Gene 97299.m00082 (T.vaginalis)
97299.m00082
Species: T.vaginalis
Alias: TvagK0884, 97299.m00082
External Links:
Annotation:
Group:
TKL
Family:
TKL-Unique
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| 97299.m00082.AA | Protein | None | 641 | None | Fasta, JSON |
| 97299.m00082.kin_dom | Protein Kinase Domain | None | 234 | None | Fasta, JSON |
Protein domains of 97299.m00082.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 97299.m00082.AA | TKL | 51-291 | 18 | 4.6e-29 | 101.78 | In-house | 24-364 (364) | Show / Hide |
Range on Protein: 51-291
Range on HMM: 24-364/364
Sequence Identity: 18% (66 aa)
DNNTEYLVKTIYL--DMGQMLNS---------------------IAFFEEVQNLSLSF--HPTILPFAGFSVSNPH---------SGRRPCVAFDSYSGM
| ... ||.. |. ..|| . ||||.. ...| || |..| |.. ..|. . .| . ..|
DTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGG
S-LSGILEMEANKVAPENWNLTSKIITAFGIALGLNYMHSYN--------FIHGNLNADSIVFGDELW--------------PYIANFSLNNFFDEDSL-
| |. .. |... .. | .||.|.||.|| | || .|. . | . . . |. | | |.....
SLLHYLH-----------WHQRCRW--ALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNM
------------------ALIAPKKQLLWRAPELNLQSDKTLKA----------------DVYAFGMLVFHIFCGKTFYEQVENSPGI---------YEK
... . . | |||. ..... .. |||.||.. . |..... |.. ..| | .
NDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMV
IHSATRPKIA------------NDVPNEIKKIIQFCWAPDPNGRPTMANVVRLF
.. || | .|.| ..||..| ||..||. ||.. .. .
CDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
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| Kinase | 97299.m00082.AA | HH498 | 203-291 | 25 | 7.6e-16 | 46.34 | In-house | 191-284 (284) | Show / Hide |
Range on Protein: 203-291 Range on HMM: 191-284/284 Sequence Identity: 25% (24 aa) WRAPELNLQSDK-TLKADVYAFGMLVFHIFCGKTFYEQVENSPGIYEKIHSATRPKIAND----VPNEIKKIIQFCWAPDPNGRPTMANVVRLF |.||| |. | . |.||. ..| .. .. .. . . | .|| |.. .| . .|| || | |..||. . .|.. WMAPEVFSQCQKYSIKVDVFSYAMCIWEMHTREVPFHHYKPAAAAAEMAYHHIRPPIPQTPTAQIPHHWSNLIQMCWHPCPENRPDFDQIVTIL |
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| Kinase | 97299.m00082.AA | MLK | 203-291 | 24 | 1.5e-14 | 46.99 | In-house | 199-291 (291) | Show / Hide |
Range on Protein: 203-291 Range on HMM: 199-291/291 Sequence Identity: 24% (23 aa) WRAPELN--LQSDK-TLKADVYAFGMLVFHIFCGKTFYE-QVENSPGIYEKIHSATRPKIANDVPNEIKKIIQFCWAPDPNGRPTMANVVRLF |.||| ....| . |.||. .|.. .. ... |. .... ... .. .|| | .. | .|| .. || .||. ||... .| . WMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL |
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| Kinase | 97299.m00082.AA | Src-Echino1 | 146-291 | 27 | 1.7e-14 | 46.26 | In-house | 105-252 (252) | Show / Hide |
Range on Protein: 146-291 Range on HMM: 105-252/252 Sequence Identity: 27% (41 aa) IALGLNYMHSYNFIHGNLNADSIVFGDELWPYIANFSLNNFFDEDS-LALIAPKKQLLWRAPELNLQSDKTLKADVYAFGMLVFHIFC-GKTFYEQVENS || |..|. | |..| .| | .. |. ||.| | . ..| . . | . | ||| | |.|.||..||.|. . |. |... | IASGMDYLGSKNVVHRDLAARNVLVGKGNVCKIADFGLARMMQKDVYCGKQGAKLPIKWTAPEAALYGRFTIKSDVWSFGILMTEMVTFGRYPYPGMMNR PGIYEKIHSATRPKIANDVPNEIKKI-IQFCWAPDPNGRPTMANVVRLF . .... | .. |. . .. . || || |||. . | -EVLDQVDRGYRMPKMHHCPDSLYMMCMMKCWHKDPQQRPTFEFLHDFF |
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| Kinase | 97299.m00082.AA | Frk | 146-295 | 25 | 6.1e-14 | 44.36 | In-house | 107-260 (260) | Show / Hide |
Range on Protein: 146-295 Range on HMM: 107-260/260 Sequence Identity: 25% (40 aa) IALGLNYMHSYNFIHGNLNADSIVFGDELWPYIANFSLNN-FFDEDS---LALIAPKKQLLWRAPELNLQSDKTLKADVYAFGMLVFHIFC-GKTFYEQV .| |. |. | |.|| | | .. |... || | | . .. . . . | ||| . |.|.||..||.|. | |. | . VAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTEIITYGRMPYPGM ENSPGIYEKIHSATRPKIANDVPNEIKKIIQFCWAPDPNGRPTMANVVRLFEESV | . . .. | . | .. .|.. || ||. ||| . .|. TNA-EVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF |
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| Kinase | 97299.m00082.AA | TAK1 | 215-290 | 28 | 9.1e-14 | 42.78 | In-house | 203-284 (284) | Show / Hide |
Range on Protein: 215-290 Range on HMM: 203-284/284 Sequence Identity: 28% (23 aa) TLKADVYAFGMLVFHIFCGKTFYEQVEN---SPGIYEKIHSATR-PKIAN--DVPNEIKKIIQFCWAPDPNGRPTMANVVRL . |.|.| .| . | |.. .| ..|. .||...| | ..| |.| |.. . || .| ||.|. .| NMKCDIYSWGIIMWEVISRKHPYDHIMNPNSAYRIMWAIHNGNRPPMETNRSDCPKRIEQFMKCCWDDNPEKRPSMQECVKY |
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| Kinase | 97299.m00082.AA | TKL-Unique | 197-291 | 27 | 1.2e-13 | 44.7 | In-house | 186-290 (290) | Show / Hide |
Range on Protein: 197-291 Range on HMM: 186-290/290 Sequence Identity: 27% (29 aa) PKKQLLWRAPELNLQ--SDKTLKADVYAFGMLVFHIFCGKT------FYEQVENSPGIYEKIHS---ATRPKIANDVPNEIKKIIQFCWAPDPNGRPTMA ... ..|.|||. . .. . |.|||.||. . |. .| |. . .. ...|..|. ||.| |. |.|....|| ||..|| ||. RCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGM-DQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFD NVVRLF ... EIIHRL |
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| Kinase | 97299.m00082.AA | Dicty5 | 217-295 | 32 | 8.2e-13 | 40.42 | In-house | 183-260 (260) | Show / Hide |
Range on Protein: 217-295 Range on HMM: 183-260/260 Sequence Identity: 32% (26 aa) KADVYAFGMLVFHIFCGKTFYEQVENSPGIYEKIHSATRPKIANDVPNEIKKIIQFCWAPDPNGRPTMANVVRLFEESV |.|||.|| . .| |. |. . |. | . . || | |.| || ..| || | ||. .. || . KCDVYSFGIVLWEMFTRKEPYDNI-NNWNIPVMVMKGERPTIPKDCPTEISNLIKKCWQQKPHNRPSFKEICKYFESII |
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| Kinase | 97299.m00082.AA | LRRK | 217-293 | 24 | 9e-13 | 41.5 | In-house | 262-351 (351) | Show / Hide |
Range on Protein: 217-293 Range on HMM: 262-351/351 Sequence Identity: 24% (22 aa) KADVYAFGMLVFHIFCGK-TFYEQVE-------NSPGIYEKIHSATRPKIAND-VPN-----EIKKIIQFCWAPDPNGRPTMANVVRLFEE |.|.|.|||. ... .. .... . .. | .|| . ||.| .. | . .. || ||. ||. ||.. .| .. KVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWME-QIEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ |
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| Kinase | 97299.m00082.AA | Dicty4-Unclassified | 203-291 | 31 | 6.6e-12 | 37.02 | In-house | 174-263 (263) | Show / Hide |
Range on Protein: 203-291 Range on HMM: 174-263/263 Sequence Identity: 31% (29 aa) WRAPELNLQSDKTLKADVYAFGMLVFHIFCGKTFYEQVENSPGIYEKIHSAT----RPKIANDVPNEIKKIIQFCWAPDPNGRPTMANVVRLF | .|| . |.||| ..|. . | | . . | . | |||| ..| .|| | || ||| |||| .. WESPECLMHESYNQKSDVYSYAMMLYELATGDEPYQEI---QSIMNAARSVCDKKLRPKIPDNCDNFWKKLIKWCWHNDPNKRPTMNQIIQYL |
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| Kinase | 97299.m00082.AA | Pkinase | 203-291 | 19 | 2.1e-10 | 37.84 | Pfam | 177-293 (293) | Show / Hide |
Range on Protein: 203-291 Range on HMM: 177-293/293 Sequence Identity: 19% (23 aa) WRAPELNL-QSDKTLKADVYAFGMLVFHIFCGKTFYEQV---ENSPGIYEKIHSATRPKIANDVP-----------------------NEIKKIIQFCWA ..|||. . ... . |.|....| ... .||.. . . .| ...| .|.. | | | |..| |.. YMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLC PDPNGRPTMANVVRL--F .||. ||| . .. | KDPKKRPTAEQILQHPWF |
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| S_TKc | 97299.m00082.AA | S_TKc | 29-291 | 17 | 1.2e-09 | -35.4 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 29-291 Range on HMM: 1-231/231 Sequence Identity: 17% (48 aa) FRPLEVIYENPLGNVTKMRDENDNNTEYLVKTIYLDMGQMLNSIAFFEEVQNLSLSFHPTILPFAGFSVSNPHSGRRPCVAFDSYSG--MSLSGILEMEA .. |..| . | | | |. . . .. .| | . . |.| |. || | . .. .. . .. .. .| .| ... YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKKRG NKVAPENWNLTSKIITAFGIALGLNYMHSYNFIHGNLNADSIVFGDELWPYIANFSLNNFFDEDSLALIAPKKQ---LLWRAPELNLQSDKTL-KADVYA . . . . |...|.|.|| ..|| | . | . . |. | | .. . . . ..|||. . |.|... RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKCDWWS FGMLVFHIFCGKTFYEQVENSPGIYEKIHSATRPKIANDVPNEIKKIIQFCWAPDPNGRPTMANVVR---------LF .| ... .||.. .. . ...|| . | | .|. |. ||. ||| . . | CGCILYEMLCGYPPFP---QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| TyrKc | 97299.m00082.AA | TyrKc | 34-291 | 20 | 1.8e-09 | -69.54 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 34-291
Range on HMM: 1-280/280
Sequence Identity: 20% (60 aa)
VIYENPLGN-------VTKMRDENDNNTEYLVKTIYLDMGQMLNSIAFFEEVQNLSLS--FHPTILPFAGFSVSN---PHSGRRPCVAFDSYSGMSLSGI
. . ||. ... .. ||.. | .| .| . .. || |. . | .. . ... . .. .|
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY
LEMEANKVAPENWNLTSKIITAFGIALGLNYMHSYNFIHGNLNADSIVFGDELWPYIANFSLNNFFDED------SLALIA----PKKQLL---WRAPEL
| .| .. .. .. || | .| || |.|| | | . |... |. | | . ..| . . .| .| | |||
LRKHRPK-----LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPEC
NLQSDK--TLKADVYAFGMLVFHIF-CGKTFYEQ-----VENSPGIYEKIHSATRPKIAND--------VPNEIKKIIQFCWAPDPNGRPTMANVVRLF
.. | | ||..|| . . || |.. |. ..|. ..|.. . |... . | |. .|.. ||. ||. |||.......|
I--NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQ-EVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
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| Kinase | 97299.m00082.AA | Pkinase_Tyr | 215-291 | 32 | 4.9e-08 | 27.83 | Pfam | 192-270 (270) | Show / Hide |
Range on Protein: 215-291 Range on HMM: 192-270/270 Sequence Identity: 32% (26 aa) TLKADVYAFGMLVFHIFC-GKTF-YEQVENSPGIYEKI-HSATRPKIANDVPNEIKKIIQFCWAPDPNGRPTMANVVRLF | | ||..|| | . || |.. |. . |. .||.| . | .. . | || .... ||..||. |||.. ... . TTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEE-VYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL |
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| Kinase | 97299.m00082.AA | Dicty4-Unclassified | 143-160 | 55 | 0.000479 | 9.71 | In-house | 115-132 (263) | Show / Hide |
Range on Protein: 143-160 Range on HMM: 115-132/263 Sequence Identity: 55% (10 aa) AFGIALGLNYMHSYNFIH || || |. ..|. |||| AFDIAQGMQHLHTRNFIH |
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| Kinase | 97299.m00082.AA | LRRK | 133-163 | 45 | 0.003138 | 7.26 | In-house | 162-192 (351) | Show / Hide |
Range on Protein: 133-163 Range on HMM: 162-192/351 Sequence Identity: 45% (15 aa) NWNLTSKIITAFGIALGLNYMHSYN--FIHGNL .|.|. || | || |..|.|| | .|| .| SWMLKLKI--ALQIAKGMEYLHSHNPPIIHRDL |
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| Kinase | 97299.m00082.AA | Dicty5 | 143-160 | 44 | 0.013067 | 4.8 | In-house | 110-127 (260) | Show / Hide |
Range on Protein: 143-160 Range on HMM: 110-127/260 Sequence Identity: 44% (8 aa) AFGIALGLNYMHSYNFIH | .|| .. ..|| | || AIDIAQSMRHLHSMNIIH |
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| Kinase | 97299.m00082.AA | TKL-Unique | 146-163 | 40 | 0.022649 | 4.39 | In-house | 119-138 (290) | Show / Hide |
Range on Protein: 146-163 Range on HMM: 119-138/290 Sequence Identity: 40% (8 aa) IALGLNYMHSYN--FIHGNL ||.|..| |... ||..| IAQGMYYLHHCEPPIIHRDL |
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| Kinase | 97299.m00082.AA | Pkinase_Tyr | 143-163 | 42 | 0.33783 | 4.68 | Pfam | 117-137 (270) | Show / Hide |
Range on Protein: 143-163 Range on HMM: 117-137/270 Sequence Identity: 42% (9 aa) AFGIALGLNYMHSYNFIHGNL .. || |..| .| |.|| | CWQIAKGMEYLESKNCIHRDL |
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| Kinase | 97299.m00082.AA | Pkinase | 146-160 | 53 | 0.822659 | 3.95 | Pfam | 117-131 (293) | Show / Hide |
Range on Protein: 146-160 Range on HMM: 117-131/293 Sequence Identity: 53% (8 aa) IALGLNYMHSYNFIH |. ||.|.|| ..|| ILRGLEYCHSMGIIH |
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| Sel1 | 97299.m00082.AA | Sel1 | 335-370 | 27 | 4.1e-10 | 36.71 | Pfam | 1-43 (43) | Show / Hide |
Range on Protein: 335-370 Range on HMM: 1-43/43 Sequence Identity: 27% (12 aa) SGAQNNYG--VMLLNGK--G-VRK-N-IAA-AARYFQQSAENDC . ||.|.| |...|. | |.. . .. |....|..||.. P-AQYNLGMYYMYYHGQFGGCVPQDDDYEKEAFYWYQKAAEQGH |
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| Sel1 | 97299.m00082.AA | Sel1 | 371-406 | 20 | 2.3e-09 | 34.22 | Pfam | 1-43 (43) | Show / Hide |
Range on Protein: 371-406 Range on HMM: 1-43/43 Sequence Identity: 20% (9 aa) IEGMNNYA--YALENGA--G-ITK-D-IDL-AAKYFKMAADKGF ...|.. |....| | ... | ... |......||..| P-AQYNLGMYYMYYHGQFGGCVPQDDDYEKEAFYWYQKAAEQGH |
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| Sel1 | 97299.m00082.AA | Sel1 | 407-442 | 25 | 2.2e-08 | 30.97 | Pfam | 1-43 (43) | Show / Hide |
Range on Protein: 407-442 Range on HMM: 1-43/43 Sequence Identity: 25% (11 aa) KNAQNSYA--QMLYKGN--G-VAK-N-TTE-AAKYFKMAAQQNS ||. .. .|.|.| | | . . . |......||.|.. P-AQYNLGMYYMYYHGQFGGCVPQDDDYEKEAFYWYQKAAEQGH |
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| Sel1 | 97299.m00082.AA | Sel1 | 443-478 | 25 | 5.8e-08 | 29.57 | Pfam | 1-43 (43) | Show / Hide |
Range on Protein: 443-478 Range on HMM: 1-43/43 Sequence Identity: 25% (11 aa) SPAQYRLG--LLHETGE--G-TTL-N-CNE-SLKCYKAAAVQKY . |||.|| .....|. | .. . .. ....|. || | . P-AQYNLGMYYMYYHGQFGGCVPQDDDYEKEAFYWYQKAAEQGH |
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| Sel1 | 97299.m00082.AA | Sel1 | 479-514 | 18 | 0.006291 | 12.86 | Pfam | 1-43 (43) | Show / Hide |
Range on Protein: 479-514 Range on HMM: 1-43/43 Sequence Identity: 18% (8 aa) PPAMYRYS--YLVINGK--V-DDK-N-MTE-AYKNILASAQMGY | |.|.. |. .|. . . . |.. .|..|. P-AQYNLGMYYMYYHGQFGGCVPQDDDYEKEAFYWYQKAAEQGH |
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| Sel1 | 97299.m00082.AA | Sel1 | 515-550 | 27 | 0.00836 | 12.45 | Pfam | 1-43 (43) | Show / Hide |
Range on Protein: 515-550 Range on HMM: 1-43/43 Sequence Identity: 27% (12 aa) PRSFCVLG--AMHVIGE--G-APK-N-IEA-AKKQFEKAIEKKE | . . || |. |. | |. . .| | . ..|| |. P-AQYNLGMYYMYYHGQFGGCVPQDDDYEKEAFYWYQKAAEQGH |
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