Gene 88600.m00005 (T.vaginalis)
88600.m00005
Species: T.vaginalis
Alias: 88600.m00005, TvagK0541
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| 88600.m00005.AA | Protein | None | 223 | None | Fasta, JSON |
| 88600.m00005.kin_dom | Protein Kinase Domain | None | 172 | None | Fasta, JSON |
Protein domains of 88600.m00005.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 88600.m00005.AA | Ciliate-E2-Unclassified | 1-169 | 24 | 2.1e-42 | 144.89 | In-house | 100-347 (352) | Show / Hide |
Range on Protein: 1-169
Range on HMM: 100-347/352
Sequence Identity: 24% (60 aa)
MEYLSGGDIQTVLEKDHH----------------LLPAEQIR------ISSEILSALSYLHRRG-ISHRDIKPANIMFDKDL---HPKLIDFGLCREL--
|||. ||| . ..| .. .. .|.. . .||..|.|||. . | |||||| ||.||.. ..|.||||.....
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ
----------------SGHLSTICDTYTLM----APEIIKTSDYDG---TKADIWSFGVSLHILATGTYPFQYHSDSQ----------------YIKAVK
. ...|.| |. | |||... ||. |.||||.|| |. . .|.|||.. .. | ... |
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIK
TNQLC------------INIKAQGLIGIVIRECLKLDPCTRKNADELL
.... .. .|. .| .. .|| .| | .....|
QKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQIL
|
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| Pkinase | 88600.m00005.AA | Pkinase | 1-172 | 27 | 6e-41 | 145.86 | Pfam | 79-293 (293) | Show / Hide |
Range on Protein: 1-172 Range on HMM: 79-293/293 Sequence Identity: 27% (59 aa) MEYLSGG----DIQTVLE--KDHHL--LPAEQIRISSEILSALSYLHRRGISHRDIKPANIMFDKDLHP----KLIDFGLCR---ELSGHLSTICDTYTL |||. || | .... .. . . | ... .||..| |.|..|| |||.||.||..|.. |. |..||||.. . .....|.| |. MEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNSMTTFCGTPWY MAPEIIKTSDYDGTKADIWSFGVSLHILATGTYPFQYH------SDSQYIKAVKTNQLCINIKAQ---------------------GLIGIVIRECLKLD ||||.|... |.|.|.|.||.|. |.....| ||. | .. | |. .. .| .. .|. ||..| MAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKD PCTRKNADELLDL--I | | .|...| . PKKRPTAEQILQHPWF |
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| Kinase | 88600.m00005.AA | CAMK | 1-121 | 24 | 1.5e-38 | 121.35 | In-house | 136-335 (425) | Show / Hide |
Range on Protein: 1-121 Range on HMM: 136-335/425 Sequence Identity: 24% (48 aa) M---EYLSGG----DIQTVLEKDHH---------------LLPAEQIRISSEILSALSYLHRRGISHRDIKPANIMFDKD-----------------LHP | || ||| |. . . . . .| |. |.||. |.| ..| |||.|| ||..|.. MEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNI KLIDFGLCRELSGH--------------------------LSTICDTYTLMA-PEIIKT-------------SDYDGTKADIWSFGVSLHILATGTYPFQ |.||||. ... . ..| | | || ||... .|.| |.|.|| || | |. .|..||. KIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFY |
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| Kinase | 88600.m00005.AA | CAMKL | 1-120 | 39 | 1e-37 | 117.84 | In-house | 100-236 (297) | Show / Hide |
Range on Protein: 1-120 Range on HMM: 100-236/297 Sequence Identity: 39% (54 aa) MEYLSGGD--IQTVLEKDHH----LLPAEQIRISSEILSALSYLHRRGISHRDIKPANIMFDKDL--HPKLIDFGLCRELS------GH-LSTICDTYTL ||| |||. . ..| | . . | |. |.||..|.|..|| |||||| ||..|.. |.||||.. . |. |.| | .. MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPY MAPEIIKT--SDYDGTKADIWSFGVSLHILATGTYPF |||||.. .||| |.|||| || | . .|..|| MAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPF |
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| Kinase | 88600.m00005.AA | Ciliate-E2 | 1-170 | 23 | 1.5e-37 | 126.43 | In-house | 113-361 (365) | Show / Hide |
Range on Protein: 1-170
Range on HMM: 113-361/365
Sequence Identity: 23% (63 aa)
MEYLSGGDIQTVLE----KDHHLLP-------AEQIRISSEILS---------------ALSYLHRRG-ISHRDIKPANIMFDKDLHPKLIDFGLCRELS
|||..||| . .. | .| .. | ..|. .||. || ||| .. | |||||| ||.| .|.|||||.....
MEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYD
G----------------------------------HLSTICDTYTLMAPEIIKTSDYDG--------TKADIWSFGVSLHILATGTYPFQYHSDSQYIKA
||| |. |||||.. .||. .|.||||.|| |... .| .|| ..
DDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF--------QQQ
VKT------NQLCINIKAQGLIGIVIRE--------------------CLKLDPCTRKN-ADELLD
| .. ... .| .| . . . .|. || | . ....|.
IKQCKIDFPCPEWQKD-TQ-CI-Q-CKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILN
|
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| Kinase | 88600.m00005.AA | MARK | 1-120 | 42 | 7.1e-37 | 118.18 | In-house | 81-206 (262) | Show / Hide |
Range on Protein: 1-120 Range on HMM: 81-206/262 Sequence Identity: 42% (54 aa) MEYLSGGDIQTVLEKD--HHLLPAEQIRISSEILSALSYLHRRGISHRDIKPANIMFDKDL--HPKLIDFGLCREL-SGH-LSTICDTYTLMAPEIIKTS ||| |||. ... ..| | || . |.||..|.|...| |||||| ||. |.. |.||||.... .| |.| | |. |||||.. MEYASGGELYDYIKAHPNGRLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKK DYDGTKADIWSFGVSLHILATGTYPF .|||.|.|||| || | .. .|..|| PYDGPKVDIWSLGVVLYFMVCGYFPF |
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| Kinase | 88600.m00005.AA | CAMKK | 1-121 | 20 | 1.3e-31 | 97.21 | In-house | 109-327 (396) | Show / Hide |
Range on Protein: 1-121
Range on HMM: 109-327/396
Sequence Identity: 20% (45 aa)
MEYLSGGDIQTVLEKDHHLLPAE------------------QIRISSE----------------------------ILSALSYLH-RRG-----------
|||...|.|. . ... . | . .| . . .. .| ||| ..
MEYCERGQIMWWPYWKQDYQPNWPYQYTELYSNRQYQNKDFSIMSEQQSISEFINQVVKQDQYFIHEDYAWKYFRDCIKGLEYLHNYQKACSYIIIYINE
--------ISHRDIKPANIMFDKDL---HPKLIDFGLCRELSGHLSTICD--------------TYTLMAPEIIKTSD---------------YDGTKAD
| |||||| || .|.. |.|..||| . ...|. .|. . |.. |||| . ... |.| .||
FIIDHFQDIIHRDIKPQNILIDEEGCGEHVKIADFGVSHIFEGQDQTLSNCESCFQRELNKTAGTPAFMAPELCSKENQKENYNGYKYRFRFIYCGKAAD
IWSFGVSLHILATGTYPFQ
||. ||.| .. .|. ||.
IWALGVTLYCFVFGKCPFW
|
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| Kinase | 88600.m00005.AA | TKL | 1-172 | 19 | 2.5e-30 | 106.43 | In-house | 117-364 (364) | Show / Hide |
Range on Protein: 1-172
Range on HMM: 117-364/364
Sequence Identity: 19% (49 aa)
MEYLSGGDIQTVLEKDHHLLPAEQIRISSEILSALSYLHR--------RGISHRDIKPANIMFDKDLH--------------PKLIDFGLCRELSGH---
||| .||. .| . .|.. .| ....||| ..| |||.|..||. |.... .|. ||||.|..|..
MEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNM
-------------------LSTICDTYTLMAPEIIKTSDYDGTKA---------------DIWSFGVSLHILATGTYPFQ-YHSDSQY---------IKA
..|.| |. ||||... .... |. |..|||. | ..|. |.. |...... ...
NDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMV
VKTN-QLCIN---------IKAQGL---IGIVIRECLKLDPCTRKNADELLDLI
.. . .. | . . . .| . || | ...|.|. .
CDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
|
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| Kinase | 88600.m00005.AA | ULK | 1-121 | 27 | 1.3e-29 | 100.54 | In-house | 99-257 (329) | Show / Hide |
Range on Protein: 1-121
Range on HMM: 99-257/329
Sequence Identity: 27% (43 aa)
MEYLSGGDIQTVLEKDHH----------LLPAEQIRISSEILSALSYLHRRGISHRDIKPANIMFDKDL------------HPKLIDFGLCRELS-G---
||| ||| .. ..|... | | | . ||... .|| ..| ||||||.||. ... . |. |||... .. .
MEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNME
---HLSTI-----CDTYTLMAPEIIK----TSDYDGTKADIWSFGVSLHILATGTYPFQ
... | | |||.|.. .|. |.||||.|. .. . .| .||.
QQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFY
|
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| Kinase | 88600.m00005.AA | RSK | 1-126 | 36 | 6.8e-29 | 102.31 | In-house | 80-217 (278) | Show / Hide |
Range on Protein: 1-126 Range on HMM: 80-217/278 Sequence Identity: 36% (51 aa) MEYLSGGDIQTVLEKDHH---LLPAEQIRISSEILSALSYLHRRGISHRDIKPANIMFDK---DLHPKLIDFGLCRELSGH----LSTICDTYTLMAPEI |||..||. | |.| | . | . .|| .|...|| .|| |||.|| ||..| . | ||.|||.|.... . . | | | ||||. MEYCRGGELFTHLQKEKHFGCFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEM IK----TSDYDGTKADIWSFGVSLHILATGTYPFQYHSDS .| . .| .|.||.|| .. . || ||| ... LKRANQQGGHD-KACDWWSLGVLMYEMLTGCPPFQG-PND |
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| Kinase | 88600.m00005.AA | ULK | 1-121 | 27 | 2.4e-28 | 97.72 | In-house | 96-253 (324) | Show / Hide |
Range on Protein: 1-121 Range on HMM: 96-253/324 Sequence Identity: 27% (43 aa) MEYLSGGDIQTVLEKDHH---------LLPAEQIRISSEILSALSYLHRRGISHRDIKPANIMFDKDL------------HPKLIDFGLCRELSG----- ||| ||| .. ..|... | | | . |.... .|| ..| ||||||.||. .. . |. |||... . MEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQ -HLSTIC------DTYTLMAPEIIK----TSDYDGTKADIWSFGVSLHILATGTYPFQ . |.. | |||.|.. .|. |.||||.|. .. . .| |||. QMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFF |
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| Kinase | 88600.m00005.AA | S_TKc | 1-172 | 22 | 5.3e-15 | 43.05 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 1-172
Range on HMM: 1-231/231
Sequence Identity: 22% (57 aa)
M-----------------------------------------------------------------EYLSG--GDIQTVLEKDHH------LLPAEQIRI
||..| || ....| . . . . ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFY
SSEILSALSYLHRRGISHRDIKPANIMFDKDLHPKLIDFGLCRELSGHLSTICDTYTLMAPEIIKTSDYDGTKADIWSFGVSLHILATGTYPFQYHSDSQ
.|..|| |.|..|| |||.||.||..|. | |..||||.|.| .|.| | ||||.. |.. |.|.||.|. | ....| ||. . .
MYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQM
YIKAVKTNQLCINIKAQGLIGIVIRECLKLDPCTRKNADELLD---------LI
.| .. . .. || ||. || | | |.| .
MFKKIG---------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
|
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| Kinase | 88600.m00005.AA | TyrKc | 1-172 | 16 | 1.8e-07 | -101.7 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 1-172
Range on HMM: 1-280/280
Sequence Identity: 16% (47 aa)
M-----------------------------------------------------------------------------EYLSGGDIQTVLEKDHH-LLPA
|| ..|| . | | .. | ..
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMK
EQIRISSEILSALSYLHRRGISHRDIKPANIMFDKDLHPKLIDFGLCRELSGH-------LSTIC----DTYTL-----MAPEIIKTSDYDGTKADIWSF
. . .. | . .|||.... |||. |.. ..... | ||||.|.. . .. |. |||| |... . || |.|||
DLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT-TKSDVWSF
GVSLH-ILATGTYPFQY-----HSDSQYIKAVKTN-QLCINIK--------AQGLIGIVIRECLKLDPCTRKNADELLDLI
|| . |. | | |... |. ||. . . . . ....| . || | . |. ...
GVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
|
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| Kinase | 88600.m00005.AA | Pkinase_Tyr | 1-72 | 27 | 0.000636 | 13.91 | Pfam | 86-161 (270) | Show / Hide |
Range on Protein: 1-72 Range on HMM: 86-161/270 Sequence Identity: 27% (21 aa) MEYLSGGDIQTVLEK----DHHLLPAEQIRISSEILSALSYLHRRGISHRDIKPANIMFDKDLHPKLIDFGLCREL ||| .|| . | | ...| . . . .. .| ....||..... |||. |.. ..... | ||||.| . MEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI |
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| Kinase | 88600.m00005.AA | Pkinase_Tyr | 86-108 | 56 | 0.232436 | 5.23 | Pfam | 181-202 (270) | Show / Hide |
Range on Protein: 86-108 Range on HMM: 181-202/270 Sequence Identity: 56% (13 aa) MAPEIIKTSDYDGTKADIWSFGV |||| |... . || |.||||| MAPECINYGKFT-TKSDVWSFGV |
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