Gene 95287.m00262 (T.vaginalis)

95287.m00262

Species: T.vaginalis
Alias: 95287.m00262, TvagK0507
External Links:
Annotation:

Classification

Group: CK1
Family: TTBK

Sequence

Name Sequence Type Origin Length Description Download
95287.m00262.AA Protein None 348 None Fasta, JSON
95287.m00262.kin_dom Protein Kinase Domain None 173 None Fasta, JSON

Protein domain

Protein domains of 95287.m00262.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 95287.m00262.AA CK1 10-264 26 2.7e-76 259.79 In-house 1-339 (339) Show / Hide 
Range on Protein: 10-264
Range on HMM: 1-339/339
Sequence Identity: 26% (89 aa)

YIVGNKIGHGAFG-EIYSA-----IDERTG-----ILWALKTEQNSAS--KKTLAFEFQIIAQVQSS-------------------PHFPRLGVFGQGRD
. |. ||| |.|| .|| .     .|. ..        |.|.| ...   . .|  |.|.... |                      ..|.. ......|
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED

--FSFFSMELLGPSLSNIVK--RIPNHKLSLSTSVRSAYHILKCIESLHIFGIVHRDIKPGNILTREGTD--------------HPLCLIDFGLSR-VYV
  . .  |.||||.|. . |  | .|.|.|..|... |. .|. .| .|  |..||||||.|..   ...              . . .||||..|  |.
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR

NP-----------QTGQHLLPRA---RVGFRG-TKAYASRHAHFGEDLSRRDDLISWFYLSLELIVGY--LPWRGINDKAT-----ILALKDNFDVGQTI
..            |.||  ||    ..|||| |  |.|...| | ...||||| ||||. .|...|   |||....|.       .   | .|   .  
DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKM

SP------------FAPELFEIWRHISSLGFTDTPNYALM
|             . .|. .|. .|.|| . |.|.|.  
STPFFLCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI
Kinase 95287.m00262.AA TTBKL 10-268 29 6.2e-64 214.75 In-house 1-288 (288) Show / Hide 
Range on Protein: 10-268
Range on HMM: 1-288/288
Sequence Identity: 29% (85 aa)

YIVGNKIGHGAFGEIYSAIDERT-GILWALKTEQNSASK--KTLAFEFQIIAQVQ--SSPHFPRLGVFGQGRDFSFFSMELLGPSLSNIVKRIPNHK-LS
. .  .|| |.||..| ..|  . .   |.| | |. ..  ... .| ..  . |  .|||||..   |.  |..|. |.|.||.|. . |..|| | .|
WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS

LSTSVRSAYHILKCIESLHIFGIVHRDIKPGNILTREGTD-----HPLCLIDFGLSRVYVNPQTGQ----------HLLPRA---RVGFRGTKAYASRHA
 .|..| .. .|...  .|  |..|||.||.|. .   ..     . . |||||..| |.... ..          .  ||    ...||||  |.|  .
DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNM

HFGEDLSRRDDLISWFYLSLELIVGYLPWRGINDKATILALKDNFDVGQTI--SP----FAPELFEIWRHISSLGFTDTPNYALMYNSL
| . ...| ||| ||.|   || .| |||....||  | ..| |    .    .|    . .|. .. .|..|| . |.|.|  .|. .
HDRKEQGRHDDLWSWMYMIIELHCG-LPWTNMEDKMEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF
Kinase 95287.m00262.AA TTBK 10-264 36 3e-56 193.21 In-house 1-257 (257) Show / Hide 
Range on Protein: 10-264
Range on HMM: 1-257/257
Sequence Identity: 36% (95 aa)

YIVGNKIGHGAFGEIYSAIDERTG-ILWALKTEQNSASKKTLAFEFQIIAQVQSSPHFPRLGVFGQGRDFSFFSMELLGPSLSNIVKRIPNHKLSLSTSV
  |  ||| |.|||||.| |  .     |.| |   . |  |  |  .  . |  .|  |    |   .| .  |.|.| .|..     |  . |||| .
WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQPKQVLKMEVAVLKKLQGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLSTTL

RSAYHILKCIESLHIFGIVHRDIKPGN--ILTREGTDHPLCLIDFGLSRVYVNPQTGQHLLPRARVGFRGTKAYASRHAHFGEDLSRRDDLISWFYLSLE
|    ||. ||| |  |  |||||| |  .     |     ..|||| | |.|  .|.   ||.  |||||  |||  ||   .. |.||| | ||.  |
RLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTN-ACGEVRPPREVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVE

LIVGYLPWRGINDKATILALKDNFDVGQTISPFAPELFEIWRHISSLGFTDTPNYALM
 ..| |||| | ||  .  .|. .|    .    .|.     ||.||.. |.|.|.|.
FVQGQLPWRKIKDKDQVGEMKEKYDHRMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI
Kinase 95287.m00262.AA Worm6 10-264 30 1.7e-55 190.67 In-house 1-279 (279) Show / Hide 
Range on Protein: 10-264
Range on HMM: 1-279/279
Sequence Identity: 30% (85 aa)

YIVGNKIGHGAFGEIYSAIDERTGI--LWALKTEQ--NSASKKTLAFEFQIIAQV--QSSPHFPRLGVFGQGRD--FSFFSMELLGPSLSNIVKRIPNHK
. |. ||| |.|| .|.. |. ..     |.| |.   ..... | .|  .   |  . ..||...   |. .   | .  |.|.|..|... |  |. |
WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK

LSLSTSVRSAYHILKCIESLHIFGIVHRDIKPGNI-LTR-----EGTDHPLCLIDFGLSR--VYVNPQTGQHLLPR-ARVGFRGTKAYASRHAHFGEDLS
.|..|. . |   |. || || .| .|||.||||    |      .  | ....|||..|  .| | . ..   || ...|||||  ||....| | ...
FSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCN-KGNELRTPRWTACGFRGTVRYAPLACHKGQEQC

RRDDLISWFYLSLELIVGYLPWRGINDKATILALKDNFDVGQ-----TISPF-AP--ELFEIWRHISSLGFTDTPNYALM
|.||. ||||. .|.||| ||||...|.     .|   .        .   .  |  |. .|   | .. . |.|.|.  
RKDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI
Kinase 95287.m00262.AA CK1-A 10-264 32 3.1e-40 139.86 In-house 1-261 (261) Show / Hide 
Range on Protein: 10-264
Range on HMM: 1-261/261
Sequence Identity: 32% (84 aa)

YIVGNKIGHGAFGEIYSAIDERTGILWALKTEQNSASKKTLAFEFQIIAQVQSSPHFPRLGVFGQGRDFSFFSMELLGPSLSNIVKRIPNHKLSLSTSVR
| .  ||| |.||.|| .|  . |   |.| |.| |    | .| ..  ..|  . .|..  .|...|.  . |.|||||| ..   . . . .. | . 
YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKARHPQLIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFN-FCKRRFTMKTVLM

SAYHILKCIESLHIFGIVHRDIKPGNILTREGTD-HPLCLIDFGLSRVYVNPQTGQHLLPRARVGFRGTKAYASRHAHFGEDLSRRDDLISWFYLSLELI
 |  ..  || .|  . .|||||| | |   |     | ||||||.. |  ..| ||.  |      ||  ||| .|| | . |||||. |  |  .   
LADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVMMYFN

VGYLPWRGINDKAT------ILALKDNFDVGQTISPFAPELFEIWRHISSLGFTDTPNYALM
 | ||| |.  ..       |.  |    . |    |  |.  .  .. .|.| ..|.|  .
RGKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL
Kinase 95287.m00262.AA CK1-Unclassified 10-217 37 5.9e-40 115.62 In-house 1-219 (244) Show / Hide 
Range on Protein: 10-217
Range on HMM: 1-219/244
Sequence Identity: 37% (82 aa)

YIVGNKIGHGAFGEIYSAIDERTGILWALKTEQNSASKKTLAFEFQIIAQVQSSP-------HFPRLGVFGQG--RDFSFFSMELLGPSLSNIVKRIPNH
| |. ||| |.||||| .|.  |. . |.| | . .  ..| .| .|  ..|          ..|..  .||   .|. .  |.||||||  . .   | 
YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSKHPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDLFNMC-NR

KLSLSTSVRSAYHILKCIESLHIFGIVHRDIKPGNIL--TREGTDHPLCLIDFGLSRVYVNP-QTGQHLLPRARVGFRGTKAYASRHAHFGEDLSRRDDL
|.|| |    |  ... || ||  ...|||||| |.|   ...  | . .||||||  |. .  ||.|   |   .. ||  |||  || |   ||||||
KFSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINAHLGIEQSRRDDL

ISWFYLSLELIVGYLPWRGI
 |  |. . .. |.||| .|
ESLGYVLIYFLKGSLPWQNI
Kinase 95287.m00262.AA CK1-D 10-264 31 3.4e-33 114.39 In-house 1-261 (261) Show / Hide 
Range on Protein: 10-264
Range on HMM: 1-261/261
Sequence Identity: 31% (83 aa)

YIVGNKIGHGAFGEIYSAIDERTGILWALKTEQNSASKKTLAFEFQIIAQVQSSPHFPRLGVFGQGRDFSFFSMELLGPSLSNIVKRIPNHKLSLSTSVR
| .| ||| |.||.||   .  |.   |.| |   .    | .| ..   .|     |..  .||  |.    |.||||||  .     . | || | . 
YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTKHPQLHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFNYC-HRKFSLKTVLM

SAYHILKCIESLHIFGIVHRDIKPGNILTREGTD-HPLCLIDFGLSRVYVNPQTGQHLLPRARVGFRGTKAYASRHAHFGEDLSRRDDLISWFYLSLELI
 |  ... || .|    .|||||| | |   |   .   .|||||.. |  ..| ||.  |      ||  |||   | | . |||||| |  |. .   
LADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVLMYFN

VGYLPWRGINDKA------TILALKDNFDVGQTISPFAPELFEIWRHISSLGFTDTPNYALM
 | ||| |.   .       |   | .  . .  . .  |  .   .  .| | | |.|. .
RGSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL
Kinase 95287.m00262.AA CK1 10-217 36 6.8e-33 110.65 In-house 1-219 (271) Show / Hide 
Range on Protein: 10-217
Range on HMM: 1-219/271
Sequence Identity: 36% (81 aa)

YIVGNKIGHGAFGEIYSAIDERT----GILWALKTEQNSASKKTLAFEFQIIAQVQS------SPHFPRLGVFGQG--RDFSFFSMELLGPSLS---NIV
| || ||| |.||.|| .|.  |    . . | | | | .    | .| .|  . |       ....|..  .||   .|. .  |.||||||    |. 
YRVGRKIGQGSFGDIYLGINM-TNGEEN-HVAIKLEKNKSKHPQLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDLFNFC

KRIPNHKLSLSTSVRSAYHILKCIESLHIFGIVHRDIKPGNIL-TR-EGTDHPLCLIDFGLSRVYVNPQTGQHLLPRARVGFRGTKAYASRHAHFGEDLS
.|    |.|| | .  |  ... || .|  ...|||||| |.|  | .   | . .|||||.  |. . |.||   |   .. ||  |||  .| |   |
NR----KFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQS

RRDDLISWFYLSLELIVGYLPWRGI
||||. |  |  . .. | ||| |.
RRDDMESLGYVLMYFLRGSLPWQGL
Kinase 95287.m00262.AA CK1-Unique 10-215 26 1.1e-29 100.04 In-house 1-233 (337) Show / Hide 
Range on Protein: 10-215
Range on HMM: 1-233/337
Sequence Identity: 26% (62 aa)

YIVGNKIGHGAFGEIYSAIDERTG------ILWALKTEQNSASKK---------TLAFEFQIIAQVQSSPHFPRLGVFGQGRDFSFFSMELLGPSLSNIV
..|  .|| | .|  .  |.. .|         . |||| ...|           ..|     .| . . ||. .  |.| || .. .| ..|||.  . 
WCVIKHIGYGGYGCVHRVIFVNNGTFRIDDDMYCMKTEQHFMQKHDQRLHIERNVMKFICKCEYQCKYWRHFCEVHDFHQHRDWWWIVMTMHGPSMEECC

KRIPNHKLSLS------TSVRSAYHILKCIESLHIFGIVHRDIKPGNILTREGT---DHPLCLIDFGLS-RVYVNPQTGQHLLPRARVGFRGTKAYASRH
    | .  |.      . .. .| .|  ||  |  |  ||..||.|. .       .| .  .|.| . ||      .|   || .. |||.| |... 
MMMKNFQFTLNEKKNQLCAIQCGYQCLNVIECMHWHGFHHRHMKPNNYCYMAPSQQHQHCYYMLDYGICRRVFFVSNNHQIRQPRPITPFRGCKDYCPCS

AHFGEDLSRRDDLISWFYLSLELIVGY--LPWR
 |  ....||||. ||||. . |. .   | |.
CHQCREHGRRDDMESWFYMLYHLVHNTRGLSWK
Kinase 95287.m00262.AA CK1-G 10-216 31 7.6e-25 81.08 In-house 1-210 (266) Show / Hide 
Range on Protein: 10-216
Range on HMM: 1-210/266
Sequence Identity: 31% (67 aa)

YIVGNKIGHGAFGEIYSAIDERTGILWALKTEQNSASKKTLAFEFQIIAQVQSSP-HFPRLGVFGQGRDFSFFSMELLGPSLSNIVKRIPNHKLSLSTSV
| || ||| | |||..      ..   | | |        |  |..   .  . |   |.   |||   .    |.||||||      . . | |. | .
YRVGKKIGCGNFGELFEGKNMYNNEHVAIKFEPMKSRAPQLHDEYRFYKILNGCPEGIPQVYYFGQCGKYNIMVMDLLGPSLEDLFD-WCDRKFSVKTVC

RSAYHILKCIESLHIFGIVHRDIKPGNIL-TREGT--DHPLCLIDFGLSRVYVNPQTGQHLLPRARVGFRGTKAYASRHAHFGEDLSRRDDLISWFYLSL
  |  ... .| .|    . ||.|| | |  |...  .| . .||||. . |. |.|.||   | .    ||  | |   |.|   |||||. .   . .
MVAIQMIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQHVIHIIDFGMAKQYIDPETKQHIPYREHKSLTGTARYMSINTHLGREQSRRDDMEALGHMFM

ELIVGYLPWRG
    | ||| |
YFLRGSLPWQG
Kinase 95287.m00262.AA Pkinase 10-182 26 4.3e-19 68.6 Pfam 1-179 (293) Show / Hide 
Range on Protein: 10-182
Range on HMM: 1-179/293
Sequence Identity: 26% (50 aa)

YIVGNKIGHGAFGEIYSAIDERTGILWALKTEQNSASKKTL---AF---EFQIIAQVQSSPHFPRL-GVFGQGRDFSFFSMELLGP-----SLSNIVK--
| .| ||| |.||. | ...  ||...|.|.   .  |.     ..   | || . . ..|.  || ..|   .|   . ||...      .|. ...  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYISTW

-RIPNHKLSLSTSVRSAYHILKCIESLHIFGIVHRDIKPGNILTREGTDHP---LCLIDFGLSRVYVNPQTGQHLLPRARVGFRGTKAYAS
 . .   .|  .  . .| ||. .| .|  ||.|||.|| |||    ..|.   ....||||....       .   .   .| ||  |..
RHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFD------Y-NNS-MTTFCGTPWYMA
Kinase 95287.m00262.AA S_TKc 10-283 20 7.1e-15 41.21 SMART 1-231 (231) Show / Hide 
Range on Protein: 10-283
Range on HMM: 1-231/231
Sequence Identity: 20% (61 aa)

YIVGNKIGHGAFGEIYSAIDERTGILWALKTEQNSASKKTLAFEFQIIAQVQSSPHFPRLGVFGQGRDFSFFSMELLGP---SLSNIVKRIPNHK----L
| ...|||.||||. | ... .|| . |.|        ...  | ||  .    |.  .|  . |  |. .. ||...    .|  . |. . |.    .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

SLSTSVRSAYHILKCIESLHIFGIVHRDIKPGNILTREGTDHPLCLIDFGLSRVYVNPQTGQHLLPRARVGFRGTKAYAS--RHAHFGEDLSRRDDLISW
.  .  . .| |.. .| .|  ||.|||.|| |||  |     . ..||||.|..                | ||  | .                    
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL--------------TTFCGTPWYMAPEVL----------------

FYLS------------LELIVGYLPWRGINDKATILALKDNFDVGQTISPFAPELFEIWRHISSLGFTDTPNYALMYNSLKRILTRIGA-----KLDDPF
 |               |...|| |..  ......  ..                        |  . |  .  | ..  ||.   . .     |..  |
GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG------------------------SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase 95287.m00262.AA TyrKc 10-230 17 9.5e-05 -145.83 SMART 1-280 (280) Show / Hide 
Range on Protein: 10-230
Range on HMM: 1-280/280
Sequence Identity: 17% (50 aa)

YIVGNKIGHGAFGEIYSAIDERTGILWALKTEQNSASKKTLAFEFQIIAQV-QSSPH-FPRLGVFGQGR------DFSFFSMELLGP-SLSNIVKRIPNH
   | |.|.|||||.| ..     |  | |. ...| .. .  | .|  ..  . |.    .||  |.       .  .  ||.    .| .  ..  ..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

KLSLSTSVRSAYHILKCIESLHIFGIVHRDIKPGNILTREGTDHPLCLIDFGLSRVYVNP-QTGQHLLPRARVGFR----GTK-----------AYASRH
 |.... .  .. | .  | ||  ...|||.   |.|  |.        ||||||   .  |.|     .  .       |.|           .   . 
-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFGLSRDIYDDDQQG----ESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

-----------------AHFGEDLSRRDDL--ISWFYLSLELIVGYLPWRGIN---------------------DK-----ATILALKDNF
                   .|.     . .  .|.. .   .  || . .  |                     .       |  .... |
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 95287.m00262.AA APH 124-156 20 0.000407 14.92 Pfam 170-204 (248) Show / Hide 
Range on Protein: 124-156
Range on HMM: 170-204/248
Sequence Identity: 20% (7 aa)

FGIVHRDIKPGNILTR--EGTDHPLCLIDFGLSRV
....|.| .|||.. .  .. ..   .||.. ...
PCWCHGDFHPGNVMWDPRPDGGRVTGVIDWDDACW
Kinase 95287.m00262.AA CK1 248-262 26 0.022207 4.24 In-house 257-271 (271) Show / Hide 
Range on Protein: 248-262
Range on HMM: 257-271/271
Sequence Identity: 26% (4 aa)

RHISSLGFTDTPNYA
... .|.| ..|.|.
NYCRQLHFEEKPDYM