Gene 83211.m00083 (T.vaginalis)

83211.m00083

Species: T.vaginalis
Alias: 83211.m00083, TvagK0787
External Links:
Annotation:

Classification

Group: PKL
Family: PIK
Subfamily: FRAP

Sequence

Name Sequence Type Origin Length Description Download
83211.m00083.AA Protein None 2146 None Fasta, JSON
83211.m00083.kin_dom Protein Kinase Domain None 282 None Fasta, JSON

Protein domain

Protein domains of 83211.m00083.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
HEAT 83211.m00083.AA HEAT 191-221 32 0.015849 12.61 Pfam 1-31 (31) Show / Hide 
Range on Protein: 191-221
Range on HMM: 1-31/31
Sequence Identity: 32% (10 aa)

TQSLLLRALHEPDKAVQKAASQALGSFLSIS
  ..||..|. ||  |..|| ..||......
ILPHLLKCLNDPDWEVREAACWCLGQLCEHC
HEAT 83211.m00083.AA HEAT 527-553 25 0.001641 16.02 Pfam 1-27 (31) Show / Hide 
Range on Protein: 527-553
Range on HMM: 1-27/31
Sequence Identity: 25% (7 aa)

LIQPLFALLHDANAAVRKTALQKLSSI
....|. .|.| .. ||..|.. |...
ILPHLLKCLNDPDWEVREAACWCLGQL
Rapamycin_bind 83211.m00083.AA Rapamycin_bind 1681-1776 43 5e-46 147.13 Pfam 1-100 (100) Show / Hide 
Range on Protein: 1681-1776
Range on HMM: 1-100/100
Sequence Identity: 43% (43 aa)

ELIRIGTSWFEIWTQALEETSKMY----DHVKAANILLPLHAVIEKPPETMFEVSFAAQFGSVLLQAHSLLDAFLNDHDEDAYNRAWSIYVPVLKKVRLI
||||.  .|.|.| ..||| |..|    ...| .|||.|||...||.||||.|.||..|||. | .||... ......||  .|.||.||. | ...|  
ELIRVAILWHEMWHEGLEEASRQYFGDHNIEKMFNILEPLHEMLEKGPETMREISFVQQFGRDLQEAHEWCQKYKRTGDENCLNQAWDIYYQVFRRIRKQ
Kinase 83211.m00083.AA FRAP 1841-2091 47 7.1e-98 331.46 In-house 4-251 (251) Show / Hide 
Range on Protein: 1841-2091
Range on HMM: 4-251/251
Sequence Identity: 47% (120 aa)

FLLKANEDTRLDKRIMQLFDFINSAIERAPDRPRR-LRIILYKVIPITNKVGLIGWVNNCQTLSLVISQYREPRGVPSLAEYEAIVKECPDFDKLSATMD
||||  || | | |.||||  ||  ..  |.  .. | |  | .||.  . ||||||..| ||   | .||.   .   .||. . ..|.|.|.|     
FLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVHHCDTLHILIRDYRKKYHIRYNIEYNIMDRMCNDYDHLPLM--

DDELVRLFHIGVSITPGNELKDALFIMSSDSSHWLKRRALFTESLASTSMAGFILGLGDRHPANIMLHDTTAKLVHIDFGDCFEVAMRREKFQERVPFRL
  . | .|   .  | |..||  | . |  |  |. ||  .| |||  ||||.||||||||| ||||   | |.|||||||||||||||||| |..||||
--NKVEIFRYIMNNTKGEDLKKLLWLKSPNSEIWFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRL

TRSLVNALGVNGLDGEFTKACETMLTIMRENGVQIMALLEAFIYDPLLQWLM
|| ||||. . |..| .  .||. . ..||.   .|| ||||.||||. | .
TRMLVNAMEACGIEGNYRNTCELVMKVIREHKESVMAVLEAFVYDPLFYWRL
Kinase 83211.m00083.AA PIKK 1809-2081 35 3.1e-85 289.47 In-house 1-290 (290) Show / Hide 
Range on Protein: 1809-2081
Range on HMM: 1-290/290
Sequence Identity: 35% (103 aa)

TIHSVDKQLIVVESKQRPRRVTLRTNEGNSIDFLLKANEDTRLDKRIMQLFDFINSAIERAPD-RPRRLRIILYKVIPITNKVGLIGWVNNCQTLSLVIS
 | . |. ..|  .||.|.. ..|   | .  .|.|  || |.| |.|||| ..|   .. |  . |.| |  |.||| ... |||.||.|| ||   . 
RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYK

QYRE------PRGVPS---LAEYEAIVKECP--DFDKLSATMD-----DDELVRLFHIGVSITPGNELKDALFIMSSDSSHWLKRRALFTESLASTSMAG
|...        .. .   . .|  ..|     ... ..  |.     ..| | .|   .. ||.. .|...  ...|.  |. ||  .| |.|. .|.|
QWCQKKHIRHEQEAQMNYQTCMYRDWLKQMSYYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCMVG

FILGLGDRHPANIMLHDTTAKLVHIDFGDCFEVAMRREKFQERVPFRLTRSLVNALGVNGLDGEFTKACETMLTIMRENGVQIMALLEAF
.||||||||| |||.  .|...||||||.|||.||.|... | ||||||| .|||.|. |..| |...||. . .||..   .|...|.|
YILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF
Kinase 83211.m00083.AA PI3Kc 1840-2139 26 7.1e-59 202.83 SMART 1-336 (336) Show / Hide 
Range on Protein: 1840-2139
Range on HMM: 1-336/336
Sequence Identity: 26% (90 aa)

DFLLKANEDTRLDKRIMQLFDFINSAIERA-PDRPRRLRIILYKVIPITNKVGLIGWVNNCQTLSLVISQYREPRGVPSLAEYEAIVKECPDFDKLSA--
 ...|...| | | |.||.|  .|    .  . | | |..  ||.||.  | |.|.||.|| ||  . . |......|       ....   ||.| .  
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMP------MDYHQWFMFDML-VPE

----------------------TMDDDELVRLFHIGVSITPGNELKDALFIMSSDSS-HWLKRRALFTESLASTSMAGFILGLGDRHPANIMLHDTTAKL
                      .|. .| . .|.  .. .... |.| .  .. |..  | ..|  || |.|  .|...|||.||||. ||||. .| ..
IQKNMYMMIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHC

VHIDFGDCFEVAMRREKFQ----ERVPFRLTRSLVNALG----VNGLDGEFTKACETMLTIMRENGVQIMALLEAFIYDPL-LQWLMA-RSDAGERPEIE
.|||||..|. ......|.    ||||||||. .|.. |    . |..|.| . |.. ...||..  .||.|.|...|||.  .| |   . . .|  ..
FHIDFGHIFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMMEKDIKYLRQRFR

TM-KRIKEKINDARG------VKQQVASLVEAATDERNLARMF
 . .  .| .. .         .  ..|.  .. .. .. ...
LDHLSDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
Kinase 83211.m00083.AA PI3_PI4_kinase 1838-2091 25 7.1e-58 203.39 Pfam 1-300 (300) Show / Hide 
Range on Protein: 1838-2091
Range on HMM: 1-300/300
Sequence Identity: 25% (78 aa)

SIDFLLKANEDTR--LDKRIMQLF-----------------------DFINSAI-ERAPDRPRRLRIILYKVIPITNKVGLIGWVNNCQTLSLVISQYRE
 . |..| ..| |   | |.||..                        ..|     .. || |.. .  |..||   . |.|.||.|| |.. ... |..
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV

PRGVPSLAEYEAIVKECPDFDKLSATMDDDELVRLFHIGVSITPGNELKDALFIMSSDS-SHWLKRRALFTESLASTSMAGFILGLGDRHPANIML--HD
 ..     ..|.... ..  |.....    . | .| .  . ||.. | . .  .. |    |...|  |..|.|  .....|||.||||. |||.  ..
-KCKHKHFNKEHKMWMKMWPDWWHLM--RMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDK

TTAKLVHIDFGDCFE-VAMRREKFQERVPFRLTR------SLVNAL------GVNGLDGEFTKACETMLTIMRENGVQIMALL-------EAFIYDPLLQ
|| .|.|||||.||. ..| .... ||||||.|.       .|.|.      .. | .|.| . |.... ..|.... .|.||       |....|.|. 
TTGHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVHDGLPM

WLM
| .
WRS
Kinase 83211.m00083.AA ATM 1969-2091 41 1.1e-32 101.45 In-house 129-250 (304) Show / Hide 
Range on Protein: 1969-2091
Range on HMM: 129-250/304
Sequence Identity: 41% (51 aa)

DSSHWLKRRALFTESLASTSMAGFILGLGDRHPANIMLHDTTAKLVHIDFGDCFEVAMRREKFQERVPFRLTRSLVNALGVNGLDGEFTKACETMLTIMR
|   |  .|  .| | |  |. |.||||||||  ||.. .  | ||||| |  ||   .     | ||||||| .|  .|. | .| | . ||  . .||
DPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQG-KILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMR

ENGVQIMALLEAFIYDPLLQWLM
     .. . |  .||||  | |
NSQETLLTIVEVLLYDPLFDWTM
Kinase 83211.m00083.AA ATR 1969-2081 35 1.4e-27 90.75 In-house 156-267 (267) Show / Hide 
Range on Protein: 1969-2081
Range on HMM: 156-267/267
Sequence Identity: 35% (40 aa)

DSSHWLKRRALFTESLASTSMAGFILGLGDRHPANIMLHDTTAKLVHIDFGDCFEVAMRREKFQERVPFRLTRSLVNALGVNGLDGEFTKACETMLTIMR
|.  |   |  .  | |. .| |.|.||||||  ||..   .  .||.|.   |    . |   | ||||||. .|...|  . .| | .||| .. .||
DPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDYNCIFNSGEQFE-VPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMR

ENGVQIMALLEAF
..  .||.....|
DHRDDIMSVWDCF
Kinase 83211.m00083.AA DNAPK 1809-1902 37 1.3e-14 49.46 In-house 3-97 (301) Show / Hide 
Range on Protein: 1809-1902
Range on HMM: 3-97/301
Sequence Identity: 37% (36 aa)

TIHSVDKQLIVVESKQRPRRVTLRTNEGNSIDFLLKANEDTRLDKRIMQLFDFINSAIERAPD-RPRRLRIILYKVIPITNKVGLIGWVNNCQTL
 |   |    |. |  ||.|. .|  .     |. |  || |.| || |||   |  .|  |    | |    | .|| ||  ||| ||.|  .|
RIAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYKGIEDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWVDNTVVL
Kinase 83211.m00083.AA FATC 2114-2146 45 7.8e-14 47.35 Pfam 1-33 (33) Show / Hide 
Range on Protein: 2114-2146
Range on HMM: 1-33/33
Sequence Identity: 45% (15 aa)

DARGVKQQVASLVEAATDERNLARMFRGWYPWL
    | |||  |.. |||..||..|. || ||.
EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW
Kinase 83211.m00083.AA ATR 1809-1908 27 8.7e-12 36.01 In-house 2-102 (267) Show / Hide 
Range on Protein: 1809-1908
Range on HMM: 2-102/267
Sequence Identity: 27% (28 aa)

TIHSVDKQLIVVESKQRPRRVTLRTNEGNSIDFLLKANEDTRLDKRIMQLFDFINSAIER-APDRPRRLRIILYKVIPITNKVGLIGWVNNCQTLSLVIS
 |   |  . .. | |.|....|.  .|     . |  .| | | | |.  . ||    . . .| | . .  | |||. .. ..| ||||  ||  .. 
YIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATLRPILD

Q
.
K
Kinase 83211.m00083.AA SMG1 1983-2023 53 5.7e-10 29.05 In-house 193-233 (242) Show / Hide 
Range on Protein: 1983-2023
Range on HMM: 193-233/242
Sequence Identity: 53% (22 aa)

SLASTSMAGFILGLGDRHPANIMLHDTTAKLVHIDFGDCFE
| |  || |.|.||||||  |...  ||   ||||.  |||
STAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFE
Kinase 83211.m00083.AA DNAPK 1959-2091 27 5.9e-10 32.24 In-house 169-301 (301) Show / Hide 
Range on Protein: 1959-2091
Range on HMM: 169-301/301
Sequence Identity: 27% (37 aa)

LKDALFIMSSDSSHWLKRRALFTESLASTSMAGFILGLGDRHPANIMLHDTTAKLVHIDFGDCFEVAMRREKFQERVPFRLTRSLVNALGVNGLDGEFTK
.. |.  ||.    .|  |  |  . |     ..||| ||||  | |    .   . ||||  |  |       |  ||||||  .| .   .  | .  
FRRAFVRMSTTCETYLYLREHFIRNYAVICISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMYQ

ACETMLTIMRENGVQIMALLEAFIYDPLLQWLM
     .  .|      .   . || ||.. |  
IMIHSMMAFRKDRNILTNFCDVFINDPSFDWKN
Kinase 83211.m00083.AA SMG1 1817-1896 32 2.2e-07 20.33 In-house 1-81 (242) Show / Hide 
Range on Protein: 1817-1896
Range on HMM: 1-81/242
Sequence Identity: 32% (27 aa)

LIVVESKQRPRRVTLRTNEGNSIDFLLKANEDTRLDKRIMQLFDFIN---SAIERAPDRPRRLRIILYKVIPITNKVGLIGWV
. ..  | .|...     .| |  .| |  ||  || ||||    .|     | |  . | |     | | |.  . ||| ||
ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQ-ETP-RFHARHYSVTPLGTRSGLIQWV
Kinase 83211.m00083.AA ATM 1842-1895 34 2e-06 15.83 In-house 3-57 (304) Show / Hide 
Range on Protein: 1842-1895
Range on HMM: 3-57/304
Sequence Identity: 34% (19 aa)

LLKANEDTRLDKRIMQLFDFINSAIERAPD-RPRRLRIILYKVIPITNKVGLIGW
| |  .| | |  . | |   |  . |  . | |.| |  |||.|.  . | . |
LVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEW