Gene 82761.m00601 (T.vaginalis)
82761.m00601
Species: T.vaginalis
Alias: 82761.m00601, TvagK0989
External Links:
Annotation:
Group:
TKL
Family:
TKL-Unique
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| 82761.m00601.AA | Protein | None | 650 | None | Fasta, JSON |
| 82761.m00601.kin_dom | Protein Kinase Domain | None | 232 | None | Fasta, JSON |
Protein domains of 82761.m00601.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 82761.m00601.AA | TKL | 53-245 | 15 | 1.6e-30 | 107.07 | In-house | 69-364 (364) | Show / Hide |
Range on Protein: 53-245
Range on HMM: 69-364/364
Sequence Identity: 15% (48 aa)
KEQFIREVKLLKECVHPALAHYEG---YNPP--------GADNKCMIATSYI-ATTLEEILKRISSGEKFEFGPTQMIIITLGIISGLKFLHSLK-----
......|..... . || . .. | ..|. | .....| . |. .|...| . |.. . |.| .|. .||| .
RFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----------WHQRCRWALDIARGMNYLHSMNPKWCT
---ITHKNLKPSNVLIDKNFR--------------PLVSDFYLNF---------------------------HHPQIKSLYYPDEEMMQES---------
| | .||..|.|.|.|.. . ..|| | ...|. .... |.....
KPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGI
-------------DIFAYGTILYEMFTGKVIN--GSQFPQT-----------------KPSLP------------THLPMIIRKIISACWSENPMHRPSA
|....| .|.|..|... .|. .| .| .. | ..|.. ||...| |||.
DEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSF
NDIFQLL
..| . |
QEILKRL
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| Kinase | 82761.m00601.AA | TKL-Unique | 182-245 | 25 | 2.4e-14 | 47.17 | In-house | 209-290 (290) | Show / Hide |
Range on Protein: 182-245 Range on HMM: 209-290/290 Sequence Identity: 25% (21 aa) SDIFAYGTILYEMFTGKV----------INGSQFPQTKPS--------LPTHLPMIIRKIISACWSENPMHRPSANDIFQLL ||....|..|.|..|.|. .. | ... . .|.|.| ..|..| .|| .| ||| ..| | SDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL |
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| Kinase | 82761.m00601.AA | STE | 49-148 | 26 | 1.2e-13 | 44.66 | In-house | 68-185 (359) | Show / Hide |
Range on Protein: 49-148 Range on HMM: 68-185/359 Sequence Identity: 26% (31 aa) DKAQKEQFIREVKLLKECV--HPALAHYEGYNP-----PGADNKCMIATSYIA-TTLEEILKRISSGEK---------FEFGPTQMIIITLGIISG-LKF .. ...|...|.|..|.| || .| |. ..|... |. |.. .|..|.|. . | . | .| ..|. |. | |.. NHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYY LHSLKITHKNLKPSNVLI |||..| | .||.|.|. LHSHHIIHRDIKPANILL |
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| S_TKc | 82761.m00601.AA | S_TKc | 14-252 | 20 | 1.3e-13 | 22.68 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 14-252
Range on HMM: 1-231/231
Sequence Identity: 20% (52 aa)
VSQIRQFTQGPRGDTFLCKFKAKKRKLVFKYVAFQDKAQKEQFIREVKLLKECVHPALAHYEGYNPPGADNKCMIATSYIAT---TLEEILKRISS-GEK
.|. .| | ..|. | .|. | . |...||...||. || . .. .. .. . . |. . .| ...|. . | .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR
FEFGPTQMIIITLGIISGLKFLHSLKITHKNLKPSNVLIDKNFRPLVSDF----YLNFHHPQIKSLYY-----PDEEMMQ-ESDIFAYGTILYEMFTGKV
| | . . .. |...|...||..| | |||.|.|.|. . ..|| | . .. ...| ..|. . | |||||..|.
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---TTFCGTPWYMAPEVL--GYGKCKCDWWSCGCILYEMLCGYP
INGSQFPQTKPSLPTHLPMIIRKIISACWSENPMHRPSANDIFQ--LLSINLDQI
| .. . . . .|. |. .| .||.| ...| .. . .
PFP-QMQMMFKKIG---SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | 82761.m00601.AA | Ciliate-E1 | 84-161 | 24 | 2.4e-12 | 36.92 | In-house | 70-155 (202) | Show / Hide |
Range on Protein: 84-161 Range on HMM: 70-155/202 Sequence Identity: 24% (21 aa) NKCMIATSYIATTLEEILK--------RISSGEKFEFGPTQMIIITLGIISGLKFLHSLKITHKNLKPSNVLIDKNFRPLVSDFYL . |.| . . .|.. |. . . ....| .|.. |. .| || ||...|.| ..||.|.||... . . .||.. YICIIIFECCCCSLKDYLQNHNRLEYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGI |
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| Kinase | 82761.m00601.AA | AGC | 120-159 | 39 | 8.3e-11 | 22.66 | In-house | 158-199 (395) | Show / Hide |
Range on Protein: 120-159 Range on HMM: 158-199/395 Sequence Identity: 39% (17 aa) ITLG-IISGLKFLHS-LKITHKN-LKPSNVLIDKNFRPLVSDF | .| |...| .||| ..| | ||| |.|.|.. .|| I-CGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDF |
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| Kinase | 82761.m00601.AA | TK | 181-245 | 14 | 6.5e-10 | 28.63 | In-house | 374-486 (486) | Show / Hide |
Range on Protein: 181-245 Range on HMM: 374-486/486 Sequence Identity: 14% (16 aa) ESDIFAYGTILYEMFT-GKVINGSQFPQ---------------------------------TKPSLPTHLP--------------MIIRKIISACWSENP .||....| ..|.|| |.. . . . . | | | .. .. ||...| KSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDP MHRPSANDIFQLL .||. .. . | EDRPTFSQLHEQL |
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| Kinase | 82761.m00601.AA | Dicty3 | 182-242 | 22 | 1.5e-09 | 27.48 | In-house | 278-351 (351) | Show / Hide |
Range on Protein: 182-242 Range on HMM: 278-351/351 Sequence Identity: 22% (17 aa) SDIFAYGTILYEMFTGKVINGSQFPQ-------------TKPSLPTHLPMIIRKIISACWSENPMHRPSANDIF |||. | .. ||. | . .| . .|. |.|.. . .| || ..| ||.... . SDIWSLGCTVWEMVGGNLCHCEQDINEMAFMVNDNKQNIWIPQIPDHVSNFCKNFIQHCWQIDPNHRWDMHELI |
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| Kinase | 82761.m00601.AA | LRRK | 180-247 | 20 | 2.6e-09 | 29.1 | In-house | 261-351 (351) | Show / Hide |
Range on Protein: 180-247 Range on HMM: 261-351/351 Sequence Identity: 20% (19 aa) QESDIFAYGTILYEMFTGKVINGSQFP-----------------QTKPSLPTH-LPM-----IIRKIISACWSENPMHRPSANDIFQLLSI ...|....| ||.| |.... ... . .|..| | | . | ||...| ||....|.. || EKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ |
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| TyrKc | 82761.m00601.AA | TyrKc | 14-245 | 16 | 2.9e-09 | -72.81 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 14-245
Range on HMM: 1-280/280
Sequence Identity: 16% (50 aa)
VSQIRQFTQGPRGDTFLCKFKAKKRKLVFKYVA---FQDKAQKEQFIREVKLLKEC--VHPALAHYEGYNPPGA------DNKCMIATSYIATTLEEILK
.. ... | | .... | || .. | .| |.|| ..... || . |. . . ... | . |.
ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR
RISSGEKFEFGPTQMIIITLGIISGLKFLHSLKITHKNLKPSNVLIDKNFRPLVSDFYLNFHHPQI------KSLYYP-----DE----------EMM--
. . . ... . . | .| .||| .. | | |.|...|.. .||| | . |. | . | .
KHRPK----LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY
----QESDIFAYGTILYEMFTGKVINGSQFPQT-------------------KPSLPTH--------LPMIIRKIISACWSENPMHRPSANDIFQLL
.||....| ..|.|| .| | . . | . | . .|.. || |.| ||. ..| ...
GKFTTKSDVWSFGVCMWEIFT----YGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
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| Kinase | 82761.m00601.AA | Dicty4-Unclassified | 209-245 | 35 | 7.1e-09 | 26.49 | In-house | 227-263 (263) | Show / Hide |
Range on Protein: 209-245 Range on HMM: 227-263/263 Sequence Identity: 35% (13 aa) KPSLPTHLPMIIRKIISACWSENPMHRPSANDIFQLL .| .| . ..| | ||.. | ||. |.| | | RPKIPDNCDNFWKKLIKWCWHNDPNKRPTMNQIIQYL |
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| Kinase | 82761.m00601.AA | Dicty4-Unclassified | 115-159 | 35 | 1.4e-08 | 25.52 | In-house | 109-153 (263) | Show / Hide |
Range on Protein: 115-159 Range on HMM: 109-153/263 Sequence Identity: 35% (16 aa) TQMIIITLGIISGLKFLHSLKITHKNLKPSNVLIDKNFRPLVSDF | | . . | |. .||. . | .| ||.|.||.| . || TLIIKYAFDIAQGMQHLHTRNFIHRDIKSSNILMDKHFNIKIADF |
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| Kinase | 82761.m00601.AA | Dicty3 | 108-151 | 20 | 3.8e-07 | 19.45 | In-house | 104-148 (351) | Show / Hide |
Range on Protein: 108-151 Range on HMM: 104-148/351 Sequence Identity: 20% (9 aa) EKFEFGPTQMIIITLGIISGLKFLHSL-KITHKNLKPSNVLIDKN ....| ... ..|. .. .|...| .| | ..|. |...|.. KNNRFNEHEISKIICDLVKTLNYIHKNCHIIHRDIKCDNIMLDND |
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| Kinase | 82761.m00601.AA | Dicty5 | 120-159 | 35 | 1e-06 | 18.65 | In-house | 109-148 (260) | Show / Hide |
Range on Protein: 120-159 Range on HMM: 109-148/260 Sequence Identity: 35% (14 aa) ITLGIISGLKFLHSLKITHKNLKPSNVLIDKNFRPLVSDF . ..| ....||| | | || |.|| .|. . || MAIDIAQSMRHLHSMNIIHRDLKSMNFLITENWKIKIIDF |
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| Kinase | 82761.m00601.AA | TKL-Unique | 126-159 | 34 | 4e-06 | 17.71 | In-house | 121-161 (290) | Show / Hide |
Range on Protein: 126-159 Range on HMM: 121-161/290 Sequence Identity: 34% (14 aa) SGLKFLHSLK--ITHKNLKPSNVLIDKN-----FRPLVSDF .|. .||... |.| .||.||.|.| | .. ..|| QGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDF |
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| Kinase | 82761.m00601.AA | Dicty5 | 210-248 | 35 | 9e-06 | 15.88 | In-house | 221-260 (260) | Show / Hide |
Range on Protein: 210-248 Range on HMM: 221-260/260 Sequence Identity: 35% (14 aa) PSLPTHLPMIIRKIISACWSENPMHRPSANDIFQLL-SIN | .| | | ..| .|| . | ||| | . . || PTIPKDCPTEISNLIKKCWQQKPHNRPSFKEICKYFESII |
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| Kinase | 82761.m00601.AA | Pkinase | 120-159 | 38 | 2.4e-05 | 19.99 | Pfam | 113-156 (293) | Show / Hide |
Range on Protein: 120-159 Range on HMM: 113-156/293 Sequence Identity: 38% (17 aa) ITLGIISGLKFLHSLKITHKNLKPSNVLIDKNFRP----LVSDF . . |..||...|| .| | |||.|.|||.| . ..|| YMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDF |
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| Kinase | 82761.m00601.AA | TK | 112-159 | 20 | 0.000342 | 9.11 | In-house | 232-295 (486) | Show / Hide |
Range on Protein: 112-159 Range on HMM: 232-295/486 Sequence Identity: 20% (13 aa) FGPTQMIIITLGIISGLKFLHSL------KITHKNLKPSNVLIDKNFR-----------PLVSDF . . |.. . . | .|. .|||. .. | .| |.|...| . ..|| LTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADF |
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| Kinase | 82761.m00601.AA | AGC | 180-198 | 33 | 0.0005 | 4.72 | In-house | 282-302 (395) | Show / Hide |
Range on Protein: 180-198 Range on HMM: 282-302/395 Sequence Identity: 33% (7 aa) QESDIFA--YGTILYEMFTGK .. |. . .| ..||| ||. KACDWWSFGLGCLMYEMLTGY |
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| Kinase | 82761.m00601.AA | LRRK | 120-148 | 41 | 0.001153 | 8.82 | In-house | 169-199 (351) | Show / Hide |
Range on Protein: 120-148 Range on HMM: 169-199/351 Sequence Identity: 41% (13 aa) ITLGIISGLKFLHSLK--ITHKNLKPSNVLI | | | .|...||| . | | .||. |.|. IALQIAKGMEYLHSHNPPIIHRDLKSPNILL |
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| Kinase | 82761.m00601.AA | Dicty5 | 180-198 | 47 | 0.001715 | 7.88 | In-house | 182-200 (260) | Show / Hide |
Range on Protein: 180-198 Range on HMM: 182-200/260 Sequence Identity: 47% (9 aa) QESDIFAYGTILYEMFTGK | |....| .|.|||| | QKCDVYSFGIVLWEMFTRK |
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| Kinase | 82761.m00601.AA | STE | 182-247 | 18 | 0.002526 | 7.74 | In-house | 249-359 (359) | Show / Hide |
Range on Protein: 182-247 Range on HMM: 249-359/359 Sequence Identity: 18% (20 aa) SDIFAYGTILYEMFTGKVINGS-QFP-----------------------QTKPSLPTHLP-------------------MIIRKIISACWSENPMHRPSA .|| | . || |||. . . .. |.||.|| . |. | .| .||.| CDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTA NDIFQ--LLSI .. . | SQLLKSEHPFI |
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| Kinase | 82761.m00601.AA | Dicty4-Unclassified | 180-197 | 50 | 0.010147 | 5.1 | In-house | 187-204 (263) | Show / Hide |
Range on Protein: 180-197 Range on HMM: 187-204/263 Sequence Identity: 50% (9 aa) QESDIFAYGTILYEMFTG | ||.. |. .|||. || QKSDVYSYAMMLYELATG |
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| Kinase | 82761.m00601.AA | Pkinase | 180-198 | 42 | 0.099099 | 7.2 | Pfam | 191-209 (293) | Show / Hide |
Range on Protein: 180-198 Range on HMM: 191-209/293 Sequence Identity: 42% (8 aa) QESDIFAYGTILYEMFTGK ...|....| |||||..|. PKVDMWSCGCILYEMLCGR |
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| Kinase | 82761.m00601.AA | Pkinase | 221-245 | 29 | 0.812015 | 3.97 | Pfam | 267-293 (293) | Show / Hide |
Range on Protein: 221-245 Range on HMM: 267-293/293 Sequence Identity: 29% (8 aa) RKIISACWSENPMHRPSANDIFQL--L ...|. |. .| ||.| .|.| . KDFIKWCLCKDPKKRPTAEQILQHPWF |
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| Ank | 82761.m00601.AA | Ank | 421-444 | 25 | 1.01164 | 6.86 | Pfam | 1-24 (33) | Show / Hide |
Range on Protein: 421-444 Range on HMM: 1-24/33 Sequence Identity: 25% (6 aa) SGLTVFHIAAQLGKVDMLKAICSC | | |.|.. | ....| .. DGFTPLHLACRCGHTEVVKMLLQH |
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| Ank | 82761.m00601.AA | Ank | 457-479 | 39 | 0.000745 | 18.16 | Pfam | 1-23 (33) | Show / Hide |
Range on Protein: 457-479 Range on HMM: 1-23/33 Sequence Identity: 39% (9 aa) WGRTALHYAAEAGQLEAVQYIVQ |.|.||.|.. |..| |.. .| DGFTPLHLACRCGHTEVVKMLLQ |
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| Ank | 82761.m00601.AA | Ank | 593-626 | 41 | 7e-09 | 36.3 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 593-626 Range on HMM: 1-33/33 Sequence Identity: 41% (14 aa) EGRTPLHYAAFQGQLAAVQKLLSCKGIDINARNS .|.||||.|.. |.. |. ||. .| |.||.. DGFTPLHLACRCGHTEVVKMLLQ-HGADVNAQDD |
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| Ank | 82761.m00601.AA | Ank | 525-558 | 38 | 5e-08 | 33.2 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 525-558 Range on HMM: 1-33/33 Sequence Identity: 38% (13 aa) NGYTALHFACEGGHLQAAQVLLNFKGTNPNERDE .|.|.|| ||. ||.. .. ||. .| ..| .| DGFTPLHLACRCGHTEVVKMLLQ-HGADVNAQDD |
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| Ank | 82761.m00601.AA | Ank | 559-592 | 44 | 7.2e-08 | 32.63 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 559-592 Range on HMM: 1-33/33 Sequence Identity: 44% (15 aa) EGATPLHYACAEGRVDVVSLLVECKQVDVNCTDS .| ||||.|| |...||..|.. . ||| .| DGFTPLHLACRCGHTEVVKMLLQ-HGADVNAQDD |
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| Ank | 82761.m00601.AA | Ank | 491-524 | 47 | 4.7e-07 | 29.71 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 491-524 Range on HMM: 1-33/33 Sequence Identity: 47% (16 aa) DGRTPLHDATTEGRTDVIKFLLSCKDVDANKRDE ||.|||| | |.|.|.|.||. . | | .| DGFTPLHLACRCGHTEVVKMLLQ-HGADVNAQDD |
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