Gene 91023.m00088 (T.vaginalis)
91023.m00088
Species: T.vaginalis
Alias: TvagK0086, 91023.m00088
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| 91023.m00088.AA | Protein | None | 278 | None | Fasta, JSON |
| 91023.m00088.kin_dom | Protein Kinase Domain | None | 176 | None | Fasta, JSON |
Protein domains of 91023.m00088.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 91023.m00088.AA | MARK | 1-176 | 42 | 1.3e-72 | 236.73 | In-house | 81-262 (262) | Show / Hide |
Range on Protein: 1-176 Range on HMM: 81-262/262 Sequence Identity: 42% (78 aa) MEYCSRGELFSYLLQN--GVLADFQIKHMLSQLVNALVYLHGRNIAHRDIKPENILIDQDL--NVKLADFCLCHSTSNQQMLLTPCGSPFYAPPEIISNI |||.|.|||..|. . | | ... .|.| |. |.| .||.||||||||||||.. |.|..|| .. . |.| | ||.| |..|||.. MEYASGGELYDYIKAHPNGRLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKK PYDGKKGDMWSLGVVVFTMATGALPWTETN--QTQLLQQIVNADYVVPVTVSPNIRHLIQALMDPNPSKRPSAEEVKSLPWM ||||.| |.|||||| ..| .| .|. ... . .| ..|.. .| .| ||. .|.||| |. .||..||..||. . ||| PYDGPKVDIWSLGVVLYFMVCGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM |
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| Kinase | 91023.m00088.AA | CAMKL | 1-176 | 37 | 3.8e-71 | 226.24 | In-house | 100-297 (297) | Show / Hide |
Range on Protein: 1-176 Range on HMM: 100-297/297 Sequence Identity: 37% (75 aa) MEYCSRGE--LFSYLLQN----GVLADFQIKHMLSQLVNALVYLHGRNIAHRDIKPENILIDQDL--NVKLADFCLC---HS--TSNQQMLLTPCGSPFY ||||| || || |. .. | . . ... |.| |. |.| ..|.||||||||||.|.. |.|..|| .. . |.| | |||| | MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPY APPEIISN--IPYDGKKGDMWSLGVVVFTMATGALPWTET--------NQTQLLQQIVNADYVVP--VTVSPNIRHLIQALMDPNPSKRPSAEEVKSLPW ..|||.. ||||.| |.||.||. ..| .|.||. . |. |. .| | | . || |.||. .. .||.|||....... || MAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPW M | M |
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| Kinase | 91023.m00088.AA | CAMK | 1-176 | 23 | 4e-70 | 224.93 | In-house | 136-425 (425) | Show / Hide |
Range on Protein: 1-176 Range on HMM: 136-425/425 Sequence Identity: 23% (68 aa) M---EYCSRGEL----FSYLLQN---------------GVLADFQIKHMLSQLVNALVYLHGRNIAHRDIKPENILIDQD-----------------LNV | |||| ||| |.|. .. | . . ... |.. |. |.| .||.|||.||||||.|.. |. MEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNI KLADFCLC--HSTSN----------------------QQMLLTPCGSPFYAP-PEIISN-------------IPYDGKKGDMWSLGVVVFTMATGALPWT |..|| . .. |.. |.||.| |.. ||... .||.|.| ||||.||. ..| .| .|. KIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFY ET-------------NQTQLLQQIVNADY--VVPV----------------------TVSPNIRHLIQALMDPNPSKRPSAEEVKSLPWM . |. .|...| ...| | .||. ..||. .. ..|.||...|.... ||| GDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM |
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| Kinase | 91023.m00088.AA | NuaK | 1-176 | 39 | 8.1e-65 | 169.11 | In-house | 78-252 (252) | Show / Hide |
Range on Protein: 1-176 Range on HMM: 78-252/252 Sequence Identity: 39% (69 aa) MEYCSRGELFSYLLQNGVLADFQIKHMLSQLVNALVYLHGRNIAHRDIKPENILIDQDLNVKLADFCLCHSTSNQQMLLTPCGSPFYAPPEIISNIPYDG ||| |.|||. |. . ..| ..|. | | |. | | .|.||| | |||| ||. |.| ||| | ..|..| | |||| || |||. || | MEYASGGELYDYISECKSLPEREARHFFRQIVSAVHYCHKHRICHRDLKLENILLDQNCNAKIADFGLSNYYHDQKFLHTFCGSPLYASPEIVNGQPYHG KKGDMWSLGVVVFTMATGALPWTETNQTQLLQQIVNADYVVPVTVSPNIRHLIQALMDPNPSKRPSAEEVKSLPWM | |||||. .|| | .| . .| .|| . .| | . | . || .. || .| . ... . .|. PEVDCWSLGVLLYTMVYGTMPFDGHDFKHLVKQISQGAYYEPCKPS-DACMLIRWMLMVNPRRRATIYDICHHWWV |
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| Kinase | 91023.m00088.AA | AMPK | 1-176 | 38 | 1e-64 | 191.09 | In-house | 79-254 (254) | Show / Hide |
Range on Protein: 1-176 Range on HMM: 79-254/254 Sequence Identity: 38% (67 aa) MEYCSRGELFSYLLQNGVLADFQIKHMLSQLVNALVYLHGRNIAHRDIKPENILIDQDLNVKLADFCLCHSTSNQQMLLTPCGSPFYAPPEIISNIPYDG ||| | ||||.| ..| | . . . | .... |.| .|.||| ||||.|.|.. |.|..|| | . ..| | |||| || ||.||. .| | MEYVSGGELFDYIVKHGRLQEREACRFFQQIISGVEYCHRHMIVHRDLKPENLLLDHNKNIKIVDFGLSNMMKDGEFLKTACGSPCYAAPEMISGKLYCG KKGDMWSLGVVVFTMATGALPWTETNQTQLLQQIVNADYVVPVTVSPNIRHLIQALMDPNPSKRPSAEEVKSLPWM . | || ||. . | | || . |...| . |.| .| .| .||... ||. . ..| || . .... || PEVDIWSCGVILYAMLCGYLPFDDENTPTLYKKIKNGEYYIPKFLSPEAKDLIKHMLQVDPMKRITIHDIRNHPWF |
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| Kinase | 91023.m00088.AA | Pkinase | 1-176 | 28 | 6.7e-58 | 203.47 | Pfam | 79-293 (293) | Show / Hide |
Range on Protein: 1-176 Range on HMM: 79-293/293 Sequence Identity: 28% (62 aa) MEYCSRG----ELFSYLL--QNGVL--ADFQIKHMLSQLVNALVYLHGRNIAHRDIKPENILIDQDLNV----KLADFCLCHS--TSNQQMLLTPCGSPF |||| | .||.|. ..|.. . ..|... |.. .| |.| ..| |||.||||||||.. .. |..|| |. . |.. . |.||.|. MEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPW YAPPEIISNIPYDGKKGDMWSLGVVVFTMATGALPWTET------NQTQLLQQIVNADYVVPVTVS---------------------PNIRHLIQALMDP |..||.| .|.|.| ||||.|.... |..| .|. . .| |....| ... . . .. ...| . .. YMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCK NPSKRPSAEEVKSLPWM .|.|||.||... ||. DPKKRPTAEQILQHPWF |
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| Kinase | 91023.m00088.AA | TSSK | 1-176 | 32 | 1.3e-57 | 187.65 | In-house | 96-289 (289) | Show / Hide |
Range on Protein: 1-176 Range on HMM: 96-289/289 Sequence Identity: 32% (64 aa) MEYCSRGELFSYLLQN------GVLADFQIKHMLSQLVNALVYLHGRNIAHRDIKPENILIDQDLNVKLADF---CLCHSTSNQQM---LLTPCGSPFYA |||...| |..| . | | . | . . .|.| |. |.|..|..|||.| |||| | . |.||.|| . . .... .. . | ||| || MEYAEHGDLLEYIQRRTQERCCGALHEEQARKWFRQMVSAVKYCHSHNVVHRDLKCENILLDKHWNIKLTDFGFARYWPRDDPGRCCHLSKTFCGSYAYA PPEIISNIPYDGKKGDMWSLGVVVFTMATGALPWTE--TNQTQLLQQIV--NADYVV--PVTVSPNIRHLIQALMDPNPSKRPSAEEVKSLPWM .|||. ||||.|..| ||.||. ..| .| .| .. .| ...|.|. .. .. ...|. ..|| .. |.|..||...|... .|| APEILRGIPYDPKWYDVWSMGVILYIMVCGCMPFDDDKSNIHKMLWQQQEHKVCFPKPHSCWISQECKDLIRHMLQPHPCNRPHINEICHHCWM |
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| Kinase | 91023.m00088.AA | Ciliate-E2-Unclassified | 1-176 | 27 | 2.2e-51 | 176.49 | In-house | 100-352 (352) | Show / Hide |
Range on Protein: 1-176 Range on HMM: 100-352/352 Sequence Identity: 27% (69 aa) MEYCSRGELFSYLLQNGV-----------------LADFQIK-----HMLSQLVNALVYLHGRN-IAHRDIKPENILIDQDL---NVKLADFCLC-HSTS |||| |.|. |. ... . ..|.| ... |....| ||| | | ||||||||||.|.. ..|..|| .. .. . MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ N---------------QQMLLTPCGSPFYA----PPEIISNIPYDG---KKGDMWSLGVVVFTMATGALPWTETNQTQ----------------LLQQIV | |||. | ||.| | .||.. . ||. .| |.|||||. . | .| .| .|..| |.|.| NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIK NADYVVPV--------TVSPNIRHLIQ----ALMDPNPSKRPSAEEVKSLPWM . .. .| ..||. ..|. ... ||.||...|... ||. QKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF |
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| Kinase | 91023.m00088.AA | Ciliate-E2 | 1-176 | 25 | 2.6e-50 | 170.88 | In-house | 113-365 (365) | Show / Hide |
Range on Protein: 1-176 Range on HMM: 113-365/365 Sequence Identity: 25% (67 aa) MEYCSRGELFSYLLQN-----------GVLADFQIKHMLSQLVN---------------ALVYLHGRN-IAHRDIKPENILIDQDLNVKLADFCLCHSTS ||||. |.||.|. .| . . ...||.. |... || ||| .| | ||||||||||. .|..|| |. . MEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYD NQ--------------------------------QMLLTPCGSPFYAPPEIISNIPYDG--------KKGDMWSLGVVVFTMATGALPWTETNQTQLLQQ .. .| | ||.| | .|||... .||. .| |.|||||. . | .| .|. .|| DDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF--------QQQ IVNADYVVP------------------VTVSPNIRHLIQA----LMDPNPSKRPS-AEEVKSLPWM | . .. | .|.. .||. ... .|.||.. .|... ||. IKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF |
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| Kinase | 91023.m00088.AA | QIK | 1-176 | 34 | 2.4e-49 | 170.28 | In-house | 77-272 (272) | Show / Hide |
Range on Protein: 1-176 Range on HMM: 77-272/272 Sequence Identity: 34% (68 aa) MEYCSRGELFSYLLQNGV--------------------LADFQIKHMLSQLVNALVYLHGRNIAHRDIKPENILIDQDLNVKLADFCLCHSTSNQQMLLT .|||| ||.| || ..| .| . . . .|.. | |.| |||.|||.| ||||.|...|.|.||| . . |.| | TEYCSNGEMFDYLCKHGRKGVKMVNSPDIGDQVLMGVPMAENEARRWFWQICSAVHYCHKRNIVHRDLKAENILLDNNMNIKIADFGFSNWFKQGQLLMT PCGSPFYAPPEIISNIPYDGKKGDMWSLGVVVFTMATGALPWTETNQTQLLQQIVNADYVVPVTVSPNIRHLIQALMDPNPSKRPSAEEVKSLPWM |||| || ||. . ||| | | ||.||| . . .|||| . ..| | .. . .| .| ||| . .|..| . . .. .|| WCGSPPYAAPEMFEGKEYDGPKVDIWSMGVVLYVLVCGALPFDGKTLQNLRQRVLSGKFRIPFFMSQDCEHLIRHMLVVDPEHRYTIMQICQHRWM |
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| Kinase | 91023.m00088.AA | BRSK | 1-176 | 39 | 1.6e-48 | 163.44 | In-house | 79-254 (254) | Show / Hide |
Range on Protein: 1-176 Range on HMM: 79-254/254 Sequence Identity: 39% (69 aa) MEYCSRGELFSYLLQNGVLADFQIKHMLSQLVNALVYLHGRNIAHRDIKPENILIDQDLNVKLADFCLCHSTSNQQMLLTPCGSPFYAPPEIISNIPYDG .|. | |||| || . | | . | . || . | .|| ||| |||| | | . |.| ||| . . || | |||| || ||.|. . ||| LEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHNICHRDLKPENLLLDEKNNIKIADFGMASLQVKDMMLHTSCGSPHYACPEVIRGEKYDG KKGDMWSLGVVVFTMATGALPWTETNQTQLLQQIVNADYVVPVTVSPNIRHLIQALMDPNPSKRPSAEEVKSLPWM .| |.|| ||. . . .|||| | ||| . . . .| . | . | .... .|.|| | .|.. || RKADVWSCGVILYALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIHPDCQDLLRGMIEVDPDKRISLKEIQKHPWY |
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| Kinase | 91023.m00088.AA | S_TKc | 1-176 | 21 | 3.8e-31 | 110.72 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 1-176
Range on HMM: 1-231/231
Sequence Identity: 21% (56 aa)
M-----------------------------------------------------------------EYCSR--GELFSYLLQNGV------LADFQIKHM
|||. |.||.|. ..| . .....
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFY
LSQLVNALVYLHGRNIAHRDIKPENILIDQDLNVKLADFCLCHSTSNQQMLLTPCGSPFYAPPEIISNIPYDGKKGDMWSLGVVVFTMATGALPWTETNQ
. |...|| |.| ..| |||.||||||.|. ..|..|| |. | ||.|.| .||.. .|...| |.||.|.... |..| |. ..
MYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QM
TQLLQQIVNADYVVPVTVSPNIRHLIQALMDPNPSKRPSAEEVKS-------LPWM
.....|. || ...|. ... .|.|||.| |. ||.
QMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | 91023.m00088.AA | TyrKc | 1-174 | 13 | 6.3e-07 | -110.62 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 1-174
Range on HMM: 1-280/280
Sequence Identity: 13% (38 aa)
M-----------------------------------------------------------------------------EYCSRGELFSYLLQNGV-LADF
||.. | | .|| .. |
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMK
QIKHMLSQLVNALVYLHGRNIAHRDIKPENILIDQDLNVKLADFCLCHSTSNQ-------QMLLT----PCG--SP-FYAPPEIISNIPYDGKKG-----
. .. | . ||| .|. |||. |.|.. .. || .|| |. . .. . . | .|| | ..|
DLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-------NYGKFTTK
-DMWSLGVVVF-TMATGALPWTE-----TNQTQLLQQIVNADYVVPVTV---------SPNIRHLIQALMDPNPSKRPSAEEVKSLP
| || ||. . . |. |. . . ....... . .. . .. . ... . .|..||. .|....
SDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
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| Kinase | 91023.m00088.AA | Pkinase_Tyr | 1-66 | 31 | 4.5e-05 | 17.8 | Pfam | 86-155 (270) | Show / Hide |
Range on Protein: 1-66 Range on HMM: 86-155/270 Sequence Identity: 31% (22 aa) MEYCSRGELFSYLLQ----NGVLADFQIKHMLSQLVNALVYLHGRNIAHRDIKPENILIDQDLNVKLADF |||. | | .|| . .. | .. .| | ... ||. .|. |||. |.|.. .. || .|| MEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDF |
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