93242.m00178

Species: T.vaginalis
Alias: 93242.m00178, TvagK0228
External Links:
Annotation:

Classification

Group: CAMK
Family: CAMKL
Subfamily: CAMKL-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
93242.m00178.AA Protein None 224 None Fasta, JSON
93242.m00178.kin_dom Protein Kinase Domain None 176 None Fasta, JSON

Protein domain

Protein domains of 93242.m00178.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 93242.m00178.AA Ciliate-E2-Unclassified 1-176 24 1.5e-41 141.91 In-house 100-352 (352) Show / Hide
Range on Protein: 1-176
Range on HMM: 100-352/352
Sequence Identity: 24% (62 aa)

MEYCPE-TLQSKIKKE-----------------GRLDPNLAI-----QYAREILIGLSLCHANG-ISHGDIKTSNILIDAYG---RIKICDFGMSDFSDD
||||.  .|.  |||                   ... . |.     .|...|| ||. .| .. | | ||| .|||.|  |   .|||.||| | ....
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

P---------------EGLSQHFRGSFPFM----AIEIIDKKAYDR---FKADIYSFGVTLFYTLTGHYPWKGIHREE----------------IINNIQ
.               . ....| |.  .|    | |..... ||    .|.||.|.|| |.. |.| || ..  .|.                ...||.
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIK

NGNTLVNL-------IGIP-ELESVID----RCISLCPENRPTADELLEMPIF
..|. ..         ... | .  |     ...  .|..|.|....|. |.|
QKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF

Pkinase 93242.m00178.AA Pkinase 1-176 28 1.8e-41 147.73 Pfam 79-293 (293) Show / Hide
Range on Protein: 1-176
Range on HMM: 79-293/293
Sequence Identity: 28% (61 aa)

MEYCPE-----TLQSKIK--KEGRL--DPNLAIQYAREILIGLSLCHANGISHGDIKTSNILIDAYGRI----KICDFGMSDFS-DDPEGLSQHFRGSFP
||||.       | . |.  ..|..  ... .. |...|| ||  ||..|| | |.| .|||||  | |    |||||| . .    . .  ..| |. .
MEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPW

FMAIEIIDKKAYDRFKADIYSFGVTLFYTLTGHYPWKGI------HREEIINNIQNGNTLVNLIGI---------------------PELESVIDRCISL
.|| |.| .  |.  |.|..|.|..|.. |.|. |..|          ..|..|  . .  .                         .|. ..|..|. .
YMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCK

CPENRPTADELLEMPIF
.|. ||||...|. | |
DPKKRPTAEQILQHPWF

Kinase 93242.m00178.AA CAMKL 1-176 30 2.1e-41 129.79 In-house 100-297 (297) Show / Hide
Range on Protein: 1-176
Range on HMM: 100-297/297
Sequence Identity: 30% (61 aa)

MEYCPET---LQSKIKKE----GRLDPNLAIQYAREILIGLSLCHANGISHGDIKTSNILIDAYG--RIKICDFGMSDFSDD----PEGLSQHFRGSFPF
||||.     |. .|.|.    ||.... | .| | |. ... || .|| | |||  |||.|  |   |||.|||.| . ..    |. .   | || |.
MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPY

MAIEIIDK--KAYDRFKADIYSFGVTLFYTLTGHYPWKGIH---------REEIINNIQNGNTLVNLIGIPELESVIDRCISLCPENRPTADELLEMPIF
|| ||. .  | || .|.|| | ||.|.  ..|..|... .         ... ..... ..  . .    .... | .    .|| |||...... | .
MAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM





Kinase 93242.m00178.AA CAMK 1-176 20 5.4e-37 116.22 In-house 136-425 (425) Show / Hide
Range on Protein: 1-176
Range on HMM: 136-425/425
Sequence Identity: 20% (59 aa)

M---EYCPET-----LQSKIKKE---------------GRLDPNLAIQYAREILIGLSLCHANGISHGDIKTSNILIDAY-----------------GRI
|   |||.       | ..|..                ||..   | .| | |. ..  || ..| | |.|  |||.|                   . |
MEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNI

KICDFGMSDFSDDPEG-----------------------LSQHFRGSFPFMA-IEIIDK-------------KAYDRFKADIYSFGVTLFYTLTGHYPWK
||.|||.. . |. |.                       . . | |. ..||  |.. .             | |. .|.|. | || |.  |.|..|. 
KIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFY

GIHREEIIN-------------NIQNGN-T-LVNLIGI----------------------PELESVIDRCISLCPENRPTADELLEMPIF
| ...||..             .|..|. .     . .                      .|  . | ..    ||.|.|... |. | .
GDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM

Kinase 93242.m00178.AA Ciliate-E2 1-176 20 1.6e-34 115.92 In-house 113-365 (365) Show / Hide
Range on Protein: 1-176
Range on HMM: 113-365/365
Sequence Identity: 20% (56 aa)

MEYCPE-TLQSKIK------------KEGRLDPNLAIQYAREIL---------------IGLSLCHANG-ISHGDIKTSNILIDAYGRIKICDFGMSDFS
||||   .|.. ||            . .... . .... ..||                .|  .| .. | | ||| .|||.     |||.|||.| . 
MEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKY

DDPEG-------------------------------LSQHFRGSFPFMAIEIIDKKAYDR--------FKADIYSFGVTLFYTLTGHYPWKGIHREEIIN
||..                                . . . |. ..|| ||. .| ||         .|.||.|.||.|.. |.| .|.        ..
DDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF--------QQ

NIQNGNTLVN------------------LIGIPELESVIDR----CISLCPENRPT-ADELLEMPIF
.|....   .                  .   .|    | .    ..   ||.|.| ....|. |.|
QIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF

Kinase 93242.m00178.AA MARK 1-176 36 9.2e-32 101.23 In-house 81-262 (262) Show / Hide
Range on Protein: 1-176
Range on HMM: 81-262/262
Sequence Identity: 36% (67 aa)

MEYCPET-LQSKIKKE--GRLDPNLAIQYAREILIGLSLCHANGISHGDIKTSNILIDAYG--RIKICDFGMSDFSDDPEGLSQHFRGSFPFMAIEIIDK
|||.... | . ||.   |||  ..| .. | |. ... || ..| | |||  |||||. |   |||.|||.|     |. .   | |. |.|| ||. |
MEYASGGELYDYIKAHPNGRLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFS-ICIPPGQKLNTFCGTPPYMAPEIFLK

KAYDRFKADIYSFGVTLFYTLTGHYPWKGIH--REEIINNIQNGNTLVNLIGI-PELESVIDRCISLCPENRPTADELLEMPIF
| || .|.||.| || |.. ..|..|..|     .|.  .|..|.  .    . .|... | | . . || |||..|... | .
KPYDGPKVDIWSLGVVLYFMVCGYFPFDGDTQDYKELYKKILRGKYDIPCH-VSKECRNLIQRLLTVNPEERPTIEEIMKHPWM

Kinase 93242.m00178.AA STE 1-176 25 2.9e-30 104.14 In-house 116-359 (359) Show / Hide
Range on Protein: 1-176
Range on HMM: 116-359/359
Sequence Identity: 25% (63 aa)

MEYCP-ETLQSKIK-KEGRLDP-------------NLAIQYAREILIG-LSLCHANGISHGDIKTSNILIDAYGRIKICDFGMSDFSDD-----------
|||..  .| . || | |...|             .. . ..|.|| | |.. | ..| | ||| .|||.     .|.|||| .   .|           
MEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNII

----PEG-LSQHFRGSFPFMAIEIIDK------KAYDRFKADIYSFGVTLFYTLTGHYPWKGIHREEIINNIQNG--------------NTLVNLIGI--
      .  ...| |.  .|| |.|..      | ||. |.||.|.| |.   .||..||   |  . . .|...              ..   |     
DCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDT-KCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLS

-------------------PELESVIDRCISLCPENRPTADELLE--MPIF
                   ||.   |..|    |..||||..||.   | .
QNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI

Kinase 93242.m00178.AA ULK 1-176 26 1.7e-28 96.65 In-house 99-329 (329) Show / Hide
Range on Protein: 1-176
Range on HMM: 99-329/329
Sequence Identity: 26% (61 aa)

MEYCPE-TLQSKIKKEGR----------LDPNLAIQYAREILIGLSLCHANGISHGDIKTSNILIDAY------------GRIKICDFGMSDFSDDP---
||||.  .|.. ||| ..          |  . |||. . || |.   | ..| | ||| .||||.              |..||.||| . . |..   
MEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNME

EGLSQHFR------GSFPFMAIEIID----KKAYDRFKADIYSFGVTLFYTLTGHYP---WKGIHRE-----EIINN-------IQNGNTLVNLIG----
. . . .       |.  .|| .|.     .| |. .|.||.|.|. ... |.| .|   |           . |||       |.. ..  .  |    
QQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQ

-IPELESVIDRCISLCPENRPTADELLEMPIF
  ||... | |..   .. | . .||...|.|
ISPECKDLIRRMLQYDEKDRISWEELFNHPWF

Kinase 93242.m00178.AA ULK 1-176 27 6.5e-27 92.57 In-house 96-324 (324) Show / Hide
Range on Protein: 1-176
Range on HMM: 96-324/324
Sequence Identity: 27% (63 aa)

MEYCPE-TLQSKIKKE---------GRLDPNLAIQYAREILIGLSLCHANGISHGDIKTSNILIDAY------------GRIKICDFGMSDFSDDPE---
||||.  .|.. |||          .||  . |||. . |. |.   | ..| | ||| .||||               |..||.||| . . |...   
MEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQ

GLSQHFR------GSFPFMAIEIID----KKAYDRFKADIYSFGVTLFYTLTGHYP---WKGIHRE----EIINN-------IQNGNTLVNL----IGI-
 . | .       |.  .|| .|.     .| |. .|.||.|.|. ... |.| ||   |     .    . |||       |.| .   ..    . | 
QMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKIS

PELESVIDRCISLCPENRPTADELLEMPIF
||... | |..   .. | . .|....|.|
PECKDLIRRMLQYDEKDRISWEEIFNHPWF

Kinase 93242.m00178.AA RSK 11-176 27 2e-22 79.04 In-house 91-278 (278) Show / Hide
Range on Protein: 11-176
Range on HMM: 91-278/278
Sequence Identity: 27% (52 aa)

KIKKEGR---LDPNLAIQYAREILIGLSLCHANGISHGDIKTSNILIDA---YGRIKICDFGMSDF-SDDPEGLSQHFRGSFPFMAIEIID----KKAYD
...||..   .. . | .|..||   ..  |  || | |.| .||| |     |.||..||| .   . | ... . |...  .|| |..     ....|
HLQKEKHFGCFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHD

RFKADIYSFGVTLFYTLTGHYPWKG---IHREEIINNIQNGN---TLV--NLIGIPELESVIDRCISLCPENRPT-----ADELLEMPIF
.  .|..|.|| ..  |||. | .|    .|.||...||.|.   |.   . .  .|  . | ..    |..|..     |.|... | |
K-ACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLS-QEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF

Kinase 93242.m00178.AA TKL 1-174 19 8.8e-22 75.21 In-house 117-364 (364) Show / Hide
Range on Protein: 1-174
Range on HMM: 117-364/364
Sequence Identity: 19% (49 aa)

MEYCPE-TLQSKIKKEGRLDPNLAIQYAREILIGLSLCHANG--------ISHGDIKTSNILIDAYGR--------------IKICDFGMSDFSDDPEG-
|||||  .| . .       ... .. |..|  |..  |...        | | |.|..|||.|  ..              .|||||| | | .  .. 
MEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNM

------------------LSQHFRGSFPFMAIEIIDKKAYDR---------------FKADIYSFGVTLFYTLTGHYPWKGIHRE---------EIINNI
                   . . .|.. .|| |..... ...                |.|.||||. |.  ||.  |..... .         |..  .
NDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMV

QNGNTLVNLI--------------GIPELESVIDRCISLCPENRPTADELLEMP
 . .    .                 |.. . . .| .  ||.||...|.|.  
CDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL

Kinase 93242.m00178.AA S_TKc 1-176 23 2.4e-15 48.12 SMART 1-231 (231) Show / Hide
Range on Protein: 1-176
Range on HMM: 1-231/231
Sequence Identity: 23% (60 aa)

M-----------------------------------------------------------------EYCPE---TLQSKIKKEGR------LDPNLAIQY
                                                                  |||.    .| . ||| ||      ...  |  |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFY

AREILIGLSLCHANGISHGDIKTSNILIDAYGRIKICDFGMSDFSDDPEGLSQHFRGSFPFMAIEIIDKKAYDRFKADIYSFGVTLFYTLTGHYPWKGIH
...|. .|  || .|| | |.| .|||.|   .|||||||.. .         .| |.  .|| |..    |...|.|..|.|..|.  |.|  |.   .
MYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--Q

REEIINNIQNGNTLVNLIGIPELESVIDRCISLCPENRPTADELLE-------MPIF
 ......|            ||. . |..|    ||.|||| |.|.       .| |
MQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase 93242.m00178.AA TyrKc 6-174 16 8.1e-07 -112.4 SMART 1-280 (280) Show / Hide
Range on Protein: 6-174
Range on HMM: 1-280/280
Sequence Identity: 16% (47 aa)

ETLQSKI------------------------------------------------------------------------------------KKEGRLDPN
 ||  |.                                                                                    |....| . 
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMK

LAIQYAREILIGLSLCHANGISHGDIKTSNILIDAYGRIKICDFGMSDFSDDP-------EGLSQHF--RGS--FPF--MAIEIIDKKAYDRFKADIYSF
  ....  |  | .  | ... | |. . |.|... ...||.|||.| . .|        .  ..     |   .|   ||.| |... .  .| |..||
DLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT-TKSDVWSF

GVTLF--YTLTGHYPWKG-----IHREEIINNIQNGNTLVNLIG---------IPELESVIDRCISLCPENRPTADELLEMP
||...  .|. |  |. |     .  .|.|.....|. .               .|. ... .|    ||.|||  |. |  
GVCMWEIFTY-GQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF

Kinase 93242.m00178.AA Pkinase_Tyr 51-140 28 8.4e-05 16.89 Pfam 141-235 (270) Show / Hide
Range on Protein: 51-140
Range on HMM: 141-235/270
Sequence Identity: 28% (27 aa)

NILIDAYGRIKICDFGMSDFS-DDPEG--LSQHFRGSFPFMAIEIIDKKAYDRFKADIYSFGVTLFYTLT-GHYP-WKGIHREEIINNI-QNGNTL
|.|..  . .||||||..    .| .    ... .   . || | |  . .   | |..||||...  .| |  | ..|.  ||... | ..|. .
NCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFT-TKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRM