Gene 89386.m00150 (T.vaginalis)

89386.m00150

Species: T.vaginalis
Alias: 89386.m00150, TvagK0478
External Links:
Annotation:

Classification

Group: CK1
Family: TTBK

Sequence

Name Sequence Type Origin Length Description Download
89386.m00150.AA Protein None 343 None Fasta, JSON
89386.m00150.kin_dom Protein Kinase Domain None 172 None Fasta, JSON

Protein domain

Protein domains of 89386.m00150.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 89386.m00150.AA CK1 18-271 27 6.3e-89 301.75 In-house 1-339 (339) Show / Hide 
Range on Protein: 18-271
Range on HMM: 1-339/339
Sequence Identity: 27% (95 aa)

YEITKHIGRGGYG-DIYNV-----RDLNKN------VYAMKTEYL-SAKRKALLSEMYFLEKL---------------------QGSDFFPKLIEKGKTE
....|.|| ||.| .|| |     .|.. |       ||||.|   |.... .| |.| . |.                     .|. ...... .|...
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED

KFY-YCIMELLGPSLSKMRR--CLPDSHYKTYSVLRLSSEMLKCIQEFHNCGFVHRDIKPSNFLIRA--------------NRDHPICLIDFGLSA-FFI
..| | .|.||||.|.. |.  .... .    ..|..   ||. ... |.|||.||||||.||.. .              |. . . .||||..   ..
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR

NP-----------KTGKHIDFDP---NCGYVG-TCRYASLNSHLGFSLSRRDDLMSWFYSVIELAEGH--VPWPGSKDMEL-----SEKLKTLMSAQDLC
..           ||..|. . .   ..|..| |.||.|.|.|||  ..||||| |||| .||.  |.   || . || .       || |  . . ...
DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKM

KS------------LPPEFIEIYKTIQSLQFDETPPYDHI
.             .|.|| .|.| | ||.....|.|. |
STPFFLCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI
Kinase 89386.m00150.AA Worm6 18-271 31 1.1e-68 234.53 In-house 1-279 (279) Show / Hide 
Range on Protein: 18-271
Range on HMM: 1-279/279
Sequence Identity: 31% (89 aa)

YEITKHIGRGGYGDIYNVRDLNKNV---YAMKTEY--LSAKRKALLSEMYFLEKL--QGSDFFPKLIEKGKTEK--FYYCIMELLGPSLSKMRRCLPDSH
...|| || ||.|..| | |  ..    .||| |    ..||. |  |.. | ..  ... .|.|....||...  | |..|.|.|..|. .|. .|| .
WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK

YKTYSVLRLSSEMLKCIQEFHNCGFVHRDIKPSNFLIRA------NRDHPICLIDFGLSA-FFINPKTGKHIDFD-PNCGYVGTCRYASLNSHLGFSLSR
.     |......|. |.. |||||.|||.||.|| |        |  | |...|||..  .. . | .. .    ..||..|| |||.|..| |  ..|
FSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQEQCR

RDDLMSWFYSVIELAEGHVPWPGSKDMELSEKLKTL----MS---AQDLCKSLPP-EFIEIYKTIQSLQFDETPPYDHI
.||. |||| ..|.  |  || ..||.   ||.|       .   . .. .  |. || .| . | .... ..| |..|
KDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI
Kinase 89386.m00150.AA TTBKL 18-275 30 1.5e-67 227.08 In-house 1-288 (288) Show / Hide 
Range on Protein: 18-275
Range on HMM: 1-288/288
Sequence Identity: 30% (88 aa)

YEITKHIGRGGYGDIYNVRDLN--KNVYAMKTEYLS-AK-RKALLSEMYFLEKLQ--GSDFFPKLIEKGKTEKFYYCIMELLGPSLSKMRRCLPDSH-YK
..|.| ||.||.| .| |.|..  | ..||| |. . ..  . .  |.. | |||  || .|||... ||.... . .|.|.||.|.. |. .|  .   
WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS

TYSVLRLSSEMLKCIQEFHNCGFVHRDIKPSNFLIRANRD-----HPICLIDFGLSAFFINPKTG-------------KHIDFDPNCGYVGTCRYASLNS
  ...|..   |..... | |||.|||.||.|. . .. .     . . |||||..  ....  .             .. .| . ..  || ||.|.| 
DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNM

HLGFSLSRRDDLMSWFYSVIELAEGHVPWPGSKDMELSEKLKTLMSAQDLCKS------LPPEFIEIYKTIQSLQFDETPPYDHILIMI
|..  ..| ||| ||.|..|||..|  || ...| .  |..|  |. .||.|       .|.|| ...|.. ||.. ..|.|. |.  .
HDRKEQGRHDDLWSWMYMIIELHCG-LPWTNMEDKMEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF
Kinase 89386.m00150.AA TTBK 18-271 35 4.7e-56 192.54 In-house 1-257 (257) Show / Hide 
Range on Protein: 18-271
Range on HMM: 1-257/257
Sequence Identity: 35% (91 aa)

YEITKHIGRGGYGDIYNVRDLNKN--VYAMKTEYLSAKRKALLSEMYFLEKLQGSDFFPKLIEKGKTEKFYYCIMELLGPSLSKMRRCLPDSHYKTYSVL
  ..| || ||.| ||.  |.  .    |.| |   ...  |  |   | |||| |.  . |  |  .|| | .|.|.| .|. .||  |.  .   . |
WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQPKQVLKMEVAVLKKLQGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLSTTL

RLSSEMLKCIQEFHNCGFVHRDIKPSNFLI-RANRDHPIC-LIDFGLSAFFINPKTGKHIDFDPNCGYVGTCRYASLNSHLGFSLSRRDDLMSWFYSVIE
||   .|. |.. |. || ||||||||| . |.     .| ..||||   ..|  .|      .  |. || |||| |.|.   . |.||| | ||  .|
RLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTN-ACGEVRPPREVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVE

LAEGHVPWPGSKDMELSEKLKTLMSAQDLCKSLPPEFIEIYKTIQSLQFDETPPYDHI
 ..|  ||   || .   ..|     ..| | .|.||    . |.||.. ..| |  |
FVQGQLPWRKIKDKDQVGEMKEKYDHRMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI
Kinase 89386.m00150.AA CK1-A 18-271 34 1.8e-46 160.72 In-house 1-261 (261) Show / Hide 
Range on Protein: 18-271
Range on HMM: 1-261/261
Sequence Identity: 34% (91 aa)

YEITKHIGRGGYGDIY-NVRDLNKNVYAMKTEYLSAKRKALLSEMYFLEKLQGSDFFPKLIEKGKTEKFYYCIMELLGPSLSKMRRCLPDSHYKTYSVLR
| . ..|| | .||||  .   | .  |.| |   |.   |. |    . |||   .|..   |.   .   .|.||||||  .   . . ..    || 
YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKARHPQLIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDL-FNFCKRRFTMKTVLM

LSSEMLKCIQEFHNCGFVHRDIKPSNFLIRANRD-HPICLIDFGLSAFFINPKTGKHIDFDPNCGYVGTCRYASLNSHLGFSLSRRDDLMSWFYSVIELA
|   |.  |   |. .|.|||||| |||.  .|    . ||||||.  .  ..| .|| .      .|| ||||.| |||   |||||. |  | ..   
LADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVMMYFN

EGHVPWPGSKDME-------LSEKLKTLMSAQDLCKSLPPEFIEIYKTIQSLQFDETPPYDHI
 |..|| | | |        .||| |. .. . |||  | ||  . . ...|.|.|.| | ..
RGKLPWQGMKAMTKKQKYEKISEK-KMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL
Kinase 89386.m00150.AA CK1-D 18-271 34 2.9e-45 156.72 In-house 1-261 (261) Show / Hide 
Range on Protein: 18-271
Range on HMM: 1-261/261
Sequence Identity: 34% (91 aa)

YEITKHIGRGGYGDIYNVRDLNKN-VYAMKTEYLSAKRKALLSEMYFLEKLQGSDFFPKLIEKGKTEKFYYCIMELLGPSLSKMRR-CLPDSHYKTYSVL
| | . || | .||||   ... |   |.| | . .|   |  |  |   .||    |..   |.   .   .|.||||||  .   |     .||  ||
YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTKHPQLHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFNYCHRKFSLKT--VL

RLSSEMLKCIQEFHNCGFVHRDIKPSNFLIR-ANRDHPICLIDFGLSAFFINPKTGKHIDFDPNCGYVGTCRYASLNSHLGFSLSRRDDLMSWFYSVIEL
 |.  |.. |.  |   |.|||||| |||.    | . . .|||||.  .  ..| .|| .  |    || ||||.| |.|   |||||| |  | ..  
MLADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVLMYF

AEGHVPWPGSKDMELSEKLKTLM------SAQDLCKSLPPEFIEIYKTIQSLQFDETPPYDHI
. | .|| | | .   .|   ..      . ..||| .| || .     ..|.||. | | ..
NRGSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL
Kinase 89386.m00150.AA CK1-Unclassified 121-204 51 6.4e-40 115.52 In-house 113-199 (244) Show / Hide 
Range on Protein: 121-204
Range on HMM: 113-199/244
Sequence Identity: 51% (45 aa)

MLKCIQEFHNCGFVHRDIKPSNFLI--RANRDHPICLIDFGLSAFFINP-KTGKHIDFDPNCGYVGTCRYASLNSHLGFSLSRRDDL
|.. |. .||..|.|||||| |||.  . .. | . .||||||  .| . ||||||... | . .||.||||.|.|||   ||||||
MIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINAHLGIEQSRRDDL
Kinase 89386.m00150.AA CK1 121-269 38 1.1e-38 130.79 In-house 114-271 (271) Show / Hide 
Range on Protein: 121-269
Range on HMM: 114-271/271
Sequence Identity: 38% (61 aa)

MLKCIQEFHNCGFVHRDIKPSNFLI-R-ANRDHPICLIDFGLSAFFINPKTGKHIDFDPNCGYVGTCRYASLNSHLGFSLSRRDDLMSWFYSVIELAEGH
|.. |. .||..|.|||||| |||. |  .. | . .|||||.  .. .||..|| .  | . .||.||||.|.|||   |||||. |  |  . .. |.
MIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDMESLGYVLMYFLRGS

VPWPGSKDMELSEK------LKTLMSAQDLCKS-LPPEFIEIYKTIQSLQFDETPPYD
 || | |  .  .|       |.  . ..|||  .| ||..  . . .|.|.|.| |.
LPWQGLKANTKKQKYEKIMEKKMSTPVEQLCKGNFPNEFAMYLNYCRQLHFEEKPDYM
Kinase 89386.m00150.AA CK1-G 18-271 29 1.3e-31 104.3 In-house 1-266 (266) Show / Hide 
Range on Protein: 18-271
Range on HMM: 1-266/266
Sequence Identity: 29% (80 aa)

YEITKHIGRGGYGDIYNVRDLNKNVY-AMKTEYLSAKRKALLSEMYFLEKLQGS-DFFPKLIEKGKTEKFYYCIMELLGPSLSKMRRCLPDSHYKTYSVL
| . | || | .| ..  . . .|.. | | |    .   |  |  |   | |  .  |.    |   |.   .|.||||||  .   . | ..   .|.
YRVGKKIGCGNFGELFEGKNMYNNEHVAIKFEPMKSRAPQLHDEYRFYKILNGCPEGIPQVYYFGQCGKYNIMVMDLLGPSLEDLFD-WCDRKFSVKTVC

RLSSEMLKCIQEFHNCGFVHRDIKPSNFLI---RANRDHPICLIDFGLSAFFINPKTGKHIDFDPNCGYVGTCRYASLNSHLGFSLSRRDDLMSWFYSVI
 ..  |.. ... |    . ||.|| ||||     ...| | .||||.   .| |.|..|| .       || || | | |||   |||||. .     .
MVAIQMIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQHVIHIIDFGMAKQYIDPETKQHIPYREHKSLTGTARYMSINTHLGREQSRRDDMEALGHMFM

ELAEGHVPWPGSKDMELSEK------LKTLMSAQDLCKS--LPPEFIEIYKTIQSLQFDETPPYDHI
    |. || | |   . |.       |  .  .|||..  .| .|    . . .|.|.|.| ||..
YFLRGSLPWQGLKADNNKERYQKIGDTKRKTNIEDLCQNNAFPEQFATYLRYVRRLDFFECPDYDYL
Kinase 89386.m00150.AA CK1-Unique 18-214 23 1.1e-30 103.66 In-house 1-223 (337) Show / Hide 
Range on Protein: 18-214
Range on HMM: 1-223/337
Sequence Identity: 23% (52 aa)

YEITKHIGRGGYGDIYNVRDLNKN-------VYAMKTEYLSAKRK-----ALLSEMYFLEKLQ----GSDFFPKLIEKGKTEKFYYCIMELLGPSLSKMR
. ..|||| ||||. . | ..|          |.||||. ....       ....| |. |.      .  |....  . .    . .| ..|||.   .
WCVIKHIGYGGYGCVHRVIFVNNGTFRIDDDMYCMKTEQHFMQKHDQRLHIERNVMKFICKCEYQCKYWRHFCEVHDFHQHRDWWWIVMTMHGPSMEECC

RCLPDSHYKTY------SVLRLSSEMLKCIQEFHNCGFVHRDIKPSNFLIRANR---DHPICLIDFGLS--AFFINPKTGKHIDFDPNCGYVGTCRYASL
. .  . .          .....   |  |   |  || ||..|| |.   |.    .| .  .|.| .  .||.  . .   .  |   . |. .|.. 
MMMKNFQFTLNEKKNQLCAIQCGYQCLNVIECMHWHGFHHRHMKPNNYCYMAPSQQHQHCYYMLDYGICRRVFFVS-NNHQIRQPRPITPFRGCKDYCPC

NSHLGFSLSRRDDLMSWFYSVIEL
 .|.   ..||||. ||||. . |
SCHQCREHGRRDDMESWFYMLYHL
Kinase 89386.m00150.AA Pkinase 18-172 20 2.9e-17 62.13 Pfam 1-169 (293) Show / Hide 
Range on Protein: 18-172
Range on HMM: 1-169/293
Sequence Identity: 20% (36 aa)

YEITKHIGRGGYGDIYNVRDLNKNV-YAMKTEYLSAKRKALL------SEMYFLEKLQGSDFFPKLIEKGKTEKFYYCIMELLGP-----SLS-----KM
|.| . ||.|..|  |  .. . .  .|.|.  .. ...  .      || . . .| ....  .|..   ... .| .||...      .|.     ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

RRCL--PDSHYKTYSVLRLSSEMLKCIQEFHNCGFVHRDIKPSNFLIRANRDHP---ICLIDFGLSAFF-INPKTGKH
..|.  .. .     . .   ..|. ..  |..|..|||.||.|.||  |..|.   ....||||...| . ...  .
HGCFYFSEWE-----CKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MT
Kinase 89386.m00150.AA CK1-Unclassified 18-97 28 8.2e-17 46.17 In-house 1-90 (244) Show / Hide 
Range on Protein: 18-97
Range on HMM: 1-90/244
Sequence Identity: 28% (26 aa)

YEITKHIGRGGYGDIYNVRDL-NKNVYAMKTEYLSAKRKALLSEMYFLEKLQGSD-------FFPKLIEKGKTEK--FYYCIMELLGPSL
|.... || |  |.|| . .. .. ..|.| |   .| . |. | ...  ||.          .||... |. |.  . . .|.||||||
YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSKHPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSL
Kinase 89386.m00150.AA CK1 18-97 28 2.2e-16 53.07 In-house 1-91 (271) Show / Hide 
Range on Protein: 18-97
Range on HMM: 1-91/271
Sequence Identity: 28% (26 aa)

YEITKHIGRGGYGDIYNVRDLNKNV---YAMKTEYLSAKRKALLSEMYFLEKLQG------SDFFPKLIEKGKT--EKFYYCIMELLGPSL
|.... || |  |||| . ......   .|.| |   .|   |. | ...  |||      .  .|...  |.   ... . .|.||||||
YRVGRKIGQGSFGDIYLGINMTNGEENHVAIKLEKNKSKHPQLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSL
Kinase 89386.m00150.AA S_TKc 18-289 15 1.7e-14 35.59 SMART 1-231 (231) Show / Hide 
Range on Protein: 18-289
Range on HMM: 1-231/231
Sequence Identity: 15% (48 aa)

YEITKHIGRGGYGDIYNVRDLN-KNVYAMKTEYLSAKRKALLSEMYFLEKLQGSDFFPKLIEKGKTEKFYYCIMELLGP---SLSKMRRCLPDSH----Y
||| ..||.|..|  | .|. . . ..|.|        . ...|.  |.|  . ..  ||..   . ...| .||...    .| .. .  .       .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

KTYSVLRLSSEMLKCIQEFHNCGFVHRDIKPSNFLIRANRDHPICLIDFGLSAFFINPKTGKHIDFDPNCGYVGTCRYASLNSHLGFSLSRRDDLMSWFY
    . ..  .... ..  |. |..|||.||.| |.       | ..||||....                ..||  | .                   |
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL--------------TTFCGTPWYMAPEVL--------------GY

SV------------IELAEGHVPWPGSKDMELSEKLKTLMSAQDLCKSLPPEFIEIYKTIQSLQFDETPPYDHILIMID-NAIDRL---CHQ-------P
.             .|.. |  |.|   .... .|..                               .  | |  . . .  .|.   . |        
GKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG-----------------------------SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCH

RYF
 .|
PWF