94489.m00120

Species: T.vaginalis
Alias: 94489.m00120, TvagK0876
External Links:
Annotation:

Classification

Group: Other
Family: VPS15

Sequence

Name Sequence Type Origin Length Description Download
94489.m00120.AA Protein None 952 None Fasta, JSON
94489.m00120.kin_dom Protein Kinase Domain None 180 None Fasta, JSON

Protein domain

Protein domains of 94489.m00120.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 94489.m00120.AA VPS15 104-272 28 5.3e-17 55.46 In-house 96-296 (296) Show / Hide
Range on Protein: 104-272
Range on HMM: 96-296/296
Sequence Identity: 28% (58 aa)

TMVEKQWIAYQVCIILLRLHQSG-LYHSDLKPSNIFVSDSFFTYVTDLAPYKPETISPNRMNLYYHFFTTSSTSGYYLAPERFT---NEQKKIDM-----
.| || ||| |  . |  .| .|   | |.|..|| |. .   | || |..||  .       .  || ||.    |.|||||    . . .        
QMIEKKWIAFQTLCALEQCHKQGNVCHGDIKSENILVTSWNWCYLTDFACFKPCYLPEDNPADFTFFFDTSRRRTCYIAPERFVSNTEQDQDSNNGNMRD

-------------------KAADLFSLGCVLYFIFSDG-KHLFDVMSGLKYGCGEDTI--SDKLSKVADEKMRNLIKSLISLD-ITKRLEAENMILQSFS
                   .| | ||.|||.  .| .|   .||  . .||  || .      . |  ||. |||....|  |   ||...|  . .  .
IHTDSIDRQQNPWLFGELTPAMDIFSAGCVIAELFCEGDQPPFDYSQLCKYRSGEYHPNREQIMEKIQDEHIRNLCHHMIQKDNPMKRMSCEEYLNKWRG

E
 
F

S_TKc 94489.m00120.AA S_TKc 7-271 17 1.6e-13 21.47 SMART 1-231 (231) Show / Hide
Range on Protein: 7-271
Range on HMM: 1-231/231
Sequence Identity: 17% (51 aa)

ITDYKHLESGTFFMVFQGKIQN--SNVVLKAYEYTAEIISLEEAKRSLDFFTKLEEYSLNLPGIVKYTDLKCEGTTAFLIRPKFQT---SLEDLLVFQEP
 .  ... .|.|  |....  .    | .|           | ..| ..   |      . | |||. |   . .  ...     .   .| |... . .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

P-----ITMVEKQWIAYQVCIILLRLHQSGLYHSDLKPSNIFVSDSFFTYVTD--LAPYKPETISPNRMNLYYHFFTTSSTSGYYLAPERFTNEQKKIDM
.     ..  . . ..||.|  |  .|. |  | ||||.||....     ..|  ||                   ||   . .|.||| .     . . 
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------------TTFCGTPWYMAPEVL-----GYGK

KAADLFSLGCVLYFIFSDGKHLFDVMSGLKYGCGEDTISDKLSKVADEKMRNLIKSLISLDITKRLEAENMIL-------QSFS
...|  |.||.||  .. |. .|.          .... .|.    .. ....|. .   | .||. |              . 
CKCDWWSCGCILYEMLC-GYPPFP---------QMQMMFKKIG---SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase 94489.m00120.AA SCY1 179-271 18 3.8e-10 31.42 In-house 226-337 (337) Show / Hide
Range on Protein: 179-271
Range on HMM: 226-337/337
Sequence Identity: 18% (21 aa)

YLAPERFTNEQ-----------KKIDMKAADLFSLGCVLYFIFSDGKHLFDVMSGL-----KYGCGEDTISDKLSKVADEKMRNL----IKSLISLDITK
.|||| . . |            | .. |.|.|||||. ..... .| ...  | .     .|  .....| ...    .. ...    .. |.. |.|.
WLAPEYIHEDQHTPASYNWGQEQKCTW-ASDMFSLGCLIWWVYNGKKPQITCNSNPYSTFHRYMEQWNAMSHCWWDHIPKELQEHLGHCYCHLLHQDPTC

RLEAENMILQSFS
|  ...... .. 
RPDPQQFLQHCYF

Kinase 94489.m00120.AA IRE 179-264 25 4.6e-09 27.11 In-house 195-285 (292) Show / Hide
Range on Protein: 179-264
Range on HMM: 195-285/292
Sequence Identity: 25% (24 aa)

YLAPERFTNEQKKIDMKAADLFSLGCVLYFIFSDGKHLFDVMSG-LKYGCGEDTIS-----DKLSKVADEK---MRNLIKSLISLDITKRLEAEN
. .||  ..  .|   |. | ||.|||.|.... |.| |    |  |.     ...     |.|..  ...    . ||.. |. |  ||.....
WHPPEMLQEFCQKRKTKSVDIFSMGCVFYYVMTNGQHPF----GNDKLHRQANILKGKYNLDQLKHHNHWHIVIACDLIHQMIHHDPQKRPTIKE

Kinase 94489.m00120.AA Ciliate-E2 122-271 17 5e-08 23.62 In-house 176-365 (365) Show / Hide
Range on Protein: 122-271
Range on HMM: 176-365/365
Sequence Identity: 17% (37 aa)

LHQSG-LYHSDLKPSNIFVSDSFFTYVTDLA-------PYKPETISPNRMNLYYHFF-TTSSTSG------------------YYLAPERFTNEQ-----
||. .   | |.||.||..       ..|.        ... .|.  .....|   .  || |.|                  .|.||| . ...     
LHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQ

-KKIDMKAADLFSLGCVLYFIFSDGKHLFDVMSGLKYGCGEDTISDKLSKVADEKMR---------------------NLIKS----LISLDITKRLE-A
 .|   ...|..|||..||.  . ||. |           .. | ..  .   ....                     .|||     ..  |  ||.  .
KQKGYDYKCDIWSLGVILYEMLF-GKPPF-----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGW

ENMILQSFS
|  .   . 
EQILNHPWF

Kinase 94489.m00120.AA Ciliate-E4 111-149 38 7.6e-08 22.74 In-house 112-150 (150) Show / Hide
Range on Protein: 111-149
Range on HMM: 112-150/150
Sequence Identity: 38% (15 aa)

IAYQVCIILLRLHQSGLYHSDLKPSNIFVSDSFFTYVTD
||..    .  | | ...| ||||||||....|   . |
IAFCCINAMYYLQQVNITHGDLKPSNIFFDQYFMVKIAD

Kinase 94489.m00120.AA C8 99-206 25 5.9e-07 20.31 In-house 116-226 (226) Show / Hide
Range on Protein: 99-206
Range on HMM: 116-226/226
Sequence Identity: 25% (29 aa)

QEPPITMVEKQWIAYQVCIILLRLHQSGLYHSDLKPSNIFVSDSFFTY----VTDLAPYKPETISPNRMNLYYHFFTTSSTSGYYLAPERFTN--EQKKI
.. ...  .|. || |.   .  .|.    | |.||.|. |  .          |..     ..| |.   . ... |  | . |.|||  .   .| |.
KQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFG--FASQVSKNKSHIQSKKMNTCGTWA-YFAPEIEKKQDNQYKQ

DMKAADLFSLGCVL
  .  ||||.| ||
YRIQSDLFSVGLVL

Kinase 94489.m00120.AA Ciliate-E1 13-200 17 2e-06 17.2 In-house 1-202 (202) Show / Hide
Range on Protein: 13-200
Range on HMM: 1-202/202
Sequence Identity: 17% (37 aa)

LESGTFFMVFQGKIQNSN-----VVLKAYEYTAEIISLEEAKRSLDFFTKLEEYSLNLPGIVKYTDLKCEGTTAFLIRPKFQTSLEDLL---------VF
...| |..||..|.||.|     ...  ...  . ..... ..  . . |  .   ..  |..| ...   .......   .. .. |           .
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQC

QEPPITMVEK--QWIAYQVCIILLRLHQSGLYHSDLKPSNIFVSDSFFTYVTDLAPYKPETISPNR--MNLYYHFFTTSSTSGYYLAPERFT------NE
|.  . . ..    |..|    |  ||| ...|.|.||.|| ....   ||          ..  .  .|  ..    .    ||  ||  .      |.
QQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GNYVYC-------DFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNK

QKKIDMKAADLF
..||..|  |..
NQKINYK-SDIY

Kinase 94489.m00120.AA Ciliate-E3 111-142 34 9e-06 14.29 In-house 108-139 (202) Show / Hide
Range on Protein: 111-142
Range on HMM: 108-139/202
Sequence Identity: 34% (11 aa)

IAYQVCIILLRLHQSGLYHSDLKPSNIFVSDS
|. |.   .. .|.  . |||.||.|| |. .
ICIQIIQGMIAIHEKNIIHSDIKPDNILVDKN

Kinase 94489.m00120.AA IKS 122-143 36 9e-06 13.32 In-house 169-190 (360) Show / Hide
Range on Protein: 122-143
Range on HMM: 169-190/360
Sequence Identity: 36% (8 aa)

LHQSGLYHSDLKPSNIFVSDSF
|| .|. | |.||.|. .  ..
LHHIGIIHRDIKPPNCLIHQPY

Kinase 94489.m00120.AA CLK 109-156 39 1e-05 12.35 In-house 117-164 (350) Show / Hide
Range on Protein: 109-156
Range on HMM: 117-164/350
Sequence Identity: 39% (19 aa)

QWIAYQVCIILLRLHQSGLYHSDLKPSNIFVSDSFFTYVTDLAPYKPE
. .||| |  .  ||  .| | |||| ||  .|| ||..    .|...
RHMAYQLCEAVKFLHDMKLTHTDLKPENICFVDSRFTHFDCTFKYNHK

Kinase 94489.m00120.AA IRE 122-141 45 0.01207 4.5 In-house 132-151 (292) Show / Hide
Range on Protein: 122-141
Range on HMM: 132-151/292
Sequence Identity: 45% (9 aa)

LHQSGLYHSDLKPSNIFVSD
||...  | |||| || ...
LHSQNIVHRDLKPHNILIHM

Kinase 94489.m00120.AA IKS 196-209 42 0.12675 0.22 In-house 270-283 (360) Show / Hide
Range on Protein: 196-209
Range on HMM: 270-283/360
Sequence Identity: 42% (6 aa)

AADLFSLGCVLYFI
..|..||| ..||.
KCDMWSLGMICYFM