|. ..    || |..|.| ...  . 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------FCVVTQFMPGGTLYYDLHQRHSLDPTDLTIA-LYDVARGMKFLHAQN--------IIHRDLKTLNVLIDDKKR--------------A
            .| |....|||.|...||        ....   .|.|||| .||..|        |||||||. |.|.|.. .              .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

KLSDFGFSKQMDSNQLMTMN--------------------VGTPHWMAPELLANNGPQTPGA---------QYDTKVDVYAFAIVMWEALVKEIPYHGME
|..|||.|. |. .. |...                    .||| |||||.| .... |  .         .|..|.|||.|.||.|| |  ..||... 
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYP

PMQIV---------AQVMMNDLRPHIP------------KDTPPAFEDLMKQCWARNPTMRPNFAEIVRKF
.|...         ..|  . ||| ||            .|.|| . .||..||. .|. ||.| ||. ..
YMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase 92777.m00080.AA MLK 209-465 31 2.2e-75 256.74 In-house 1-291 (291) Show / Hide 
Range on Protein: 209-465
Range on HMM: 1-291/291
Sequence Identity: 31% (94 aa)

LLYEKEIGSGVSAVVYSGYYTPTN---ELVAIKKLKYEK----LTGPQLQAFQRELSILATAVHPT----ILKFIGA-TDT-HPFCVVTQFMPGGTLYYD
.. .. |||| . .|..|..  ..     ||.|. . ..     |. . ..|..|  .|.   ||     | .| |. ... ..||.|.....|| ||  
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LHQRHS--------------LDPTDLTIALYDVARGMKFLHAQN---IIHRDLKTLNVLIDD------KKRAKLSDFGFSKQMDSN-QLMTMNVGTPHWM
|| . |               |.  .    ...|||| .||..    |||||||  |.|||.      .. .| .||| |. . .. . |. | ||. ||
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYAWM

APELLANNGPQTPGAQYDTKVDVYAFAIVMWEALVKEIPYH-GMEPMQIVAQVMMNDLRPHIPKDTPPAFEDLMKQCWARNPTMRPNFAEIVRKF
||| .       .. .|. |.||. ...|.|| | .|.||. ...||.| ..| .| |||.||.. |. .. ||||||  .|  ||.|..|| ..
APEVIQQ----FRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase 92777.m00080.AA TKL-Unique 213-465 32 5e-72 245.6 In-house 3-290 (290) Show / Hide 
Range on Protein: 213-465
Range on HMM: 3-290/290
Sequence Identity: 32% (96 aa)

KEIGSGVSAVVYSGYYTPTNELVAIKKLKY-EKLTGPQLQAFQRELSILATAV-HPTILKFIGATD----THP-FCVVTQFMPGGTLYYDLH--------
. ||.|....|| | .    . ||||...  |..    .| | .|.... .   || |....|..     . | .| |. ..|||.||  ||        
NKIGEGGYGQVYKGKW--RGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

--QRHSLDPTDLTIALYDVARGMKFLHAQN--IIHRDLKTLNVLIDDK-----KRAKLSDFGFSKQMDSNQLMTMN----------VGTPHWMAPELLAN
  . . |..        |.|.|| .||  .  |||||||..|.|.| .      ..|..|||.||  ...  || |          .|.. |||||.| .
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRM

NGPQTPGAQYDTKVDVYAFAIVMWEALVKEI------PYHGMEPMQIVAQVMM--NDLRPHIPKDTPPAFEDLMKQCWARNPTMRPNFAEIVRKF
|      .||..|.|||.|.||.|| .  .|      ||.||.. |. . |      .|| || . |. . ||..|||...|. ||.| ||. . 
NF-----CQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase 92777.m00080.AA Pkinase 209-465 24 3.3e-70 244.37 Pfam 1-293 (293) Show / Hide 
Range on Protein: 209-465
Range on HMM: 1-293/293
Sequence Identity: 24% (75 aa)

LLYEKEIGSGVSAVVYSGYYTPTNELVAIKKLKYEKLTGPQLQAFQR--ELSILATAVHPTILKFIGATDTHPFCV-VTQFMPGG----TLYYDLH--QR
.  .. |||| ...|| ..   |...||.|..|...    ..|.  |  |..|..   || |......  ... .  |. ...||     |.  ..  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

HSL--DPTDLTIALYDVARGMKFLHAQNIIHRDLKTLNVLIDDKKRA----KLSDFGFSKQ--MDSNQLMTMNVGTPHWMAPELLANNGPQTPGAQYDTK
 ..  .. ..   .| ..||....|...|||||||  |.|||..       |..|||..||    .|. ||  .|||..||||..        |  |..|
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR------GGQYYGPK

VDVYAFAIVMWEALVKEIPYHGM------EPMQIVAQVMMNDLRPHIPKDTP-------------------PAFEDLMKQCWARNPTMRPNFAEIVRK--
||.... ....| | .. |. |       ..||.....|. .|. ..|.. .                   ... |..| |....|. ||....|.    
VDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPW

F
|
F
Kinase 92777.m00080.AA Dicty4 235-467 38 2.8e-67 223.48 In-house 25-277 (277) Show / Hide 
Range on Protein: 235-467
Range on HMM: 25-277/277
Sequence Identity: 38% (101 aa)

VAIKKL--KYEKLTGPQLQAFQRELSILATAVHPTILKFIGATDT----HP--FCVVTQFMPGGTLYYDLHQ-------RHSLD-PTDLT---IALYDVA
||.|||  . ...    |..| .| .|..   || |..| ||  |    ||  .| || .|| |.||  ||        . .|| |. .    .|. |.|
VAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGAC-TAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAF-DAA

RGMKFLHAQN--IIHRDLKTLNVLIDDKKRAKLSDFGFSK----QMDSNQ-LMTMNVGTPHWMAPELLANNGPQTPGAQYDTKVDVYAFAIVMWEALVKE
|||  ||. |  |||||||. | |.|. .|.| .|||.|.      | .. .||. .||| ||||| .....       |. |.||| |.|| || | ..
RGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTA-CGTPCWMAPEVMMHQP-------YNEKADVYSFGIVLWEILTRQ

IPYH--GMEPMQIVAQVMMNDLRPHIPKDTPPAFEDLMKQCWARNPTMRPNFAEIVRK--FRS
.||   .|..||.|. |    ||| ||...|| . .|.. ||  .|. || |.||. .    .
EPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase 92777.m00080.AA S_TKc 209-467 23 3.2e-66 227.22 SMART 1-231 (231) Show / Hide 
Range on Protein: 209-467
Range on HMM: 1-231/231
Sequence Identity: 23% (65 aa)

LLYEKEIGSGVSAVVYSGYYTPTNELVAIKKLKYEKLTGPQLQAFQRELSILATAVHPTILKFIGATDTHPFCVVTQFMPG--GTLYYDLHQRHS-----
    ..||.|  ..|| .. . |...||||..|         . ..||..||    || | |.... ... ...|. ...|  |.|.  ...| .     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-LDPTDLTIALYDVARGMKFLHAQNIIHRDLKTLNVLIDDKKRAKLSDFGFSKQMDSNQLMTMNVGTPHWMAPELLANNGPQTPGAQYDT-KVDVYAFAI
 ... .    .| ........| ..|||||||  |.|.|.  . |..|||...|.      |  .|||..||||.|          .|.. |.|.... .
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL----------GYGKCKCDWWSCGC

VMWEALVKEIPYHGMEPMQIVAQVMMNDLRPHIPKDTPPAFEDLMKQCWARNPTMRPNFAEIVR-------KFRS
...| |. . |..    || . ....           .| . |....|. ..|. ||   |. .           
ILYEMLCGYPPFP---QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 92777.m00080.AA Pkinase_Tyr 209-465 30 1.9e-64 218.93 Pfam 1-270 (270) Show / Hide 
Range on Protein: 209-465
Range on HMM: 1-270/270
Sequence Identity: 30% (84 aa)

LLYEKEIGSGVSAVVYSGYYT----PTNELVAIKKLKYEKLTGPQ--LQAFQRELSILATA-VHPTILKFIGA-T-DTHP--FCVVTQFMPGGTLYYDLH
.   |..|.|   .|| |...     |.  ||.|.|| |. . .|  ...| ||..|. .   || |....|. | .  |   ..|. .||.| |.  |.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK-EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

Q----RHSLDPTDLTIALYDVARGMKFLHAQNIIHRDLKTLNVLIDDKKRAKLSDFGFSKQM--DSNQLMTMNVGTP---HWMAPELLANNGPQTPGAQY
.    ...|.. ||    ...|.|| .|...|.||||| . |.|..... .| .||| .. .  |..  ...  |..    ||||| ....        .
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGK-------F

DTKVDVYAFAIVMWEALVKE-IP-YHGMEPMQIVAQVMMNDLRPHIPKDTPPAFEDLMKQCWARNPTMRPNFAEIVRKF
 || ||..| ..||| .    .| | || . ......  .  |  .|...|.   |||||||. .| .|| |.||....
TTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase 92777.m00080.AA LRRK 209-467 26 2.9e-61 209.86 In-house 1-351 (351) Show / Hide 
Range on Protein: 209-467
Range on HMM: 1-351/351
Sequence Identity: 26% (93 aa)

LLYEKEIGSGVSA-VVYSGYYT--------------------------PTNELVAIKKLKYE---------KLTG-----------------------PQ
| .|..||.|... .|| . .                              . |||||.. .           ..                         
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

LQAFQRELSILATAVHPTILKFIGATDTHPFCVVTQFMPGGTLYYDLH--QRHSL-----D---PTDLTIALYDVARGMKFLHAQN--IIHRDLKTLNVL
.. |..|..|. .  || |.. .| .  ||.| |. ..| |.||  ||  .....     .    . | ||| ..|.||..|| .|  |||||||. |.|
FREFRHEVWIMSHLNHPNIVSLKGFC-IHPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIAL-QIAKGMEYLHSHNPPIIHRDLKSPNIL

I---D---------DKKRAKLSDFGFSK--QMDSNQLMTMNVGTPHWMAPELLANNGPQTPGAQYDTKVDVYAFAIVMWEALVKE-IPYHGME-P-----
.   .         .   ||..||| |   | . . .    ||.| ||||| . .||    . .|..|||.|.|....|| |  . .|. ... .     
LWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNG----EEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQW

MQIVAQVMMNDLRPHIPKD-TPP-----AFEDLMKQCWARNPTMRPNFAEIVRKFRS
| .. . ... ||| || .  ||      ..||...||. .|. || | .|| .  .
MEQIEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase 92777.m00080.AA DRK 235-467 36 9.9e-58 194.1 In-house 25-258 (258) Show / Hide 
Range on Protein: 235-467
Range on HMM: 25-258/258
Sequence Identity: 36% (88 aa)

VAIKKLKYEKLT-GPQLQAFQRELSILATAVHPTILKFIGA-TDTHPFCVVTQFMPGGTLYYDLHQRH-SLD-PTDLTIALYDVARGMKFLHAQN--IIH
||.|.|.         |. |.||  ..    || |  |.|. .     |... .|| | ||  ||    ..| |  . ... |.|.|| .||  |  |||
VAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPLMKQMMF-DCAKGMIYLHCCNPIIIH

RDLKTLNVLIDDKKRAKLSDFGFSK----QMDSNQLMTMNVGTPHWMAPELLANNGPQTPGAQYDTKVDVYAFAIVMWEALVKEIPYHGMEPMQIVAQVM
||||. | |.|.  . | .||| |       .    ||| .||| | ||| |.| .       |  | ||| |||| || .  ..|| || ..|.|  | 
RDLKSHNLLVDEHWQVKVADFGLSTRFKKHKQHKFAMTM-CGTPCWTAPEVLRNQR-------YTEKADVYSFAIVLWECVTRQDPYFGMPTFQVVFSVG

MNDLRPHIPKDTPPAFEDLMKQCWARNPTMRPNFAEIVRKFRS
   .|| .|.  || .  ||. ||  .|. || . |..    .
RHGMRPPMPQWCPPKYIQLMNDCWNEDPQHRPSMQECLERLEA
Kinase 92777.m00080.AA Dicty5 209-471 35 4.2e-57 195.08 In-house 1-260 (260) Show / Hide 
Range on Protein: 209-471
Range on HMM: 1-260/260
Sequence Identity: 35% (96 aa)

LLYEKEIGSGVSAVVYSGYYTPTNELVAIKKLKYEKLTGPQLQAFQRELSILATAV--HPTILKFIGA--TDTHPFCVVTQFMPGGTLYYDLHQRHS---
    . | || |  ||.| |      |||| .  |   .  .. |.||  |.      || . .. ||   ..     || .   |.|   | ..     
VSFHDWIASGASGRVYNGIYKGMD--VAIKVYSQENCMCFDWNEFYREVTIMSIFQSDHPNFIRCYGAHQYNDKYPFHVTEYCHNGSLFNYLNDQRKTTG

---LDPTDLTIALYDVARGMKFLHAQNIIHRDLKTLNVLIDDKKRAKLSDFGFSKQMDSNQLMTMNVGTPHWMAPELLANNGPQTPGAQYDTKVDVYAFA
   . .. | .|. |.|..|..||  |||||||| .|.||     .|. ||| |   |    |||.|||. |||.||   ..       |. |.|||.|.
QPIAYFQQLHMAI-DIAQSMRHLHSMNIIHRDLKSMNFLITENWKIKIIDFGTSRFVDNRYHMTMHVGTQCWMACELFNGQP-------YHQKCDVYSFG

IVMWEALVKEIPYHGMEPMQIVAQVMMNDLRPHIPKDTPPAFEDLMKQCWARNPTMRPNFAEIVRKFRSGKIS
|| || . .  ||  .    |   ||  . || |||| |  .  | | ||   |  || | ||.  |.|  |.
IVLWEMFTRKEPYDNINNWNIPVMVMKGE-RPTIPKDCPTEISNLIKKCWQQKPHNRPSFKEICKYFES--II
Kinase 92777.m00080.AA TK 209-465 16 1.6e-55 184.19 In-house 1-486 (486) Show / Hide 
Range on Protein: 209-465
Range on HMM: 1-486/486
Sequence Identity: 16% (79 aa)

LLYEKEIGSGVSA---VVYSGYYTPTN-------------------------ELVAIKKLK-YEKLTGPQLQA--------------FQRELSILAT--A
. ..|..|.|      .|| | . . |                         . ||.| ||     .  . ..              . .|....     
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

VHPTILKFIG-ATDT------------HPFCVVTQFMPGGT----LYYDLHQRH----------------------------------------------
 || |....|  |.             .|...|. .||.|     |   |....                                              
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

----------SLDPTDLTI-------------------ALYDVARGMKFLHAQ------NIIHRDLKTLNVLIDDKKR-----------AKLSDFG----
          .|. .||                       ...|.|| .||..      |..|||| . |.|......           .|..|||    
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ

----FSKQMDS--NQLMTMNVGTPH-------------------------WMAPELLANNGPQTP--GAQYDTKVDVYAFAIVMWEALVKE-IPYHGMEP
     .. ..|  .   . . ||.                          ||||| |. . . .      . || ||..| ..||| .     ||.|. .
GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMS

M---------QIVAQVMMND--------------LRPHIPKDTP--------------PAFEDLMKQCWARNPTMRPNFAEIVRKF
          | | .   .               .|.  |.. |              ....|||.|||...|  ||.|.......
NQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase 92777.m00080.AA Dicty4-Unclassified 209-465 31 7.6e-55 186.25 In-house 1-263 (263) Show / Hide 
Range on Protein: 209-465
Range on HMM: 1-263/263
Sequence Identity: 31% (85 aa)

LLYEKEIGSGVSAVVYSGYYTPTNELVAIKKLKYEKLTGP--QLQAFQRELSILATAVHPTILKFIGATDTHP------FCVVTQFMPGGTLYYDLH---
.   ..|| |  . |. |     .  ||.||.   |       .| | .|  ||    ||  .|  |.    |      .|.|. ||. |.|    |   
IQIDQFIGKGHFSKVHKGNWKGKD--VAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYC-INPRSHKSTMCIVMEFMHKGNLFEVIHSKP

--QRHSLDPTD---LTIALYDVARGMKFLHAQNIIHRDLKTLNVLIDDKKRAKLSDFGFSKQMDSNQLMTMNVGTPHWMAPELLANNGPQTPGAQYDTKV
  |  ..   |   . .|. |.|.|| .||  |.||||.|  |.|.|    .|  ||| |   | |. ||   ||| | .|| |        .  |  | 
SEQQQPIKLDDTLIIKYAF-DIAQGMQHLHTRNFIHRDIKSSNILMDKHFNIKIADFGISRVIDFNFNMTTIAGTPKWESPECLM-------HESYNQKS

DVYAFAIVMWEALVKEIPYHGME-PMQIVAQVMMNDLRPHIPKDTPPAFEDLMKQCWARNPTMRPNFAEIVRKF
||| .|....| .  . || .   .| .   |    ||| ||   .. .  | | ||   |  || . .|. . 
DVYSYAMMLYELATGDEPYQEIQSIMNAARSVCDKKLRPKIPDNCDNFWKKLIKWCWHNDPNKRPTMNQIIQYL
Kinase 92777.m00080.AA STE 210-466 20 2e-53 183.84 In-house 1-359 (359) Show / Hide 
Range on Protein: 210-466
Range on HMM: 1-359/359
Sequence Identity: 20% (75 aa)

LYE-KEIGSGVSAVVYSGYYT------PTNEL---------VAIKKLKYEKLT---------------GPQLQAFQRELSILATAV--HPTILKFIGATD
.   ..||.| . .|| ...       .|.|.         .|||....|. .                 ..| ...|..|.      || | |..|.  
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

THP--------FCVVTQFMPGGTLYYDLHQRHSLDPT------------DLTI--ALYDVARG-MKFLHAQNIIHRDLKTLNVLIDDKKRAKLSDFGFSK
            ...  .|.||.|   ......   .               |   .... .| ...|| ..|||||.|  |.|.     .||.|||...
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

QMDS----------------NQLMT-MNVGTPHWMAPELLANNGPQTPGAQYDTKVDVYAFAIVMWEALVKEIPYHGMEPMQIVAQVMMN----------
|...                .| ..   |||| ||||| . .||      .||||.|.. . ....| .  . |.| | ||.   . ..|          
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQG-RDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL

----DLRPHIPKDTP-------------------PAFEDLMKQCWARNPTMRPNFAEIVR---KFR
    .  | .| ..                    | | | ...|  ..|  ||.  .  .   .| 
CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 92777.m00080.AA TyrKc 209-465 28 4.4e-53 183.57 SMART 1-280 (280) Show / Hide 
Range on Protein: 209-465
Range on HMM: 1-280/280
Sequence Identity: 28% (83 aa)

LLYEKEIGSGVSAVVYSGYYTPTNELVAIKKLKYEKLTGPQLQAFQRELSILATA--VHPTILKFIGATDT--------HPFCVVTQFMPGGTLYYDLHQ
.  .|..|.|   .|| | ..   . ||.|.|| ..     ...| ||..|.      || |....|.  .        .| ..|. .||.| |   |. 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

RHS-LDPTDLTIALYDVARGMKFLHAQNIIHRDLKTLNVLIDDKKRAKLSDFGFSKQMDSN-------QLMTMNV--GTP-----HWMAPELLANNGPQT
..  | . ||    ...|.|| .|| .|.||||| . |.|.......| |||| |.  ..        .  ..    |.       ||||| .  .    
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG----

PGAQYDTKVDVYAFAIVMWEALVK-EIPYHG-----MEPMQIVAQVMMNDLRPHIPKD-------TPPAFEDLMKQCWARNPTMRPNFAEIVRKF
    . || ||..| ..||| .   . || |     |.. .....|.  . .|  | |        |..  ..|||||...| .||.|.||...|
---KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF