Gene TVAG_437100 (T.vaginalis)
TVAG_437100
Species: T.vaginalis
Alias: TvagK1071, TVAG_437100
External Links:
Annotation:
Group:
TKL
Family:
TKL-Unique
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| TVAG_437100.AA | Protein | None | 893 | None | Fasta, JSON |
| TVAG_437100.kin_dom | Protein Kinase Domain | None | 175 | None | Fasta, JSON |
Protein domains of TVAG_437100.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | TVAG_437100.AA | NAK | 224-252 | 41 | 5.8e-10 | 29.37 | In-house | 271-299 (299) | Show / Hide |
Range on Protein: 224-252 Range on HMM: 271-299/299 Sequence Identity: 41% (12 aa) SDPMIDLIKKCIDSDPKNRPTIEEIINQM |. |.|||..... ||..||.|....||. SQQMHDLIRYMLTPDPEQRPNIYQVLNQL |
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| Kinase | TVAG_437100.AA | TKL | 196-252 | 19 | 6.4e-09 | 28.26 | In-house | 271-364 (364) | Show / Hide |
Range on Protein: 196-252 Range on HMM: 271-364/364 Sequence Identity: 19% (18 aa) DIYSFGCILACLLHKSTKFE-VSF-------------VNNA---------------------SSDP--MIDLIKKCIDSDPKNRPTIEEIINQM |.|||| .| .| . .. . . .. .. | |..|...| |.||..||. .||. .. DVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL |
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| Kinase | TVAG_437100.AA | Dicty4 | 228-254 | 41 | 6.7e-09 | 26.01 | In-house | 249-277 (277) | Show / Hide |
Range on Protein: 228-254 Range on HMM: 249-277/277 Sequence Identity: 41% (12 aa) IDLIKKCIDSDPKNRPTIEEIINQ--MSS ..||..| | ||..||. ||||.. . . KHLIQWCWDHDPQHRPSFEEIIQRRILEH |
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| S_TKc | TVAG_437100.AA | S_TKc | 12-259 | 18 | 1.9e-08 | -53.12 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 12-259 Range on HMM: 1-231/231 Sequence Identity: 18% (48 aa) LRVIQQLSDKKNHSTDLVQDLSRGLIFVLSKFKRDLTDKSKKTDANEYYKKYSTISHACLASPHRTYQFDFSDNQYIRYTMPYFLN--SSVSSMIDQEKR ...... . .... . | |. . . | .. .| . | . . ..| ... | | . .. ..|.. .| YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKKRGR GKHPISWTVTKKSIVAYGIAQGIKALHSQNIIHGLLTPSNVFLSRTFEPLISEFWLRELYDISDIDANTSKSF-----------LPTDNTEILAPPYDIY .. . . ..| |..... .||..||| | |.|..|.. . |. | | .. ..| | .. |.. HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL-----GYGKCKCDWW SFGCILACLLHKSTKFE---VSFVNNASSDPMIDLIKKCIDSDPKNRPTIEEIIN--QMSSDHVVF |.||||. .| . |. . | . |....|.|.|| . ||..|||. |. . . | | SCGCILYEMLCGYPPFPQMQMMFKKIG-SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | TVAG_437100.AA | NAK-Unclassified | 224-254 | 32 | 2.4e-08 | 24.95 | In-house | 375-405 (405) | Show / Hide |
Range on Protein: 224-254 Range on HMM: 375-405/405 Sequence Identity: 32% (10 aa) SDPMIDLIKKCIDSDPKNRPTIEEIINQMSS |. . |||... || .||.| ...|. . SNQLHNLIKIMLNEDPIQRPNIYQVLNHICQ |
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| Kinase | TVAG_437100.AA | Ciliate-E2 | 196-250 | 24 | 3e-08 | 24.41 | In-house | 278-361 (365) | Show / Hide |
Range on Protein: 196-250 Range on HMM: 278-361/365 Sequence Identity: 24% (21 aa) DIYSFGCILACLLHKSTKFEVSFVNNAS---------------------------SDPMIDLIKK----CIDSDPKNRPT-IEEIIN ||.|.|.|| ..| . . | . .. |. ..||||| ... ||..|.| .|.|.| DIWSLGVILYEMLFGKPPF---QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILN |
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| Kinase | TVAG_437100.AA | LRRK | 227-254 | 39 | 6.5e-08 | 24.07 | In-house | 324-351 (351) | Show / Hide |
Range on Protein: 227-254 Range on HMM: 324-351/351 Sequence Identity: 39% (11 aa) MIDLIKKCIDSDPKNRPTIEEIINQMSS . |||..| . |||.||. ..|. ..|. YQDLIQHCWQHDPKKRPHFSQIVKRLSQ |
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| Kinase | TVAG_437100.AA | Pkinase | 196-252 | 20 | 1.2e-07 | 28.08 | Pfam | 194-293 (293) | Show / Hide |
Range on Protein: 196-252 Range on HMM: 194-293/293 Sequence Identity: 20% (20 aa) DIYSFGCILACLLHKSTKFEVS----------FVNNASS-------------------------------DPMIDLIKKCIDSDPKNRPTIEEIINQ--M |..|.||||...| . . | . ... . ....|.||.|.. ||| |||.|.| . . DMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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| Kinase | TVAG_437100.AA | Dicty4-Unclassified | 230-252 | 47 | 1.2e-07 | 22.28 | In-house | 241-263 (263) | Show / Hide |
Range on Protein: 230-252 Range on HMM: 241-263/263 Sequence Identity: 47% (11 aa) LIKKCIDSDPKNRPTIEEIINQM ||| | ||. |||...||. . LIKWCWHNDPNKRPTMNQIIQYL |
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| Kinase | TVAG_437100.AA | TKL-Unique | 229-252 | 45 | 3.6e-07 | 21.53 | In-house | 267-290 (290) | Show / Hide |
Range on Protein: 229-252 Range on HMM: 267-290/290 Sequence Identity: 45% (11 aa) DLIKKCIDSDPKNRPTIEEIINQM |||..| ..|| .||. .|||. DLIQQCWHHDPSQRPSFDEIIHRL |
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| Kinase | TVAG_437100.AA | PLK | 126-157 | 43 | 5e-06 | 15.7 | In-house | 107-138 (258) | Show / Hide |
Range on Protein: 126-157 Range on HMM: 107-138/258 Sequence Identity: 43% (14 aa) YGIAQGIKALHSQNIIHGLLTPSNVFLSRTFE | |.||.| ||...||| |...|.||.. . YQIVQGLKYLHQHRIIHRDLKLGNLFLNDNMH |
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| Kinase | TVAG_437100.AA | TK-Unique | 223-252 | 30 | 9e-06 | 16.01 | In-house | 265-294 (294) | Show / Hide |
Range on Protein: 223-252 Range on HMM: 265-294/294 Sequence Identity: 30% (9 aa) SSDPMIDLIKKCIDSDPKNRPTIEEIINQM .|. | |.| |. ..|. ||....|... CSHEMYNLMKSCWQWEPEERPSFRQIKHRL |
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| Kinase | TVAG_437100.AA | LRRK | 111-152 | 35 | 3.8e-05 | 14.13 | In-house | 151-199 (351) | Show / Hide |
Range on Protein: 111-152 Range on HMM: 151-199/351 Sequence Identity: 35% (18 aa) KHP-------ISWTVTKKSIVAYGIAQGIKALHSQN--IIHGLLTPSNVFL ... |||... | .|. || |.. |||.| ||| |.. |..| QDGFHFMKAHISWMLKLK--IALQIAKGMEYLHSHNPPIIHRDLKSPNILL |
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| Kinase | TVAG_437100.AA | TKL | 125-161 | 23 | 0.000134 | 12.49 | In-house | 138-196 (364) | Show / Hide |
Range on Protein: 125-161 Range on HMM: 138-196/364 Sequence Identity: 23% (14 aa) AYGIAQGIKALHSQN--------IIHGLLTPSNVFLSRTFE--------------PLIS |..||.|. |||.| ||| |...|... . .. . |. ALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKIC |
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| Kinase | TVAG_437100.AA | Pkinase_Tyr | 229-252 | 50 | 0.000307 | 14.98 | Pfam | 247-270 (270) | Show / Hide |
Range on Protein: 229-252 Range on HMM: 247-270/270 Sequence Identity: 50% (12 aa) DLIKKCIDSDPKNRPTIEEIINQM ||.|.| . ||..||| .||..|. DLMKQCWHYDPEDRPTFSEIHEQL |
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| TyrKc | TVAG_437100.AA | TyrKc | 26-252 | 16 | 0.000325 | -154.48 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 26-252
Range on HMM: 1-280/280
Sequence Identity: 16% (50 aa)
TDLVQDLSRG--LIFVLSKFKRDLTD---KSKKTDANEYYKKY-------STI--SH--------ACLAS-------PHRTYQFDFSDN----QYIRYTM
| . | .| . .. . | .. |. | || . . . .| .|. . . . . .. .|.|..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR
PYFLNSSVSSMIDQEKRGKHPISWTVTKKSIVAYGIAQGIKALHSQNIIHGLLTPSNVFLSRTFEPLISEFWL-RELYDI-------SDIDANT---SK-
| .. .. .. ||.| |||.|.|| | |. ... . || | | |..|| . ... . .|
PK---------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKT
----------SFLPTDN---------------TEIL---APPYDI-----YSFGCILACLLHK--STKFEV----SFVNNASSDPMIDLIKKCIDSDPKN
.. .. ||. ..|| | ..... . . . || .| | ...|.| . ||..
MLPIRWMAPECI--NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF--VCCPDEMYQIMKQCWHEDPED
RPTIEEIINQM
||| .||. ..
RPTFSEIHECF
|
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| Kinase | TVAG_437100.AA | Ciliate-E2 | 128-152 | 26 | 0.000483 | 9.75 | In-house | 154-194 (365) | Show / Hide |
Range on Protein: 128-152 Range on HMM: 154-194/365 Sequence Identity: 26% (11 aa) IAQ---------------GIKALHSQN-IIHGLLTPSNVFL |.| ... |||.| ||| . |.|... ILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF |
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| Kinase | TVAG_437100.AA | TK-Unique | 125-184 | 28 | 0.001012 | 8.85 | In-house | 137-199 (294) | Show / Hide |
Range on Protein: 125-184 Range on HMM: 137-199/294 Sequence Identity: 28% (18 aa) AYGIAQGIKALHS--QNIIHGLLTPSNVFLSRTFEPLISEF-WLRELYDISDIDANTSKSFLP |..||.| . |.| ..|.|. | .||.|.. .. |. | |..|. ... ..|.. .| AWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIP |
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| Kinase | TVAG_437100.AA | PLK | 229-250 | 45 | 0.001408 | 7.64 | In-house | 233-254 (258) | Show / Hide |
Range on Protein: 229-250 Range on HMM: 233-254/258 Sequence Identity: 45% (10 aa) DLIKKCIDSDPKNRPTIEEIIN |||.| .. .| ||||..|.. DLIQKMLNWNPDERPTIDQILQ |
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| Kinase | TVAG_437100.AA | Dicty4-Unclassified | 124-142 | 52 | 0.002362 | 7.3 | In-house | 114-132 (263) | Show / Hide |
Range on Protein: 124-142 Range on HMM: 114-132/263 Sequence Identity: 52% (10 aa) VAYGIAQGIKALHSQNIIH .| ||||. ||. |.|| YAFDIAQGMQHLHTRNFIH |
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| Kinase | TVAG_437100.AA | TKL-Unique | 128-154 | 41 | 0.003232 | 7.41 | In-house | 119-147 (290) | Show / Hide |
Range on Protein: 128-154 Range on HMM: 119-147/290 Sequence Identity: 41% (12 aa) IAQGIKALHSQN--IIHGLLTPSNVFLSR |||| ||. . |||. |..||. ... IAQGMYYLHHCEPPIIHRDLKSSNFLVDN |
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| Kinase | TVAG_437100.AA | NAK | 126-142 | 28 | 0.010594 | 4.75 | In-house | 126-146 (299) | Show / Hide |
Range on Protein: 126-142 Range on HMM: 126-146/299 Sequence Identity: 28% (6 aa) YGIAQGIKALHSQN----IIH .....|..|.|... ||| CDVCEGVQAMHQCQPPKPIIH |
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| Kinase | TVAG_437100.AA | Pkinase | 124-142 | 42 | 0.059631 | 7.98 | Pfam | 113-131 (293) | Show / Hide |
Range on Protein: 124-142 Range on HMM: 113-131/293 Sequence Identity: 42% (8 aa) VAYGIAQGIKALHSQNIIH ..| |..|.. .||..||| YMYQILRGLEYCHSMGIIH |
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| Sel1 | TVAG_437100.AA | Sel1 | 380-415 | 40 | 2.9e-13 | 47.17 | Pfam | 1-43 (43) | Show / Hide |
Range on Protein: 380-415 Range on HMM: 1-43/43 Sequence Identity: 40% (18 aa) QDAQYRLG--LMYAHGE--G-VST-D-PKL-AEKYLRLAADQGH |||.|| .|| ||. | | | ... | .....||.||| P-AQYNLGMYYMYYHGQFGGCVPQDDDYEKEAFYWYQKAAEQGH |
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| Sel1 | TVAG_437100.AA | Sel1 | 347-379 | 20 | 0.083635 | 9.13 | Pfam | 1-43 (43) | Show / Hide |
Range on Protein: 347-379 Range on HMM: 1-43/43 Sequence Identity: 20% (9 aa) PYAQYQASYYM---VSK-----PK-S-LNE-AIAYLTSSADSGY | |||. .|. . |. ... |..... .|. |. P-AQYNLGMYYMYYHGQFGGCVPQDDDYEKEAFYWYQKAAEQGH |
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| Sel1 | TVAG_437100.AA | Sel1 | 323-346 | 16 | 11.195377 | 2.07 | Pfam | 14-43 (43) | Show / Hide |
Range on Protein: 323-346 Range on HMM: 14-43/43 Sequence Identity: 16% (5 aa) KGR--G-CSV-N-KNA-SLKSFRFAADAGN .|. | . . .. ... .. ||..|. HGQFGGCVPQDDDYEKEAFYWYQKAAEQGH |
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| Sel1 | TVAG_437100.AA | Sel1 | 452-486 | 20 | 4.182018 | 3.49 | Pfam | 1-43 (43) | Show / Hide |
Range on Protein: 452-486 Range on HMM: 1-43/43 Sequence Identity: 20% (9 aa) SQAQLSYAKYL--IDKAFEE-NKQ-D-IVE----LLTRASDQGN . ||. .. |. . | .| | . . ....| .||. P-AQYNLGMYYMYYHGQFGGCVPQDDDYEKEAFYWYQKAAEQGH |
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| Sel1 | TVAG_437100.AA | Sel1 | 559-594 | 18 | 0.002088 | 14.45 | Pfam | 1-43 (43) | Show / Hide |
Range on Protein: 559-594 Range on HMM: 1-43/43 Sequence Identity: 18% (8 aa) DRAMVQYA--QILREGK--G-VNV-D-KNG-CYSYLKRSAEEKH |. ... ... .|. | | | .. . .....|| | P-AQYNLGMYYMYYHGQFGGCVPQDDDYEKEAFYWYQKAAEQGH |
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| Sel1 | TVAG_437100.AA | Sel1 | 536-558 | 27 | 0.002737 | 14.06 | Pfam | 15-43 (43) | Show / Hide |
Range on Protein: 536-558 Range on HMM: 15-43/43 Sequence Identity: 27% (8 aa) GK----VQVDD-PVL-AAKYFKMAADKGD |. | || . . |......||..|. GQFGGCVPQDDDYEKEAFYWYQKAAEQGH |
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| Sel1 | TVAG_437100.AA | Sel1 | 610-629 | 30 | 5.443014 | 3.11 | Pfam | 19-43 (43) | Show / Hide |
Range on Protein: 610-629 Range on HMM: 19-43/43 Sequence Identity: 30% (8 aa) G-NKW-NSDLEK----FMKMAADAGH | . . |.|| ....||..|| GCVPQDD-DYEKEAFYWYQKAAEQGH |
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| Sel1 | TVAG_437100.AA | Sel1 | 661-696 | 25 | 0.382058 | 6.94 | Pfam | 1-43 (43) | Show / Hide |
Range on Protein: 661-696 Range on HMM: 1-43/43 Sequence Identity: 25% (11 aa) PRAYYELADYY--LTGK--F-MSD-D-KLL-PARLMKGAADLGY | |.|.|. || ..|. | . . ..... ||..|. P-AQYNLGMYYMYYHGQFGGCVPQDDDYEKEAFYWYQKAAEQGH |
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| Sel1 | TVAG_437100.AA | Sel1 | 734-769 | 25 | 5.2e-09 | 33.05 | Pfam | 1-43 (43) | Show / Hide |
Range on Protein: 734-769 Range on HMM: 1-43/43 Sequence Identity: 25% (11 aa) EKSQYRYA--EMLADGD--T-LDE-D-IQQ-AVYYFELAAKQGN .||... .|. .|. . | ... |.|....||.||. P-AQYNLGMYYMYYHGQFGGCVPQDDDYEKEAFYWYQKAAEQGH |
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| Sel1 | TVAG_437100.AA | Sel1 | 770-801 | 35 | 5.7e-07 | 26.28 | Pfam | 1-38 (43) | Show / Hide |
Range on Protein: 770-801 Range on HMM: 1-38/43 Sequence Identity: 35% (14 aa) PKANYALG--LIYEMGE-GP-IQK-D-EKK-ARAYYKKA | | |.|| ..|. |. | . . | .| |...|.|| P-AQYNLGMYYMYYHGQFGGCVPQDDDYEKEAFYWYQKA |
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| Sel1 | TVAG_437100.AA | Sel1 | 712-733 | 33 | 0.003122 | 13.87 | Pfam | 20-43 (43) | Show / Hide |
Range on Protein: 712-733 Range on HMM: 20-43/43 Sequence Identity: 33% (8 aa) CLPTDN-VKT-AAEYYKMAADLGD | | |. . |...|..||..|. CVPQDDDYEKEAFYWYQKAAEQGH |
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