Gene 95718.m00005 (T.vaginalis)

95718.m00005

Species: T.vaginalis
Alias: TvagK0251, 95718.m00005
External Links:
Annotation:

Classification

Group: CAMK
Family: CAMKL
Subfamily: CAMKL-Tvag1

Sequence

Name Sequence Type Origin Length Description Download
95718.m00005.AA Protein None 312 None Fasta, JSON
95718.m00005.kin_dom Protein Kinase Domain None 246 None Fasta, JSON

Protein domain

Protein domains of 95718.m00005.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 95718.m00005.AA Ciliate-E2-Unclassified 15-259 19 2.1e-28 95.66 In-house 2-352 (352) Show / Hide 
Range on Protein: 15-259
Range on HMM: 2-352/352
Sequence Identity: 19% (67 aa)

RYEKVIARGANGLIYLVYSESQQRKFAMKKYPQFIFKD--------------KDLENI----------------IAINNPHLLKFTQYFKFNDQVYLLME
.  |.| .|..| .|... ..|. ..|||   ... ..              | ..|.                . ...|...|.  .|.  . .|. ||
KIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVME

YCP-TNLEKLITEP-----------------QMVSKEILR-----NYIYDVVTCVKTCHDNN-ISISDFTLSNFLIDENG---KIKINFLSL--------
||.  .|.. |..                  .... .  .     .|.. .. . . .| .| |   | ...| |.|.||   .|||  ...        
YCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNN

-------KHIVQEQEENAPARFKTMNYF---LPPEVIEQSEYDEM---CSDIWSLGCILYFMASKSLPFNSKDMKS----------------LKDQIKKC
         . . .....  .  | ||    ..|||... .||..   ..||||||.|||.|    .||.... ..                |...||..
NCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQK

EYNNEKVE--------DLNLREVIS----RCLKIDPNSRTTVGNLLKMKYF
.... | .        . .  . |.    ..|| .||.| |   .|.  .|
NIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 95718.m00005.AA Ciliate-E2 14-259 18 1.6e-27 91.55 In-house 1-365 (365) Show / Hide 
Range on Protein: 14-259
Range on HMM: 1-365/365
Sequence Identity: 18% (72 aa)

LRYEKVIARGANGLIYLV--YSESQQR----------------KFAMKKYPQFIFKDKD---LENIIAIN--------------------NPHLLKFTQY
    |.| .|. | .|..  ... .|                 |...|.|   |.| ..   ....| |.                    .|...|.  .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FK--FNDQVYLLMEYCPT-NLEKLIT-----------------EPQMV--SKEILR-------NYIYDVVTCVKTCHDNN-ISISDFTLSNFLIDENGKI
|.   .. .|| ||||   .|...|                  | ..   .|.||.       .||  .. ... .| .| |   |  ..| |.     |
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KINFLSL-KHIVQEQEENA------PARFKT------------------------MNYFLPPEVIEQSE---------YDEMCSDIWSLGCILYFMASKS
||  . | | . ......          |                          . ....||...  .         ||..| ||||||.|||.| .. 
KIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKC-DIWSLGVILYEMLFGK

LPFNSKDMKSLKDQIKKCEYN------------------NEKVEDLNLREVISR----CLKIDPNSRTT-VGNLLKMKYF
.||         .|||.|...                  . |  ...    |..    .|. ||. | |    .|. ..|
PPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 95718.m00005.AA PLK1 61-259 27 7.1e-27 85.16 In-house 56-253 (253) Show / Hide 
Range on Protein: 61-259
Range on HMM: 56-253/253
Sequence Identity: 27% (55 aa)

INNPHLLKFTQYFKFNDQVYLLMEYCPTN-LEKLITEPQMVSKEILRNYIYDVVTCVKTCHDNNISISDFTLSNFLIDENGKIKINFLSLKHIVQEQEEN
.. .|. || ..|  .. ||...| |  . |  |    . .     | |.| .|  ..  |.|.|   |. | |  .... ..||    |   .... | 
LHHRHIVKFHHFFEDKQNVYIVLELCRRRSLMELHKRRKAITEPECRYYMYQIVEGCQYLHNNKIIHRDLKLGNLFLNDHLQVKIGDFGLATKCEYDGER

APARFKTMNYFLPPEVIEQSEYDEMCSDIWSLGCILYFMASKSLPFNSKDMKSLKDQIKKCEYNNEKVEDLNLREVISRCLKIDPNSRTTVGNLLKMKYF
   .  | || . |||...        ||||.|||.| .   . || .| .|    .|||.||   .      ...| . |. ||..| |. ..|....|
KKTLCGTPNY-IAPEVLNKKGH-SFEVDIWSIGCIMYILLFGQPPFETKCLKETYSRIKKNEYRIPSHISQPAAQLIRKMLDPDPTRRPTIEQVLNDEFF
S_TKc 95718.m00005.AA S_TKc 14-259 23 1.9e-26 95.08 SMART 1-231 (231) Show / Hide 
Range on Protein: 14-259
Range on HMM: 1-231/231
Sequence Identity: 23% (62 aa)

LRYEKVIARGANGLIYLVYSESQQRKFAMKKYPQFIFKDKDLENIIAINNPHLLKFTQYFKFNDQVYLLMEYCPT---NLEKLITEPQM------VSKEI
 .  ..| .|| |  |...  . .|..|.|. .  .   . ..     . |.. |.  .|   | .|. ||||..   .| ..| . .        .   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-H

LRNYIYDVVTCVKTCHDNNISISDFTLSNFLIDENGKIKI------NFLSLKHIVQEQEENAPARFKTMNYFLPPEVIEQSEYDEMCSDIWSLGCILYFM
 | |.| ..  .. ||...|   |   .| |.||   |||       .|                  | .| ..|||.    |.   .|.||.||||| |
ARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------------TTFCGTPWY-MAPEVL---GYGKCKCDWWSCGCILYEM

ASKSLPFNSKDMKSLKDQIKKCEYNNEKVEDLNLREVISRCLKIDPNSRTTVGNLLK-------MKYF
..   ||   .|. . ..|.          .  ... |..||. ||. | |.  .|.       . .|
LCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 95718.m00005.AA CAMK 169-259 17 3.6e-22 67.6 In-house 284-425 (425) Show / Hide 
Range on Protein: 169-259
Range on HMM: 284-425/425
Sequence Identity: 17% (25 aa)

YFLP-PEVIEQ-------------SEYDEMCSDIWSLGCILYFMASKSLPFNSK-------------DMKSLKDQIKKCEY--NNEKVEDLN--------
.. . |||...              .|.   .|.||.|.|||.| .  .||...             ... |. .|.|..|    ... ..         
EYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWW

--------------LREVISRCLKIDPNSRTTVGNLLKMKYF
               .  |...|. ||. | |.   |. . .
DDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 95718.m00005.AA CAMK-Unique 173-259 25 7.1e-21 65.47 In-house 244-363 (363) Show / Hide 
Range on Protein: 173-259
Range on HMM: 244-363/363
Sequence Identity: 25% (30 aa)

P--------------EVIEQSEYDEMCS---DIWSLGCILYFMASKSLPFNSKDMK--------SLKDQIKKCEY-N-NEKVEDL------NLREVISRC
|              |||... ||. ||   |||||| |.|.|.. ..||.. . .        .. . |.|..| |  .|....      ..  .. .|
PEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECEDRDYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCC

LKIDPNSRTTVGNLLKMKYF
...||..| .  .||.  ..
MTVDPDHRWSAKELLEHQWI
Kinase 95718.m00005.AA Pkinase 169-259 22 1.8e-17 62.84 Pfam 176-293 (293) Show / Hide 
Range on Protein: 169-259
Range on HMM: 176-293/293
Sequence Identity: 22% (27 aa)

YFLPPEVIE-QSEYDEMCSDIWSLGCILYFMASKSLPFNSK------DMKSLKDQIKKCEYNNEKVED---------------------LNLREVISRCL
....||||  ...|.  . |.||.||||| |... .|| ..      |.. . ..|.....  .  ..                      .....|..||
WYMAPEVIRGGQYYGPKV-DMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCL

KIDPNSRTTVGNLLKMKYF
. ||..| |   .|. ..|
CKDPKKRPTAEQILQHPWF
Kinase 95718.m00005.AA MARK 170-259 32 8.8e-17 51.55 In-house 171-262 (262) Show / Hide 
Range on Protein: 170-259
Range on HMM: 171-262/262
Sequence Identity: 32% (30 aa)

FLPPEVIEQSEYDEMCSDIWSLGCILYFMASKSLPFN--SKDMKSLKDQIKKCEYN-NEKVEDLNLREVISRCLKIDPNSRTTVGNLLKMKYF
. .||.... .||    |||||| .|||| . ..||   ..|.| |. .| ...|    .| .  .|  |.| |...|. | |. ...| . .
YMAPEIFLKKPYDGPKVDIWSLGVVLYFMVCGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKE-CRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase 95718.m00005.AA ULK 169-259 21 2.1e-15 50.32 In-house 216-329 (329) Show / Hide 
Range on Protein: 169-259
Range on HMM: 216-329/329
Sequence Identity: 21% (25 aa)

YFLPPEVIE----QSEYDEMCSDIWSLGCILYFMASKSLP----FNSKD---MKSLKDQ---------IKKCEYN---NEKVEDLNLREVISRCLKIDPN
..  |....    | .|..  .||||||||.| |     |    ||. .   ...|...          .. ...   |...   .... |.|.|..|..
LYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEK

SRTTVGNLLKMKYF
 | .   |.... |
DRISWEELFNHPWF
Kinase 95718.m00005.AA ULK 169-259 22 1.2e-14 48.43 In-house 212-324 (324) Show / Hide 
Range on Protein: 169-259
Range on HMM: 212-324/324
Sequence Identity: 22% (25 aa)

YFLPPEVIE----QSEYDEMCSDIWSLGCILYFMASKSLP----FNSKD--MKSLKDQ-------IKK--CEYN---NEKVEDLNLREVISRCLKIDPNS
..  |....    | .|..  .||||||||.| |   . |    ||. .  ...|...       ||.   ...   ....   .... |.|.|..|.. 
LYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSWFNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKD

RTTVGNLLKMKYF
| .   ..... |
RISWEEIFNHPWF
Kinase 95718.m00005.AA NEK 169-259 33 2.4e-14 47.31 In-house 189-286 (286) Show / Hide 
Range on Protein: 169-259
Range on HMM: 189-286/286
Sequence Identity: 33% (33 aa)

YFLPPEVIEQSEYDEMCSDIWSLGCILYFMASK--SLPFNSK--DMKSLKDQIKKC-EYN--NEK-VEDLNLREVISRCLKIDPNSRTTVGNLLKMKYF
|.. |||...  |..  ||||||||.|| |..     ||...  .|.||  .|.|. .|.  ... .    |...||..|. || .| ..  .|.| . 
YYMSPEVCQNKPYNNK-SDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase 95718.m00005.AA STE 173-259 23 1.5e-12 40.79 In-house 231-359 (359) Show / Hide 
Range on Protein: 173-259
Range on HMM: 231-359/359
Sequence Identity: 23% (31 aa)

PEVIEQ------SEYDEMCSDIWSLGCILYFMASKSLPFNS-KDMKSLKDQIKK---CE---------YNNEKVED----------------------LN
||||.|      ..||. | ||||||| .  ||    |.   ..|. .   ...   ..          .  . .|                       .
PEVIQQNGQGRDKGYDTKC-DIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPE

LREVISRCLKIDPNSRTTVGNLLK--MKYF
... |..||..||| | |.  |||   . .
FKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 95718.m00005.AA CAMK 19-124 11 1.1e-08 23.35 In-house 1-200 (425) Show / Hide 
Range on Protein: 19-124
Range on HMM: 1-200/425
Sequence Identity: 11% (24 aa)

VIARGANGLIYLVYSESQQ------------RKFAMKKYPQF-----------------------------IFKDKDLENIIAI-----------NNPHL
.. ||. |  .|..  . .            .|.|.| ..                                .. | ... |.|           . |..
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

LKFTQYFK------------FNDQ--------VYLLM---EYCPTN------LEKLITEPQ--------------MVSKEILRNYIYDVVTCVKTCHDNN
.|. ...             . ..        .|. |   |||.        .....  ..               .. .  | |.  ..  |. ||..|
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

I
|
I
Kinase 95718.m00005.AA Pkinase 14-144 22 6.6e-07 25.5 Pfam 1-153 (293) Show / Hide 
Range on Protein: 14-144
Range on HMM: 1-153/293
Sequence Identity: 22% (34 aa)

LRYEKVIARGANGLIYLVYSESQQRKFAMKKYPQFIFKDKDLENIIA---------INNPHLLKFTQYFKFNDQVYLLMEYCPT-----NLEKLIT---E
.. ...| .|. |  |. .  . ....|.|. .    |.. ... .          .| |. ...  .|  .| .|. ||||.       |  .|.   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

PQM-VSKEILRNYIYDVVTCVKTCHDNNISISDFTLSNFLIDENGKI----KI
  .  | . ...|.| ..  .. ||...|   |  ..|.|||.|| |    ||
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKI
Kinase 95718.m00005.AA TyrKc 14-259 12 1e-06 -116.49 SMART 1-280 (280) Show / Hide 
Range on Protein: 14-259
Range on HMM: 1-280/280
Sequence Identity: 12% (40 aa)

LRYEKVIARGANGLIYL-VYSESQQRKFAMKKYPQFIFKDKDLEN----IIAI--NNPHLLKFTQYFKFN-------DQVYLLMEYCPT-NLEKLITEPQ
.. .|.. .|| | .|. ...    .. | |.        .|. .       .  ..|.....  .           ......|||.|  .| . . ...
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

MVSKEILRNYIYDVVTCVKTCHDNNISISDFT------------------------LSNFLIDENGKIKINFLSLKHIVQEQ-------EENAPA---RF
                         .. .|.                           | |..||. .||    |   . .        .   ..     
PK-----------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGG

KT-MNYF-LPPEVIEQSEYDEMCSDIWSLGCILYFMASK-SLPFNS-----KDMKSLKDQIKKCEYNNEKVE---------DLNLREVISRCLKIDPNSR
|| . .  ..||.|  ... .  ||.|| |  .. . .    |        .. . .  ..|. ..     .            . .....| . ||..|
KTMLPIRWMAPECINYGKFTTK-SDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDR

TTVGNLLKMKYF
 |  ..   ..|
PTFSEI--HECF
Kinase 95718.m00005.AA STE 14-106 12 0.000229 11.47 In-house 1-162 (359) Show / Hide 
Range on Protein: 14-106
Range on HMM: 1-162/359
Sequence Identity: 12% (21 aa)

LRYEKVIARGANGLIYLVYSE------SQQRK---------FAMKKYP------------------QFIFKD----KDLENIIAIN--NPHLLKFTQYFK
..  ..| .|| |  |. .        . ...         .|.|. .                   .. .     |...     |   |.  |.  .. 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

FN-------DQVYLLMEYCP-TNLEKLIT--------------------EPQM--VSKEILR
 .       |.... |||..   |...|                     |.|   . ..||.
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILK
Kinase 95718.m00005.AA ULK 61-113 20 0.006889 6.02 In-house 74-140 (329) Show / Hide 
Range on Protein: 61-113
Range on HMM: 74-140/329
Sequence Identity: 20% (14 aa)

IN-NPHLLKFTQYFKFN--DQVYLLMEYCPT-NLEKLIT----------EPQMVSKEILRNYIYDVV
.| .|.  |.  .|.    . .|. ||||.  .||..|           |..  | .. ...... .
KNHHPNIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQIL
Kinase 95718.m00005.AA ULK 61-124 21 0.01989 4.5 In-house 70-147 (324) Show / Hide 
Range on Protein: 61-124
Range on HMM: 70-147/324
Sequence Identity: 21% (17 aa)

INNPH--LLKFTQYFKFN--DQVYLLMEYCPT-NLEKLIT---------EPQMVSKEILRNYIYDVVTCVKTCHDNNI
...|.    |.  .|.    . .|. ||||.  .||..|          |..  | .. ...... .   |  |..||
LKHPNHHIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNI
Kinase 95718.m00005.AA CAMK-Unique 64-96 18 0.084486 1.49 In-house 76-128 (363) Show / Hide 
Range on Protein: 64-96
Range on HMM: 76-128/363
Sequence Identity: 18% (10 aa)

PHLLKFTQY----FKFND---------------QVYLLMEYCPTN-LEKLITE
|...|. ..    |   .                 |..||||. . | ..| .
PNIIKLYDWNNPIFCDRKYPLCDLIIKTPRALPYMYIVMEYCQGGDLFDWIQK
Kinase 95718.m00005.AA MARK 131-144 62 0.254693 0.27 In-house 132-147 (262) Show / Hide 
Range on Protein: 131-144
Range on HMM: 132-147/262
Sequence Identity: 62% (10 aa)

LSNFLIDENG--KIKI
. | ||||||  .|||
PENILIDENGNHNIKI