Gene 80462.m00063 (T.vaginalis)
80462.m00063
Species: T.vaginalis
Alias: 80462.m00063, TvagK0812
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| 80462.m00063.AA | Protein | None | 803 | None | Fasta, JSON |
| 80462.m00063.kin_dom | Protein Kinase Domain | None | 245 | None | Fasta, JSON |
Protein domains of 80462.m00063.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| PI3Ka | 80462.m00063.AA | PI3Ka | 286-464 | 22 | 6.1e-18 | 66.84 | SMART | 1-232 (232) | Show / Hide |
Range on Protein: 286-464
Range on HMM: 1-232/232
Sequence Identity: 22% (52 aa)
KSSFLK--DSKVTKILNKVKSYGPLVELQPMEVNCLYNNFR-ACL-QDQALMP-----ALFRAVNWENKDERVEIEQMLKDR--DPIDAEYALEFFTDRY
. ... . | . .| |. || | . .. || .| . .| ..|.|||.. || . |.... .|||.| |||.. ..
DYDLKPRWNEEERDQLEDIMKYPPTYELTEEEKDLIW-KFRHYYLTNHPKALPSMCFPKFLRCVNWSWADEVKQAYQLMHQWWWPPIDPEDALELLDPKF
NI---QSIRQFAVKCISAMKHEDILLYLPQILQATKVQ---------------------------YTEG-LVDILVNNALGDPIFASTLYWNAQVEK---
. . .||.||.|. .| ...|.||.|. || | | .. |.. |. || .| ... .||. ..|
PDYNCPHVRQYAVQCLEQMSDDELLHYLLQLVQALKYENFDHIKHHFCEFDQDQSMSMTKEEDGPYHDSPLCRFLLQRALCNPRIGHFFYWYLKSEMYDH
---------EQFSVLLEKLTSNLTGEVKQQLED
..| .||| . . ..|. .. | .
CQLHDPHYCQRFGMLLEMYCRGCCGHHMRHLFK
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| PI3Ka | 80462.m00063.AA | PI3Ka | 287-463 | 22 | 2.5e-14 | 50.82 | Pfam | 1-211 (211) | Show / Hide |
Range on Protein: 287-463
Range on HMM: 1-211/211
Sequence Identity: 22% (48 aa)
SSFLK-DSKVTKILNKVKSYGPLVELQPMEVNCLYNNFR-ACL--QDQALM-----PALFR-AVNWENKDERVEIEQMLKD--RDPIDAEYALEFFTDRY
.. . ..| |.|... .| ||..| | . .. || |. .|| | ... |.| . |.. . | ... .|||.. ||| . .
KDLKPVNNKERKQLEQIIKYDPLSQLTAEEKCLIW-KFRHYCCMNNPKALPLMCVGPKFLQLCVKWHDYDQVAQAYQLMDCRVWPPIDPCDALELLDCNF
NI--QSIRQFAVKCISA-MKHEDILLYLPQILQATKVQ------YTEGLVDILVNNALGDP-IFASTLYWNAQVEK----------E---QFSVLLEKLT
...||.||||. | ...|.||.|. ||.| . |. .|.. |. . .... ..|. .| . .|.|||| .
PDNCPMVRQYAVKCLESYMSDDELLCYLLQLVQALKYENFDEPFHDSYLSRFLLWRAWQNRQRIGHFFFWYMKSEMYKDDEGHDKDYICQRFGVLLESYC
SNLTGEVKQQLE
..... .. ..
RECGTHMQHLNK
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| Kinase | 80462.m00063.AA | PI3Kc | 551-795 | 20 | 6.5e-38 | 133.2 | SMART | 1-336 (336) | Show / Hide |
Range on Protein: 551-795
Range on HMM: 1-336/336
Sequence Identity: 20% (69 aa)
RAIFKIGDDMRQDQLILQLFEVMAHIFKAA----SMQLNITAYKTLAFSETFGCCQFIDNSRAILDIAK-------------------------------
. ||| |||.|||....|.|..| .| . . | .. || .. .. | ... |. . | |
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMYM
-----------------------------------DGMNILQFLANPDG-TVDSGKIDIFTESLAAYSVMTYVLKIGDRHDNNILVT-KDGRLLHIDYGF
. .. .|| . .| || |.|.|...||.| ||||| .||... |.| ..|||.|.
MIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFGH
ILGDVTKPFTP--------PLKLSKEMIETIG-----ANGMQRLCDWACPAFNSLRKRARLILVLIELMFTAPL-ECFQNNPKRRLQQVENCLLLR-CTE
|.| |.... | .| ..|.. .| . .. . .| |.. .|| . ||. |.|.| .|. |.. . . ....... . | ..
IFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMM-EKDIKYLRQRFRLDHLSD
IEASKSLQA-----TFTQSLNSKMQVFWDAVHTVAVS
||.. .. |..|. . . |..|
EEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
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| Kinase | 80462.m00063.AA | PI3_PI4_kinase | 549-744 | 17 | 5.7e-36 | 130.62 | Pfam | 1-300 (300) | Show / Hide |
Range on Protein: 549-744
Range on HMM: 1-300/300
Sequence Identity: 17% (52 aa)
KYRAIFKIGDDMR--QDQLILQLF-----------------------EVMAHIFKAASMQLN----ITAYKTLAFSETFGCCQFIDNSRAILDIAKDG--
|..||| |||.| ||....|.. ..| . | .. .. ...|. .. .. | ....|. . | .
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV
------------------------------------------MNILQFLANPDGTV--DSG-KIDIFTESLAAYSVMTYVLKIGDRHDNNILV---TKDG
. ..|.. ... . . .| |..|.| ..|..|.| .|||| .||.| ...|
KCKHKHFNKEHKMWMKMWPDWWHLMRMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDKTTG
RLLHIDYGFILG-----DVTKPFTPPLKLSK------EMIETIGA-------NGMQRLCDWACPAFNSLRKRARLILVLI-------ELMFTAPLECFQN
| |||.|.... ||...| .. . .|.. .| .....| . |...||. ..|.. |. |.|....| ..
HLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVHDGLPMWRS
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| Kinase | 80462.m00063.AA | ATR | 642-735 | 26 | 5e-10 | 29.92 | In-house | 170-267 (267) | Show / Hide |
Range on Protein: 642-735 Range on HMM: 170-267/267 Sequence Identity: 26% (26 aa) SLAAYSVMTYVLKIGDRHDNNILVTK-DGRLLHIDYGFILGD---VTKPFTPPLKLSKEMIETIGANGMQRLCDWACPAFNSLRKRARLILVLIELMF | |..... |.. .|||| .|||. | | . |.|| | . . | . | .| . |. ..|. . . | || . . | .. . | SYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDYNCIFNSGEQFEVPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRDHRDDIMSVWDCF |
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| Kinase | 80462.m00063.AA | PIKK | 639-685 | 33 | 3.4e-08 | 26.3 | In-house | 189-236 (290) | Show / Hide |
Range on Protein: 639-685 Range on HMM: 189-236/290 Sequence Identity: 33% (16 aa) FTESLAAYSVMTYVLKIGDRHDNNILVTKD-GRLLHIDYGFILGDVTK .| |.| .. |.| .|||| .||.. .. | ..|||.|.. .. .. YTRSYAVMCMVGYILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQ |
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| Kinase | 80462.m00063.AA | FRAP | 639-677 | 45 | 3.1e-07 | 22.81 | In-house | 140-179 (251) | Show / Hide |
Range on Protein: 639-677 Range on HMM: 140-179/251 Sequence Identity: 45% (18 aa) FTESLAAYSVMTYVLKIGDRHDNNILVTKD-GRLLHIDYG .| ||| |. |.| .|||| ||. . |...|||.| YTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFG |
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| Kinase | 80462.m00063.AA | ATM | 639-677 | 45 | 4e-06 | 15.14 | In-house | 140-179 (304) | Show / Hide |
Range on Protein: 639-677 Range on HMM: 140-179/304 Sequence Identity: 45% (18 aa) FTESLAAYSVMTYVLKIGDRHDNNILVTKDG-RLLHIDYG .| | | |.. |.| .|||| |||. | ||| | YTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLG |
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| Kinase | 80462.m00063.AA | PIKK | 519-573 | 30 | 5.9e-05 | 14.39 | In-house | 1-54 (290) | Show / Hide |
Range on Protein: 519-573 Range on HMM: 1-54/290 Sequence Identity: 30% (17 aa) FVVGIDTSDVKVFKSKLCPVCLCFKLQNGGKYRAIFKIGDDMRQDQLILQLFEVM . ..| . | | ..| | . .. .| |. .| ..| |||| ..||| .| RIRFMDRM-VTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLM |
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| Kinase | 80462.m00063.AA | DNAPK | 553-577 | 56 | 0.001122 | 9.04 | In-house | 36-60 (301) | Show / Hide |
Range on Protein: 553-577 Range on HMM: 36-60/301 Sequence Identity: 56% (14 aa) IFKIGDDMRQDQLILQLFEVMAHIF ..| . |.|||| | ||| || || CYKGIEDLRQDQRIEQLFQVMNNIF |
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| Kinase | 80462.m00063.AA | DNAPK | 651-681 | 43 | 0.011055 | 5.37 | In-house | 202-233 (301) | Show / Hide |
Range on Protein: 651-681 Range on HMM: 202-233/301 Sequence Identity: 43% (14 aa) YVLKIGDRHDNNILVT-KDGRLLHIDYGFILG ..| ||||| || .| | ||.|. | WILGIGDRHLNNFMVNMENGDIISIDFGHSFG |
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| Kinase | 80462.m00063.AA | ATM | 551-570 | 45 | 0.052514 | 1.74 | In-house | 1-20 (304) | Show / Hide |
Range on Protein: 551-570 Range on HMM: 1-20/304 Sequence Identity: 45% (9 aa) RAIFKIGDDMRQDQLILQLF | . | ||.||| . | | RQLVKGRDDLRQDAVMQQVF |
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| Kinase | 80462.m00063.AA | FRAP | 549-570 | 40 | 0.097112 | 2.35 | In-house | 1-22 (251) | Show / Hide |
Range on Protein: 549-570 Range on HMM: 1-22/251 Sequence Identity: 40% (9 aa) KYRAIFKIGDDMRQDQLILQLF | . | .|.||| ..||| EYHFLLKGHEDIRQDERVMQLF |
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