Gene 89263.m00074 (T.vaginalis)

89263.m00074

Species: T.vaginalis
Alias: TvagK0305, 89263.m00074
External Links:
Annotation:

Classification

Group: TKL
Family: TKL-Tvag1

Sequence

Name Sequence Type Origin Length Description Download
89263.m00074.AA Protein None 1059 None Fasta, JSON
89263.m00074.kin_dom Protein Kinase Domain None 253 None Fasta, JSON

Protein domain

Protein domains of 89263.m00074.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 89263.m00074.AA TKL 226-472 24 3.8e-78 265.92 In-house 1-364 (364) Show / Hide 
Range on Protein: 226-472
Range on HMM: 1-364/364
Sequence Identity: 24% (91 aa)

IGNGGFGTVFLGTRYS--------TGEYMAVKEIKPDKITTGGLSS-------------------------LFSEIMVMSKLKHRHVIELTGIYNRRP--
|| ||||.|. |.           ||. .||| .| .      ..|                         .  |||.||.|.| ... . |. .. |  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------YQIITRFCPGQSLFDRLHRPQGKPLTTMQKTRLAYQMAKGLEHLHSQG--------VVHRDLKTLNILLDNHDA--------------
            . |.. .||| ||...||          |. |.|...|.|...|||..        ..|||||. |||.|..                
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWC

AIIADFGLCGVITPKSK-------------------ELTGSVGTPNYTAPEVL----------------GHKKYNELVDVYSYGVILWEMATNLIPFR--
. |.||||. .......                    .   .|||.. |||||                ....|.| .||||.|..|||..|  .|..  
CKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDY

-EKTQA------EIIDHVVHRGLRLKIP------------KNITDGLRRLIVNCWAANPSERPQFKEIVKLF
 . ..       |..  |...|||. ||            ... .....|.  ||...|..|| |.||.| .
PYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Pkinase 89263.m00074.AA Pkinase 220-472 27 8.1e-71 246.38 Pfam 1-293 (293) Show / Hide 
Range on Protein: 220-472
Range on HMM: 1-293/293
Sequence Identity: 27% (81 aa)

MKIETKIGNGGFGTVFLGTRYSTGEYMAVKEIKPDKITTGGLSSLFS--EIMVMSKLKHRHVIELTGIY--NRRPYQIITRFCPGQ----SLFDRLHRPQ
 .|. ||| |.||.|..... .||.  |||.|| ...  . . ...   || .| .|.| ....| ...  ....| ... .|.|     .|||.... .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIY-MVMEYCEGGLYVMDLFDYISTWR

GKPL--TTMQKTRLAYQMAKGLEHLHSQGVVHRDLKTLNILLDNHDAA----IIADFGLCGVI-TPKSKELTGSVGTPNYTAPEVLG-HKKYNELVDVYS
....  .  .  . .||...|||..||.|..|||||  |||.||..       |.||||. .. . ..  .|. .|||.| ||||.  ...|   ||..|
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

YGVILWEMATNLIPFREK------TQAEIIDHVVHRGLRLKIPKNIT-------------------DGLRRLIVNCWAANPSERPQFKEIVKL--F
.|.||.||..   ||...      .| ..|. . .. |.  .|. ..                   . .. .| .|.. .|..|| ...|..   |
CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 89263.m00074.AA MLK 220-472 27 1.6e-64 220.64 In-house 1-291 (291) Show / Hide 
Range on Protein: 220-472
Range on HMM: 1-291/291
Sequence Identity: 27% (82 aa)

MKIETKIGNGGFGTVFLGTRYSTGE----YMAVKEIKPDKITTGGLS-----SLFSEIMVMSKLKHRH----VIELTGIYNRRPYQ--IITRFCPGQSLF
 .....||.|.|| |..| |.   .      |||... ...   . .      .  |..  ..|.|.     .|.. |. .. |..  |.. .|.| ||.
IQFHEWIGSGSFGKVWKG-RWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLY

DRLHRPQGKPL------------TTMQKTRLAYQMAKGLEHLHSQG---VVHRDLKTLNILLDN------HDAAIIADFGLCGVITPKSKE-LTGSVGTP
. ||  ..|.             .  .. . |.|.|.|.. |||.    ..|||||  |||.|.      |. . |.|||.   .. .  .  ..  ||.
NVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTY

NYTAPEVL---GHKKYNELVDVYSYGVILWEMATNLIPFR-EKTQAEIIDHVVHRGLRLKIPKNITDGLRRLIVNCWAANPSERPQFKEIVKLF
 . ||||.    . ||.| .||.|.||.|||| |  .|.. .  ...|.  |.. |||. ||... ... .|. .|| ..|..|| |..||. .
AWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase 89263.m00074.AA S_TKc 220-472 27 1.1e-63 218.86 SMART 1-231 (231) Show / Hide 
Range on Protein: 220-472
Range on HMM: 1-231/231
Sequence Identity: 27% (74 aa)

MKIETKIGNGGFGTVFLGTRYSTGEYMAVKEIKPDKITTGGLSSLFSEIMVMSKLKHRHVIELTGIYNRRPYQIITRFCPG--QSLFDRLHRPQG----K
 .|  ||| |.||.|....  .||...|.|.||          .. .|| ...| .| ... | ...    . ... .|.|   .|||.... ..    .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

PLTTMQKTRLAYQMAKGLEHLHSQGVVHRDLKTLNILLDNHDAAIIADFGLCGVITPKSKELTGSVGTPNYTAPEVLGHKKYNE-LVDVYSYGVILWEMA
|..  .  ...||....||..||.|..|||||  |||||.     |.||||. ..       |  .|||.| |||||   .|.   .|..| |.||.||.
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML

TNLIPFREKTQAEIIDHVVHRGLRLKIPKNITDGLRRLIVNCWAANPSERPQFKEIVK---------LF
.   ||.  ..........            .. .. .| .|.  .|..||   |. .          |
CGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 89263.m00074.AA TKL-Unique 222-472 29 3.6e-60 206.2 In-house 1-290 (290) Show / Hide 
Range on Protein: 222-472
Range on HMM: 1-290/290
Sequence Identity: 29% (87 aa)

IETKIGNGGFGTVFLGTRYSTGEYMAVKEIKP-DKITTGGLSSLFSEIMVMSKLK-HRHVIELTGIYN----RRP-YQIITRFCPGQSLFDRLHR-----
.  ||| ||.|.|. |.    |.  |.| ..|  ..    .  . .|. .|.||. |  .  . |.        | . |.. .||| || | ||.     
FWNKIGEGGYGQVYKGKW--RGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNN

---PQGKPLTTMQKTRLAYQMAKGLEHLHSQG--VVHRDLKTLNILLDNH-----DAAIIADFGLCGVITPKSKELTG---------SVGTPNYTAPEVL
   .. ..|.  |. ..| ..|.|...||. .  . |||||..|.|.||.       . |.||||. . .  .|. ..          .|.... |||||
NNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVL

GH--KKYNELVDVYSYGVILWEMATNLI------PFREKTQAEIIDHVVH--RGLRLKIPKNITDGLRRLIVNCWAANPSERPQFKEIVKLF
    ..|.| .||||.|..|||.||. |      |... .| ...  |    ...|..|| ..   .| ||  ||. .||.|| | ||..  
RMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase 89263.m00074.AA Pkinase_Tyr 220-472 27 1e-59 202.89 Pfam 1-270 (270) Show / Hide 
Range on Protein: 220-472
Range on HMM: 1-270/270
Sequence Identity: 27% (76 aa)

MKIETKIGNGGFGTVFLGTRY----STGEYMAVKEIKPDKITTGG---LSSLFSEIMVMSKL-KHRHVIELTGIYN--RRP--YQIITRFCPGQSLFDRL
 ..  |.| | ||.|..|| .    .|.   ||| .|.   ..     . ....|. .|..| .| ... | |.    ..|  . |.. ..|. .| | |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE--GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

HRP--QGKPLTTMQKTRLAYQMAKGLEHLHSQGVVHRDLKTLNILLDNHDAAIIADFGLCGVITPKSKE---LTGSVGTPNYTAPEVLGHKKYNELVDVY
...  ...|||. ..   ..| |||.|.|.|.. .|||| . |.|...   . |.||||.  |....      .|.      .|||.. ..|...  ||.
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVW

SYGVILWEMAT-NLIP-FREKTQAEIIDHVVHRGLRLKIPKNITDGLRRLIVNCWAANPSERPQFKEIVKLF
|.|| .||. |   .| . . . .|.....  .| |...|.| .| . .|.  ||...|..|| |.||.  .
SFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase 89263.m00074.AA Dicty4 220-474 29 1.2e-57 190.85 In-house 1-277 (277) Show / Hide 
Range on Protein: 220-474
Range on HMM: 1-277/277
Sequence Identity: 29% (83 aa)

MKIETKIGNGGFGTVFLGTRYSTGEYMAVKEIKPDKIT--TGGLSSLFSEIMVMSKLKHRHVIELTGIYN---RRP--YQIITRFCPGQSLFDRLHR---
 .|| .|| |.||.|..||    |   |||  . ....     |...  |.  |.|. | ... . |  .     |   .| | ..|  .|.  ||    
INIEQRIGKGSFGEVYKGT--WRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPS

----PQGKPLTTMQK-TRLAYQMAKGLEHLHS--QGVVHRDLKTLNILLDNHDAAIIADFGLCGVITPKS--KE-LTGSVGTPNYTAPEVLGHKKYNELV
       ...... .  |.|   |.|. .||.    ..|||||. |.| | .  . ..||||  .. . .  |  ... .||| ..||||. |. ||| .
EQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKA

DVYSYGVILWEMATNLIPFR--EKTQAEIIDHVVHRGLRLKIPKNITDGLRRLIVNCWAANPSERPQFKEIVKL--FET
||||.| .|||..|  .|.    .   .... |.  .||..||..  . ...||. ||  .|. || |.||..    |.
DVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase 89263.m00074.AA TyrKc 220-472 26 1.6e-53 185.0 SMART 1-280 (280) Show / Hide 
Range on Protein: 220-472
Range on HMM: 1-280/280
Sequence Identity: 26% (78 aa)

MKIETKIGNGGFGTVFLGTRYSTGEYMAVKEIKPDKITTGGLSSLFSEIMVMSKL--KHRHVIELTGIYNR--------RPYQIITRFCPGQSLFDRLHR
 . . |.|.| ||.|..|| .   .  ||| .|.|.     .  . .|. .|.||  .| ... | |.            |. |.. ..|. .| |.|..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

PQGKPLTTMQKTRLAYQMAKGLEHLHSQGVVHRDLKTLNILLDNHDAAIIADFGLCGVITPK------SKELTGSV--GTP-----NYTAPEVLGHKKYN
...| |.. ..   ..| |.| |.|||....|||| . |.|...   . |.||||.  |. .      ..  . .   |.        .|||.. ..|..
HRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

ELVDVYSYGVILWEMATN-LIPFRE-----KTQAEIIDHVVHRGLRLKIPKN--------ITDGLRRLIVNCWAANPSERPQFKEIVKLF
.  ||.|.|| .||. |.   |  .     .. .|.| .|  .| |...|.|         .| . ...  ||...|..|| |.||...|
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVK-QGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 89263.m00074.AA TK 220-472 15 6e-52 172.03 In-house 1-486 (486) Show / Hide 
Range on Protein: 220-472
Range on HMM: 1-486/486
Sequence Identity: 15% (75 aa)

MKIETKIGNGGFG---TVFLGTRYSTG-------------------------EYMAVKEIKPDKITTGGLSSL---------------FSEIMVMS--KL
 ... |.| | ||   .|..|. .. .                         .  ||| .|..  ..     .                .|...|.  ..
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

KHRHVIELTG-IYNR------------RPYQIITRFCPGQS----LFDRLH--RPQGKP-----------------------------------------
.| ... | | .               .|. |.. ..|. .    | | |.  || ...                                         
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LTTMQKTRLAYQMAKGLEHLHSQ------GVVHRDLKTLNILLDNHDA-----------AIIADFG---
                               ||. |.   ..| |.|.|.|||.      ..||||| . |.|.....            . |||||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LCGVITP-KSKELTGSVGTPN-------------------------YTAPEVLG---------HKKYNELVDVYSYGVILWEMATNL-IPFRE-K
     |.  | . .    ..| ||.                          ..|||.|          ..|. .  ||.|.|| .||. |.   |. .  
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

TQ---------AEIIDHVVHR-------------GLRLKIPKNIT--------------DGLRRLIVNCWAANPSERPQFKEIVKLF
.          .|......               ..|.. |.. .              . . .|.  ||...|..|| |..... .
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase 89263.m00074.AA LRRK 267-474 31 1.1e-47 164.76 In-house 107-351 (351) Show / Hide 
Range on Protein: 267-474
Range on HMM: 107-351/351
Sequence Identity: 31% (78 aa)

EIMVMSKLKHRHVIELTGIYNRRPYQIITRFCPGQSLFDRLHRPQGKP-------LTTMQKTRLAYQMAKGLEHLHSQG--VVHRDLKTLNILLDNHD--
|. .||.|.| ... | |.   .|. ... . |  .| ..|| ..  .       .. | | ..|.| |||.|.|||.   ..|||||. ||||  ..  
EVWIMSHLNHPNIVSLKGF-CIHPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILLWSSPQN

-------AAI---IADFGLCGVITPKSKE-LTGSVGTPNYTAPEVLG---HKKYNELVDVYSYGVILWEMATNL-IPFREKT-Q-----AEIIDHVVHRG
       |..   |||||. .. ..  .. . |.||.| . |||...    . |.| ||.||.|.||||  | . .||.| .        |.|   . .|
HSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIEDKIIEG

LRLKIPKN-ITD-----GLRRLIVNCWAANPSERPQFKEIVKLFET
|| .|| .  .       .  ||. ||...| .|| | .|||  ..
LRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase 89263.m00074.AA CAMK 225-470 18 1.8e-46 147.32 In-house 1-421 (425) Show / Hide 
Range on Protein: 225-470
Range on HMM: 1-421/425
Sequence Identity: 18% (76 aa)

KIGNGGFGTVFLGTRYSTG------------EYMAVKEIKPDKIT--------------------------TGGLSSLFSEIMVMSK-------LKHRHV
..| |.||.|.|... .|.            .  |.| |. .|..                             . ....|| .|.|       |.|...
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IELTGIYN--------------------RRPYQIIT---RFCPGQ----SLFDRLHRPQG-------------KPLTTMQKTRLAYQMAKGLEHLHSQGV
| |  .|                     .. . ...    .|.|      |||.. .  .             . .|  .  |.  |.. .....||...
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VHRDLKTLNILLDNHD----------------A-AIIADFGLCGVITPK-----------------------SKELTGSVGTPNYTA-PEVLGHKK----
||||||  |||||...                .   |.|||.  ...|.                        . .. ..||| | | ||||  |.    
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

----------YNELVDVYSYGVILWEMATNLIPFREKTQAEIID------------HVVHRGLRLKIPKN---------------ITDG--------LRR
          |.. .|. | ||||  | .   ||..... ||..            . . .|    .|.                |.|          . 
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LIVNCWAANPSERPQFKEIVK
|| ..   .|..|.  ... .
LIRKMLQVDPEKRMTIEQCLN
Kinase 89263.m00074.AA RAF 220-474 25 2.2e-46 148.26 In-house 1-282 (282) Show / Hide 
Range on Protein: 220-474
Range on HMM: 1-282/282
Sequence Identity: 25% (72 aa)

MKIETKIGNGGFGTVFLGTRYSTGEYMAVKEIKPDKITTGGLSS---LFSEIMVMSKLKHRHVIELTGIYNRRP---YQIITRFCPGQSLFDRLHRPQG-
... |.|| | ||||. |  . .    ||| ..  . |   .        |. |. |  | ...   |   .     | |.| .| . ||. ..|  .  
VMVMTRIGSGSFGTVYRGHWHGD---VAVKMLNVNDPTPEQMQADVFFKNEVAVYKKTRHCNILLFMGYMSKPQTNTYAIVTQWCEHSSLYHHIHVQETR

KPLTTMQKTRLAYQMAKGLEHLHSQGVVHRDLKTLNILLDNHDAAIIADFGLCGVITPKS----KELTGSVGTPNYTAPEVLG--------------HKK
. .  ..    . |...|.. ||.  ..|||||. ||.|..     | ||||  | |  |    ...    .   . |||| .              .  
EKFDMHWLIDISRQVCQGMDYLHAKNIIHRDLKSNNIFLHEDMTVKIGDFGLMTVKTRWSPRGNQQFEQPTHWILWMAPEVIRNLMIDWRGDVLMQDENP

YNELVDVYSYGVILWEMATNLIPF-REKTQAEIIDHVVHRGLRL----KIPKNITDGLRRLIVNCWAANPSERPQFKEIVKLFET
|    ||||.|....|. |. .|.  .  . . |   . ||. .    |. ...   ..||. .||. .. ||| |..|.|  . 
YSFQSDVYSFGIVMYELMTRHMPYGCHIWNRDQIIFMCGRGYLRPDLSKVRQDCPKAMHRLMEDCWKFQREERPLFQQILKRITV
Kinase 89263.m00074.AA Ciliate-E2 220-470 19 4.9e-44 149.05 In-house 1-361 (365) Show / Hide 
Range on Protein: 220-470
Range on HMM: 1-361/365
Sequence Identity: 19% (74 aa)

MKIETKIGNGGFGTVFLGTRYSTGEYMAVKEIKPDK-------------------ITTGGLSSLFSEIMVM----------------SKLKHRHVIELTG
 |.  |||.|.||.|..........  | | |. .|                   .   .. ....|| .|                ..|.| ..|..  
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

IY---NRRPYQIITRFCPGQSLFDRLH-----------RPQGKPLTTMQKTRLAYQMAK---------------GLEHLHSQG-VVHRDLKTLNILLDNH
 .   ..  . ... .| |..|||..              . |..|  .  .. .| ..               .||.|||.. ..|||.|  |||.   
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEK-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---

DAAIIADFGLCGVITPK---------SKELTGSV-----------------------GTPNYTAPEVLGHKK---------YNELVDVYSYGVILWEMAT
    |.||||.  ....         .|...                          |||.| |||.|. ||         |.. .|..| |||| || .
--IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF

NLIPFREKTQAEIID-------------HVVHRGLRLK--IPKNITDGLRRLIVN----CWAANPSERPQ-FKEIVK
.  ||    | .|..             .     . .|  ..|....    || .    .   .|..|.. ...| .
GKPPF----QQQIKQCKIDFPCPEWQKDTQ-CI-Q-CKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILN
Kinase 89263.m00074.AA STE 220-463 22 2.1e-43 150.49 In-house 1-346 (359) Show / Hide 
Range on Protein: 220-463
Range on HMM: 1-346/359
Sequence Identity: 22% (78 aa)

MKIETKIGNGGFGTVFLGTRYS---------------TGEYMAVKEIKPDKITT---------------GGLSSLFSEIMVMSKLK--HRHVIELTGIYN
 ..  |||.|.||||... .                 |||.||.|... .. ..                 . ..  || .|.|..  | ....  | | 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

RRP--------YQIITRFCPGQSLFDRLHR--PQGKPLT----------TMQKTRLAYQMAKG-LEHLHSQGVVHRDLKTLNILLDNHDAAIIADFGLCG
.            |.  ...| || | ...    ||||.            |  . ..|  || |..|||....|||.|  ||||     . ..|||.||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

VITPK----------------SKELTGSVGTPNYTAPEVLGH------KKYNELVDVYSYGVILWEMATNLIPFREKTQA----EIIDH-VVHR------
 .|..                ... .  |||| . ||||.        |.|.. .|..| |  ..||||   |. . .      .|..  ....      
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

---GLRLKIPK-------------------NITDGLRRLIVNCWAANPSERP
   |   ..|                    . .. ..  | .|   .|..||
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRP
Kinase 89263.m00074.AA LRRK 220-235 58 0.000421 10.39 In-house 1-17 (351) Show / Hide 
Range on Protein: 220-235
Range on HMM: 1-17/351
Sequence Identity: 58% (10 aa)

MKIETKIGNGGFG-TVF
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LKIEEQIGRGGFGTFVY