Gene 88546.m00273 (T.vaginalis)
88546.m00273
Species: T.vaginalis
Alias: 88546.m00273, TvagK0883
External Links:
Annotation:
Group:
TKL
Family:
TKL-Unique
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| 88546.m00273.AA | Protein | None | 643 | None | Fasta, JSON |
| 88546.m00273.kin_dom | Protein Kinase Domain | None | 147 | None | Fasta, JSON |
Protein domains of 88546.m00273.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 88546.m00273.AA | TKL | 58-292 | 16 | 1.7e-28 | 99.75 | In-house | 31-364 (364) | Show / Hide |
Range on Protein: 58-292
Range on HMM: 31-364/364
Sequence Identity: 16% (57 aa)
VKTLNIDL-----------------------SQTQNASRFFKEVQNLSLSY--FPTILPFAGFTISNPH---------NGRKPAVAFDHYSGQK-LSEIL
||..... .... |||.|.. ...| | |..| |. ...|. . ... . ..| |. ..
VKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH
ELETKNQSPETWDLTMKIRTSLGVALALNYMHGYR--------CPHGNLNADNVVFGDDFW--------------PYLTDFSLNNFYDENTIKNL-----
|...... .|..|...||.| . | .|. .|. ... . ..|| | | .... .|
-----------WHQRCRW--ALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTM
------------VPGEN-HPIWKAPEL-EGETAKTQKG---------------DVYSFGMLVFQLFIGKTQFDIISNTPDI---------YQKLKSSTRP
. .| | |||. .|.. |.| ||||||.. . .. ... .. . . | | .. . . ||
MESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRP
KIP------------DNVPLEIKNIIQSCWAPNPNDRPTMSNVIKLF
|| ...| ..|...| ||...|..||... ..| .
PIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
|
|||||||||
| Kinase | 88546.m00273.AA | MLK | 202-292 | 21 | 3.9e-17 | 56.11 | In-house | 197-291 (291) | Show / Hide |
Range on Protein: 202-292 Range on HMM: 197-291/291 Sequence Identity: 21% (21 aa) PIWKAPEL----EGETAKTQKGDVYSFGMLVFQLFIGKTQFD-IISNTPDIYQKLKSSTRPKIPDNVPLEIKNIIQSCWAPNPNDRPTMSNVIKLF ..| ||| ..|. . | ||.|.|.. ... ... .. .... ... ..|| || . | .|. .. || ..|..||... ... . YAWMAPEVIQQFRCEKY-SEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL |
|||||||||
| Kinase | 88546.m00273.AA | RGC | 178-294 | 20 | 1.8e-16 | 54.52 | In-house | 127-300 (300) | Show / Hide |
Range on Protein: 178-294
Range on HMM: 127-300/300
Sequence Identity: 20% (36 aa)
LTDFSL-----NNFYDENTIK--------NLVPGENHP-----IWKAPELEGETAK-------------TQKGDVYSFGMLVFQLFIGKT-----QFDI-
.||| | . | ... .. . . || |.|||. |.. ||||||||||. ... | | .
ITDFGLNNPLCHWFKHGQINPPCKSDDKSWQRQHDEHPYYKKMLWTAPEHLREWRMPHQWGPHRQTQRGTQKGDVYSFGIIMYEIITRKGPWDLEPFCMW
----ISNTPDIYQKLKS--------STRPKIPDN-------VPLEIKNIIQSCWAPNPNDRPT-MSNVIKLFEE
.. .|....| ..||.|... .. .. ... ||| .| .||. .... |....
PGEYELSPMEIIEEVKYPPKKGGQKPFRPSIHEDEEGHMIECNPCLLHLMRDCWAEDPEERPDMFDQIRKQLKT
|
|||||||||
| Kinase | 88546.m00273.AA | RGC | 178-294 | 20 | 2.2e-16 | 54.52 | In-house | 127-300 (300) | Show / Hide |
Range on Protein: 178-294
Range on HMM: 127-300/300
Sequence Identity: 20% (36 aa)
LTDFSL-----NNFYDENTIK--------NLVPGENHP-----IWKAPELEGETAK-------------TQKGDVYSFGMLVFQLFIGKT-----QFDI-
.||| | . | ... .. . . || |.|||. |.. ||||||||||. ... | | .
ITDFGLNNPLCHWFKHGQINPPCKSDDKSWQRQHDEHPYYKKMLWTAPEHLREWRMPHQWGPHRQTQRGTQKGDVYSFGIIMYEIITRKGPWDLEPFCMW
----ISNTPDIYQKLKS--------STRPKIPDN-------VPLEIKNIIQSCWAPNPNDRPT-MSNVIKLFEE
.. .|....| ..||.|... .. .. ... ||| .| .||. .... |....
PGEYELSPMEIIEEVKYPPKKGGQKPFRPSIHEDEEGHMIECNPCLLHLMRDCWAEDPEERPDMFDQIRKQLKT
|
|||||||||
| Kinase | 88546.m00273.AA | Dicty4 | 202-294 | 28 | 3e-16 | 50.85 | In-house | 181-277 (277) | Show / Hide |
Range on Protein: 202-294 Range on HMM: 181-277/277 Sequence Identity: 28% (28 aa) PIWKAPELEGETAKTQKGDVYSFGMLVFQLFIGKTQFD-IISNTPDIYQKLKS-STRPKIPDNVPLEIKNIIQSCWAPNPNDRPTMSNVIKL--FEE | | ||| . . ..| ||||||.. .... .. . ..... .. . ||.|||..| .| || || ..|. ||... .|. |. PCWMAPEVMMHQPYNEKADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH |
|||||||||
| Kinase | 88546.m00273.AA | NZAK | 206-292 | 31 | 6e-16 | 49.56 | In-house | 240-329 (329) | Show / Hide |
Range on Protein: 206-292 Range on HMM: 240-329/329 Sequence Identity: 31% (28 aa) APELEGETAKTQKGDVYSFGMLVFQLFIGKTQFDIIS--NTPDIYQKLKSSTRPKIPDNVPLEIKNIIQSCWAPNPNDR-PTMSNVIKLF ||| ..| ||.|||..|.|.| . . | | . | .| ||..||. .|..|. || .|. | | .| . APENKNNHRINEKSDVWSFGCTVWQMFGYNPPNTIYSPKEMASMVSDQKFNYIPQIPFHVPDKMKDFITQCWDIDPKKRPKDFSHMIEKL |
|||||||||
| Kinase | 88546.m00273.AA | Dicty4-Unclassified | 202-292 | 36 | 2.3e-15 | 49.07 | In-house | 172-263 (263) | Show / Hide |
Range on Protein: 202-292 Range on HMM: 172-263/263 Sequence Identity: 36% (34 aa) PIWKAPE-LEGETAKTQKGDVYSFGMLVFQLFIGKTQFDIISNTPDIYQKLKSST-RPKIPDNVPLEIKNIIQSCWAPNPNDRPTMSNVIKLF | | .|| | .| . .|| ||||..|. . | | . | .. . |||||||.. .| | || || |||| .|. PKWESPECLMHE-SYNQKSDVYSYAMMLYELATGDEPYQEIQSIMNAARSVCDKKLRPKIPDNCDNFWKKLIKWCWHNDPNKRPTMNQIIQYL |
|||||||||
| Kinase | 88546.m00273.AA | TKL-Unique | 202-292 | 26 | 2.4e-15 | 50.74 | In-house | 190-290 (290) | Show / Hide |
Range on Protein: 202-292 Range on HMM: 190-290/290 Sequence Identity: 26% (27 aa) PIWKAPE-LEGE-TAKTQKGDVYSFGMLVFQLFIGKT------QFDIISNTPDIYQKLKS---STRPKIPDNVPLEIKNIIQSCWAPNPNDRPTMSNVIK ..| ||| |... . ..| ||||||. . .. .| .. .. . ....... . ||.||.. | |....|| ||...| .||. ...|. FRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQE-QWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIH LF RL |
|||||||||
| Kinase | 88546.m00273.AA | Gdt | 220-292 | 33 | 1.1e-14 | 46.67 | In-house | 216-289 (289) | Show / Hide |
Range on Protein: 220-292 Range on HMM: 216-289/289 Sequence Identity: 33% (25 aa) DVYSFGMLVFQLFIGKTQFDIISNTPDIYQKLKSSTRPKIPDNVPLE--IKNIIQSCWAPNPNDRPTMSNVIKLF ||||||.| . ..|... | | .| . . .|| .. |.||| ||..||. ||| . .|. DVYSFGILFYEMMIERIPFHEI-CHWEIPNFVQDGWRPTLDQDIFDDNDIRNIIECCWNKNPHKRPTFDEISKHL |
|||||||||
| Kinase | 88546.m00273.AA | LRRK | 202-294 | 29 | 2.2e-14 | 47.3 | In-house | 243-351 (351) | Show / Hide |
Range on Protein: 202-294 Range on HMM: 243-351/351 Sequence Identity: 29% (32 aa) PIWKAPELEGET---AKTQKGDVYSFGMLVFQLFIGK-TQFDIIS-N-----TPDIYQKLKSSTRPKIPDN-VPL-----EIKNIIQSCWAPNPNDRPTM |.| ||| ... |.| |.|||||. . | .. || .. . | .| .. ||.|| . | . .. ||.||. .|..||.. PGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHF SNVIKLFEE | ..| .. SQIVKRLSQ |
|||||||||
| Kinase | 88546.m00273.AA | Pkinase_Tyr | 216-292 | 31 | 3e-13 | 45.49 | Pfam | 192-270 (270) | Show / Hide |
Range on Protein: 216-292 Range on HMM: 192-270/270 Sequence Identity: 31% (25 aa) TQKGDVYSFGMLVFQLFI-GKTQ-FDIISNTPDIYQKL-KSSTRPKIPDNVPLEIKNIIQSCWAPNPNDRPTMSNVIKLF | | ||.||| | . .| |.. . . ..|... .. | ..|.| | || .....||...|.||||.| .. . TTKSDVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL |
|||||||||
| S_TKc | 88546.m00273.AA | S_TKc | 29-292 | 14 | 2.4e-10 | -25.2 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 29-292 Range on HMM: 1-231/231 Sequence Identity: 14% (41 aa) YDPREVIFDSPLGNITLMINENENDFKYFVKTLNIDLSQTQNASRFFKEVQNLSLSYFPTILPFAGFTISNPHNGRKPAVAFDHYSG--QKLSEILELET |. ..| | . .. . . .. .| .. .. .|.| |. | | . .. . . . ... .| | .... YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKKRG KNQSPETWDLTMKIRTSLGVALALNYMHGYRCPHGNLNADNVVFGDDFWPYLTDFSLNNFYDENTIKNLVPGENH----PIWKAPELEGETAKTQ-KGDV .. . . . . ...||.|.| . | | .|. . . ..|| | .. .. | . |||. . | |. RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------------TTFCGTPWYMAPEVL---GYGKCKCDW YSFGMLVFQLFIGKTQFDIISNTPDIYQKLKSSTRPKIPDNVPLEIKNIIQSCWAPNPNDRPTMSNVIK---------LF .|.| ... .. |.. |. . ...|.. . | |..|. |. .|..||| . . | WSCGCILYEMLCGYPPFP---QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
|||||||||
| TyrKc | 88546.m00273.AA | TyrKc | 34-292 | 20 | 3.5e-10 | -58.11 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 34-292 Range on HMM: 1-280/280 Sequence Identity: 20% (60 aa) VIFDSPLGN-------ITLMINENENDFKYFVKTLNIDLSQTQNASRFFKEVQNLSLS--YFPTILPFAGFTISNPHNG---RKPAVAFDHYSGQKLSEI . .. ||. .. . ||.|. | | .| . .. | |. . | .. | . . . . .. | . ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY LELETKNQSPETWDLTMKIRTSLGVALALNYMHGYRCPHGNLNADNVVFGDDFWPYLTDFSLNNFYDEN--------TIKNLV-PGEN--HPI-WKAPEL | .. . .. .. .| .| | .| | | | |. |... .|| | . .. ... |.. || | ||| LRKHRPK-----LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPEC EGETAKTQKGDVYSFGMLVFQLF-IGKTQFDI-----ISNTPDIYQKLKSSTRPKIPDN--------VPLEIKNIIQSCWAPNPNDRPTMSNVIKLF . | | ||.||| . . .| |.. .||. ......|. |...|.| | |. .|...||. .|.||||.|.....| INYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQ-EVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
|||||||||
| Kinase | 88546.m00273.AA | Pkinase | 204-292 | 19 | 7.7e-09 | 32.34 | Pfam | 177-293 (293) | Show / Hide |
Range on Protein: 204-292 Range on HMM: 177-293/293 Sequence Identity: 19% (23 aa) WKAPELEG-ETAKTQKGDVYSFGMLVFQLFIGKTQFDII---SNTPDIYQKLKSSTRPKIPDNVP-----------------------LEIKNIIQSCWA . |||. . ..| |..|.| ...... |.. |. | | .|... .|... . | | | .| .|.. YMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLC PNPNDRPTMSNVIKL--F ..|..||| . . | KDPKKRPTAEQILQHPWF |
|||||||||
| Sel1 | 88546.m00273.AA | Sel1 | 336-371 | 29 | 1.7e-09 | 34.66 | Pfam | 1-43 (43) | Show / Hide |
Range on Protein: 336-371 Range on HMM: 1-43/43 Sequence Identity: 29% (13 aa) ASAQNNFG--VMLLNGK--G-VHK-N-LGA-AARYFQLSADQGS . ||.| | |...|. | | . . . |....|..|.||. P-AQYNLGMYYMYYHGQFGGCVPQDDDYEKEAFYWYQKAAEQGH |
|||||||||
| Sel1 | 88546.m00273.AA | Sel1 | 444-479 | 29 | 3.4e-08 | 30.34 | Pfam | 1-43 (43) | Show / Hide |
Range on Protein: 444-479 Range on HMM: 1-43/43 Sequence Identity: 29% (13 aa) APAQYRLG--YLHETGE--G-AAM-N-YNE-ALRYYKAASIQKY . |||.|| |....|. | . |.. |...|. | | . P-AQYNLGMYYMYYHGQFGGCVPQDDDYEKEAFYWYQKAAEQGH |
|||||||||
| Sel1 | 88546.m00273.AA | Sel1 | 372-407 | 22 | 4.7e-08 | 29.88 | Pfam | 1-43 (43) | Show / Hide |
Range on Protein: 372-407 Range on HMM: 1-43/43 Sequence Identity: 22% (10 aa) MEGMHNIG--FALENGA--G-VKK-N-LPL-AILYYKAAADKGS ...|.| ....| | |.. . . . |. .|. ||..|. P-AQYNLGMYYMYYHGQFGGCVPQDDDYEKEAFYWYQKAAEQGH |
|||||||||
| Sel1 | 88546.m00273.AA | Sel1 | 408-443 | 18 | 1.9e-07 | 27.9 | Pfam | 1-43 (43) | Show / Hide |
Range on Protein: 408-443 Range on HMM: 1-43/43 Sequence Identity: 18% (8 aa) KAAQNSYA--QCLMKGN--G-IEK-N-ILE-AAKYFRMAAQQNS ||. .. .....| | ... . . . |......||.|.. P-AQYNLGMYYMYYHGQFGGCVPQDDDYEKEAFYWYQKAAEQGH |
|||||||||
| Sel1 | 88546.m00273.AA | Sel1 | 516-551 | 15 | 0.120796 | 8.6 | Pfam | 1-43 (43) | Show / Hide |
Range on Protein: 516-551 Range on HMM: 1-43/43 Sequence Identity: 15% (7 aa) AKSCCLHG--SACITGD--G-VTK-N-VDF-ARKMFEKAITKKE . ... | . .|. | |.. . . |.. ..|| . P-AQYNLGMYYMYYHGQFGGCVPQDDDYEKEAFYWYQKAAEQGH |
|||||||||
| Sel1 | 88546.m00273.AA | Sel1 | 480-515 | 25 | 0.193599 | 7.92 | Pfam | 1-43 (43) | Show / Hide |
Range on Protein: 480-515 Range on HMM: 1-43/43 Sequence Identity: 25% (11 aa) PPAMYRFG--LMILNEK--V-TGQ-N-VAE-ARKSIMTAAQMGH | |.|. | .| .. . . | . .. |.. ||..|| P-AQYNLGMYYMYYHGQFGGCVPQDDDYEKEAFYWYQKAAEQGH |
|||||||||