Gene 94502.m00084 (T.vaginalis)

94502.m00084

Species: T.vaginalis
Alias: TvagK0637, 94502.m00084
External Links:
Annotation:

Classification

Group: PKL
Family: PIK
Subfamily: FRAP

Sequence

Name Sequence Type Origin Length Description Download
94502.m00084.AA Protein None 2161 None Fasta, JSON
94502.m00084.kin_dom Protein Kinase Domain None 195 None Fasta, JSON

Protein domain

Protein domains of 94502.m00084.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
FAT 94502.m00084.AA FAT 1318-1400 18 2.886142 1.12 Pfam 11-117 (408) Show / Hide 
Range on Protein: 1318-1400
Range on HMM: 11-117/408
Sequence Identity: 18% (20 aa)

VKEYQQ--MLTYSLAME------------LDTL-----ESHILLAYALI--LNNNMK--RAEKTINSAFKLIAQQHSQ-KFKSLYSQVYPIIVQSQILYE
. ....  |  |  .|              |.      . ..  |. ..  . |. .  .|.. |. | .|  .  ..   . .|   ||..|  |.| |
LGQWDETYMDEYISVMKKLLGEDQLTFIDEDSPDEPTWDRSFFQAILCLYKHHNQFDTYEAHRYIDKARQLLDTEWTACLPGESYNRHYPVMVRVQMLAE

LTEVINF
| |.| .
LEEIIQY
FAT 94502.m00084.AA FAT 1472-1497 42 0.000669 13.29 Pfam 228-253 (408) Show / Hide 
Range on Protein: 1472-1497
Range on HMM: 228-253/408
Sequence Identity: 42% (11 aa)

TASPSIVLQYLRYLWALGQRHEALRM
.| |...  ||.|.|| ||..||...
RAPPQWTYAYLKYMWATGQQQEAFQH
FAT 94502.m00084.AA FAT 1565-1610 16 0.06094 6.73 Pfam 350-408 (408) Show / Hide 
Range on Protein: 1565-1610
Range on HMM: 350-408/408
Sequence Identity: 16% (10 aa)

WAIANFMLFKQDK------------SNMNYAINAIRGFVPCITAQIS-VNFVDLAQLIS
|| .|| .|. ..             .......|...|  .|  . .  .. |.. |..
WALYNFEVFQHYQCQPQREEQNYTHMIIQHVVPAVKCFFHSIALSQGSNSRQDTLRLLW
Kinase 94502.m00084.AA PIKK 1824-2094 34 3.9e-90 305.74 In-house 1-290 (290) Show / Hide 
Range on Protein: 1824-2094
Range on HMM: 1-290/290
Sequence Identity: 34% (101 aa)

YIEKIKDALEVLPSKQHPRRLEMIGTDGKQYIFLLKANEDLQLDLRMMQFFSLINTLVKKDFSLASDSISLRLYNILPLSTDIGLIQWIDGSDALHNLIT
.|  . . ..|...|| |... . | ||| |..|.|  ||| .| |.||.|.|.||.  ||    .   ..| |.. |.|.  |||.| |... |. ...
RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYK

EYRVFHGIDQVIE-------------------GHMMCQKSINDFNNLRPIQRLEIINETDVETSADDLRKVFWLKSPSADAWLERSLHFQKSMGISSIVG
...   .| . .|                   ..  .|.  .. . .   ...|. .|    | .|...| ||.|.|....|.||  ..  |   ...||
QWCQKKHIRHEQEAQMNYQTCMYRDWLKQMSYYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCMVG

YILGLGDRHALNIMIDRSSGEVIHIDFGDCFEVDMRRVVFPELIPFRLTRMIIRAFGIGGVDSDFRAVCERVVNVARENSTPLKSVIEMF
|||||||||  |||||...||..|||||.|||. |.|  .||..||||||... | |. ||.  ||. || |. . |..  .| .| | |
YILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF
Kinase 94502.m00084.AA FRAP 1853-2098 43 2.5e-88 299.74 In-house 1-245 (251) Show / Hide 
Range on Protein: 1853-2098
Range on HMM: 1-245/251
Sequence Identity: 43% (107 aa)

QYIFLLKANEDLQLDLRMMQFFSLINTLVKKDFSLASDSISLRLYNILPLSTDIGLIQWIDGSDALHNLITEYRVFHGIDQVIEGHMMCQKSINDFNNLR
 |.||||  ||.  | | || | |||.| . .       .|.. | |.|||.. ||| |.   | || || .||  . |   || . . ....||.. | 
EYHFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVHHCDTLHILIRDYRKKYHIRYNIE-YNIMDRMCNDYDHLP

PIQRLEIINETDVETSADDLRKVFWLKSPSADAWLERSLHFQKSMGISSIVGYILGLGDRHALNIMIDRSSGEVIHIDFGDCFEVDMRRVVFPELIPFRL
 ... ||       |  .||.|. |||||. . |.||   . .|. . |..||||||||||  |||..| .| ..|||||||||| |||  |||.|||||
LMNKVEIFRYIMNNTKGEDLKKLLWLKSPNSEIWFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRL

TRMIIRAFGIGGVDSDFRAVCERVVNVARENSTPLKSVIEMFLNEP
|||.. |  . |..  .| .|| |..| ||.   .  |.| |   |
TRMLVNAMEACGIEGNYRNTCELVMKVIREHKESVMAVLEAFVYDP
Kinase 94502.m00084.AA PI3Kc 1855-2147 22 2.9e-59 204.13 SMART 1-336 (336) Show / Hide 
Range on Protein: 1855-2147
Range on HMM: 1-336/336
Sequence Identity: 22% (76 aa)

IFLLKANEDLQLDLRMMQFFSLINTLVKKDFSLASDSISLRLYNILPLSTDIGLIQWIDGSDALHNLITEYRVFHGIDQVIEGHMMCQK-----------
 ...|...||  | ||||.|.|.|.. .||   .  .  .| |...|.. ..|.|.|.  .. ||..  .|.   ...  ..   | ..           
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMYM

---------SINDFNNLRPIQRLEIINETDVETSADDLRKVFWLKSPSAD-AWLERSLHFQKSMGISSIVGYILGLGDRHALNIMIDRSSGEVIHIDFGD
          . .  ... ...|. . ..   .  ..|.. || ..|... .| |.  .| .|.   ..|.||||.||||  |||.|. .|...|||||.
MIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFGH

CFEVDMRRVVFP----ELIPFRLTRMIIRAFG----IGGVDSDFRAVCERVVNVARENSTPLKSVIEMFLNEPG-EDYDND----EYTREQIISR-LWDK
.|. ......|.    |. |||||.... . |    . |..  ||  |.|. ...|..|  . ...||... |   . . .    .| |...    | |.
IFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMMEKDIKYLRQRFRLDHLSDE

LNGKDF--------DPEIALSVPQQVSALIEAARNK
.  . |        ... . | . ..  ...  .. 
EAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
Kinase 94502.m00084.AA PI3_PI4_kinase 1853-2095 25 3.3e-56 197.86 Pfam 1-291 (300) Show / Hide 
Range on Protein: 1853-2095
Range on HMM: 1-291/300
Sequence Identity: 25% (75 aa)

QYIFLLKANEDLQ--LDLRMMQFF-----------------------SLINTLVKKDFSLASDSISLRLYNILPLSTDIGLIQWIDGSDALHNLITEYRV
 | |..| ..||    | ||||..                       .|.|.. |||  .   ..... | ..|.... |.|.|.. .. .|... .|.|
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV

FHGIDQVIEGHMMCQKSINDFNNLRPIQRLEIINETDVETSADDLRKVFWLKSPSA-DAWLERSLHFQKSMGISSIVGYILGLGDRHALNIMI--DRSSG
  ..      |.|. |.  |  .|  .|..|. ..    |  ..|...|| ..|.| ..|.|.  .| .|.   ..|.||||.||||. |||.  |...|
KCKHKHFNKEHKMWMKMWPDWWHLMRMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDKTTG

EVIHIDFGDCFE-VDMRRVVFPELIPFRLTR------MIIRAF------GIGGVDSDFRAVCERVVNVARENSTPLKSVI-------EMFL
...|||||.||. ..| .  .||..|||.|.      ... |.      .  | .  || .|... .. |.... . ...       |...
HLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMV
Kinase 94502.m00084.AA ATR 1823-2094 27 3.8e-45 151.56 In-house 1-267 (267) Show / Hide 
Range on Protein: 1823-2094
Range on HMM: 1-267/267
Sequence Identity: 27% (75 aa)

VYIEKIKDALEVLPSKQHPRRLEMIGTDGKQYIFLLKANEDLQLDLRMMQFFSLINTLVKKDFSLASDSISLRLYNILPLSTDIGLIQWIDGSDALHNLI
 ||  . | .|.| | |.|... . |.||| || . |  .||. | | |.| .||| . .||       . .| | ..||  . ..| |..   .|. ..
AYIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATLRPIL

TEYRVFHGIDQVIEGHMMCQKSINDFNNLRPIQRLEIINETDVETSADDLRKVFWLKSPSADAWLERSLHFQKSMGISSIVGYILGLGDRHALNIMIDRS
.  ....   |  ... . | .     ..   ... .. |  .       .  |  . | .  |      . .|. . ..||||.||||||. ||.||. 
D--KLWKEKKQYMQFYQLRQCMDKKSREE--WEKQKVFREFLLPRHPPIFHDWFNRRFPDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKI

SGEVIHIDFGDCFEVDMRRVVFPELIPFRLTRMIIRAFGIGGVDSDFRAVCERVVNVARENSTPLKSVIEMF
 ||..|.|.  |     ...  ||..|||||. .. ..|  . .  ||  || .. . |..  .. ||.. |
NGECVHVDY-NCIFNSGEQFEVPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRDHRDDIMSVWDCF
Kinase 94502.m00084.AA ATM 1986-2098 46 6.3e-33 102.25 In-house 133-244 (304) Show / Hide 
Range on Protein: 1986-2098
Range on HMM: 133-244/304
Sequence Identity: 46% (52 aa)

WLERSLHFQKSMGISSIVGYILGLGDRHALNIMIDRSSGEVIHIDFGDCFEVDMRRVVFPELIPFRLTRMIIRAFGIGGVDSDFRAVCERVVNVARENST
| |. | . .|.  ||||||||||||||  ||.|   | |..||| |  ||   . .  || .|||||| |.   || ||.  ||  ||. . | |    
WFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFE-QGKILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQE

PLKSVIEMFLNEP
 |  ..|. | .|
TLLTIVEVLLYDP
Kinase 94502.m00084.AA SMG1 1832-1921 42 7.9e-22 68.97 In-house 1-90 (242) Show / Hide 
Range on Protein: 1832-1921
Range on HMM: 1-90/242
Sequence Identity: 42% (38 aa)

LEVLPSKQHPRRLEMIGTDGKQYIFLLKANEDLQLDLRMMQFFSLINTLVKKDFSLASDSISLRLYNILPLSTDIGLIQWIDGSDALHNL
. .|| |  |..|  .| ||| | .| |  ||| || |.||| |..||.              | | . || |  |||||.||   |  |
ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWVDGATPLFGL
Kinase 94502.m00084.AA FATC 2129-2161 51 1.1e-16 56.52 Pfam 1-33 (33) Show / Hide 
Range on Protein: 2129-2161
Range on HMM: 1-33/33
Sequence Identity: 51% (17 aa)

IALSVPQQVSALIEAARNKYNLAHLYSGWCPLW
  |||.|||. ||. | . .||...|.|||| |
EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW
Kinase 94502.m00084.AA SMG1 1972-2046 41 2.4e-14 43.8 In-house 169-242 (242) Show / Hide 
Range on Protein: 1972-2046
Range on HMM: 169-242/242
Sequence Identity: 41% (31 aa)

LRKVFWLKSPSADAWLERSLHFQKSMGISSIVGYILGLGDRHALNIMIDRSSGEVIHIDFGDCFEVDMRRVVFPE
| |  |      | |      . .|  . |.||||.||||||  |..||   |||.|||.  |||   . .  ||
LAKELWSSCTTPDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFE-KGKKLNVPE
Kinase 94502.m00084.AA DNAPK 2002-2054 49 1.5e-13 45.48 In-house 199-251 (301) Show / Hide 
Range on Protein: 2002-2054
Range on HMM: 199-251/301
Sequence Identity: 49% (26 aa)

IVGYILGLGDRHALNIMIDRSSGEVIHIDFGDCFEVDMRRVVFPELIPFRLTR
| ..||| ||||  | |.  . |..| ||||  |         ||| ||||||
ISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTR
Kinase 94502.m00084.AA DNAPK 1823-1913 32 4.6e-11 36.33 In-house 2-92 (301) Show / Hide 
Range on Protein: 1823-1913
Range on HMM: 2-92/301
Sequence Identity: 32% (30 aa)

VYIEKIKDALEVLPSKQHPRRLEMIGTDGKQYIFLLKANEDLQLDLRMMQFFSLINTLVKKDFSLASDSISLRLYNILPLSTDIGLIQWID
| |    .   |. |   |.|. . | | .   |. |  ||| .| |  | |   |     |    .    || ||| |.    ||| |.|
VRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYKGIEDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWVD
Kinase 94502.m00084.AA ATM 1857-1914 31 5.1e-05 11.54 In-house 3-60 (304) Show / Hide 
Range on Protein: 1857-1914
Range on HMM: 3-60/304
Sequence Identity: 31% (18 aa)

LLKANEDLQLDLRMMQFFSLINTLVKKDFSLASDSISLRLYNILPLSTDIGLIQWIDG
| |  .||  |  | | | . |||...        . .  | . |||   | . |  |
LVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTG