TVAG_182480

Species: T.vaginalis
Alias: TvagK1053, TVAG_182480
External Links:
Annotation:

Classification

Group: PKL
Family: PIK
Subfamily: FRAP

Sequence

Name Sequence Type Origin Length Description Download
TVAG_182480.AA Protein None 2138 None Fasta, JSON
TVAG_182480.kin_dom Protein Kinase Domain None 258 None Fasta, JSON

Protein domain

Protein domains of TVAG_182480.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase TVAG_182480.AA FATC 2106-2138 39 3.9e-11 38.68 Pfam 1-33 (33) Show / Hide
Range on Protein: 2106-2138
Range on HMM: 1-33/33
Sequence Identity: 39% (13 aa)

TDVSLETELQQLIESATDINNIAKMPPSWYPWW
.  | |   ..||..|||..|...| . | |||
EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW

Kinase TVAG_182480.AA PIKK 1916-2056 22 1.4e-10 35.09 In-house 142-290 (290) Show / Hide
Range on Protein: 1916-2056
Range on HMM: 142-290/290
Sequence Identity: 22% (34 aa)

VDYSQLSVEDRVNALKNVRKYFEGNELSRAILVTSKDADAWAYRTSHFSSSLGAMSALAFMLGSVDHSPQQFLIDKITGNVTFSSFAG--GSRKQ-----
..|. .. ...| ..  .     .. . .. . .. |...| .|.... .|.  |.   . ||  |  |. ..||..|| .    |.   .| .|     
MMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCMVGYILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVP

-SVPFRLTPQLSNALGRCQYSGPFSSYFTQTMKDIRKRAISLAPVLQFF
  ||||||....||.| .. .|.| .   ..|. .|.   .|  |.  |
EKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF

Kinase TVAG_182480.AA ATR 1952-2056 21 6.4e-09 26.09 In-house 156-267 (267) Show / Hide
Range on Protein: 1952-2056
Range on HMM: 156-267/267
Sequence Identity: 21% (24 aa)

DADAWAYRTSHFSSSLGAMSALAFMLGSVDHSPQQFLIDKITGNVTFSSFAGGSRK-------QSVPFRLTPQLSNALGRCQYSGPFSSYFTQTMKDIRK
|.  |    . .  |  ... . ...|  |   .  |||||.| .    ..    .         ||||||  . ...|  .  | |      .|. .|.
DPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDYNCIFNSGEQFEVPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRD

RAISLAPVLQFF
.   .  |.. |
HRDDIMSVWDCF

PI3Kc TVAG_182480.AA PI3Kc 1837-2124 14 2.1e-05 -80.16 SMART 1-336 (336) Show / Hide
Range on Protein: 1837-2124
Range on HMM: 1-336/336
Sequence Identity: 14% (49 aa)

RNLKKV-----RSLATEQLVDALTPILDDI-------HHINHGSIIQLSGNLYLFEVPKGQASMYEMITVYEQSKGRIIDAEQASIKKWYNV--------
. . |.     .   . |..     |.           |..  ..| .. .  . |. .  ... ..   |.  |. ..| .|.  .    |        
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDML-VPEIQKNMY

-------------DYSQLSVEDRVNALKNVRKYFEGNELSRAILVTSKDAD-AWAYRTSHFSSSLGAMSALAFMLGSVDHSPQQFLIDKITGNV------
             .| ... . ..     ... | .. |    . ...|.. .|  . ..| .|. ...   ..||  |  ......|. ||..      
MMIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFG

-TFSSFAGGSRKQ-----SVPFRLTPQLSNALG----RCQYSGPFSSYFTQTMKDIRKRAISLAPVLQFFIADPPFTKPKI-PHSFMKQLGVEIPVEENQ
  |... .    .      ||||||... .. |      .| | | ..  .... .|| . ..  ... .. ||      | |.  |.  .  | .....
HIFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDP------IMPCWRMM--EKDIKYLRQR

TQEEKEIDEEINDIYAR-----LVGTD-VSLETELQQLIESATDI
 ...   |||.    ..     | . .  |. |.......  .  
FRLDHLSDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY

Kinase TVAG_182480.AA FRAP 2010-2066 36 0.003669 7.64 In-house 195-251 (251) Show / Hide
Range on Protein: 2010-2066
Range on HMM: 195-251/251
Sequence Identity: 36% (21 aa)

VPFRLTPQLSNALGRCQYSGPFSSYFTQTMKDIRKRAISLAPVLQFFIADPPFTKPK
.|||||  | ||.  |.  | .       || ||    |.  ||  |. || |    
IPFRLTRMLVNAMEACGIEGNYRNTCELVMKVIREHKESVMAVLEAFVYDPLFYWRL

Kinase TVAG_182480.AA FRAP 1917-1996 23 0.015532 5.31 In-house 94-173 (251) Show / Hide
Range on Protein: 1917-1996
Range on HMM: 94-173/251
Sequence Identity: 23% (19 aa)

DYSQLSVEDRVNALKNVRKYFEGNELSRAILVTSKDADAWAYRTSHFSSSLGAMSALAFMLGSVDHSPQQFLIDKITGNV
||..|   ..|   . . .   |..| . .   |   . |  |   .  ||  ||   ..||  |  |   .... || .
DYDHLPLMNKVEIFRYIMNNTKGEDLKKLLWLKSPNSEIWFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKI