Gene 86498.m00432 (T.vaginalis)

86498.m00432

Species: T.vaginalis
Alias: 86498.m00432, TvagK0471
External Links:
Annotation:

Classification

Group: CK1
Family: TTBK

Sequence

Name Sequence Type Origin Length Description Download
86498.m00432.AA Protein None 348 None Fasta, JSON
86498.m00432.kin_dom Protein Kinase Domain None 173 None Fasta, JSON

Protein domain

Protein domains of 86498.m00432.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 86498.m00432.AA CK1 10-264 26 3.3e-79 269.44 In-house 1-339 (339) Show / Hide 
Range on Protein: 10-264
Range on HMM: 1-339/339
Sequence Identity: 26% (90 aa)

YIIGEKIGVGAFG-EIYSA-----IDDRTG-----ILYAIKTETSDAV--KKTLAFEFQIIAQIQS--------------------SPHFPRLGVFGHGH
. ...||| |.|| .|| .     .|  ..       ||.|.|  ..   . .|  |.|.... |                     .||.....  |...
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED

GFS-FFSMELLGPSLSGIIK--RLPEHRLSLSTAVRSSLHILKCIESLHIFGIVHRDIKPSNILTRE-------------GTDYP-LCLIDFGLSR-VYI
..  .  |.||||.|. . |  |.. ...|..|...  . .|. .| .|  |..||||||.|..                . ..  . .||||..|  |.
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR

DS-----------SNGQHLPPRP---HVGFRG-TKPYASIHAHKGHDLSRRDDLISWFYLATELIAGY--LPWRSVTDKGV-----IMALKQKFQ--VKE
|.           ...|| |||.   ..|||| |  |.||..|.|....||||| ||||.  |.. |   |||. ..|.       ..  |..|    | 
DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKM

ILSP----------IAPELLEVWDHITSLDFYAAPNYHMI
 ...          . .|. .....| ||..| .|.|.||
STPFFLCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI
Kinase 86498.m00432.AA TTBKL 10-268 28 7.5e-65 217.88 In-house 1-288 (288) Show / Hide 
Range on Protein: 10-268
Range on HMM: 1-288/288
Sequence Identity: 28% (83 aa)

YIIGEKIGVGAFGEIYSAIDDRT-GILYAIKTETSD-AVK-KTLAFEFQIIAQIQ--SSPHFPRLGVFGHGHGFSFFSMELLGPSLSGIIKRLPEHR-LS
. | ..|| |.||..| ..|  . .  .| | |    . . ... .| ..  . |  .|||||..   |. ....|. |.|.||.|. . |..|  . .|
WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS

LSTAVRSSLHILKCIESLHIFGIVHRDIKPSNILTREGTD-----YPLCLIDFGLSRVYIDSSNGQ----------HLPPRP---HVGFRGTKPYASIHA
 .|..| .  .|...  .|  |..|||.||.|. .   ..       . |||||..| |.......          . .||.   ...||||  |.|. .
DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNM

HKGHDLSRRDDLISWFYLATELIAGYLPWRSVTDKGVIMALKQKFQVKEIL--SP----IAPELLEVWDHITSLDFYAAPNYHMIFERL
| . ...| ||| ||.| . || .| |||....||  |...|..   . .   .|    . .|....  |. ||..|  |.|.||.| .
HDRKEQGRHDDLWSWMYMIIELHCG-LPWTNMEDKMEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF
Kinase 86498.m00432.AA TTBK 10-264 37 4.7e-61 209.16 In-house 1-257 (257) Show / Hide 
Range on Protein: 10-264
Range on HMM: 1-257/257
Sequence Identity: 37% (98 aa)

YIIGEKIGVGAFGEIYSAIDDRTG-ILYAIKTETSDAVKKTLAFEFQIIAQIQSSPHFPRLGVFGHGHGFSFFSMELLGPSLSGIIKRLPEHRLSLSTAV
  .  ||| |.|||||.| |  .     ||| | ... |  |  |  .  . |  .|  |    |    | .  |.|.| .|.      |.   ||||..
WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQPKQVLKMEVAVLKKLQGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLSTTL

RSSLHILKCIESLHIFGIVHRDIKPSNI-LTREGTDYPLC-LIDFGLSRVYIDSSNGQHLPPRPHVGFRGTKPYASIHAHKGHDLSRRDDLISWFYLATE
|  . ||. ||| |  |  ||||||||  . |    .  | ..|||| | |. .. |.  |||.  |||||  |||| ||.  .. |.||| | ||. .|
RLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTNAC-GEVRPPREVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVE

LIAGYLPWRSVTDKGVIMALKQKFQVKEILSPIAPELLEVWDHITSLDFYAAPNYHMI
 . | |||| . ||  .  .|.|.  . .|  . .|.    ||| ||..   |.| .|
FVQGQLPWRKIKDKDQVGEMKEKYDHRMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI
Kinase 86498.m00432.AA Worm6 10-264 27 2.9e-59 203.19 In-house 1-279 (279) Show / Hide 
Range on Protein: 10-264
Range on HMM: 1-279/279
Sequence Identity: 27% (78 aa)

YIIGEKIGVGAFGEIYSAIDDRTGI--LYAIKTET--SDAVKKTLAFEFQIIAQI--QSSPHFPRLGVFG--HGHGFSFFSMELLGPSLSGIIKRLPEHR
. ...||| |.|| .|.. |. ..    .|.| |     . .. | .|  .   .  . ..||...   |    .|| .  |.|.|..|. ..| .|. .
WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK

LSLSTAVRSSLHILKCIESLHIFGIVHRDIKPSNI-LTR-----EGTDYPLCLIDFGLSR-VYIDSSNGQHLPPR-PHVGFRGTKPYASIHAHKGHDLSR
.|..|. . ..  |. || || .| .|||.||.|    |      .    ....|||..|  . .  ...  .|| ...||||| .||....||| ...|
FSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQEQCR

RDDLISWFYLATELIAGYLPWRSVTDKGVIM-ALKQKFQVK-----EILSPIAP--ELLEVWDHITSLDFYAAPNYHMI
.||. ||||.  |.| | |||| ..|.       |..   .     . .  . |  |. .. | |...... .|.|  |
KDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI
Kinase 86498.m00432.AA CK1-A 10-218 36 2.5e-38 132.99 In-house 1-209 (261) Show / Hide 
Range on Protein: 10-218
Range on HMM: 1-209/261
Sequence Identity: 36% (76 aa)

YIIGEKIGVGAFGEIYSAIDDRTGILYAIKTETSDAVKKTLAFEFQIIAQIQSSPHFPRLGVFGHGHGFSFFSMELLGPSLSGIIKRLPEHRLSLSTAVR
| .  ||| |.||.|| .|  . |   ||| |  .|    | .| ..  ..|  . .|..  .|... .  . |.||||||  .   . . | .. | . 
YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKARHPQLIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFN-FCKRRFTMKTVLM

SSLHILKCIESLHIFGIVHRDIKPSNILTREGTD-YPLCLIDFGLSRVYIDSSNGQHLPPRPHVGFRGTKPYASIHAHKGHDLSRRDDLISWFYLATELI
    ..  || .|  . .|||||| | |   |     | ||||||.. | ||   ||.| |      ||  ||||.|| | . |||||. |  |      
LADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVMMYFN

AGYLPWRSVT
 | |||  ..
RGKLPWQGMK
Kinase 86498.m00432.AA CK1-D 10-264 31 3e-34 118.15 In-house 1-261 (261) Show / Hide 
Range on Protein: 10-264
Range on HMM: 1-261/261
Sequence Identity: 31% (82 aa)

YIIGEKIGVGAFGEIYSAIDDRTGILYAIKTETSDAVKKTLAFEFQIIAQIQSSPHFPRLGVFGHGHGFSFFSMELLGPSLSGIIKRLPEHRLSLSTAVR
| || ||| |.||.||   .  |.   ||| |.  .    | .| ..   .|     |..  .|.   .    |.||||||  .     . . || | . 
YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTKHPQLHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFN-YCHRKFSLKTVLM

SSLHILKCIESLHIFGIVHRDIKPSNILTREGTDYPLC-LIDFGLSRVYIDSSNGQHLPPRPHVGFRGTKPYASIHAHKGHDLSRRDDLISWFYLATELI
 .. ... || .|    .|||||| | |   |    .  .|||||.. | |.   ||.| | .    ||  ||||  |.| . |||||| |  |.     
LADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVLMYFN

AGYLPW---RSVTDK---GVIMALKQKFQVKEILSPIAPELLEVWDHITSLDFYAAPNYHMI
 | |||   . .| .     |.  | . ..... .    |  .  ..  .| |   |.|  .
RGSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL
Kinase 86498.m00432.AA CK1-Unique 10-215 25 1.7e-28 95.94 In-house 1-233 (337) Show / Hide 
Range on Protein: 10-215
Range on HMM: 1-233/337
Sequence Identity: 25% (60 aa)

YIIGEKIGVGAFGEIYSAIDDRTG------ILYAIKTETSDAVKK--TLAFEFQIIAQIQSSP-------HFPRLGVFGHGHGFSFFSMELLGPSLSGII
... ..|| | .|  .  |.  .|        |. ||| . . |    |  |  . . |           ||. .  |.     .. .| ..|||.  . 
WCVIKHIGYGGYGCVHRVIFVNNGTFRIDDDMYCMKTEQHFMQKHDQRLHIERNVMKFICKCEYQCKYWRHFCEVHDFHQHRDWWWIVMTMHGPSMEECC

KRLPEHRLSLS------TAVRSSLHILKCIESLHIFGIVHRDIKPSNILTREGT---DYPLCLIDFGLS-RVYIDSSNGQHLPPRPHVGFRGTKPYASIH
  .      |.      .|.. .. .|  ||  |  |  ||..|| |. .       .  .  .|.| . || . | |.|  .||| . |||.|.|... 
MMMKNFQFTLNEKKNQLCAIQCGYQCLNVIECMHWHGFHHRHMKPNNYCYMAPSQQHQHCYYMLDYGICRRVFFVSNNHQIRQPRPITPFRGCKDYCPCS

AHKGHDLSRRDDLISWFYLATELIAGY--LPWR
 |.  ...||||. ||||..  |. .   | |.
CHQCREHGRRDDMESWFYMLYHLVHNTRGLSWK
Kinase 86498.m00432.AA CK1-Unclassified 114-197 45 5e-26 73.82 In-house 113-199 (244) Show / Hide 
Range on Protein: 114-197
Range on HMM: 113-199/244
Sequence Identity: 45% (40 aa)

ILKCIESLHIFGIVHRDIKPSNIL--TREGTDYPLCLIDFGLSRVYIDS-SNGQHLPPRPHVGFRGTKPYASIHAHKGHDLSRRDDL
... || ||  ...|||||| |.|   ...  . . .||||||  |||. ..|.| | |   .. ||  |||| ||.|.  ||||||
MIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINAHLGIEQSRRDDL
Kinase 86498.m00432.AA CK1-G 10-197 31 1.7e-24 79.84 In-house 1-191 (266) Show / Hide 
Range on Protein: 10-197
Range on HMM: 1-191/266
Sequence Identity: 31% (61 aa)

YIIGEKIGVGAFGEIYSAIDDRTGILYAIKTETSDAVKKTLAFEFQIIAQIQSSP-HFPRLGVFGHGHGFSFFSMELLGPSLSGIIKRLPEHRLSLSTAV
| .| ||| | |||..      ..   ||| |        |  |..   .  . |   |.   ||    .    |.||||||      . . . |. | .
YRVGKKIGCGNFGELFEGKNMYNNEHVAIKFEPMKSRAPQLHDEYRFYKILNGCPEGIPQVYYFGQCGKYNIMVMDLLGPSLEDLFD-WCDRKFSVKTVC

RSSLHILKCIESLHIFGIVHRDIKPSNIL-TREGTDYP--LCLIDFGLSRVYIDSSNGQHLPPRPHVGFRGTKPYASIHAHKGHDLSRRDDL
  .  ... .| .|    . ||.|| | |  |...  .  . .||||. . |||   .|| | | |    ||  | ||  | |   |||||.
MVAIQMIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQHVIHIIDFGMAKQYIDPETKQHIPYREHKSLTGTARYMSINTHLGREQSRRDDM
Kinase 86498.m00432.AA Pkinase 10-182 25 2e-22 80.36 Pfam 1-179 (293) Show / Hide 
Range on Protein: 10-182
Range on HMM: 1-179/293
Sequence Identity: 25% (49 aa)

YIIGEKIGVGAFGEIYSAIDDRTGILYAIKTETSDAVKKTL---AF---EFQIIAQIQSSPHFPRL-GVFGHGHGFSFFSMELLGP-----SLSGIIKRL
| ||.||| |.||. | ...  ||...|.|.   .  |.     ..   | || . . ..|.  || ..|   ..   . ||...      .|. .|.. 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYISTW

PEHRL--SLSTAVRSSLHILKCIESLHIFGIVHRDIKPSNILTREGTDYP---LCLIDFGLSRVYIDSSNGQHLPPRPHVGFRGTKPYAS
 . ..  |  .. .  . ||. .| .|  ||.|||.||.|||    ....   ....||||....       . . .   .| || .|..
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFD------Y-NNS-MTTFCGTPWYMA
Kinase 86498.m00432.AA CK1-Unclassified 10-90 33 1.2e-21 60.71 In-house 1-90 (244) Show / Hide 
Range on Protein: 10-90
Range on HMM: 1-90/244
Sequence Identity: 33% (30 aa)

YIIGEKIGVGAFGEIYSAIDDRTGILYAIKTETSDAVKKTLAFEFQIIAQIQSSP-------HFPRLGVFGHG--HGFSFFSMELLGPSL
| ..|||| |.||||| .|.  |. ..||| | ...  ..| .| .|  . |          ..|..  .|     .. .  |.||||||
YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSKHPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSL
Kinase 86498.m00432.AA CK1 118-197 43 2.5e-21 70.35 In-house 118-199 (271) Show / Hide 
Range on Protein: 118-197
Range on HMM: 118-199/271
Sequence Identity: 43% (36 aa)

IESLHIFGIVHRDIKPSNIL-TR-EGTDYPLCLIDFGLSRVYIDSSNGQHLPPRPHVGFRGTKPYASIHAHKGHDLSRRDDL
|| .|  ...|||||| |.|  | .     . .|||||.  |.|....|| | | . .. ||  |||| .| |.  |||||.
IEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDM
Kinase 86498.m00432.AA CK1 10-90 31 9.1e-18 57.9 In-house 1-91 (271) Show / Hide 
Range on Protein: 10-90
Range on HMM: 1-91/271
Sequence Identity: 31% (29 aa)

YIIGEKIGVGAFGEIYSAIDDRT----GILYAIKTETSDAVKKTLAFEFQIIAQIQS------SPHFPRLGVFGHG--HGFSFFSMELLGPSL
| .|.||| |.||.|| .|.  |    . ..||| | ...    | .| .|  . |       ....|..  .|      . .  |.||||||
YRVGRKIGQGSFGDIYLGINM-TNGEEN-HVAIKLEKNKSKHPQLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSL
Kinase 86498.m00432.AA S_TKc 10-286 20 8.3e-15 40.26 SMART 1-231 (231) Show / Hide 
Range on Protein: 10-286
Range on HMM: 1-231/231
Sequence Identity: 20% (61 aa)

YIIGEKIGVGAFGEIYSAIDDRTGILYAIKTETSDAVKKTLAFEFQIIAQIQSSPHFPRLGVFGHGHGFSFFSMELLGP---SLSGIIKRLPEHR----L
| |..||| ||||. | ... .|| ..|||        ...  | ||  .    |.  .|  . .  .. .. ||...    .|  .||. . |.    .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

SLSTAVRSSLHILKCIESLHIFGIVHRDIKPSNILTREGTDYPLCLIDFGLSRVYIDSSNGQHLPPRPHVGFRGTKPYASIHAHKGHDLSRRDDLISWFY
.  .| .    |.. .| .|  ||.|||.||.|||  |     . ..||||.|..                | ||  | .                .. .
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL--------------TTFCGTPWYMAPEVL------------GYGK

----------LATELIAGYLPWRSVTDKGVIMALKQKFQVKEILSPIAPELLEVWDHITSLDFYAAPNYHMIFERLEQI--LKRIKAHMDDP-------F
          .  |...|| |..       .... .|                             |    . ... |    ||. |             
CKCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG--------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCH

EWA
.| 
PWF
Kinase 86498.m00432.AA TyrKc 10-264 17 1.1e-05 -130.48 SMART 1-280 (280) Show / Hide 
Range on Protein: 10-264
Range on HMM: 1-280/280
Sequence Identity: 17% (54 aa)

YIIGEKIGVGAFGEIYSAIDDRTGILYAIKTETSDAVKKTLAFEFQIIAQI-QSSPH-FPRLGVFGHGH------GFSFFSMELLGP-SLSGIIKRLPEH
   |.|.| |||||.| .. .   |  |.|.  .|| .. .  | .|  ..  . |.    .||  ..       .  .  ||.    .|   ...  ..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

RLSLSTAVRSSLHILKCIESLHIFGIVHRDIKPSNILTREGTDYPLCLIDFGLSRVYIDS-SNGQHLPPRPHVGFRGTKPYASIHAHKGHDLS----RRD
 |.... .  .. | .  | ||  ...|||.   |.|  |.        ||||||   |  ..|                     . |    .     ..
-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFGLSRDIYDDDQQG---------------------ESKDYYRKKEHKGGK

DLISWFYLATELI-----------------------AGYLPWRS-----VTDKGVIMALKQK---FQVKE--------ILSPIAPELLEVWDHITS--LD
...    .| | |                        |  |.       .... ||  .||     | ..          . .    .. |..  .    
TMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPT

FYAAPNYHMI
| .   .. .
FSEI--HECF