Gene 96252.m00300 (T.vaginalis)

96252.m00300

Species: T.vaginalis
Alias: TvagK0437, 96252.m00300
External Links:
Annotation:

Classification

Group: Other
Family: ULK
Subfamily: Fused

Sequence

Name Sequence Type Origin Length Description Download
96252.m00300.AA Protein None 972 None Fasta, JSON
96252.m00300.kin_dom Protein Kinase Domain None 251 None Fasta, JSON

Protein domain

Protein domains of 96252.m00300.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 96252.m00300.AA Fused 4-254 51 3.6e-134 452.03 In-house 1-251 (251) Show / Hide 
Range on Protein: 4-254
Range on HMM: 1-251/251
Sequence Identity: 51% (129 aa)

YHLIQQIGEGSFGRVYKARRKFTGRLVAIKMINKLGQSKDDLTSFKREINILKKVNHPHIMRMLDMFESDTDFNVVSELARGDLFQIIDDNQTLPEDVLK
||  . .|.||||.|||||||   . ||||.| |.| |   | . .||..| ..  ||||  |.| ||.|..  || . | ..|.|. ... ..||.  .
YHVSEMVGQGSFGCVYKARRKYDSKVVAIKFIPKRGRSDKELKNLRRECEIMRRMHHPHIIHMIDSFETDKEVVVVTDYAEMELHQYLEYDGKMPEEQVR

TVAAQLTSALAYLHKNKIIHRDMKPQNILITNKGALKLCDFGFARALSSTTLFLNSIKGTPLYMAPELVQEQRYDEKIDVWSLGIILYELFYGQPPFFTN
 .|..| ||| ||| . | ||||||||||    .  |||||||||..|  |. | |||||||||||||| || ||   | |||| |||||. |||||..|
RIACHLVSALYYLHSHRILHRDMKPQNILLDKNMHIKLCDFGFARNMSINTHVLTSIKGTPLYMAPELVEEQPYDHHADMWSLGCILYELMVGQPPFCAN

SIYKLIQMIVNDPIQWPGPISENFKGFLLKMLQKDPAQRVSCEELLQHPFI
||..|..||. |...||  |.  .. ||  .| ||| .|.|  .|| |||.
SIFHLVSMIKHDDVKWPSTITSCCRNFLQGLLTKDPRHRISWPQLLCHPFV
Kinase 96252.m00300.AA S_TKc 4-254 37 3.4e-109 369.99 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-254
Range on HMM: 1-231/231
Sequence Identity: 37% (101 aa)

YHLIQQIGEGSFGRVYKARRKFTGRLVAIKMINKLGQSKDDLTSFKREINILKKVNHPHIMRMLDMFESDTDFNVVSELARG---DLFQIIDDNQT----
|.....||.|.||.|||.| | |||.||||.|.          ...|||.|||| .||.| ...|.|.. ... .| |.. |   |||..|.....    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--LPEDVLKTVAAQLTSALAYLHKNKIIHRDMKPQNILITNKGALKLCDFGFARALSSTTLFLNSIKGTPLYMAPELVQEQRYDE-KIDVWSLGIILYEL
  .|| . . ...|. .||.|.|...||||| ||.|||...   .|.||||.|| |       ... ||| |||||..    |.  |.|.||.|.||||.
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

FYGQPPFFTNSIYKLIQMIVNDPIQWPGPISENFKGFLLKMLQKDPAQRVSCEELLQ-------HPFI
..|.|||    .......|.          |. .| |. |.|||||..| .. |.||       ||..
LCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 96252.m00300.AA AGC 4-254 23 2.8e-105 272.57 In-house 1-395 (395) Show / Hide 
Range on Protein: 4-254
Range on HMM: 1-395/395
Sequence Identity: 23% (92 aa)

YHLIQQIGEGSFGRVYKARRK------FTGRLVAIKMINKLG--------QSKDDLTS--------FKREINILKKVN----------HPHIMR-MLDMF
....  ||.||||.|| .|.|       ||.. |.|...|          . .  .|         ...| |||.|.|          || | . .   |
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

ESDTD--FNVVSELAR----------G-DLFQII--D-DNQTLPEDVLKTVAAQ-------LTSALAYLHK-NKIIHRD-MKPQNILITNKGALKLCDFG
....      | |..           | .||...  . ......|.. .  ||.       ...|| |||. ..||||| .|| |||....| .||.|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

FARALSS--------------------------------------------------TTLFLNSIKG--TPLYMAPELVQEQRYDEKIDVWS--LGIILY
..  . .                                                   .   ... |  || ||||| .    |.   | ||  ||...|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

ELFYGQPPFFTN-------------SIYKLIQMIV---NDPIQWPGP----------ISENFKGFLLKMLQKDPAQRVSC----------EELLQHPFI
|. .|.|||. .              ....|.      |.....| |          .|.. | .. |.|.|||..|  |          ||. .||. 
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 96252.m00300.AA Pkinase 4-254 35 8.8e-104 355.89 Pfam 1-293 (293) Show / Hide 
Range on Protein: 4-254
Range on HMM: 1-293/293
Sequence Identity: 35% (104 aa)

YHLIQQIGEGSFGRVYKARRKFTGRLVAIKMINKLGQSKDDLTSFKR--EINILKKVNHPHIMRMLDMFESDTDFNVVSELARG-----DLFQIID--DN
||....||.||||.|||...| ||..||.| |.| ..... . .  |  || |.|..|||.| |..|.||....  .| |...|     ||| .|   ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

QTL--PEDVLKTVAAQLTSALAYLHKNKIIHRDMKPQNILITNKGAL----KLCDFGFARAL-SSTTLFLNSIKGTPLYMAPELVQ-EQRYDEKIDVWSL
 ..  .|...| .. |. ..|.|.|...|||||.||.|||| |.| .    |.||||.|. .       .... ||| |||||...  | |. |.|.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GIILYELFYGQPPFFTN------SIYKLIQMIVNDPIQWPGPIS---------------------ENFKGFLLKMLQKDPAQRVSCEELLQHPFI
|.||||.. |.|||         . ...|..|   |. .. | .                     |..| |. ..|.|||..| ..|..||||..
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 96252.m00300.AA ULK 4-254 34 5.1e-101 341.91 In-house 1-324 (324) Show / Hide 
Range on Protein: 4-254
Range on HMM: 1-324/324
Sequence Identity: 34% (113 aa)

YHLIQQIGEGSFG-RVYKAR--RKFT-GRLVAIKMINKLGQSKDDLT--------SFKREINILKKVN---HPH--IMRMLDMFESDTD--FNVVSELAR
| |....|.||||  |||.|  .. | . .||.|||.| ...|. .         ..|.||.|.|| .   ||.  | ...|.||....  .  . |.  
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

G-DLFQIIDDNQTLPEDV----------LKTVAAQLTSALAYLHKNKIIHRDMKPQNILITNK------------GALKLCDFGFARALSSTTL---FLN
| ||.|.|  |..||| .           . .  |. ... .|||..|||||.|||||||.|.            | ||..|||||. . . ..    . 
GGDLEQYIKKNKKLPE-TEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQ

SIK------GTPLYMAPELVQ----EQRYD-EKIDVWSLGIILYELFYGQPPFFTN--SIY----KLIQM-------IVNDPIQWP-----GPISENFKG
...      ||||||||...|    .. |.  | |.||||.|.||. ||..|||..  . |    |||..       | | |||.|      .||...| 
TCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSWFNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKD

FLLKMLQKDPAQRVSCEELLQHPFI
.. .|||.|. .| | ||...||..
LIRRMLQYDEKDRISWEEIFNHPWF
Kinase 96252.m00300.AA ULK 4-254 33 7.2e-101 341.41 In-house 1-329 (329) Show / Hide 
Range on Protein: 4-254
Range on HMM: 1-329/329
Sequence Identity: 33% (110 aa)

YHLIQQIGEGSFGRVYKARRKFT----GRLVAIKMINKLGQSKDDLT--------SFKREINILKKVN--------HPHIMRMLDMFESDTD--FNVVSE
|.|....|.||||.|||.| | |    . .||.||| |  ....           ..|.|| |.|| .        ||.| ...|.||....  .  . |
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

LARG-DLFQIIDDNQTLPEDV----------LKTVAAQLTSALAYLHKNKIIHRDMKPQNILITNK------------GALKLCDFGFARALSSTTL---
.  | ||.|.|  |..||||.           . .  |. ... .|||..|||||.|||||||.|.            | ||..|||||. ... ..   
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

FLNSIK------GTPLYMAPELVQ----EQRYD-EKIDVWSLGIILYELFYGQPPFFTNSIYKLI-----QMIVN----------DPIQWP-----GPIS
 . . .      ||||||||...|    .. |.  | |.||||.|.||. ||.|||... .....     . | |           |.|.|      .||
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS

ENFKGFLLKMLQKDPAQRVSCEELLQHPFI
...| .. .|||.|. .| | |||..||..
PECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 96252.m00300.AA CAMK 9-254 22 7.9e-95 305.97 In-house 1-425 (425) Show / Hide 
Range on Protein: 9-254
Range on HMM: 1-425/425
Sequence Identity: 22% (94 aa)

QIGEGSFGRVYKARRKFTG------------RLVAIKMINKLGQSKD--------------------------DLTSFKREINILKK-------VNHPHI
..|.|||| |.....| |.            . ||||.|.|   ...                          |. ...|||.|.||       ..||.|
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

MRMLDMFES-------------------DTDFNVVS---ELARG-----DLFQIIDDN---------------QTLPEDVLKTVAAQLTSALAYLHKNKI
 ......|.                   |...  |    |.. |     |||. | ..                 ..|.  ...  |. ||..|.|...|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IHRDMKPQNILITNK-----------------GALKLCDFGFARALSS-----------------------TTLFLNSIKGTPLYMA-PELVQEQR----
.||| || |||....                 . .|..|||||. . .                       ..  ..   ||| ||| ||... ..    
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

----------YDEKIDVWSLGIILYELFYGQPPFFTN-------------SIYKLIQMIVNDPIQWPGP----------------ISEN--------FKG
          |..|.|.||.|.||| .  | |||                ..|.| ..| .   ..| |                ||..         | 
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

FLLKMLQKDPAQRVSCEELLQHPFI
.. ||||.|| .| ..|. |.||..
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 96252.m00300.AA CAMKL 4-254 28 8.8e-89 283.45 In-house 1-297 (297) Show / Hide 
Range on Protein: 4-254
Range on HMM: 1-297/297
Sequence Identity: 28% (87 aa)

YHLIQQIGEGSFGRVYKARR-KFTGRLVAIKMINKLGQSKDDLTSFK-------------REINILKKVN---HPHIMRMLDMF-------ESDTDFNVV
| .....|.|||| |  |.  ..||. ||||.|.| . ..|. .. .             |||.|.|..|   ||.|.......       |. .... |
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIET-KKIYLV

SELARGD---LFQIIDDN----QTLPEDVLKTVAAQLTSALAYLHKNKIIHRDMKPQNILITNKG--ALKLCDFGFARALSS----TTLFLNSIKGTPLY
 |.. |    ||. |. .    . .||.  .    |. ||..|.|...|.||| || |||....|   .|..||||.         .  .|.   |.| |
MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPY

MAPELVQE--QRYD-EKIDVWSLGIILYELFYGQPPF----------FTNSIYKLIQMIVNDPIQWPGPISENFKGFLLKMLQKDPAQRVSCEELLQHPF
||||..|   ..||  |.|.||.|.||| . .|. ||          . .  .....|.    .  .  .|   . .. ||||..| .| .......||.
MAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPW

I
 
M
Kinase 96252.m00300.AA STE 4-254 26 1.8e-87 296.93 In-house 1-359 (359) Show / Hide 
Range on Protein: 4-254
Range on HMM: 1-359/359
Sequence Identity: 26% (98 aa)

YHLIQQIGEGSFGRVYKARRK------FTGRL---------VAIKMINKLGQSK---------------DDLTSFKREINILKKVN--HPHIMRMLDMFE
. .|..||.|.|| ||||...       ||..         .||| .|.  ...               ... ....||.|.|| |  ||.| . .....
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

SD-------TDFNVVSELAR-GDLFQIID--------DN------QTLPEDVLKTVAAQLTSA-LAYLHKNKIIHRDMKPQNILITNKGALKLCDFGFAR
 .       .. ... |.   | | .||.        .|      ...||....... |.  . |.|||...||||| ||.|||.      ||||||.. 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

ALSS---------------TTL-FLNSIKGTPLYMAPELVQEQR------YDEKIDVWSLGIILYELFYGQPPFFTNSIYKLIQMIV-------------
 |..               |.    |.. ||| .|||| .| ..      ||.| |.||||. . |.  |.||... .  . . ||              
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

---NDPIQWPGPIS-------------------ENFKGFLLKMLQKDPAQRVSCEELLQ--HPFI
   ..| . | ..|                   ..|| |. | ||||| .| . ..||.  ||||
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 96252.m00300.AA Ciliate-E2 4-254 26 3.7e-84 285.91 In-house 1-365 (365) Show / Hide 
Range on Protein: 4-254
Range on HMM: 1-365/365
Sequence Identity: 26% (100 aa)

YHLIQQIGEGSFGRVYKARRKFTGRL------------------VAIKMINKLGQSKDDLTSFKREINILKKVN----------------HPHIMRMLDM
| .|..||.|.|| |||.... ....                  |.||....  ..|... ..|.||.|....|                ||.|..| . 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FE--SDTDFNVVSELARG-DLFQIIDDNQTLP-----------EDVLKTVAAQLTS---------------ALAYLHKNK-IIHRDMKPQNILITNKGAL
|.  .|. .  | |.. | |||..| .|..             |   |.. .|...               || |||... ||||| ||.|||.     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KLCDFGFAR--------------ALSSTTLF------------------LNSIKGTPLYMAPELVQ---------EQRYDEKIDVWSLGIILYELFYGQP
|..|||...              .   .  .                   |.| ||| ||||| ..         ...||.|.|.||||.||||. .|.|
KIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PFFTNSIYKLIQMIVNDPIQWPGP------------------ISENFKGFLLK----MLQKDPAQRVS-CEELLQHPFI
||        .| | . .|. | |                  .|.. | .. |    |||||| .| .  |..|.||..
PF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 96252.m00300.AA NEK 4-254 34 9e-80 271.33 In-house 1-286 (286) Show / Hide 
Range on Protein: 4-254
Range on HMM: 1-286/286
Sequence Identity: 34% (98 aa)

YHLIQQIGEGSFGRVYKARRKFTGRL-----VAIKMINKLGQSKDDLTSFK-REINILKKVNHPHIMRMLDMFESDT--DFNVVSELAR--GDLFQI---
| .|..||.||||.|||.||| .|.      ...| ||  . |  .       |..|||. .||.| .  | |. .    .. | | .   |||.|    
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

IDDNQ----TLPEDVLKTVAAQLTSALAYLHKN-----KIIHRDMKPQNILITNKGA----LKLCDFGFARALSSTTLFLNS-IKGTPLYMAPELVQEQR
|  ..     ..|..   . .|. .|| |.|..     ||.||| ||||| .|...     .|. ||| .. |..|| ....   ||| ||.||..|.. 
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKP

YDEKIDVWSLGIILYELFYGQP--PFFTN--SIYKLIQMIVNDPIQWPGPISEN--F----KGFLLKMLQKDPAQRVSCEELLQHPFI
|..| |.|||| .|||.   .|  ||  .  ... |.  |..     . ||...  .    . .. .|||||| || ||...|..|||
YNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKG--PQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase 96252.m00300.AA STE20 4-254 34 6.5e-77 261.84 In-house 1-288 (288) Show / Hide 
Range on Protein: 4-254
Range on HMM: 1-288/288
Sequence Identity: 34% (99 aa)

YHLIQQIGEGSFGRVYKARRKFTGRL----VAIKMINKLGQSK--DDLTSFKREINILKKVNHPHIMRMLDMFESD----TDFNVVSELARG-DLFQIID
| |...||.||.| ||||. | ||..    ||||..|   ..   |.. . . ||.|.|. .||.| .... .  |    ..  .| |.  |  | .|..
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

----DNQ-----TLPEDVLKTVAAQLTSALAYLHKNKIIHRDMKPQNILITNKGALKLCDFGFARALSS----TTL-FLNSIKGTPLYMAPELVQE----
    ...     .. |.   ..  ..  .|.|||.|.||||| | .|||.| .|  ||.|||..  |..    |     |.. ||| .||||..|.    
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGP

-QRYDEKIDVWSLGIILYELFYGQPPFFT-NSIYKLIQMI--VNDP--IQW--PGPISENFKGFLLKMLQKDPAQRVSCEELLQHPFI
 . ||.| |.||||| . |.  |.||.|  .    . ...   |.|   .   |   | .|. |. |.|||||..| . ..||.||||
DKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase 96252.m00300.AA TyrKc 4-254 24 1.1e-23 85.9 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-254
Range on HMM: 1-280/280
Sequence Identity: 24% (72 aa)

YHLIQQIGEGSFGRVYKARRKFTGRLVAIKMINKLGQSKDDLTSFKREINILKKV--NHPHIMRMLDMFESD-------TDFNVVSELA-RGDLFQIIDD
 .|....||| ||.|||.. |   . ||.||...       .  | ||..|..|.  .||.| |..    ..           .| |..  ||| . . .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

NQT-LPEDVLKTVAAQLTSALAYLHKNKIIHRDMKPQNILITNKGALKLCDFGFARALSST--------TLFLNSIKGTP--L---YMAPELVQEQRYDE
..  |. . |   . |  .  .|||....||||    |.|.....  | .||| .|.. .         .    . ||.   |    ||||  .. .. .
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT

KIDVWSLGIILYELF-YGQPPFFT-----NSIYKLIQMIVNDPIQWPGPI---------SENFKGFLLKMLQKDPAQRVSCEELLQHPFI
| |||| |. ..|.| |||.|         | . .|. . .     . |          ..      ..  . ||..| . .|.  | ..
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 96252.m00300.AA Pkinase_Tyr 4-67 35 4.1e-17 58.57 Pfam 1-70 (270) Show / Hide 
Range on Protein: 4-67
Range on HMM: 1-70/270
Sequence Identity: 35% (25 aa)

YHLIQQIGEGSFGRVYKARRK----FTGRLVAIKMINKLGQSKDD--LTSFKREINILKKV-NHPHIMRML
 ......|||.||.|||.. |     |.  ||.||. | | ....  . .| ||..|.|.  .||.| |..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLY
Kinase 96252.m00300.AA Pkinase_Tyr 92-200 32 2.7e-14 49.05 Pfam 103-216 (270) Show / Hide 
Range on Protein: 92-200
Range on HMM: 103-216/270
Sequence Identity: 32% (37 aa)

DDNQTLPEDVLKTVAAQLTSALAYLHKNKIIHRDMKPQNILITNKGALKLCDFGFARAL-SSTTLFLNSIKGTPL---YMAPELVQEQRYDEKIDVWSLG
.|.| |.   |   ..|  ....||. ...||||    |.|.|...  | |||| ||.. .  .  . . .|..|    ||||  .. .. .| |||| |
EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFG

IILYELFY-GQPP-F
. ..|.|  |. | .
VLMWEIFTYGEQPTY
HEAT 96252.m00300.AA HEAT 471-502 21 29.414583 1.29 Pfam 1-31 (31) Show / Hide 
Range on Protein: 471-502
Range on HMM: 1-31/31
Sequence Identity: 21% (7 aa)

FLPIATSAVIHHPSMAVKSAAFCILTKVIDKN
.||.     ...|.  |..||.  |...... 
ILPHLL-KCLNDPDWEVREAACWCLGQLCEHC
HEAT 96252.m00300.AA HEAT 658-670 46 37.357876 0.93 Pfam 1-13 (31) Show / Hide 
Range on Protein: 658-670
Range on HMM: 1-13/31
Sequence Identity: 46% (6 aa)

ILPSLLGLFTSPS
||| || ....|.
ILPHLLKCLNDPD
HEAT 96252.m00300.AA HEAT 822-852 22 0.002335 15.49 Pfam 1-31 (31) Show / Hide 
Range on Protein: 822-852
Range on HMM: 1-31/31
Sequence Identity: 22% (7 aa)

LTPYIVTHLRDENQSAQRQAAFALGNLLTKN
. |.....|.|.. . ...|. .||.|. . 
ILPHLLKCLNDPDWEVREAACWCLGQLCEHC
Arm 96252.m00300.AA Arm 811-850 24 0.004285 14.16 Pfam 1-41 (41) Show / Hide 
Range on Protein: 811-850
Range on HMM: 1-41/41
Sequence Identity: 24% (10 aa)

RQALEEDVVNA-LTPYIVTHLRDENQSAQRQAAFALGNLLT
 ..  . |...   | .|  |...... |..|. ||.|| .
NPEQKQAVIQCGCVPPLVQLLHHPDEEVQENACWALWNLCA
Arm 96252.m00300.AA Arm 770-810 9 0.364938 7.57 Pfam 1-41 (41) Show / Hide 
Range on Protein: 770-810
Range on HMM: 1-41/41
Sequence Identity: 9% (4 aa)

SDAFIPSLLEAGVMVLAERALQSEAVQIRTAALSFIGNFTR
... .  ....|.. .  . |... ......|.  ..| ..
NPEQKQAVIQCGCVPPLVQLLHHPDEEVQENACWALWNLCA
HEAT 96252.m00300.AA HEAT 782-812 16 0.940041 6.47 Pfam 1-31 (31) Show / Hide 
Range on Protein: 782-812
Range on HMM: 1-31/31
Sequence Identity: 16% (5 aa)

VMVLAERALQSEAVQIRTAALSFIGNFTRRQ
.. .  ..|...  ..| ||.. .|.. .  
ILPHLLKCLNDPDWEVREAACWCLGQLCEHC
Arm 96252.m00300.AA Arm 867-890 33 3.5e-05 21.28 Pfam 18-41 (41) Show / Hide 
Range on Protein: 867-890
Range on HMM: 18-41/41
Sequence Identity: 33% (8 aa)

IELLQSTDSRTVENAAGVLGNIVR
..||...|....|||...|.|...
VQLLHHPDEEVQENACWALWNLCA
HEAT 96252.m00300.AA HEAT 867-892 23 3.823337 4.36 Pfam 6-31 (31) Show / Hide 
Range on Protein: 867-892
Range on HMM: 6-31/31
Sequence Identity: 23% (6 aa)

IELLQSTDSRTVENAAGVLGNIVRKK
...|...|..  |.|.  ||..... 
LKCLNDPDWEVREAACWCLGQLCEHC