Gene 90210.m00255 (T.vaginalis)

90210.m00255

Species: T.vaginalis
Alias: 90210.m00255, TvagK0309
External Links:
Annotation:

Classification

Group: TKL
Family: TKL-Tvag1

Sequence

Name Sequence Type Origin Length Description Download
90210.m00255.AA Protein None 204 None Fasta, JSON
90210.m00255.kin_dom Protein Kinase Domain None 185 None Fasta, JSON

Protein domain

Protein domains of 90210.m00255.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 90210.m00255.AA TKL 26-204 24 6.5e-52 178.79 In-house 1-275 (364) Show / Hide 
Range on Protein: 26-204
Range on HMM: 1-275/364
Sequence Identity: 24% (70 aa)

IGNGAYGEVWEGIYLPTQ--------KKVAIKKLHT--DILDGN-----------------------MHELYNREVLALSTLKNTFLLPFIGFTTVPP--
|| |..|||. |..  .         | ||.||...  | ..                         . .  ..|.. .| |.   ...|.|. . ||  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------YCIVTKFIPNNSLFNNLHGKENALQLTPTEFNIIAFGIAVGMSYLHANK--------TIHRDLKSQNVLIDDRKY-------------
            .|||. ..|. ||...||         .  .  .| .|| ||.|||...         |||||||.|.|.|.                
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADW

-PIICDFGSSKNTDLSL--------------------TMTGQGGTPSYMAPEFLQNE----------------KYDEKVDVYSY
 . ||||| |.. . |                     |   |.||| .|||| |...                .|.||.||||.
CCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSF
Kinase 90210.m00255.AA MLK 20-204 31 2.6e-46 158.66 In-house 1-222 (291) Show / Hide 
Range on Protein: 20-204
Range on HMM: 1-222/291
Sequence Identity: 31% (69 aa)

LQFVKVIGNGAYGEVWEGIYLPTQ---KKVAIKKLHTDI----LDGNMHELYNREVLALSTLKNTF----LLPFIGFTTVP-P-YCIVTKFIPNNSLFNN
.|| ..||.|..|.|| | .  .    | ||.|. ...|      .   .  ..|.  |. |.         .| |  . | . .|||. .... ||.| 
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LHGKE-----------NALQLTPTEFNIIAFGIAVGMSYLHANKT---IHRDLKSQNVLIDD------RKYPIICDFGSSKNTDLS-LTMTGQGGTPSYM
|||..           |.   ..  .. .|. .| ||.|||...    |||||||.|.|||.       .   ||||| |.    .  .|... ||. .|
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYAWM

APEFL---QNEKYDEKVDVYSY
||| .   ..|||.||.||.|.
APEVIQQFRCEKYSEKCDVWSW
Kinase 90210.m00255.AA TKL-Unique 22-204 32 1.7e-40 140.52 In-house 1-214 (290) Show / Hide 
Range on Protein: 22-204
Range on HMM: 1-214/290
Sequence Identity: 32% (71 aa)

FVKVIGNGAYGEVWEGIYLPTQKKVAIKKLHT-DILDGNMHELYNREVLALSTLK-NTFLLPFIGFTT----VPP-YCIVTKFIPNNSLFNNLH------
|...|| |.||.|  |..   ...||||..|    .   | .  ..||  ...|.   ... ..|...     || .|||. ..| .|| ..||      
FWNKIGEGGYGQVYKGKW--RGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNN

-GKENALQLTPTEFNIIAFGIAVGMSYLHANK--TIHRDLKSQNVLIDDR----KYPI-ICDFGSSKNTDLSLTMTGQG----------GTPSYMAPEFL
   .| . |..  .. .|  || || ||| ..  .|||||||.|.|.| .    .. | ||||| ||. . ...||  .          |.. .|||| |
NNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVL

QN--EKYDEKVDVYSY
 .  ..|.||.||||.
RMNFCQYSEKSDVYSF
Kinase 90210.m00255.AA Pkinase 20-204 26 3.1e-35 125.67 Pfam 1-198 (293) Show / Hide 
Range on Protein: 20-204
Range on HMM: 1-198/293
Sequence Identity: 26% (52 aa)

LQFVKVIGNGAYGEVWEGIYLPTQKKVAIKKLHTDILDGNMHELYNR--EVLALSTLKNTFLLPFIGFT-TVPPYCIVTKFIPNN----SLFNNLH-GKE
......|| |..|.|....   |.|.||.|..  .  . ....   |  |.  .  |.  . . ....  . . ...|. . ..     .||  ..  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

NALQLTPTEFNIIAFGIAVGMSYLHANKTIHRDLKSQNVLIDDRKYP----IICDFGSSKN--TDLSLTMTGQGGTPSYMAPEFLQ-NEKYDEKVDVYSY
... ... |   ..  |. |. |.|... ||||||..|.|||.. ..     |||||..|   .  .  ||.  ||| ||||| .. ...|. |||..|.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC
Kinase 90210.m00255.AA Dicty4-Unclassified 20-204 33 1.3e-34 115.99 In-house 1-194 (263) Show / Hide 
Range on Protein: 20-204
Range on HMM: 1-194/263
Sequence Identity: 33% (66 aa)

LQFVKVIGNGAYGEVWEGIYLPTQKKVAIKKLHTDILDGN--MHELYNREVLALSTLKNTFLLPFIGFTTVP-----PYCIVTKFIPNNSLFNNLH----
.|  . || |.  .|  |.     | ||.||.          | . . .||  |  .    |.   |    |      .|||. |..   ||   |    
IQIDQFIGKGHFSKVHKGNW--KGKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPS

GKENALQLTPTEFNIIAFGIAVGMSYLHANKTIHRDLKSQNVLIDDRKYPIICDFGSSKNTDLSLTMTGQGGTPSYMAPEFLQNEKYDEKVDVYSY
 ..  ..|  |    .|| || || .||    ||||.|| |.|.|      | ||| |  .|   .||  .|||   .|| |  | |  | |||||
EQQQPIKLDDTLIIKYAFDIAQGMQHLHTRNFIHRDIKSSNILMDKHFNIKIADFGISRVIDFNFNMTTIAGTPKWESPECLMHESYNQKSDVYSY
Kinase 90210.m00255.AA Dicty4 20-204 34 8.4e-34 110.23 In-house 1-203 (277) Show / Hide 
Range on Protein: 20-204
Range on HMM: 1-203/277
Sequence Identity: 34% (70 aa)

LQFVKVIGNGAYGEVWEGIYLPTQKKVAIKKL--HTDILDGNMHELYNREVLALSTLKNTFLLPFIGFTT----VP-PYCIVTKFIPNNSLFNNLHG---
... . || |..|||  |.    .|.||.|||  | . .| || .   .||  .. . .  .. | |  |     |   |||| . |  .|.. ||    
INIEQRIGKGSFGEVYKGTW--RGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPS

-KENALQLTPTEFNI---IAFGIAVGMSYLHA-N-KTIHRDLKSQNVLIDDRKYPIICDFGSSK----NTDLSLTMTGQGGTPSYMAPEFLQNEKYDEKV
 .    .|  . .     .|| .| || .||. |   ||||||| | |.|. .   .|||| |.     .|..  .... ||| .|||| .... |.||.
EQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKA

DVYSY
||||.
DVYSF
Kinase 90210.m00255.AA Dicty5 20-204 33 1.3e-29 99.11 In-house 1-189 (260) Show / Hide 
Range on Protein: 20-204
Range on HMM: 1-189/260
Sequence Identity: 33% (64 aa)

LQFVKVIGNGAYGEVWEGIYLPTQKKVAIKKLHTDI-LDGNMHELYNREVLALSTLK--NTFLLPFIGFTTVPPYC--IVTKFIPNNSLFNNLHGKENAL
  | ..|  || | |  |||    . |||| .  .  .  .. | | |||  .|  .     .  . |  .       .|| .. | |||| |  ...  
VSFHDWIASGASGRVYNGIY--KGMDVAIKVYSQENCMCFDWNEFY-REVTIMSIFQSDHPNFIRCYGAHQYNDKYPFHVTEYCHNGSLFNYLNDQRKTT

QLTPTEFNI--IAFGIAVGMSYLHANKTIHRDLKSQNVLIDDRKYPIICDFGSSKNTDLSLTMTGQGGTPSYMAPEFLQNEKYDEKVDVYSY
   .  | .  .| .|| .| .||    ||||||| |.||  .    | ||| | . |. . ||   ||. .||.|  .   |..|.||||.
GQPIAYFQQLHMAIDIAQSMRHLHSMNIIHRDLKSMNFLITENWKIKIIDFGTSRFVDNRYHMTMHVGTQCWMACELFNGQPYHQKCDVYSF
Kinase 90210.m00255.AA LRRK 20-204 23 9.1e-29 98.88 In-house 1-268 (351) Show / Hide 
Range on Protein: 20-204
Range on HMM: 1-268/351
Sequence Identity: 23% (64 aa)

LQFVKVIGNGAYG-EVWEGIYL--------------------------PTQKKVAIKKLHTD-----------------------------ILDGNMHEL
| . . || |..| .|  ...                              ..|||||...|                             ... .... 
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

YN---REVLALSTLKNTFLLPFIGFTTVPPYCIVTKFIPNNSLFNNLHGKE-NAL-----QLTPTEFNIIAFGIAVGMSYLHANK--TIHRDLKSQNVLI
..   .||  .|.|.   ... .||.   |.|.|. ..|. .|   || |. ...      .... .  ||  || || ||| ..   ||||||| |.|.
FREFRHEVWIMSHLNHPNIVSLKGFCIH-PLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILL

DDRKYPI------------ICDFGSSK--NTDLSLTMTGQGGTPSYMAPEFLQ---NEKYDEKVDVYSY
   . .             |.||| |    ....    | .|.| .|||| ..   .| |.||||.||.
WSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSF
Kinase 90210.m00255.AA STE 20-203 18 7.1e-28 95.56 In-house 1-253 (359) Show / Hide 
Range on Protein: 20-203
Range on HMM: 1-253/359
Sequence Identity: 18% (48 aa)

LQFVKVIGNGAYGEVWEGIYL------PTQKK---------VAIKKLH---------------TDILDGNMHELYNREVLALSTLK--NTFLLPFIGFTT
......||.||.|.|  ...       .|...         .|||...               ... . . .. . .|.  .. ..    .   ..|   
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

VPP--------YCIVTKFIPNNSLF---NNLHGKENALQ--------LTPTEFNIIAFGIAVG-MSYLHANKTIHRDLKSQNVLIDDRKYPIICDFGSSK
.           .|.  .... ||    .. .|. . |.        .  ..  .|.. |  | ..||| .. ||||.|..|.|.       .|||| ..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

NTDLSLT----------------MT-GQGGTPSYMAPEFLQN------EKYDEKVDVYS
. . |..                ..    ||| .|||| .|.       .||.|.|..|
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWS
Kinase 90210.m00255.AA Pkinase_Tyr 20-204 28 3.8e-26 89.18 Pfam 1-200 (270) Show / Hide 
Range on Protein: 20-204
Range on HMM: 1-200/270
Sequence Identity: 28% (57 aa)

LQFVKVIGNGAYGEVWEGIYL----PTQKKVAIKKLHTDILDGN---MHELYNREVLALSTL-KNTFLLPFIGFTT-V-PP--YCIVTKFIPNNSLFNNL
..| |..| ||.|||..|..      |. .||.|.|  .  .     . .. . |.  ...| ..  .. ..|  |    |  ..||. . |. .| . |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

HGK-ENALQLTPTEFNIIAFGIAVGMSYLHANKTIHRDLKSQNVLIDDRKYPIICDFGSSKNT----DLSLTMTGQGGTP-SYMAPEFLQNEKYDEKVDV
. . |.  .||. .   ... || ||.||.... |||||   |.|... .   ||||| ..         ....| |  |   |||| ... |. .| ||
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDV

YSY
.|.
WSF
Kinase 90210.m00255.AA STE20 131-203 34 6.8e-20 69.62 In-house 129-212 (288) Show / Hide 
Range on Protein: 131-203
Range on HMM: 129-212/288
Sequence Identity: 34% (29 aa)

GMSYLHANKTIHRDLKSQNVLIDDRKYPIICDFG-SSKNTD-----LSLTMTGQGGTPSYMAPEFLQN-----EKYDEKVDVYS
| .|||.|. ||||.|..|.|....    ..||| ... |.      . .     ||| .|||| .|       .||.|.|..|
GLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGPDKGYDYKCDIWS
Kinase 90210.m00255.AA LISK 124-164 51 1.1e-18 57.18 In-house 106-150 (296) Show / Hide 
Range on Protein: 124-164
Range on HMM: 106-150/296
Sequence Identity: 51% (23 aa)

IAFGIAVGMSYLHANKTIHRDLKSQNVLIDDR----KYPIICDFG
|| .|| ||||||... |||||||.|.|....    .  ..||||
IALDIACGMSYLHSMNIIHRDLKSKNCLVRENDNNQWRIKVCDFG
Kinase 90210.m00255.AA S_TKc 20-204 19 1.1e-13 24.02 SMART 1-231 (231) Show / Hide 
Range on Protein: 20-204
Range on HMM: 1-231/231
Sequence Identity: 19% (49 aa)

LQFVKVIGNGAYGEVWEGIYLPTQKKVAIKKLHTDILDGNMHELYNREVLALSTLKNTFLLPFIGFTTVPPYCIVTKFIPN--NSLFNNLHGKENA---L
 .....|| ||.|.|. ..   |...||||...         |   ||.  |.  .  ..  ....     ...|. ....   .||  .. .       
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

QLTPTEFNIIAFGIAVGMSYLHANKTIHRDLKSQNVLIDDRKYPIICDFGSSKNTDLSLTMTGQGGTPSYMAPEFLQNEKYDE-KVDVYS----------
.... .   ..  |. .. |.| .. |||||| .|.|.|.     |||||...        | . ||| ||||| |   .|.  |.|..|          
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

----------------------------------------------------Y
                                                     
GYPPFPQMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase 90210.m00255.AA TyrKc 20-204 18 8.8e-13 -16.02 SMART 1-280 (280) Show / Hide 
Range on Protein: 20-204
Range on HMM: 1-280/280
Sequence Identity: 18% (55 aa)

LQFVKVIGNGAYGEVWEGIYLPTQKKVAIKKLHTDILDGNMHELYNREVLALSTL--KNTFLLPFIGFTTV--------PPYCIVTKFIPNNSLFNNLHG
... |..|.||.|||..|..     .||.|.|. |      .|   ||   .. |  ..  .. ..|  |         .|..||. . |. .| . |. 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

KENALQLTPTEFNIIAFGIAVGMSYLHANKTIHRDLKSQNVLIDDRKYPIICDFGSSKNTDLS-------LTMTGQG--GTPS-----YMAPEFLQNEKY
...   |.. ..  ... || ||.||| .. |||||   |.|.....   |.||| |.. .          . . ..  |. .      |||| ..  |.
HRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

DEKVDVYS---------------------------------------------------------------------------------Y
 .| ||.|                                                                                  
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 90210.m00255.AA LISK 180-204 56 8.8e-10 27.75 In-house 201-225 (296) Show / Hide 
Range on Protein: 180-204
Range on HMM: 201-225/296
Sequence Identity: 56% (14 aa)

GTPSYMAPEFLQNEKYDEKVDVYSY
|||. |||| |  ..|||..||.|.
GTPYWMAPEMLLGQSYDESCDVFSF
Kinase 90210.m00255.AA STE20 20-54 33 4.6e-08 25.89 In-house 1-39 (288) Show / Hide 
Range on Protein: 20-54
Range on HMM: 1-39/288
Sequence Identity: 33% (13 aa)

LQFVKVIGNGAYGEVWEGIYLPTQKK----VAIKKLHTD
 .....||.|.||.|  ..  ||...    |||||.  .
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLE
Kinase 90210.m00255.AA LISK 25-53 37 1.2e-05 14.06 In-house 1-29 (296) Show / Hide 
Range on Protein: 25-53
Range on HMM: 1-29/296
Sequence Identity: 37% (11 aa)

VIGNGAYGEVWEGIYLPTQKKVAIKKLHT
.|| |..|.|  | .. | . .|||..|.
EIGKGFFGKVYKGTHRQTGQVMAIKMIHR