Gene 87955.m00263 (T.vaginalis)

87955.m00263

Species: T.vaginalis
Alias: 87955.m00263, TvagK0301
External Links:
Annotation:

Classification

Group: TKL
Family: TKL-Tvag1

Sequence

Name Sequence Type Origin Length Description Download
87955.m00263.AA Protein None 786 None Fasta, JSON
87955.m00263.kin_dom Protein Kinase Domain None 252 None Fasta, JSON

Protein domain

Protein domains of 87955.m00263.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 87955.m00263.AA TKL 29-274 24 9.6e-74 251.3 In-house 1-364 (364) Show / Hide 
Range on Protein: 29-274
Range on HMM: 1-364/364
Sequence Identity: 24% (93 aa)

IGIGGFSEVWLAEDKR--------TGDKVAYKKIRTD--------------------------ISQSALQTYVREITTMAKAEHPFFLKLIGFSVTSP--
|| |||.||. .. .         ||  || ||....                           .. . .. ..||  | .  ||  ....|..  .|  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------LVIITEYIANCSLFRFRRNETRRQKLTPTVRTNIALCLAYGMKYLHSLG--------IIHRDLKSMNILLDDNLL-------------
            | |..||. . ||. .           . .| ..||  | || |||| .        |||||||| |||.|.|.              
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADW

-PKLCDFGVARFLSSDEPMTRS--------------------AGTPNWMAPELHNDA----------------DYGPEVDVYSYGMILYELLTDEIPWKN
 .|.|||| .||.| .. |...                     |||.|||||. ...                .| . .||||.|..|.|.|| ..|...
CCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYD

LDPISVL---------RKVGVEKQRPRLP------------QRTDPFLKNLIESCWAEDPKDRPQFKEIYDLF
.......          .|.....|| .|              ..| .|.|.. ||..||..|| |.|| . .
YPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Pkinase 87955.m00263.AA Pkinase 23-274 28 3.3e-69 241.02 Pfam 1-293 (293) Show / Hide 
Range on Protein: 23-274
Range on HMM: 1-293/293
Sequence Identity: 28% (85 aa)

YDLIEQIGIGGFSEVWLAEDKRTGDKVAYKKIRTDISQS-ALQTYVR--EITTMAKAEHPFFLKLIGFSV-TSPLVIITEYIANC----SLF----RFRR
| ....|| |.|..|... .| ||..|| |.|. .   |  .|| .|  ||  |..  ||. ..|...    . . ...||  .     .||    .   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST---

NETRRQKL--TPTVRTNIALCLAYGMKYLHSLGIIHRDLKSMNILLDDNLLP----KLCDFGVARF--LSSDEPMTRSAGTPNWMAPELHN-DADYGPEV
   |. ..  .. .  .... .. |..|.|| ||||||||. |||.|.|  .    |.||||.|..  . ... ||  .|||..||||... . .|||.|
--WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV

DVYSYGMILYELLTDEIPWKNL------DPISVLRKVGVEKQRPRLPQRTD-------------------PFLKNLIESCWAEDPKDRPQFKEIYDL--F
|..|.| ||||.|. . |...       |.. ......  . .   |.  .                   . .| .|..|.. |||.|| ...|     |
DMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
S_TKc 87955.m00263.AA S_TKc 23-274 31 1.8e-66 228.04 SMART 1-231 (231) Show / Hide 
Range on Protein: 23-274
Range on HMM: 1-231/231
Sequence Identity: 31% (83 aa)

YDLIEQIGIGGFSEVWLAEDKRTGDKVAYKKIRTDISQSALQTYVREITTMAKAEHPFFLKLIGFSVTSPLVIITEYIAN--CSLFRFRRNETR---RQK
|.....|| |.|..|... .|.|| .|| |.|.        ..  |||  . |  ||.  ||... ... | ...||. .   .||.. ..  |   |..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

LTPTVRTNIALCLAYGMKYLHSLGIIHRDLKSMNILLDDNLLPKLCDFGVARFLSSDEPMTRSAGTPNWMAPELHNDADYGP-EVDVYSYGMILYELLTD
... .   ..  .. ...|.||.||||||||  |||||.    |.||||.||.|      |   |||..||||.     ||. ..|..| | ||||.|. 
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCG

EIPWKNLDPISVLRKVGVEKQRPRLPQRTDPFLKNLIESCWAEDPKDRPQFKEIYD---------LF
. |.   ..  ...|.|            .| .|..|. |.  ||..||   |.            |
YPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 87955.m00263.AA TKL-Unique 25-274 30 8.6e-66 224.88 In-house 1-290 (290) Show / Hide 
Range on Protein: 25-274
Range on HMM: 1-290/290
Sequence Identity: 30% (88 aa)

LIEQIGIGGFSEVWLAEDKRTGDKVAYKKIRT--DISQSALQTYVREITTMAKAE-HPFFLKLIGFSV----TSP-LVIITEYIANCSLFRFRR------
 .. || ||...|  .. .  |..|| |..    |.| . .|.  .|...| | . ||. ....|...    . | . |..||.   ||           
FWNKIGEGGYGQVYKGKWR--GYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNN

-NETRRQKLTPTVRTNIALCLAYGMKYLHSLG--IIHRDLKSMNILLDDN-----LLPKLCDFGVARFLS--SDEPMTRS--------AGTPNWMAPELH
 |  .  ||.. .| ..|.. | || |||...  |||||||| |.|.| |     .  |.|||| ..|.|  .... ...         |...|||||. 
NNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVL

ND--ADYGPEVDVYSYGMILYELLTDEI------PWKNLDPISVLRKVGV--EKQRPRLPQRTDPFLKNLIESCWAEDPKDRPQFKEIYDLF
..  ..|   .||||.|..|.|..| .|      | ...|..... .| .  |..|| .|..  . ...||. ||. || .|| | ||.   
RMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase 87955.m00263.AA MLK 23-274 30 5.8e-64 218.81 In-house 1-291 (291) Show / Hide 
Range on Protein: 23-274
Range on HMM: 1-291/291
Sequence Identity: 30% (88 aa)

YDLIEQIGIGGFSEVWLAEDKRTGDK-----VAYKKIRTDI-----SQSALQTYVREITTMAKAEHPF----FLKLIGFSVTS-P-LVIITEYIANCSLF
 .. | || |.| .||..  .  .       || |..|..|     . .  .   .|.   ..  ||     . .. | .  . . ..|..||... ||.
IQFHEWIGSGSFGKVWKG--RWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLY

RFRRNET-------RRQK----LTPTVRTNIALCLAYGMKYLHSLG---IIHRDLKSMNILLDD------NLLPKLCDFGVARFLSSD-EPMTRSAGTPN
.. ....         ||     .. .  |.||  | || ||||.    |||||||| |||.|.      ..  | ||||..|....  . |.  |||. 
NVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYA

WMAPEL---HNDADYGPEVDVYSYGMILYELLTDEIPWK-NLDPISVLRKVGVEKQRPRLPQRTDPFLKNLIESCWAEDPKDRPQFKEIYDLF
|||||         |   .||.|.|..|.|.|| |.| |  .||. .. .|.....|| .|.  .. .|.|.. || .||..|| |..|   .
WMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase 87955.m00263.AA LRRK 23-276 27 1.8e-54 187.3 In-house 1-351 (351) Show / Hide 
Range on Protein: 23-276
Range on HMM: 1-351/351
Sequence Identity: 27% (96 aa)

YDLIEQIGIGGFS-EVWLAEDK--------------------------RTGDKVAYKKIRTD---------------------------------ISQSA
    |||| |||  .|  |. .                          . . .|| ||. .|                                  .  |
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

LQTYVREITTMAKAEHPFFLKLIGFSVTSPLVIITEYIANCSLFRFRRNETRRQ------KLTPTVRTNIALCLAYGMKYLHSLG--IIHRDLKSMNILL
.... .|.. | . .||  ..|.||.  .|| ...||. . .| .| .|. . .      .......  |||  | ||.||||    |||||||| ||||
FREFRHEVWIMSHLNHPNIVSLKGFC-IHPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILL

---D---------DNLLPKLCDFGVAR-FLSSDEP--MTRSAGTPNWMAPELHNDA---DYGPEVDVYSYGMILYELLTDE-IPWKNLD-P-----ISVL
   .         ..   |..|||  | | ... .    .. |.| |||||  ..     |  .||.||.||||.|||| . .|  ..| .     .. .
WSSPQNHSPNYPNAHVCAKIADFGISRMF-QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQI

RKVGVEKQRPRLPQR-TDP-----FLKNLIESCWAEDPKDRPQFKEIYDLFKT
..   |..|| .||    |      ...||..||..|||.|| | .| .  ..
EDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase 87955.m00263.AA Dicty4-Unclassified 24-274 32 6e-53 179.66 In-house 2-263 (263) Show / Hide 
Range on Protein: 24-274
Range on HMM: 2-263/263
Sequence Identity: 32% (87 aa)

DLIEQIGIGGFSEVWLAEDKRTGDKVAYKKIRTDISQSA---LQTYVREITTMAKAEHPFFLKLIGFSVTSP------LVIITEYIANCSLFRFRR----
     || | ||.|     |  |  || ||.     .     .| . .|.  .    ||  .|. | ..  |      ..|..| .    ||        
QIDQFIGKGHFSKVHKGNWK--GKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCIN-PRSHKSTMCIVMEFMHKGNLFEVIHSKPS

NETRRQKLTPTVRTNIALCLAYGMKYLHSLGIIHRDLKSMNILLDDNLLPKLCDFGVARFLSSDEPMTRSAGTPNWMAPELHNDADYGPEVDVYSYGMIL
   .  ||  |.   .|.  | || .||.  .||||.|| |||.| .   |  |||..|  .    ||  |||| | .||      |    |||||.|.|
EQQQPIKLDDTLIIKYAFDIAQGMQHLHTRNFIHRDIKSSNILMDKHFNIKIADFGISRVIDFNFNMTTIAGTPKWESPECLMHESYNQKSDVYSYAMML

YELLTDEIPWKNLD-PISVLRKVGVEKQRPRLPQRTDPFLKNLIESCWAEDPKDRPQFKEIYDLF
|||.| . |.     .. . | |   | ||..|   |.|.| ||  || .||. || . .| .  
YELATGDEPYQEIQSIMNAARSVCDKKLRPKIPDNCDNFWKKLIKWCWHNDPNKRPTMNQIIQYL
Kinase 87955.m00263.AA HH498 23-274 29 7.3e-53 165.72 In-house 1-284 (284) Show / Hide 
Range on Protein: 23-274
Range on HMM: 1-284/284
Sequence Identity: 29% (84 aa)

YDLIEQIGIGGFSEVWLAEDKRTGDKVAYK--KIRTDISQSA-----LQTYVREITTMAKAEHPFFLKLIGFSVTSP--LVIITEYIANCSLFRFR----
    |.|| | | .| . |    .  || |  .. .  . |         ..||.  | . .||   . .. ..  |  . |.|.|..| |||.      
IEFHEKIGSGSFGKVYKGEWR--NKIVAVKRYRAMAFCCKSDSYQWIVDMFCREVSIMCRLNHPCVVQFVYACCDDPSQFAIVTQYCDNGSLFSILNTIP

------RNETRRQK-----LTPTVRTNIALCLAYGMKYLHS---LGIIHRDLKSMNILLDDNLLPKLCDFGVARFLSS--DEPMTRSAGTPNWMAPELHN
       |    ||     . .  .  |..  | || |||.     |||||| | |||.. .   .  |||  ||. .  |. ||   | . |||||   
IGGAGANNNNHNQKNNYRIMDLQSKMTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIHEDGHAVVADFGESRFVCDMHDDNMTKQPGNLRWMAPEVFS

-DADYGPEVDVYSYGMILYELLTDEIPWKNLDPISVLRKVGVEKQRPRLPQR----TDPFLKNLIESCWAEDPKDRPQFKEIYDLF
    |   |||.||.|...|..| |.|   . |.    ..   . || .||      .    |||  ||   | .||.| .|  . 
QCQKYSIKVDVFSYAMCIWEMHTREVPFHHYKPAAAAAEMAYHHIRPPIPQTPTAQIPHHWSNLIQMCWHPCPENRPDFDQIVTIL
Kinase 87955.m00263.AA Dicty5 68-278 36 3.3e-52 178.01 In-house 45-260 (260) Show / Hide 
Range on Protein: 68-278
Range on HMM: 45-260/260
Sequence Identity: 36% (80 aa)

REITTMAKAE--HPFFLKLIGFSVTSPLV--IITEYIANCSLFRFRRNETR--RQKLTPTVRTNIALCLAYGMKYLHSLGIIHRDLKSMNILLDDNLLPK
||.| |   .  || | .  |          ..|||. | |||   .   .   | .    .  .|.  | .|..||| .||||||||||.|.  |.  |
REVTIMSIFQSDHPNFIRCYGAHQYNDKYPFHVTEYCHNGSLFNYLNDQRKTTGQPIAYFQQLHMAIDIAQSMRHLHSMNIIHRDLKSMNFLITENWKIK

LCDFGVARFLSSDEPMTRSAGTPNWMAPELHNDADYGPEVDVYSYGMILYELLTDEIPWKNLDPISVLRKVGVEK-QRPRLPQRTDPFLKNLIESCWAED
. |||. ||      ||   ||..|||.|| |   |   .||||.| .|.|..|   | .|.  ..    | | |  || .|        |||..|| . 
IIDFGTSRFVDNRYHMTMHVGTQCWMACELFNGQPYHQKCDVYSFGIVLWEMFTRKEPYDNINNWNIP--VMVMKGERPTIPKDCPTEISNLIKKCWQQK

PKDRPQFKEIYDLFKTGK
|. || |||| . |.   
PHNRPSFKEICKYFESII
Kinase 87955.m00263.AA Dicty4 23-270 31 7.5e-50 164.52 In-house 1-269 (277) Show / Hide 
Range on Protein: 23-270
Range on HMM: 1-269/277
Sequence Identity: 31% (86 aa)

YDLIEQIGIGGFSEVWLAEDKRTGDKVAYKKI---RTDISQSALQTYVREITTMAKAEHPFFLKLIGFSVT---SP--LVIITEYIANCSLFRFRRN---
..  . || |.|.|| ..  .  | .|| ||     .. ... |.   .|.. |.|  ||  ... | .      |  ..| |||    .|..  ..   
INIEQRIGKGSFGEVYKGTWR--GKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPS

ETRRQKLTP-TVRTN---IALCLAYGMKYLHS--LGIIHRDLKSMNILLDDNLLPKLCDFGVAR----FLSSDEPMTRSAGTPNWMAPELHNDADYGPEV
|    .  . . ..    .|.  | || .||.    |||||||| |.| |.|.  | |||| ..      .    ..  .||| |||||      |   .
EQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKA

DVYSYGMILYELLTDEIPWK--NLDPISVLRKVGVEKQRPRLPQRTDPFLKNLIESCWAEDPKDRPQFKEI
||||.|..|.|.|| ..|      ..  . | |. .| || .|. ..|..| ||. || .||. || |.||
DVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEI
Kinase 87955.m00263.AA STE 23-265 23 2.1e-48 167.11 In-house 1-346 (359) Show / Hide 
Range on Protein: 23-265
Range on HMM: 1-346/359
Sequence Identity: 23% (81 aa)

YDLIEQIGIGGFSEVWLAEDKR---------------TGDKVAYKKIRTDISQ----------------SALQTYVREITTMAKAE--HPFFLKLIGFSV
...||.|| |.| .| .| ..                ||. .| |... . ..                . .| . .|| .| |    ||.  | .|  .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

TSP--------LVIITEYIANCSLFRFRR-NETRRQKLT----------PTVRTNIALCLAYG-MKYLHSLGIIHRDLKSMNILLDDNLLPKLCDFGVAR
           | |. ||... ||  . . .  . . |.           ..   |.  .  | ..||||..|||||.|. ||||      |||||||. 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

FLSS-----------------DEPMTRSAGTPNWMAPELHN------DADYGPEVDVYSYGMILYELLTDEIPWKNLDPISVLRKVGVE-----------
 |..                 ..  .  .||| |||||  .      | .|.  .|..| |  . |..| . || .. | ...     .           
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

---KQRPRLPQRTD-------------------PFLKNLIESCWAEDPKDRP
   .. |.||....                   | .|. |. |   ||..||
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRP
Kinase 87955.m00263.AA TyrKc 23-274 27 3.6e-48 167.26 SMART 1-280 (280) Show / Hide 
Range on Protein: 23-274
Range on HMM: 1-280/280
Sequence Identity: 27% (79 aa)

YDLIEQIGIGGFSEVWLAEDKRTGDKVAYKKIRTDISQSALQTYVREITTMAKA--EHPFFLKLIGFSVT--------SPLVIITEYIANCSLFRFRRNE
  |....| | | ||.... |    .|| |... |     ..   ||.  | |   .||  ..|.|  ..         || |..|| .. .|  . |. 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

TRRQKLTPTVRTNIALCLAYGMKYLHSLGIIHRDLKSMNILLDDNLLPKLCDFGVARFLSSD------EPMTRSA---GTP-----NWMAPELHNDADYG
 ..  |..    ....  | || |||| ..|||||   |.|...|.  | .||| .|.. .|      . . |..   |.       |||||  |.  . 
RPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

PEVDVYSYGMILYELLTD-EIPWKN-----LDPISVLRKVGVEKQRPRLPQ-------RTDPFLKNLIESCWAEDPKDRPQFKEIYDLF
.. ||.|.|  ..|..|. . |. .     .... |...|   . .|. |        .  . . .....||.|||.||| |.||...|
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 87955.m00263.AA Pkinase_Tyr 23-274 27 4.8e-45 153.18 Pfam 1-270 (270) Show / Hide 
Range on Protein: 23-274
Range on HMM: 1-270/270
Sequence Identity: 27% (75 aa)

YDLIEQIGIGGFSEVWLAEDK----RTGDKVAYKKIRTDISQSA--LQTYVREITTMAKA-EHPFFLKLIGFSV--TSP--LVIITEYIANCSLFRFRRN
  .....| | | ||.... |     |. .|| |... . ....  ..   ||. .| .   ||  ..|.|  .    |  . |..|| .. .|  . |.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

E-TRRQKLTPTVRTNIALCLAYGMKYLHSLGIIHRDLKSMNILLDDNLLPKLCDFGVARFL--SSDE-PMTRSAGTP-NWMAPELHNDADYGPEVDVYSY
  . .|.||.    ....  | || ||.| ..|||||   |.|...|.  | |||| || .   .    .. ..  |  |||||  |.  .  . ||.|.
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSF

GMILYELLTDE-IP-WKNLDPISVLRKVGVEKQRPRLPQRTDPFLKNLIESCWAEDPKDRPQFKEIYDLF
|  ..|..|   .| ......  |..... . .|   |. . . . .|. .||..||.||| |.||.  .
GVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase 87955.m00263.AA LISK 28-215 29 2.3e-43 138.65 In-house 1-234 (296) Show / Hide 
Range on Protein: 28-215
Range on HMM: 1-234/296
Sequence Identity: 29% (70 aa)

QIGIGGFSEVWLAEDKRTGDKVAYKKIRTD----ISQSALQTYVREITTMAKAEHPFFLKLIGFSVT--SPLVIITEYIANCSLFRFRRNET-RRQKLTP
 || |.|..|   . . ||  .| |.| .     .  ... .  ||. .| . .||. .. .| ..   . | |.||||    |... ...  .   |. 
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPW

TVRTNIALCLAYGMKYLHSLGIIHRDLKSMNILLDDN----LLPKLCDFGVARFLSSDE-----------------------------PMTRSA------
..| .|||  | || |||| .||||||||.|.|...|       |.|||| || .. ..                             .| .        
PQRVKIALDIACGMSYLHSMNIIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCENNSPCNMPREDESDPCMDNDMPMKRKIPKKCMNQRKRRMTIC

GTPNWMAPELHNDADYGPEVDVYSYGMILYELLT
|||.|||||  .. .|   .||.|.|..| |. |
GTPYWMAPEMLLGQSYDESCDVFSFGIVLCEIIT
Kinase 87955.m00263.AA LISK 260-274 60 0.000464 8.86 In-house 282-296 (296) Show / Hide 
Range on Protein: 260-274
Range on HMM: 282-296/296
Sequence Identity: 60% (9 aa)

DPKDRPQFKEIYDLF
|||.|| |||| . .
DPKNRPSFKEIVQWL