Gene 83923.m00208 (T.vaginalis)

83923.m00208

Species: T.vaginalis
Alias: TvagK0621, 83923.m00208
External Links:
Annotation:

Classification

Group: PKL
Family: PIK
Subfamily: FRAP

Sequence

Name Sequence Type Origin Length Description Download
83923.m00208.AA Protein None 2195 None Fasta, JSON
83923.m00208.kin_dom Protein Kinase Domain None 112 None Fasta, JSON

Protein domain

Protein domains of 83923.m00208.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
HEAT 83923.m00208.AA HEAT 169-193 24 10.785218 2.8 Pfam 1-25 (31) Show / Hide 
Range on Protein: 169-193
Range on HMM: 1-25/31
Sequence Identity: 24% (6 aa)

FIDIIQSCLVSDDIELQLIAAKTLK
..... .|| ..| | .. |...|.
ILPHLLKCLNDPDWEVREAACWCLG
HEAT 83923.m00208.AA HEAT 438-468 16 57.507903 0.28 Pfam 1-31 (31) Show / Hide 
Range on Protein: 438-468
Range on HMM: 1-31/31
Sequence Identity: 16% (5 aa)

VYDDIQKLVNSQNSEIRTLVSSILPFFTDKR
. . . |. |....|.|  . . |  . .. 
ILPHLLKCLNDPDWEVREAACWCLGQLCEHC
HEAT 83923.m00208.AA HEAT 477-496 30 9.892418 2.93 Pfam 8-27 (31) Show / Hide 
Range on Protein: 477-496
Range on HMM: 8-27/31
Sequence Identity: 30% (6 aa)

ALFDNNPNVRKSAVDQLINF
.| |....||..|.  | ..
CLNDPDWEVREAACWCLGQL
HEAT 83923.m00208.AA HEAT 501-531 25 0.013692 12.83 Pfam 1-31 (31) Show / Hide 
Range on Protein: 501-531
Range on HMM: 1-31/31
Sequence Identity: 25% (8 aa)

FCEMIPQVLTDPSYEVKRSAIKVISQLAPKN
..... . |.||..||...|.. ..||... 
ILPHLLKCLNDPDWEVREAACWCLGQLCEHC
HEAT 83923.m00208.AA HEAT 671-702 12 52.407107 0.42 Pfam 1-31 (31) Show / Hide 
Range on Protein: 671-702
Range on HMM: 1-31/31
Sequence Identity: 12% (4 aa)

LIAIYKDIFTSQRNDRVYAAALLSLIDIVNKF
.. .    .... ...| .||. .| ... ..
ILPHLLKCLNDP-DWEVREAACWCLGQLCEHC
FAT 83923.m00208.AA FAT 1361-1465 17 0.006611 9.96 Pfam 109-251 (408) Show / Hide 
Range on Protein: 1361-1465
Range on HMM: 109-251/408
Sequence Identity: 17% (26 aa)

TELGEVIDYK--------------EGKVNNISQRWERRLNNI-SGDSYSWMRLAEIRSMIIN--------------PTNNTRTYLKLISVLAKDRKWHLL
.|| |.| ||              ..| . . | |..|| ..   .   | |.   |. ..               |. .... .|  ..    || ...
AELEEIIQYKSQCNQNNAQNLDNSPEKQKHMRQTWWKRLPGCKQRNVEVWQRILTWRQHVFSKINQRYMNSFCYRGPHEDMWMWIKFANLC---RKHGRM

DNFQSIVYQLLD------------NPSVICSYVKILWLRGKTSEAI
.  .    .|..             |... .| |..| .|.  ||.
QLCEKTLKMLYTYDPSEEDWHPRAPPQWTYAYLKYMWATGQQQEAF
FAT 83923.m00208.AA FAT 1543-1614 16 3e-06 21.39 Pfam 322-408 (408) Show / Hide 
Range on Protein: 1543-1614
Range on HMM: 322-408/408
Sequence Identity: 16% (14 aa)

HDNIDIAIKLFIESSKLNADDYR-TWSRWAYACTKSIENDK-------------EGLYVKMAVDGFLKASFLSKE-NSLEYICQLFS
....| ... . .  ... . |.  | .||..  . .. ..              . .|  ||..|...  ||.. ||....  | .
QEQKDEILQCYMTATHFDPQWYKKAWHNWALYNFEVFQHYQCQPQREEQNYTHMIIQHVVPAVKCFFHSIALSQGSNSRQDTLRLLW
HEAT 83923.m00208.AA HEAT 1641-1671 22 0.003108 15.06 Pfam 1-31 (31) Show / Hide 
Range on Protein: 1641-1671
Range on HMM: 1-31/31
Sequence Identity: 22% (7 aa)

IIPQIVCQISHPDPTVRSVVHNILTNFSRLY
|.| ..  ...||. ||. . . |..... .
ILPHLLKCLNDPDWEVREAACWCLGQLCEHC
Kinase 83923.m00208.AA FRAP 1881-2132 46 2.2e-86 293.29 In-house 2-251 (251) Show / Hide 
Range on Protein: 1881-2132
Range on HMM: 2-251/251
Sequence Identity: 46% (116 aa)

WKFLLKGNEDLRLDQRIMQFFVLINSLIPSNKLTQKMNISILNYTITPLATNAGLISWVMGADTMHQLINDHRKSTKVHQVSVENEILINNVGDCMQTMN
. ||||| ||.| | |.|| | ||| |.  |  ||| |.||  | | || .|.||| ||   ||.| || | ||  .. .  .| .|.   . |  . . 
YHFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVHHCDTLHILIRDYRKKYHI-RYNIEYNIMDRMCND-YDHLP

SLQRIEWWPVVTNQCPATDLRDIFWMKSQNPVNWIKTVDTFVLSIALMSLAGYVVGLGDRHPSNIMIRRNSGHVVHIDLGDSFEVTQKRTKLPEKVPFRL
 ....| .  . |     ||. . |.|| |   |.     .  |.| ||.|||. |||||||||||. | .| .|||| || |||  .| |.|||.||||
LMNKVEIFRYIMNNTKGEDLKKLLWLKSPNSEIWFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRL

TRMIVNALGVSKTEGNFRKACENIMYMLRYNKPSIFAQLEIFVHEPIFASRA
|||.|||. .   |||.| .|| .|  .| .| |. | || ||  |.|  | 
TRMLVNAMEACGIEGNYRNTCELVMKVIREHKESVMAVLEAFVYDPLFYWRL
Kinase 83923.m00208.AA PIKK 1851-2122 31 6e-75 255.3 In-house 1-290 (290) Show / Hide 
Range on Protein: 1851-2122
Range on HMM: 1-290/290
Sequence Identity: 31% (92 aa)

TINYIEPILTVLGTQQHPAITNFVGNDSLRWKFLLKGNEDLRLDQRIMQFFVLINSLIPSNKLTQKMNISILNYTITPLATNAGLISWVMGADTMHQLIN
 |  . . .||. . | |    . | |     .|.|| ||||.|||.||.| |.| .   .. .|| . .|  |...|. .. ||| || ...| . ...
RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYK

DHRKSTK-------------------VHQVS-VENEILINNVGDCMQTMNSLQRIEWWPVVTNQCPATDLRDIFWMKSQNPVNWIKTVDTFVLSIALMSL
. ..  .                   . | |   .  .   ..   |  .. .. |   .. .  |. .....|| |. .|  |      .  | |.|. 
QWCQKKHIRHEQEAQMNYQTCMYRDWLKQMSYYKHQMQQQCMM--YQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCM

AGYVVGLGDRHPSNIMIRRNSGHVVHIDLGDSFEVTQKRTKLPEKVPFRLTRMIVNALGVSKTEGNFRKACENIMYMLRYNKPSIFAQLEIF
.||. |||||||.|||| . .| .||||.|..||.  .| . ||||||||||..|||.|. ..||.||..|| .|  .| .. .. . .| |
VGYILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF
Kinase 83923.m00208.AA PI3_PI4_kinase 1880-2132 25 1.8e-59 208.65 Pfam 1-300 (300) Show / Hide 
Range on Protein: 1880-2132
Range on HMM: 1-300/300
Sequence Identity: 25% (76 aa)

RWKFLLKGNEDLR--LDQRIMQFF-----------------------VLINSLIPSNKLTQKMNISILNYTITPLATNAGLISWVMGADTMHQLINDHRK
  .|..||..|||   |.|.||..                        |.| .  ..... . |...  | . |.... |.| ||  ..|.|...  ...
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV

STKVHQVSVENEILINNVGDCMQTMNSLQRIEWWPVVTNQCPATDLRDIFWMKSQNP-VNWIKTVDTFVLSIALMSLAGYVVGLGDRHPSNIMI--RRNS
. |      |.   .   .|. . |  .|. |    .... |  .|.. ||... ..  .| .  |.||.|.| |. ..|. |.||||..|||.  .. .
KCKHKHFNKEHKMWMKMWPDWWHLM-RMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDKTT

GHVVHIDLGDSFE-VTQKRTKLPEKVPFRLTR------MIVNAL------GVSKTEGNFRKACENIMYMLRYNKPSIFAQL-------EIFVHEPIFASR
||..||| |..|. . .|. . ||.||||.|.      ..|.|.      ..|. .| ||. |. ..  || .. .. . |       |..|| ...  |
GHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVHDGLPMWR

A
 
S
Kinase 83923.m00208.AA PI3Kc 1882-2184 25 2.2e-59 204.52 SMART 1-336 (336) Show / Hide 
Range on Protein: 1882-2184
Range on HMM: 1-336/336
Sequence Identity: 25% (86 aa)

KFLLKGNEDLRLDQRIMQFFVLINSLIPSNKLTQKMNISILNYTITPLATNAGLISWVMGADTMHQLINDHRKSTK----VHQVSVENEILI--------
 ...|...||| |.|.||.| |.| .  ..| .....  .  | . |.  . |.| ||  ..|.||. . ..| .|    .||    .            
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDML-VPEIQKNMY

--------NNVGDCMQTMNSLQRIEWWPVVTNQCPATDLRDIFWMKSQNP-VNWIKTVDTFVLSIALMSLAGYVVGLGDRHPSNIMIRRNSGHVVHIDLG
            . .|.|.......    .|.. .  .|.| || .. .|  .| . .|.|..| | .. ..|. |.||||..|||. ...||..|||.|
MMIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFG

DSFEVTQKRTKLP----EKVPFRLTRMIVNALG----VSKTEGNFRKACENIMYMLRYNKPSIFAQLEIFVHEPI-FASRAVQGDGNSIMKRVSMKLN-G
. |.  .|. . .    |.||||||...|.. |    .|. .|.||. |. .. ..| .. .| . .|..|. || .  |.   .   .. | .. |.  
HIFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMM--EKDIKYLRQRFRLDHL

LDPELVPG-----EPVTEELSVEEQTRRLIAIAADPMRY
 | |  .      .    | |.|..| |.. .. . . |
SDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
Kinase 83923.m00208.AA ATR 2001-2122 36 2.1e-30 100.51 In-house 147-267 (267) Show / Hide 
Range on Protein: 2001-2122
Range on HMM: 147-267/267
Sequence Identity: 36% (45 aa)

RDIFWMKSQNPVNWIKTVDTFVLSIALMSLAGYVVGLGDRHPSNIMIRRNSGHVVHIDLGDSFEVTQKRTKLPEKVPFRLTRMIVNALGVSKTEGNFRKA
.| |  .   | .|  . . .. | | ... ||..||||||  ||.| .  | .||.|    |    .. . || ||||||. .|...|  ||.| ||.|
HDWFNRRFPDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDYNCIFNSG-EQFEVPEIVPFRLTHNMVFGMGPMKTYGLFRRA

CENIMYMLRYNKPSIFAQLEIF
|| || ..| ..  | . .. |
CEVIMMCMRDHRDDIMSVWDCF
Kinase 83923.m00208.AA ATM 2024-2128 44 5.6e-29 89.42 In-house 143-246 (304) Show / Hide 
Range on Protein: 2024-2128
Range on HMM: 143-246/304
Sequence Identity: 44% (47 aa)

SIALMSLAGYVVGLGDRHPSNIMIRRNSGHVVHIDLGDSFEVTQKRTKLPEKVPFRLTRMIVNALGVSKTEGNFRKACENIMYMLRYNKPSIFAQLEIFV
|.|  |. ||..||||||  ||.|   |  .||||||  ||   |    || ||||||| ||  .|.   || ||. ||  | ..|  .  .    |. .
SVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQG-KILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQETLLTIVEVLL

HEPIF
 .|.|
YDPLF
Kinase 83923.m00208.AA SMG1 1859-1942 39 6.2e-17 52.5 In-house 1-84 (242) Show / Hide 
Range on Protein: 1859-1942
Range on HMM: 1-84/242
Sequence Identity: 39% (33 aa)

LTVLGTQQHPAITNFVGNDSLRWKFLLKGNEDLRLDQRIMQFFVLINSLIPSNKLTQKMNISILNYTITPLATNAGLISWVMGA
.|.| |.  |    |.| |   . .| || ||| || |||||  ..| .                | .||| | .||| || ||
ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWVDGA
Kinase 83923.m00208.AA FATC 2163-2195 54 1.3e-14 49.79 Pfam 1-33 (33) Show / Hide 
Range on Protein: 2163-2195
Range on HMM: 1-33/33
Sequence Identity: 54% (18 aa)

EELSVEEQTRRLIAIAADPMRYVTHYDGWCPYW
|.||||.| .|||. | || ..  .| ||||.|
EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW
Kinase 83923.m00208.AA SMG1 2005-2074 40 2.2e-12 37.2 In-house 174-242 (242) Show / Hide 
Range on Protein: 2005-2074
Range on HMM: 174-242/242
Sequence Identity: 40% (28 aa)

WMKSQNPVNWIKTVDTFVLSIALMSLAGYVVGLGDRHPSNIMIRRNSGHVVHIDLGDSFEVTQKRTKLPE
|     |  | .    .  | | ||. ||..||||||  |..|    | |||||    ||   |  . ||
WSSCTTPDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFEKG-KKLNVPE
Kinase 83923.m00208.AA DNAPK 2021-2132 27 1.6e-11 38.01 In-house 190-301 (301) Show / Hide 
Range on Protein: 2021-2132
Range on HMM: 190-301/301
Sequence Identity: 27% (31 aa)

FVLSIALMSLAGYVVGLGDRHPSNIMIRRNSGHVVHIDLGDSFEVTQKRTKLPEKVPFRLTRMIVNALGVSKTEGNFRKACENIMYMLRYNKPSIFAQLE
|. . |.    ... | ||||  | |.    | .. || | ||         ||  ||||||  .| .   |  | ..      |  .|  .       .
FIRNYAVICISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMYQIMIHSMMAFRKDRNILTNFCD

IFVHEPIFASRA
.|. .| |    
VFINDPSFDWKN
Kinase 83923.m00208.AA ATR 1850-1939 25 4e-09 26.77 In-house 1-90 (267) Show / Hide 
Range on Protein: 1850-1939
Range on HMM: 1-90/267
Sequence Identity: 25% (23 aa)

TTINYIEPILTVLGTQQHPAITNFVGNDSLRWKFLLKGNEDLRLDQRIMQFFVLINSLIPSNKLTQKMNISILNYTITPLATNAGLISWV
. |  .. .. .| . |.|    . | |   .  . |  .||| | | |.|  ||| .       ..  . .  |.. ||  ....| ||
AYIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWV
Kinase 83923.m00208.AA ATM 1882-1941 35 5.7e-09 24.37 In-house 1-60 (304) Show / Hide 
Range on Protein: 1882-1941
Range on HMM: 1-60/304
Sequence Identity: 35% (21 aa)

KFLLKGNEDLRLDQRIMQFFVLINSLIPSNKLTQKMNISILNYTITPLATNAGLISWVMG
. | || .||| |  . | | . | |.  |  | |  . |  | . ||.  .| . |  |
RQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTG
Kinase 83923.m00208.AA DNAPK 1883-1939 40 9.4e-08 24.1 In-house 35-91 (301) Show / Hide 
Range on Protein: 1883-1939
Range on HMM: 35-91/301
Sequence Identity: 40% (23 aa)

FLLKGNEDLRLDQRIMQFFVLINSLIPSNKLTQKMNISILNYTITPLATNAGLISWV
|. || ||||.|||| | |   |  .      |        | | |.    ||| ||
FCYKGIEDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWV