Gene 93835.m00220 (T.vaginalis)
93835.m00220
Species: T.vaginalis
Alias: TvagK0109, 93835.m00220
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| 93835.m00220.AA | Protein | None | 328 | None | Fasta, JSON |
| 93835.m00220.kin_dom | Protein Kinase Domain | None | 200 | None | Fasta, JSON |
Protein domains of 93835.m00220.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 93835.m00220.AA | CAMKL | 12-211 | 35 | 8.6e-76 | 241.32 | In-house | 67-297 (297) | Show / Hide |
Range on Protein: 12-211 Range on HMM: 67-297/297 Sequence Identity: 35% (82 aa) QKFD---NPFISQLFEVIDSKDY------ICLVLEYCSNGN--LVKAISER----GKFNEEDAATVFTQLLLAVNYLHNSCQVIHRNIRCENIMFDSHR- .... | | .|.|||. ... |.||.||||.|. | | .. |.. |..| |.|.. ||||.|. . ..|| | |||..|.. KMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHG-IVHRDIKPENILLDENGN -NIKLSEFGYCQHLEK-----EAVSITHYGSPAYIAPEVIQG--KPYS-FASDVWSCGIVLYAMVCGHLPFYDV--------DLSTFTHKILYMDITFPI |||.. || . . .. . |. |||.| |||..|| ||| .. |.||||..|||||||.||| | . .. .|| .|| NNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPI HLSI-GIKDLLKKMLAKNPAHRIKAADIFKHPFL .... .||..||| .|| .|... .| .||.. WYHVSDCRDLIRKMLQVNPEKRPTIHQIMNHPWM |
|||||||||
| Kinase | 93835.m00220.AA | CAMK | 13-211 | 22 | 4.4e-75 | 241.2 | In-house | 94-425 (425) | Show / Hide |
Range on Protein: 13-211 Range on HMM: 94-425/425 Sequence Identity: 22% (75 aa) KFDNPFISQLFEVIDS-------------------KDYICLVL---EYCSNG----NLVKAISER---------------GKFNEEDAATVFTQLLLAVN | | | | .|.||... ......|. ||||.| | | |. |.|.|..|...| |.. ||. KLDHPNIIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVH YLHNSCQVIHRNIRCENIMFDSH-----------------RNIKLSEFGYCQHLEKEAVSI------------------------THYGSPAYIA-PEVI |.|. ..|| . .|||..|.. |||.. || ..... . | |.|.|.| |||. YCHSHN-IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVL QG--------------KPYSFASDVWSCGIVLYAMVCGHLPFYDV-------------DLSTFTHKILYMDITFPIH----------------------- .| ..|....|.||||..||.|.||..|||. ... .||. . .|| . NGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHH -LSIGIKDLLKKMLAKNPAHRIKAADIFKHPFL .| |||..||| ..| .|...... .||.. FVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM |
|||||||||
| Kinase | 93835.m00220.AA | MARK | 12-211 | 37 | 5.6e-69 | 224.64 | In-house | 54-262 (262) | Show / Hide |
Range on Protein: 12-211 Range on HMM: 54-262/262 Sequence Identity: 37% (78 aa) QKFDNPFISQLFEVID--SKDY-ICLVLEYCSNGNLVKAISER--GKFNEEDAATVFTQLLLAVNYLHNSCQVIHRNIRCENIMFDSHR--NIKLSEFGY .| | | | .||.||. . |.|..||.|.|.| | .. |. ||.| . |.|.. ||||.|. ..|| | .|||. |... |||.. ||. KKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGRLHEEEARRIFRQIVSAVNYCHSKN-IVHRDIKPENILIDENGNHNIKIIDFGF CQHLEKEAVSITHYGSPAYIAPEVIQGKPYS-FASDVWSCGIVLYAMVCGHLPFY--DVDLSTFTHKILYMDITFPIHLSIGIKDLLKKMLAKNPAHRIK . . . . |. |.|.| |||....||| .. |.||.|.|||.||||..|| ..|. . ||| . ..| |.| ....|....| || |.. SICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMVCGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPT AADIFKHPFL . .| |||.. IEEIMKHPWM |
|||||||||
| Kinase | 93835.m00220.AA | AMPK | 17-211 | 40 | 7.9e-67 | 197.45 | In-house | 59-254 (254) | Show / Hide |
Range on Protein: 17-211 Range on HMM: 59-254/254 Sequence Identity: 40% (79 aa) PFISQLFEVI-DSKDYICLVLEYCSNGNLVKAISERGKFNEEDAATVFTQLLLAVNYLHNSCQVIHRNIRCENIMFDSHRNIKLSEFGYCQHLEKEAVSI | |.||.||| .... | .|.|| |.| | | .|. .|..|. .| | . .| |.|. . || ||. .| . |||. || .. PHIIQLYEVIIETPTDIFMVMEYVSGGELFDYIVKHGRLQEREACRFFQQIISGVEYCHR-HMIVHRDLKPENLLLDHNKNIKIVDFGLSNMMKDGEFLK THYGSPAYIAPEVIQGKPY-SFASDVWSCGIVLYAMVCGHLPFYDVDLSTFTHKILYMDITFPIHLSIGIKDLLKKMLAKNPAHRIKAADIFKHPFL | ||| | |||.|.||.| . |.||||..||||.|| ||| | . .| ||. . . | .|| .|||.|.|| ..| ||. || .||.. TACGSPCYAAPEMISGKLYCGPEVDIWSCGVILYAMLCGYLPFDDENTPTLYKKIKNGEYYIPKFLSPEAKDLIKHMLQVDPMKRITIHDIRNHPWF |
|||||||||
| Kinase | 93835.m00220.AA | AGC | 15-211 | 22 | 5.5e-64 | 163.35 | In-house | 88-395 (395) | Show / Hide |
Range on Protein: 15-211 Range on HMM: 88-395/395 Sequence Identity: 22% (71 aa) DNPFISQ-LFEVIDSKDY--ICLVLEYCS---------NG-NLVKAIS---ERGKFNEEDAATVFTQ-------LLLAVNYLHNSCQVIHRN-IRCENIM ..||| . |. .||. ...|.||.. | | . .|.|.|| | . . ..||. |||. .||| . |||. HHPFIVKILHYSFQDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENIL FDSHRNIKLSEFGYCQHLEKE-------------------------------------------------AVSITH--YG--SPAYIAPEVIQGKPYSFA .|.. .|||. || | . .. |. | .| |.|||.. |..| LDEDGHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKA SDVWS--CGIVLYAMVCGHLPFYDVDLS----------TFTHKIL------YMDITFP----------IHLSIGIKDLLKKMLAKNPAHRIK-------- | || |...| |..|. |||. . .||. ...|| ..| |||.||.| |.|..|. CDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGD --AADIFKHPFL | .| .||. KGAEEIKNHPWF |
|||||||||
| Kinase | 93835.m00220.AA | Ciliate-E2 | 15-211 | 24 | 5.7e-60 | 204.54 | In-house | 90-365 (365) | Show / Hide |
Range on Protein: 15-211 Range on HMM: 90-365/365 Sequence Identity: 24% (72 aa) DNPFISQLFEVID--SKDYICLVLEYCSNGNLVKAISER-----------GKFNEEDAATVFTQLLL---------------AVNYLHNSCQVIHRNIRC ..|.| ...|. ....| ||.|||. |.| . | .. ..|.|. ......|.| |..|||. .|||.| NHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKP ENIMFDSHRNIKLSEFGYCQHLEKEAVSITH--------------------------------YGSPAYIAPEVIQGKP---------YSFASDVWSCGI |||.| ||.. ||... . .. .|| .|.| | |||...||. |....|.||.|. ENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGV VLYAMVCGHLPFYDVDLSTFTHKILYMDITFP------------------IHLSIGIKDLLKK----MLAKNPAHRIK-AADIFKHPFL .|| |..| .|| .|. .| || ..| |||.|| || |.| || . .|..||.. ILYEMLFGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF |
|||||||||
| Kinase | 93835.m00220.AA | Ciliate-E2-Unclassified | 10-211 | 28 | 1.7e-56 | 194.02 | In-house | 64-352 (352) | Show / Hide |
Range on Protein: 10-211 Range on HMM: 64-352/352 Sequence Identity: 28% (81 aa) VR----------QKFDNPFISQLFEVIDSKDYICLVLEYCSNGNLVKAISERGK-----------------FNEEDAA-----TVFTQLLLAVNYLHNSC .| . ...||| .|.. .|..|..|.||| .|.| . |..|.| | |. |. . | |.|.. .||| . QRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKN QVIHRNIRCENIMFDSHR---NIKLSEFGYCQHLE----------------KEAVSITHYGSPAYI----APEVIQGKPYS----FASDVWSCGIVLYAM .|||.| .|||.||. .||.. || . ... |. . | |.| |. ||||.||. |. ...|.||.|..||.| NIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEM VCGHLPFYDVDLST----------------FTHKILYMDITFP--------IHLSIGIKDLLK----KMLAKNPAHRIKAADIFKHPFL . | .|||| . . .|. .| || |.| ||... ||| ||| || . .|..||.. LFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF |
|||||||||
| Kinase | 93835.m00220.AA | QIK | 17-211 | 31 | 3.5e-55 | 189.63 | In-house | 58-272 (272) | Show / Hide |
Range on Protein: 17-211 Range on HMM: 58-272/272 Sequence Identity: 31% (68 aa) PFISQLFEVIDSKDYICLVLEYCSNGNLVKAISERGK--------------------FNEEDAATVFTQLLLAVNYLHNSCQVIHRNIRCENIMFDSHRN |.| |..|. ..|.. .| |||||| . .. . |. .|..|. .|.|...|| |.|. ...|| . |||..|. | PHIIKLYQVMETDDMMYIVTEYCSNGEMFDYLCKHGRKGVKMVNSPDIGDQVLMGVPMAENEARRWFWQICSAVHYCHKR-NIVHRDLKAENILLDNNMN IKLSEFGYCQHLEKEAVSITHYGSPAYIAPEVIQGKPYS-FASDVWSCGIVLYAMVCGHLPFYDVDLSTFTHKILYMDITFPIHLSIGIKDLLKKMLAKN ||. ||. . .... | |||.| |||. .|| | .|.|| |.|||..||| ||| . | . ...| | .| . .| ..|| . IKIADFGFSNWFKQGQLLMTWCGSPPYAAPEMFEGKEYDGPKVDIWSMGVVLYVLVCGALPFDGKTLQNLRQRVLSGKFRIPFFMSQDCEHLIRHMLVVD PAHRIKAADIFKHPFL |.||. . | .|. . PEHRYTIMQICQHRWM |
|||||||||
| Kinase | 93835.m00220.AA | Pkinase | 17-211 | 29 | 1.5e-52 | 185.73 | Pfam | 60-293 (293) | Show / Hide |
Range on Protein: 17-211
Range on HMM: 60-293/293
Sequence Identity: 29% (69 aa)
PFISQLFEVIDSKDYICLVLEYCSNG----NLVKAIS--ERGKF--NEEDAATVFTQLLLAVNYLHNSCQVIHRNIRCENIMFDSHRNI----KLSEFGY
|.| .|... .||.|..|.||| .| | || ..|.| |... ...|.| ...|.|. . .||| . |||..|.. .| |.. ||
PNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILIDNNGHIDACVKICDFGL
CQHL-EKEAVSITHY-GSPAYIAPEVIQ-GKPYSFASDVWSCGIVLYAMVCGHLPFYDV------DLSTFTHKILYMDITFPIHLS--------------
. .. . . |.. |.| |.|||||. |..|. ..|.||||..|| |.||..||.. | .|.. .. |.. .
AKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFH
-------IGIKDLLKKMLAKNPAHRIKAADIFKHPFL
||..|..|.|.|. |. |..|..||..
WTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
|
|||||||||
| Kinase | 93835.m00220.AA | TSSK | 15-211 | 35 | 1.3e-51 | 167.61 | In-house | 74-289 (289) | Show / Hide |
Range on Protein: 15-211 Range on HMM: 74-289/289 Sequence Identity: 35% (76 aa) DNPFISQLFEVIDSKD-YICLVLEYCSNGNLVKAISER------GKFNEEDAATVFTQLLLAVNYLHNSCQVIHRNIRCENIMFDSHRNIKLSEFGYCQH ..|.| |..| ... . |..|.||...| | | .| | ||.| ..| |. || |.| |. | || . |||| | |.||||. || KHPNIIQFYEMFETCQGKIYMVMEYAEHGDLLEYIQRRTQERCCGALHEEQARKWFRQMVSAVKYCH-SHNVVHRDLKCENILLDKHWNIKLTDFGFARY LEKEA------VSITHYGSPAYIAPEVIQGKPYS-FASDVWSCGIVLYAMVCGHLPFYD--VDLSTFTHKILYMDITFPI----HLSIGIKDLLKKMLAK ... . | | || || |||...|.||. ...||||.|..||.||||..|| | .. . . . ..||. ..| |||...||. WPRDDPGRCCHLSKTFCGSYAYAAPEILRGIPYDPKWYDVWSMGVILYIMVCGCMPFDDDKSNIHKMLWQQQEHKVCFPKPHSCWISQECKDLIRHMLQP NPAHRIKAADIFKHPFL .| |... .| .|. . HPCNRPHINEICHHCWM |
|||||||||
| S_TKc | 93835.m00220.AA | S_TKc | 1-211 | 26 | 5.8e-48 | 166.57 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 1-211 Range on HMM: 1-231/231 Sequence Identity: 26% (68 aa) MDIIKN----------------------------------DLWVRQKFDNPFISQLFEVIDSKDYICLVLEYCSN--GNLVKAISERGK------FNEED .|.. .. . . |.| .|..|... |....|.|||.. |.| . | .||. |.| . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKK---HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-H AATVFTQLLLAVNYLHNSCQVIHRNIRCENIMFDSHRNIKLSEFGYCQHLEKEAVSITHYGSPAYIAPEVIQGKPYSF-ASDVWSCGIVLYAMVCGHLPF |. .. |...|..|.|. ..||| . |||..|. .||.. || . .| | |.| |.||||. .|.. ..|.||||..|| |.|| || ARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPF YDVDLSTFTHKILYMDITFPIHLSIGIKDLLKKMLAKNPAHRIKAADIFK-------HPFL . .. . .||. | ||...|.| |.|..|. | .... ||.. P--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
|||||||||
| Kinase | 93835.m00220.AA | MELK | 19-211 | 37 | 2.3e-47 | 159.76 | In-house | 59-254 (254) | Show / Hide |
Range on Protein: 19-211 Range on HMM: 59-254/254 Sequence Identity: 37% (74 aa) ISQLFEVIDSKDYICLVLEYCSNGNLVKAISERGKFNEEDAATVFTQLLLAVNYLHNSCQVIHRNIRCENIMFDSHRNIKLSEFGYCQHLEKEAVSI--- | ||. .|. .| | .|.|||. |.. | .. ...||.. .| |.. |. |.| | ||... ||..|| . ..|| .|| | . ICQLYHYIETEDKIFMVMEYCPGGEMFDYIIRQDRLEEEETRHFFRQIVSAIAYVH-SQGYAHRDLKPENLLFDEDHHLKLIDFGLCAKTKGRKDYHNLQ THYGSPAYIAPEVIQGKPYSFA-SDVWSCGIVLYAMVCGHLPFYDVDLSTFTHKILYMDITFPIHLSIGIKDLLKKMLAKNPAHRIKAADIFKHPFL | ||||| |||.|||| | . |||| ||.||...|| ||| | .. . .||. | .|| |.||..|| .| .||. .. .||.. TCCGSPAYAAPELIQGKQYIGSEADVWSMGILLYVLMCGFLPFDDDNMMIMYKKIMSGCYEEPKWLSPESKQLLRHMLQVDPKKRISMKNLLNHPWV |
|||||||||
| TyrKc | 93835.m00220.AA | TyrKc | 3-211 | 15 | 1.3e-10 | -50.96 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 3-211 Range on HMM: 1-280/280 Sequence Identity: 15% (43 aa) IIKNDL---------------------WVR--------------QKF--DNPFISQLFEVIDSK-------DYICLVLEYCSNGNLVKAISERGK-FNEE | ... .. |. ..| | .|. |. .. . ...|.||...|.| . . .... .. . ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMK DAATVFTQLLLAVNYLHNSCQVIHRNIRCENIMFDSHRNIKLSEFGYCQHLEKE------AVSITH-Y--GSP-----AYIAPEVIQGKPYSFASDVWSC | .| .||| | ..||| . . |.. .. . .| | || . .. . ... |. |||.|. . ....||||| DLLSFCWQIACGMEYLH-SKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSF GIVLY-AMVCGHLPFYD-----VDLSTFTHKILYMDITFPIHL---------SIGIKDLLKKMLAKNPAHRIKAADIFKHPFL |.... . | | .. .. . ... . . . . . .. |. . .|. | ..| | .. GVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF |
|||||||||
| Kinase | 93835.m00220.AA | Pkinase_Tyr | 125-169 | 27 | 0.000345 | 14.81 | Pfam | 182-228 (270) | Show / Hide |
Range on Protein: 125-169 Range on HMM: 182-228/270 Sequence Identity: 27% (13 aa) APEVIQGKPYSFASDVWSCGIVLYAMVC-GHLP-FYDVDLSTFTHKI |||.|. . .. .||||| |.... .. | | ..... . . ..| APECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYI |
|||||||||
| Kinase | 93835.m00220.AA | Pkinase_Tyr | 31-103 | 22 | 0.028247 | 8.33 | Pfam | 81-156 (270) | Show / Hide |
Range on Protein: 31-103 Range on HMM: 81-156/270 Sequence Identity: 22% (17 aa) YICLVLEYCSNGNLVKAISE----RGKFNEEDAATVFTQLLLAVNYLHNSCQVIHRNIRCENIMFDSHRNIKLSEFG .|..|.||. .|.| . . ..... .| .| . .||.. ||| ... |.. .. . .| . || QIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN-CIHRDLAARNCLVTENNVVKICDFG |
|||||||||