Gene 83472.m00456 (T.vaginalis)

83472.m00456

Species: T.vaginalis
Alias: TvagK0729, 83472.m00456
External Links:
Annotation:

Classification

Group: STE
Family: STE20
Subfamily: PAKA

Sequence

Name Sequence Type Origin Length Description Download
83472.m00456.AA Protein None 438 None Fasta, JSON
83472.m00456.kin_dom Protein Kinase Domain None 249 None Fasta, JSON

Protein domain

Protein domains of 83472.m00456.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PBD 83472.m00456.AA PBD 9-43 18 0.071227 2.84 SMART 1-38 (38) Show / Hide 
Range on Protein: 9-43
Range on HMM: 1-38/38
Sequence Identity: 18% (7 aa)

ISEPF-ELLHHIHIT-VNA-KGTYLNVPRSMIEHIPSG
|| |.    | .|.  ...  |.. . | .    ... 
ISTPTGNFKHIVHVGPWDGQTGEFTGLPHQWQHLLKHC
PBD 83472.m00456.AA PBD 8-35 23 2.388538 4.24 Pfam 1-30 (60) Show / Hide 
Range on Protein: 8-35
Range on HMM: 1-30/60
Sequence Identity: 23% (7 aa)

SISEP-FELLHHIHITVNA-KGTYLNVPRS
 || | .   |..|.. ..  |.. . |..
MISTPLTNFKHTMHVGWDGQTGFFTGMPPE
PBD 83472.m00456.AA PBD 69-126 36 2e-17 63.44 Pfam 1-60 (60) Show / Hide 
Range on Protein: 69-126
Range on HMM: 1-60/60
Sequence Identity: 36% (22 aa)

KISKP-TDVEHKIHVSLDSENG-LIGLPSEYECLLKNSGLTKDDVISNPESTVDVLNFFN
 ||.| |...|..||  |...| ..|.| | . ||. ||..|..  .||....||. | .
MISTPLTNFKHTMHVGWDGQTGFFTGMPPEWQKLLQSSGISKPEQKHNPQAVFDVVQFYQ
PBD 83472.m00456.AA PBD 70-104 36 1.2e-07 32.65 SMART 1-38 (38) Show / Hide 
Range on Protein: 70-104
Range on HMM: 1-38/38
Sequence Identity: 36% (14 aa)

ISKPT-DVEHKIHVS-LDS-ENGLIGLPSEYECLLKNS
|| || ...|..||   |  . .. |||.. . |||..
ISTPTGNFKHIVHVGPWDGQTGEFTGLPHQWQHLLKHC
Kinase 83472.m00456.AA PAKA 162-409 45 2.7e-120 405.96 In-house 2-260 (260) Show / Hide 
Range on Protein: 162-409
Range on HMM: 2-260/260
Sequence Identity: 45% (119 aa)

QNMQVIAEGSTCIIYTAIYNGIE----VAVKEMHLNEKKEK-YLLDETRLMYTMKDEHIIRFYDAYKDGNTLWIIMEYMDAGALTYVARYCD---CM---
..|. | .|...  |.|.  ...    ||.| | ...   |  .. | ..| . | . |....|.|.    ||..||||..| || |   |.   |    
KFMEKIGQGASGEVYVATNIKTNQEENVAIKQMNMKNQPKKELIINEILVMKECKHKNIVNYIDSYLVDDELWVVMEYMEGGCLTDVITQCCNIQCNYMD

EPHIAYIAREILLALKYIHSQNKIHRDIKTDNVLLSQKGHVKLADFGYAAQLTTAAERRNSMVGTPFWMAPELIQRTPYSFAVDIWSLGILCRELAEGEP
| .|||. ||.| .|..|||.. |||||| ||.|| . | ||..|||..||||   ..||.||||| |||||.|.|  |.  ||||||||...|..||||
EGQIAYVCRECLQGLEFIHSKHRIHRDIKSDNILLGMDGSVKITDFGFCAQLTQEQQKRNTMVGTPYWMAPEVIRRKQYDEKVDIWSLGIMAIEMIEGEP

PYVDEPPMRATFLIVIKGIPEISDKESRSPELLDFLDKCLRKDPKLRPTAEELLNHPFL
|| .||| || .||  .|.|.| |... |.|. ||||||| .|.. |..|.|||.||||
PYLNEPPLRAMYLIATNGKPDIKDPDKWSQEFCDFLDKCLCVDVDRRASAQELLHHPFL
Kinase 83472.m00456.AA STE20 161-409 42 1.1e-117 397.22 In-house 1-288 (288) Show / Hide 
Range on Protein: 161-409
Range on HMM: 1-288/288
Sequence Identity: 42% (121 aa)

LQNMQVIAEGSTCIIYTAIYN--GIE----VAVKEMHLNEK----KEK-YLLDETRLMYTMKDEHIIRFYDAYKDG----NTLWIIMEYMDAGALTYVAR
 .....| .||.. .|.|. .  | .    ||.| | |...    .|.  .. | . |   | ..|...|..|  .    . |||.|||...| || . .
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

YCD--CM--------EPHIAYIAREILLALKYIHSQNKIHRDIKTDNVLLSQKGHVKLADFGYAAQLTT----AAE-RRNSMVGTPFWMAPELIQR----
 |   .         |..|||| ||.| .|.|.||...|||||| ||.||...| |||||||..||||.    .   .||..||||.|||||.||.    
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGP

-TPYSFAVDIWSLGILCRELAEGEPPYVDEPPMRATFLIV--IKGIPEISD--KESRSPELLDFLDKCLRKDPKLRPTAEELLNHPFL
  .| . .||||||| . |.||||||| |..|||| |.|    .. |. .|  ... |||. ||.|||| |||. ||||..||.|||.
DKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase 83472.m00456.AA STE 161-409 30 1.5e-108 366.9 In-house 1-359 (359) Show / Hide 
Range on Protein: 161-409
Range on HMM: 1-359/359
Sequence Identity: 30% (111 aa)

LQNMQVIAEGSTCIIYTAIYN-----------------GIEVAVKEMHLNE------------------KKEKYLLDETRLMYTMK--DEHIIRFYDAYK
......| .|..   |.|...                 |  .|.|.|.|..                  .... .| | ..|  ..   ..|...|..| 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DG-------NTLWIIMEYMDAGALTYVAR-YCDCM--------------EPHIAYIAREILLA-LKYIHSQNKIHRDIKTDNVLLSQKGHVKLADFGYAA
..       ..|||.|||||.| |. . . .. |               |. ||||.|.|| . |.|.||...|||||| .|.||     |||.||| ..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

QLT----------------TAAERRNSMVGTPFWMAPELIQR------TPYSFAVDIWSLGILCRELAEGEPPYVDEPPMRATFLIVIK-----------
|||                | ...||..|||| ||||| ||.       .|.. .||||||... |.|.|.||. |..|||| |.| ..           
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

----GIPEISD-----------------KESRSPELLDFLDKCLRKDPKLRPTAEELLN--HPFL
    ..| . |                 ... |||. ||..|||.|||. ||||..||.  |||.
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 83472.m00456.AA YSK 211-409 47 1.1e-89 270.21 In-house 55-257 (257) Show / Hide 
Range on Protein: 211-409
Range on HMM: 55-257/257
Sequence Identity: 47% (96 aa)

KDEHIIRFYDAYKDGNTLWIIMEYMDAGALTYVARY---CDCMEPHIAYIAREILLALKYIHSQNKIHRDIKTDNVLLSQKGHVKLADFGYAAQLTTAAE
.   | ..| .|  .  |||||||   | .    .        |..|| | ||||..|.|.||..|||||||  ||||| .| |||.||| |.|.|    
DSPYITKYYGSYLKDTKLWIIMEYCGGGSCLDLMKPKYVGQFDEKYIAIILREILKGLDYLHSERKIHRDIKAANVLLSEHGDVKLCDFGVAGQITDTQI

RRNSMVGTPFWMAPELIQR--TPYSFAVDIWSLGILCRELAEGEPPYVDEPPMRATFLIVIKGIPEISDKESRSPELLDFLDKCLRKDPKLRPTAEELLN
.|| .||||.|||||.|.   . | | .|||||||   |.| ||||| |  |||. |||. .  |. ..... |  . .| . || |||. ||.|.||| 
KRNTFVGTPYWMAPEVICQEVSYYDFKADIWSLGITAYEMAKGEPPYCDYHPMRVMFLIPKNNPPKLEGRSY-SKMFKEFVECCLNKDPEQRPSAKELLK

HPFL
| | 
HKFI
Kinase 83472.m00456.AA S_TKc 161-409 29 1.5e-83 284.8 SMART 1-231 (231) Show / Hide 
Range on Protein: 161-409
Range on HMM: 1-231/231
Sequence Identity: 29% (79 aa)

LQNMQVIAEGSTCIIYTAIYNG--IEVAVKEMHLNEKKEKYLLDETRLMYTMKDEHIIRFYDAYKDGNTLWIIMEYMDA--GALTYVARYCDC-------
 . ...| .|.    | .. ..   .||.|...      . .. | ...   . ..|...||.. | . |...|||.|   | |  . . . .       
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

MEPHIAYIAREILLALKYIHSQNKIHRDIKTDNVLLSQKGHVKLADFGYAAQLTTAAERRNSMVGTPFWMAPELIQRTPYSF-AVDIWSLGILCRELAEG
 | |.......|..||.|.||.. ||||.| .|.||..  |.|..||| |.||       ....|||..||||..   .|.. ..|.||.|..  |.. |
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCG

EPPYVDEPPMRATFLIVIKGIPEISDKESRSPELLDFLDKCLRKDPKLRPTAEELLN-------HPFL
.||.     | ..| ..             |||..||..|||.|||. |||| |.|.       ||..
YPPFP---QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 83472.m00456.AA PAKB 161-409 46 1.6e-83 283.82 In-house 1-252 (252) Show / Hide 
Range on Protein: 161-409
Range on HMM: 1-252/252
Sequence Identity: 46% (116 aa)

LQNMQVIAEGSTCI--IYTAIYNGIEVAVKEMHLNEKKEKYLL-DETRLMYTMKDEHIIRFYDAYKDGNTLWIIMEYMDAGALTYVARYCDCMEPHIAYI
|.|   | |||| |  | | .  |  |||| | |       ||  |   |   . . |...|. |  |. ||..||.|. |||| .       |. ||..
LDNYVKIGEGSTGIVCIATEKHTGRQVAVKKMDLRKQQRRELLFNEVVIMRDYQHPNIVEMYSSYLVGDELWVVMEFMEGGALTDIVTHTRMNEEQIATV

AREILLALKYIHSQNKIHRDIKTDNVLLSQKGHVKLADFGYAAQLTTAAERRNSMVGTPFWMAPELIQRTPYSFAVDIWSLGILCRELAEGEPPYVDEPP
 | .| || | |.|  |||||| | .|| . | ||| |||. ||.     .| |.||||.|||||.| | ||   ||||||||.  |. .|||||  |||
CRQVLQALAYLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMVDGEPPYFNEPP

MRATFLIVIKGIPEISDKESRSPELLDFLDKCLRKDPKLRPTAEELLNHPFL
..|   |  .  | ...    ||.| .|||..| .||. | ||.|||.||||
LQAMKRIRDMHPPRLKNHHKVSPRLREFLDRMLVRDPNQRWTAQELLRHPFL
Kinase 83472.m00456.AA MST 181-409 44 1.2e-80 256.08 In-house 23-254 (254) Show / Hide 
Range on Protein: 181-409
Range on HMM: 23-254/254
Sequence Identity: 44% (104 aa)

NGIEVAVKEMHLNEK-KEKYLLDETRLMYTMKDEHIIRFYDAYK--DGNTLWIIMEYMDAGALTYVARYCD--CMEPHIAYIAREILLALKYIHSQNKIH
.|..||.| .  ||   |  .. | . |  .| ..| ..|. |     |..||.||| ..| .  . .  .    |  || | .  |. |.| |.  |||
TGKIVAIKMVPVNEDLQE--IIKEISIMQQCKSKYIVKYYGSYFDAKNNHCWIVMEYCGMGSVCDIMKITQRTLNEQQIACILYDTLQGLQYLHDNKKIH

RDIKTDNVLLSQKGHVKLADFGYAAQLTTAAERRNSMVGTPFWMAPELIQRTPYSFAVDIWSLGILCRELAEGEPPYVDEPPMRATFLIVIKGIPEISDK
||||  | ||...|. |||||| ..|||     ||. .|||.||||| ||   |   .||||||| . |.|||.||| |  |||| |.|  | .|  .| 
RDIKAGNILLNHEGECKLADFGVSGQLTDTMAKRNTVIGTPYWMAPEVIQEIKYDCKADIWSLGITAIEMAEGMPPYSDIHPMRAMFMIPQKPPPTFKDP

ESRSPELLDFLDKCLRKDPKLRPTAEELLNHPFL
|  |.|. ||. ||| |.| .|.|||.||.||| 
EQWSQEFNDFVCKCLQKNPEQRWTAEQLLQHPFI
Kinase 83472.m00456.AA Pkinase 161-409 28 4e-76 264.01 Pfam 1-293 (293) Show / Hide 
Range on Protein: 161-409
Range on HMM: 1-293/293
Sequence Identity: 28% (83 aa)

LQNMQVIAEGSTCIIYTAIYNGIE--VAVKEMHLNEKKEKYL-----LDETRLMYTMKDEHIIRFYDAYKDGNTLWIIMEYMDAG----ALT-YVA--RY
..  ..| .||    | ..  | .  ||||.. . ..|.. .     | | ..|  .. ..|.|.||.. |.. ....|||.. |     |  |.   |.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

CDC--MEPHIAYIAREILLALKYIHSQNKIHRDIKTDNVLLSQKGHV----KLADFGYAAQL-TTAAERRNSMVGTPFWMAPELIQ-RTPYSFAVDIWSL
.     | ..  ....|| .|.|.||.. ||||.| .|.|....||.    |..||| |.|. .   .  .. .|||..||||.|. ...|. .||.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GILCRELAEGEPPYVDE-----PPMRATFLIVIKGIPEISDKESRS-------------------PELLDFLDKCLRKDPKLRPTAEELLNHPFL
|... |.. |.||. ..       ... .  . ..... .  ...|                   .|..||...||.|||| |||||..|.||..
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 83472.m00456.AA MKC 215-409 37 2.2e-64 220.23 In-house 63-260 (260) Show / Hide 
Range on Protein: 215-409
Range on HMM: 63-260/260
Sequence Identity: 37% (74 aa)

IIRFYDAYKDGN-TLWIIMEYMDAGALTYVARY-CDCMEPHIAYIAREILLALKYIHSQNKIHRDIKTDNVLLSQKGHVKLADFGYAAQLTTAAERRNSM
|. .. .. ... ..|..||.|. | |.  .       |  |||...|.| .| | |..| .|||.|  |.  . .| .|| |||  . ...  |. . |
IVKYHCSHMKHDDEIWMVMEFMQGGTLEEASQNSHKFCESCIAYVCKEMLQGLMYLHEHNIVHRDLKSANIMMNTDGEIKLIDFGLCIDVSHEKEEIH-M

VGTPFWMAPELIQRTPYSFAVDIWSLGILCRELAEGEPPYVDEPPMRATFLIVIKGIPE---ISDKESRSPELLDFLDKCLRKDPKLRPTAEELLNHPFL
.| ||||.|| ||  ..| ..||||.||   |.| |.||. .  .| | |.  . |.       |..  |... ||| .||  ||  |||||.|| |||.
CGSPFWMSPEMIQQKQHSYPCDIWSFGICLLEMANGRPPHHKS-RMKAMFMVATNGCKFPKEFDDPCHWSDCFHDFLWQCLQMDPHKRPTAEQLLKHPFI
Kinase 83472.m00456.AA KHS 162-409 38 2.3e-62 208.5 In-house 2-258 (258) Show / Hide 
Range on Protein: 162-409
Range on HMM: 2-258/258
Sequence Identity: 38% (99 aa)

QNMQVIAEGSTCIIYTA--IYNGIEVAVKEMHLNEKKE-KYLLDETRLMYTMKDEHIIRFYDAYKDGNTLWIIMEYMDAGALTYVARYCDCM-EPHIAYI
. .| .  |    .| |  |  .  .||| . ..   . . .  |  .| . .   |. .. .|   . |||.|||  .|.|  . .    . |  |||.
ELLQRVGSGTYGDVYKARDIQSDELAAVKVIKMEPGDDFAVIQQEIMMMKDCRHPNIVAYFGSYLRRDKLWICMEYCGGGSLQDIYHVTGPLSELQIAYV

AREILLALKYIHSQNKIHRDIKTDNVLLSQKGHVKLADFGYAAQLTTAAERRNSMVGTPFWMAPELI---QRTPYSFAVDIWSLGILCRELAEGEPPYVD
.||.| .|.|.||. |.|||||  |.||...|.||||||| .||.| .  .| | .|||.|||||     ..  |    |||..||   ||||  ||  |
CRETLQGLHYLHSMGKMHRDIKGANILLTDQGDVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDIWAVGITAIELAELQPPMFD

EPPMRATFLIVIKGI--PEISDKESRSPELLDFLDKCLRKDPKLRPTAEELLNHPFL
  |||| ||.   .   |.. ||.  |.   .|.  .| |.|| ||||| ||.|||.
LHPMRALFLMTKSNFQPPKLKDKHKWSQTFHHFVKMALTKNPKKRPTAEKLLQHPFV
Kinase 83472.m00456.AA STE11 181-409 32 1.2e-60 207.84 In-house 23-303 (303) Show / Hide 
Range on Protein: 181-409
Range on HMM: 23-303/303
Sequence Identity: 32% (92 aa)

NGIEVAVKEMHL---N------EKKEKY------LLDETRLMYTMKDEHIIRFYDAYK---DGNTLWIIMEYMDAGALTYVAR--YCD--CMEPHIAYIA
.| ..|||....   |      ||. .       . .| .|| ... ..|.|.|..     . ... |.|||.  | |  . |  .      |. | .  
TGELMAVKQIEIQNNNQMKEDQEKEYQSHKMHKAIQEEIKLMKHLNHKNIVRYYGCCLHDNQNDHVNIFMEYCPGGSLSSMLRHKWGPMKFDEMVIRKYT

REILLALKYIHSQNKIHRDIKTDNVLLSQKGH-VKLADFGYAAQLTTAAERRNS----------MVGTPF--------WMAPELIQRTP---YSFAVDIW
. || .|.| ||.. |||||| .|.|| ..|. .|||||| | .| . . .  .          | |||.        ||||| | ...   |. ..|||
KQILEGLQYLHSHGIIHRDIKGANILLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTGTPYNSMMGTPMWMAPEVIKQEGRDGYGRKADIW

SLGILCRELAEGEPPYVDEP--PMRATFLIVIKGIPEISDKESRS------PELLDFLDKCLRKDPKLRPTAEELLNHPFL
|||    | | | ||. .    .| | | |. .  | .   |. |      .|. |||..|. .||| |||| .||.|||.
SLGCTVIEMATGKPPWHNYDHNHMAAMFKIGMGHKPHPPIPEHMSPISWISEECRDFLRHCFEHDPKKRPTANQLLQHPFI
Kinase 83472.m00456.AA SLK 189-409 35 2.3e-60 202.32 In-house 33-259 (259) Show / Hide 
Range on Protein: 189-409
Range on HMM: 33-259/259
Sequence Identity: 35% (82 aa)

EMHLNEKKEKYLLDETRLMYTMKDEHIIRFYDAYKDGNTLWIIMEYMDAGALTYVARYCD--CMEPHIAYIAREILLALKYIHSQNKIHRDIKTDNVLLS
|.. .|. | |.  |  .. ..|  .|.. |.||   | ||...|. | ||.  .    .    |. |.|...... ||...||.. ||||.|  |.|. 
EIKDEEELEDYMV-EIDILSECKHPNIVKLYEAYYYDNKLWMMIEFCDGGAVDNIMVELEHPLTEDQIQYVCKHMCEALNWLHSNKVIHRDLKAGNILMT

QKGHVKLADFGYAAQLTTAAERRNSMVGTPFWMAPELI-----QRTPYSFAVDIWSLGILCRELAEGEPPYVDEPPMRATFLIVIKGIPEISDKESRSPE
. |.|.||||| .|...   ..| . .|||.|||||..     . .|| . .|||||||   |.|..|||. .  |||  . |     |..      | |
MDGDVRLADFGVSAKNKHTMQKRDTFIGTPYWMAPEVVMCETFKDQPYDYKADIWSLGITLIEMAQMEPPHHEMNPMRVLLKIQKSEPPTLEQPSHWSKE

LLDFLDKCLRKDPKLRPTAEELLNHPFL
  ||| ||| |||. |.|...|..|...
FKDFLKKCLVKDPQNRWTTAQLMQHQWV
Kinase 83472.m00456.AA TyrKc 161-409 22 5.1e-22 80.39 SMART 1-280 (280) Show / Hide 
Range on Protein: 161-409
Range on HMM: 1-280/280
Sequence Identity: 22% (65 aa)

LQNMQVIAEGSTCIIYTAIYNGIEVAVKEMHLNEKKEKYLLDETRLMYTM--KDEHIIRFYDAYKDG-------NTLWIIMEYMDAGALTYVARYCD--C
..  ... ||  ...| .... |.|||| .. .   .. ...| |.|     . ..|.|.| .  ..         |.|.||||. |.|    |..    
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKL

MEPHIAYIAREILLALKYIHSQNKIHRDIKTDNVLLSQKGHVKLADFGYAAQLTTA-----AERRNSM---VGTP-----FWMAPELIQRTPYSFAVDIW
  ..  ...  |     |.||.| ||||. . |.|.. ...|| .||| .  ..       ..   ..    |.       ||||| |.   .... |.|
CMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVW

SLGILCRELAE-GEPPYVDE----PPMRATFLIVIKG-IPEISDKES------RSPELLDFLDKCLRKDPKLRPTAEELLNHPFL
| |... |.   |..|| ..     . .  .  | .|  ... .          ..|. .   .| . ||. ||| .|.  | ..
SFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 83472.m00456.AA Pkinase_Tyr 264-368 30 6.9e-14 47.65 Pfam 123-232 (270) Show / Hide 
Range on Protein: 264-368
Range on HMM: 123-232/270
Sequence Identity: 30% (34 aa)

ALKYIHSQNKIHRDIKTDNVLLSQKGHVKLADFGYAAQL----TTAAERRNSMVGTPFWMAPELIQRTPYSFAVDIWSLGILCRELAE-GEPP-YVDEPP
.. | .|.| ||||. . |.|.. ...|| .||| |  .    .     | .     .||||| |.   .. . |.|| |.|. |.   || | | . ..
GMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSN

MRATFLIVIKG
 .   .|  .|
EEVYEYIYEDG
Kinase 83472.m00456.AA Pkinase_Tyr 161-240 22 3.3e-07 25.03 Pfam 1-94 (270) Show / Hide 
Range on Protein: 161-240
Range on HMM: 1-94/270
Sequence Identity: 22% (21 aa)

LQNMQVIAEGSTCIIYTAIYN------GIEVAVKEM--HLNEKK--EKYLLDETRLMYTM-KDEHIIRFYDAYK-DGNT--LWIIMEYMDAGAL
.. .... ||.   .| ....      .|.|||| .  .  ..    . .. | ..| .. . ..|.|.| .   .|    ..|.||||  | |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDL
Kinase 83472.m00456.AA Pkinase_Tyr 379-409 35 1.624582 2.37 Pfam 242-270 (270) Show / Hide 
Range on Protein: 379-409
Range on HMM: 242-270/270
Sequence Identity: 35% (11 aa)

SPELLDFLDKCLRKDPKLRPTAEELLNHPFL
..|. | . .| ..||. ||| .|.  | .|
PDEIYDLMKQCWHYDPEDRPTFSEI--HEQL