TVAG_347940

Species: T.vaginalis
Alias: TvagK1066, TVAG_347940
External Links:
Annotation:

Classification

Group: TKL
Family: TKL-Unique

Sequence

Name Sequence Type Origin Length Description Download
TVAG_347940.AA Protein None 915 None Fasta, JSON
TVAG_347940.kin_dom Protein Kinase Domain None 152 None Fasta, JSON

Protein domain

Protein domains of TVAG_347940.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase TVAG_347940.AA Pkinase 250-306 18 4.7e-07 26.04 Pfam 194-293 (293) Show / Hide
Range on Protein: 250-306
Range on HMM: 194-293/293
Sequence Identity: 18% (18 aa)

DIYSYGAILACLATKSQCFSPN----------LLNEDIK-------------------------------PEIKSLISKCLDEEPSNRPKIEDILSS--F
|..|.| ||......   |.            ..... .                               .| |..|..||.  |. || .|.|| .  |
DMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF





S_TKc TVAG_347940.AA S_TKc 68-307 17 8.1e-07 -76.93 SMART 1-231 (231) Show / Hide
Range on Protein: 68-307
Range on HMM: 1-231/231
Sequence Identity: 17% (48 aa)

IRQIKQLAL------RKGRNTDLIQDLVDGRILVLSSFAIKLPNNAKSINPDDYYRKYALISHPCLACPHGEYLFDFSEAGSMRYM-MPYYLK--GSLGN
 . ....        .|.|...               .|||  .       .. .|  .. ..    .|.   |.|. .  .  || | |     |.|  
YEILRKIGKGAFGKVYKCRHKK-----------TGRIVAIKIIK-------EHIRREIQILKK---HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFD

ILQLESQGKHPFQWTSTAKSICSFGILVGLKGLHLKKIVHGLLNPNNILLNRKLEPKISEYWMSELYDKESIDMEYDSNFIDKSTSQG------------
...    .. .|. .          |. .|. .| ..|.|  | | ||||..  . ||.   .. ..                .|  |            
YIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------------TTFCGTPWYMAPEVLGY

-E-FNDIYSYGAILACLATKSQCFSPNLLNEDI------KPEIKSLISKCLDEEPSNRPKIEDILS--------SFV
     |..| | ||. ...    |.    ...        || |..|.|||. .|..|| . ..|          ..
GKCKCDWWSCGCILYEMLCGYPPFP----QMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase TVAG_347940.AA TKL 274-306 33 9.8e-07 20.29 In-house 332-364 (364) Show / Hide
Range on Protein: 274-306
Range on HMM: 332-364/364
Sequence Identity: 33% (11 aa)

NEDIKPEIKSLISKCLDEEPSNRPKIEDILSSF
..|. |..|.|. .| |..|..||  ..||. .
CPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL

Kinase TVAG_347940.AA ARK 279-305 40 2e-06 19.99 In-house 254-280 (280) Show / Hide
Range on Protein: 279-305
Range on HMM: 254-280/280
Sequence Identity: 40% (11 aa)

PEIKSLISKCLDEEPSNRPKIEDILSS
.  |.||..|.|..|.|||  |.|...
EQLKNLIQCCWDQDPDNRPSCEEIMEE

Kinase TVAG_347940.AA MLK 279-306 25 2e-06 18.54 In-house 264-291 (291) Show / Hide
Range on Protein: 279-306
Range on HMM: 264-291/291
Sequence Identity: 25% (7 aa)

PEIKSLISKCLDEEPSNRPKIEDILSSF
. .|.|...| ...|..||.   |.. .
EHWKKLMKQCWNQDPHKRPSFRQIVQHL

Kinase TVAG_347940.AA PIM 279-303 44 2e-06 17.96 In-house 231-255 (260) Show / Hide
Range on Protein: 279-303
Range on HMM: 231-255/260
Sequence Identity: 44% (11 aa)

PEIKSLISKCLDEEPSNRPKIEDIL
.|.. ||..||  .|| |...|.||
HECCQLIRWCLTFKPSHRCSLEQIL

Kinase TVAG_347940.AA Dicty3 282-303 22 6e-06 15.42 In-house 330-351 (351) Show / Hide
Range on Protein: 282-303
Range on HMM: 330-351/351
Sequence Identity: 22% (5 aa)

KSLISKCLDEEPSNRPKIEDIL
| .| .|....|..|.... ..
KNFIQHCWQIDPNHRWDMHELI

Kinase TVAG_347940.AA CAMK 274-307 31 7e-06 14.16 In-house 392-425 (425) Show / Hide
Range on Protein: 274-307
Range on HMM: 392-425/425
Sequence Identity: 31% (11 aa)

NEDIKPEIKSLISKCLDEEPSNRPKIEDILS-SFV
.  . .| |.||.|.|  .|..|..||..|.  ..
H-FVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM

Kinase TVAG_347940.AA NAK 280-306 29 7e-06 15.46 In-house 273-299 (299) Show / Hide
Range on Protein: 280-306
Range on HMM: 273-299/299
Sequence Identity: 29% (8 aa)

EIKSLISKCLDEEPSNRPKIEDILSSF
....||...|...|..||.|...|.  
QMHDLIRYMLTPDPEQRPNIYQVLNQL

Kinase TVAG_347940.AA Dicty4 279-309 34 1e-05 15.21 In-house 246-277 (277) Show / Hide
Range on Protein: 279-309
Range on HMM: 246-277/277
Sequence Identity: 34% (11 aa)

PEIKSLISKCLDEEPSNRPKIEDILSS-FVNG
| .|.|| .|.|..|..||  | |..    . 
PSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH

TyrKc TVAG_347940.AA TyrKc 68-306 15 1.7e-05 -133.89 SMART 1-280 (280) Show / Hide
Range on Protein: 68-306
Range on HMM: 1-280/280
Sequence Identity: 15% (47 aa)

IRQIKQL------ALRKGRNTDLIQDLVDGRILVLSSFAIKLPNNAKSINPDDYYRKYAL---------I--SHPCLACPHGEYLFD---FSEAGSMRYM
|. .|.|        .||. .          | |    |.|  .. .         . ..         .  .||.. . .|  . .   | ... .   
ITLGKKLGEGAFGEVYKGTWK----------IQV----AVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIV

MPYYLKGSLGNILQLESQGKHPFQWTSTAKSICSFGILVGLKGLHLKKIVHGLLNPNNILLNRKLEPKISEYWMSELYDKE----SIDMEYDSNF--IDK
| |  .|.| . |.           .   .   .. |  |   || |...|  |   |.|.....  |||   .|   . .      .  |..      |
MEYMPHGDLKDYLRKHRPK-----LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGK

-----------STSQGEFN---DIYSYG-------------------------AILACLATKSQCFSPNL-LNEDI-----KPEIKSLISKCLDEEPSNR
           .   |.|.   |..|.|                          ..... .      |   . . .      .|. .....| .|.|..|
TMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-P-MSFVCCPDEMYQIMKQCWHEDPEDR

PKIEDILSSF
|  ..| . |
PTFSEIHECF

Kinase TVAG_347940.AA TK-Unique 279-306 28 0.000128 11.99 In-house 267-294 (294) Show / Hide
Range on Protein: 279-306
Range on HMM: 267-294/294
Sequence Identity: 28% (8 aa)

PEIKSLISKCLDEEPSNRPKIEDILSSF
.|. .|.. |. .||. || ...|.. .
HEMYNLMKSCWQWEPEERPSFRQIKHRL

Kinase TVAG_347940.AA TBCK 184-211 46 0.000451 10.35 In-house 89-116 (346) Show / Hide
Range on Protein: 184-211
Range on HMM: 89-116/346
Sequence Identity: 46% (13 aa)

ILVGLKGLHLKKIVHGLLNPNNILLNRK
|| ||  .| . |||. | |.||.|...
ILCGLSYMHKHHIVHRFLHPHNIYLDDN

Kinase TVAG_347940.AA Pkinase_Tyr 279-306 28 0.000774 13.62 Pfam 243-270 (270) Show / Hide
Range on Protein: 279-306
Range on HMM: 243-270/270
Sequence Identity: 28% (8 aa)

PEIKSLISKCLDEEPSNRPKIEDILSSF
.|| .|. .| ...|..||  ..|.. .
DEIYDLMKQCWHYDPEDRPTFSEIHEQL

Kinase TVAG_347940.AA TBCK 280-308 24 0.008303 5.75 In-house 318-346 (346) Show / Hide
Range on Protein: 280-308
Range on HMM: 318-346/346
Sequence Identity: 24% (7 aa)

EIKSLISKCLDEEPSNRPKIEDILSSFVN
. ...| |||   |. || ..  . . . 
WLIQIIRKCLQMCPMKRPSPTELMEHPMF

Kinase TVAG_347940.AA TK-Unique 193-233 33 0.026565 3.89 In-house 151-192 (294) Show / Hide
Range on Protein: 193-233
Range on HMM: 151-192/294
Sequence Identity: 33% (14 aa)

LKKIVHGLLNPNNILLNRKLEPKISEYWMS-ELYDKESIDME
.|||||. |   |.||..... ||. . |. ..|. . ..|.
RKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMM

Kinase TVAG_347940.AA Dicty3 187-209 29 0.145693 0.7 In-house 123-146 (351) Show / Hide
Range on Protein: 187-209
Range on HMM: 123-146/351
Sequence Identity: 29% (7 aa)

GLKGLHLK-KIVHGLLNPNNILLN
.|. .| . .|.|. ....||.|.
TLNYIHKNCHIIHRDIKCDNIMLD

Sel1 TVAG_347940.AA Sel1 437-472 33 1.9e-08 31.16 Pfam 1-43 (43) Show / Hide
Range on Protein: 437-472
Range on HMM: 1-43/43
Sequence Identity: 33% (15 aa)

VDAQYRLAGFLY---TGQ-N--FPK-N-FEL-SEKYYLLAVEQGH
. |||.|. ..|   .|| .   |. . .|. . ..| .| ||||
P-AQYNLG-MYYMYYHGQFGGCVPQDDDYEKEAFYWYQKAAEQGH

Sel1 TVAG_347940.AA Sel1 365-400 20 0.00156 14.87 Pfam 1-43 (43) Show / Hide
Range on Protein: 365-400
Range on HMM: 1-43/43
Sequence Identity: 20% (9 aa)

ARCQFLFGCFR--REGV--G-ISV-N-KNA-ALKSFKAAADQGI
.  |.  |...   .|   | .   . ..  |.. .. ||.|| 
P-AQYNLGMYYMYYHGQFGGCVPQDDDYEKEAFYWYQKAAEQGH

Sel1 TVAG_347940.AA Sel1 473-507 29 0.00591 12.95 Pfam 1-43 (43) Show / Hide
Range on Protein: 473-507
Range on HMM: 1-43/43
Sequence Identity: 29% (13 aa)

LDSLLKLA--ENYQNKQFPG-G-----EEK-AKKYYRLAALQGN
  . ..|.  . |.. || |        || | ..|..|| ||.
P-AQYNLGMYYMYYHGQFGGCVPQDDDYEKEAFYWYQKAAEQGH

Sel1 TVAG_347940.AA Sel1 401-436 24 2.104662 4.48 Pfam 1-43 (43) Show / Hide
Range on Protein: 401-436
Range on HMM: 1-43/43
Sequence Identity: 24% (11 aa)

PEAQYLVS--I--IMGA----KPK-NQNIRQEANNYLVDAADNGF
| ||| .        |      |. . ....||  ..  ||..| 
P-AQYNLGMYYMYYHGQFGGCVPQDD-DYEKEAFYWYQKAAEQGH

Sel1 TVAG_347940.AA Sel1 508-539 15 11.430679 2.04 Pfam 1-43 (43) Show / Hide
Range on Protein: 508-539
Range on HMM: 1-43/43
Sequence Identity: 15% (7 aa)

SDSIFKYGNYLV--EEGK----------LEE-ASDFLIRSADQGN
. . ...| ..   ..|.          .|. |  .. ..|.||.
P-AQYNLG-MYYMYYHGQFGGCVPQDDDYEKEAFYWYQKAAEQGH

Sel1 TVAG_347940.AA Sel1 561-574 28 0.718231 6.03 Pfam 30-43 (43) Show / Hide
Range on Protein: 561-574
Range on HMM: 30-43/43
Sequence Identity: 28% (4 aa)

NAIKYIKKACDSGD
.|... .||.. |.
EAFYWYQKAAEQGH

Sel1 TVAG_347940.AA Sel1 611-646 11 0.127689 8.52 Pfam 1-43 (43) Show / Hide
Range on Protein: 611-646
Range on HMM: 1-43/43
Sequence Identity: 11% (5 aa)

ETCLLRYA--DLLLDGK-Y--VQH-D-ENK-AIECFKRSWKEHN
    ....   ....|. .  |   |  .| |....... .  .
P-AQYNLGMYYMYYHGQFGGCVPQDDDYEKEAFYWYQKAAEQGH

Sel1 TVAG_347940.AA Sel1 776-811 31 2.6e-08 30.71 Pfam 1-43 (43) Show / Hide
Range on Protein: 776-811
Range on HMM: 1-43/43
Sequence Identity: 31% (14 aa)

PRAQLKYG--QMLMDGD--G-VER-D-IAL-AVTNFEKAAQFGI
| ||...|  .|...|.  | |.. | ... |.  ..|||. | 
P-AQYNLGMYYMYYHGQFGGCVPQDDDYEKEAFYWYQKAAEQGH

Sel1 TVAG_347940.AA Sel1 812-838 28 0.007854 12.54 Pfam 1-34 (43) Show / Hide
Range on Protein: 812-838
Range on HMM: 1-34/43
Sequence Identity: 28% (10 aa)

AQANFELS--YIYERGL-LG--ER-D-EEK-AKKY
. | ..|   |.|..|.  |  .. |  || | ..
P-AQYNLGMYYMYYHGQFGGCVPQDDDYEKEAFYW

Sel1 TVAG_347940.AA Sel1 708-739 22 0.087189 9.07 Pfam 1-43 (43) Show / Hide
Range on Protein: 708-739
Range on HMM: 1-43/43
Sequence Identity: 22% (10 aa)

LLAQYDLANYK---LKT--G-H-----KQE-AYKLLEDAANKGN
  ||| |. |         |       ... |..... ||..|.
P-AQYNLGMYYMYYHGQFGGCVPQDDDYEKEAFYWYQKAAEQGH

Sel1 TVAG_347940.AA Sel1 740-775 18 0.240044 7.61 Pfam 1-43 (43) Show / Hide
Range on Protein: 740-775
Range on HMM: 1-43/43
Sequence Identity: 18% (8 aa)

VEAMSRFA--RLGLNGKFD--TED-D-EVF--IEWLKKASDLGD
. |. . .  .. ..|.|.  ..  |      ..|..|| ..|.
P-AQYNLGMYYMYYHGQFGGCVPQDDDYEKEAFYWYQKAAEQGH