Gene 92247.m00071 (T.vaginalis)

92247.m00071

Species: T.vaginalis
Alias: TvagK0489, 92247.m00071
External Links:
Annotation:

Classification

Group: CK1
Family: TTBK

Sequence

Name Sequence Type Origin Length Description Download
92247.m00071.AA Protein None 300 None Fasta, JSON
92247.m00071.kin_dom Protein Kinase Domain None 190 None Fasta, JSON

Protein domain

Protein domains of 92247.m00071.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 92247.m00071.AA CK1 10-264 25 4.6e-79 268.98 In-house 1-339 (339) Show / Hide 
Range on Protein: 10-264
Range on HMM: 1-339/339
Sequence Identity: 25% (87 aa)

YKIQKQFGHGSFG-QVYIV-----KSEKDG-----KLYAGKAEVRNNK--HSSLLFEIKLYPTLQQSQ--------------------YIPRFIEGG-ST
.|. |. | |.|| |.| |     |..|..     . || |.| ....  |..|. |...|  ||. .                    ...... .|   
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED

NFSNYLIIEFIGPSILSMLS--TLKRNSFSLSSGLRISYHMLKAVKEIHDLKVIHRDLKPSNVLITK--------------DRAIPIKIIDFGLSR-IYI
.. ||....  ||.. . .   .. .. ||....|.| . ||.|....||   ||||.||.|...                ...  . .||||..|  |.
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR

NH-----------KTGAMIPERD---SPGFRG-TALYCSVNAHLHKDLSRCDDLFSWYFVSADLINGG--LPWKGIENRDE-----IIKYKRDHDMGQLF
.            ||. ..| |.     |||| || |||.|.||.|...| ||| || .. .... |.  |||....  ..     ..| |... . ...
DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKM

RSTI------------PEYAEIWNQIKNLKYDDQPDYQTM
  ..            .|. .|.. |..|||.| |||.  
STPFFLCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI
Kinase 92247.m00071.AA TTBKL 10-268 29 1.2e-73 247.99 In-house 1-288 (288) Show / Hide 
Range on Protein: 10-268
Range on HMM: 1-288/288
Sequence Identity: 29% (84 aa)

YKIQKQFGHGSFGQVYIVKSEKD-GKLYAGKAEVRNNKH--SSLLFEIKLYPTLQ--QSQYIPRFIEGGSTNFSNYLIIEFIGPSILSMLSTLKRNS-FS
..|.|. | | ||||| |.. || .. .| |.|.. . .  | . .|...   ||   | ..|.....| .   |... .  ||..    ......  ||
WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS

LSSGLRISYHMLKAVKEIHDLKVIHRDLKPSNVLI--T---KDRAIPIKIIDFGLSRIYINHKTG----------AMIPERD---SPGFRGTALYCSVNA
 .. .||..  |.|.|..||   ||||.||.|. .  .   ..|.  . .||||..| |...  .           | ..|.   ...||||  |||.|.
DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNM

HLHKDLSRCDDLFSWYFVSADLINGGLPWKGIENRDEIIKYKRDHDMGQLF------RSTIPEYAEIWNQIKNLKYDDQPDYQTMFTLI
|..|...|.|||.||... . |  | |||...|...||.. |... . .||      ..  .| ...   ...|.| |.|||. .. ..
HDRKEQGRHDDLWSWMYMIIELHCG-LPWTNMEDKMEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF
Kinase 92247.m00071.AA Worm6 10-264 27 5.2e-50 172.45 In-house 1-279 (279) Show / Hide 
Range on Protein: 10-264
Range on HMM: 1-279/279
Sequence Identity: 27% (76 aa)

YKIQKQFGHGSFGQVYIVKSEKDGK--LYAGKAEV--RNNKHSSLLFEIKLYPTLQQSQ--YIPRFIEGGSTNF--SNYLIIEFIGPSILSMLSTLKRNS
.|. |  | |.|| || |. ..|.|   .| |.|   .|.|.. | .|.    .. ...  . ..... | ..    ||......|..   .  ..  . 
WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK

FSLSSGLRISYHMLKAVKEIHDLKVIHRDLKPSNVLITK------DRAIPIKIIDFGLSR-IYINHKTGAMIPER-DSPGFRGTALYCSVNAHLHKDLSR
||.. ||.|.  .|.|. . |    ||||.||.|  |        .    | ..|||..| .. . | . ... | .  |||||  |.....| .....|
FSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQEQCR

CDDLFSWYFVSADLINGGLPWKGIENRDEII---KYKRDHD---MGQLFRSTIP--EYAEIWNQIKNLKYDDQPDYQTM
 ||. ||  . ...| |.|||.... .|.     |..|..    |  .|  ..|  |. .|   | ...| | |||.. 
KDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI
Kinase 92247.m00071.AA TTBK 10-264 32 4.1e-45 156.2 In-house 1-257 (257) Show / Hide 
Range on Protein: 10-264
Range on HMM: 1-257/257
Sequence Identity: 32% (84 aa)

YKIQKQFGHGSFGQVYIVKSEKDG-KLYAGKAEVRNNKHSSLLFEIKLYPTLQQSQYIPRFIEGGSTNFSNYLIIEFIGPSILSMLSTLKRNSFSLSSGL
 |. |  | | || .|  |         | | |  . .   |  |.     ||  ... |||  |  .  ||.. .  | .   .     |  ||||. |
WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQPKQVLKMEVAVLKKLQGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLSTTL

RISYHMLKAVKEIHDLKVIHRDLKPSNVLITKDRAIPIKI--IDFGLSRIYINHKTGAMIPERDSPGFRGTALYCSVNAHLHKDLSRCDDLFSWYFVSAD
|.   .|.....||..   ||| ||||  . .  .   |.  .|||| | |.| . |   | | . |||||. | |.|||. ... | ||| | ...   
RLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTNAC-GEVRPPREVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVE

LINGGLPWKGIENRDEIIKYKRDHDMGQLFRSTIPEYAEIWNQIKNLKYDDQPDYQTM
 ..| |||  |  .|.. . |   |.  |     .|     . || |.| |.|||| .
FVQGQLPWRKIKDKDQVGEMKEKYDHRMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI
Kinase 92247.m00071.AA CK1-A 10-264 31 2e-40 140.48 In-house 1-261 (261) Show / Hide 
Range on Protein: 10-264
Range on HMM: 1-261/261
Sequence Identity: 31% (83 aa)

YKIQKQFGHGSFGQVYIVKSEKDGKLYAGKAEVRNNKHSSLLFEIKLYPTLQQSQYIPRFIEGGSTNFSNYLIIEFIGPSILSMLSTLKRNSFSLSSGLR
|.. .. | |||| .|.  . ..|.  | | | .. .|  |..| |.|  ||    ||.    |.    | .... .|||.  .    ||  |..   | 
YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKARHPQLIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFNFCKRR-FTMKTVLM

ISYHMLKAVKEIHDLKVIHRDLKPSNVLITKDRAI-PIKIIDFGLSRIYINHKTGAMIPERDSPGFRGTALYCSVNAHLHKDLSRCDDLFSWYFVSADLI
.   |.  .  .|    ||||.|| | |.  .|    . .|||||.. |  ..|   || |.     ||| | |.||||  . || ||. |  .|     
LADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVMMYFN

NGGLPWKGIENRDEIIKY------KRDHDMGQLFRSTIPEYAEIWNQIKNLKYDDQPDYQTM
 | |||.|..      ||      |    . || .    |.. . | ..||....||||  .
RGKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL
Kinase 92247.m00071.AA CK1-D 10-264 32 2.9e-38 132.54 In-house 1-261 (261) Show / Hide 
Range on Protein: 10-264
Range on HMM: 1-261/261
Sequence Identity: 32% (85 aa)

YKIQKQFGHGSFGQVYIVKSEKDGKLYAGKAEVRNNKHSSLLFEIKLYPTLQQSQYIPRFIEGGSTNFSNYLIIEFIGPSILSMLSTLKRNSFSLSSGLR
|.| .. | ||||..|  .  . .   | | |    ||  | .| |.| ..|    ||.    |.    | .... .|||.  .    .|  |||   | 
YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTKHPQLHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFNYCHRK-FSLKTVLM

ISYHMLKAVKEIHDLKVIHRDLKPSNVLI-TKDRAIPIKIIDFGLSRIYINHKTGAMIPERDSPGFRGTALYCSVNAHLHKDLSRCDDLFSWYFVSADLI
..  |.. .. ||  . ||||.|| | |.    |   . ||||||.. |   .|   || |.     ||| | |.| |.  . || ||| |  .|     
LADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVLMYFN

NGGLPWKGI------ENRDEIIKYKRDHDMGQLFRSTIPEYAEIWNQIKNLKYDDQPDYQTM
 | |||.|.      .  . |.  | .  . .| .    |...  |  .|||.||.|||  .
RGSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL
Kinase 92247.m00071.AA CK1-Unclassified 10-197 35 3.1e-37 107.47 In-house 1-199 (244) Show / Hide 
Range on Protein: 10-197
Range on HMM: 1-199/244
Sequence Identity: 35% (70 aa)

YKIQKQFGHGSFGQVYIVKSEKDGKLYAGKAEVRNNKHSSLLFEIKLYPTLQQSQ-------YIPRFIEGGSTNF--SNYLIIEFIGPSILSMLSTLKRN
|.. .  | ||||..| ..  ......| | | .|.||. |..|.|..  ||          .||. .. |  .    |... .. |||. . .   .| 
YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSKHPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDLFNMCNR-

SFSLSSGLRISYHMLKAVKEIHDLKVIHRDLKPSNVLI--TKDRAIPIKIIDFGLSRIYINH-KTGAMIPERDSPGFRGTALYCSVNAHLHKDLSRCDDL
 |||   | |   |.. .  .|    ||||.|| | |.  .  ..  . |||||||  ||   |||  || |.  .. ||| | |.|||| .  || |||
KFSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINAHLGIEQSRRDDL
Kinase 92247.m00071.AA CK1 10-197 33 7.5e-31 103.54 In-house 1-199 (271) Show / Hide 
Range on Protein: 10-197
Range on HMM: 1-199/271
Sequence Identity: 33% (66 aa)

YKIQKQFGHGSFGQVYIVKSEKDGKL--YAGKAEVRNNKHSSLLFEIKLYPTLQQ------SQYIPRFIEGGST--NFSNYLIIEFIGPSILSMLSTLKR
|.. .  | ||||..| ..  ..|.   .| | | ...||. |..|.|.|  ||       . .||. .  |    .  |...... |||  . .   .|
YRVGRKIGQGSFGDIYLGINMTNGEENHVAIKLEKNKSKHPQLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDLFNFCNR

NSFSLSSGLRISYHMLKAVKEIHDLKVIHRDLKPSNVLITK--DRAIPIKIIDFGLSRIYINHKTGAMIPERDSPGFRGTALYCSVNAHLHKDLSRCDDL
  |||   | |   |.. .  .|    ||||.|| | |.     ..  . ||||||.  |.  ||.  || |.  .. ||| | |.|.|| .  || ||.
-KFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDM
Kinase 92247.m00071.AA CK1-G 10-264 27 7.1e-29 94.94 In-house 1-266 (266) Show / Hide 
Range on Protein: 10-264
Range on HMM: 1-266/266
Sequence Identity: 27% (73 aa)

YKIQKQFGHGSFGQVYIVKSEKDGKLYAGKAEVRNNKHSSLLFEIKLYPTLQQSQ-YIPRFIEGGSTNFSNYLIIEFIGPSILSMLSTLKRNSFSLSSGL
|.. |  | |.|| ..  |    .   | | | .  .   |  | . |  | .    ||.    |     | ....  |||   .     |  ||. . .
YRVGKKIGCGNFGELFEGKNMYNNEHVAIKFEPMKSRAPQLHDEYRFYKILNGCPEGIPQVYYFGQCGKYNIMVMDLLGPSLEDLFDWCDRK-FSVKTVC

RISYHMLKAVKEIHDLKVIHRDLKPSNVLITK---DRAIPIKIIDFGLSRIYINHKTGAMIPERDSPGFRGTALYCSVNAHLHKDLSRCDDLFSWYFVSA
 ..  |.. ....|.   | || || | || .    ..  | |||||. . ||  .|.  || |      ||| | |.| || .  || ||. .   .  
MVAIQMIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQHVIHIIDFGMAKQYIDPETKQHIPYREHKSLTGTARYMSINTHLGREQSRRDDMEALGHMFM

DLINGGLPWKGIENRDEIIKY------KRDHDMGQLFRS-TIP-EYAEIWNQIKNLKYDDQPDYQTM
    | ||| |        .|      ||   .  |  . ..| ..|     . .|.....|||  .
YFLRGSLPWQGLKADNNKERYQKIGDTKRKTNIEDLCQNNAFPEQFATYLRYVRRLDFFECPDYDYL
Kinase 92247.m00071.AA Pkinase 10-229 23 3.7e-26 93.59 Pfam 1-230 (293) Show / Hide 
Range on Protein: 10-229
Range on HMM: 1-230/293
Sequence Identity: 23% (56 aa)

YKIQKQFGHGSFGQVYIVKSEKDGKLYAGKAEVRNNKHSSL----LF--EIKLYPTLQQSQYIPRFIEGGSTNFSNYLIIEFIGP-----SILSMLSTLK
|.| .. | ||||.||. .  ..||..| |   . ...|.     .   ||..   | .. .| |...   .. . |.. |. .      .  ...|| .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

RNSF--SLSSGLRISYHMLKAVKEIHDLKVIHRDLKPSNVLITKDRAI--PIKIIDFGLSRIYINHKTGAMIPERDSPGFRGTALYCSVNAHL-HKDLSR
...|  |     .. | .|.... .|. ..|||||||.|.|| ..  |  ..||.||||.. .         . .   .| ||  |..   .. ... ..
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD------Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGP

CDDLFSWYFVSADLINGGLPWKGI----ENRDEIIKYKRD
  | .|   . . ...| .|..|     . .|.. ...|.
KVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRI
Kinase 92247.m00071.AA CK1-Unique 10-215 19 7.7e-26 86.57 In-house 1-233 (337) Show / Hide 
Range on Protein: 10-215
Range on HMM: 1-233/337
Sequence Identity: 19% (45 aa)

YKIQKQFGHGSFGQVYIVKSEKDG------KLYAGKAEVRNNKHS--------SLLFEIKLYP-TLQQSQYIPRFIEGGSTNFSNYLIIEFIGPSILSML
....| .| |..| |. |  ...|      . |..| |.   .          . . .| ..  ......  .  .  . .    ...  ..|||...  
WCVIKHIGYGGYGCVHRVIFVNNGTFRIDDDMYCMKTEQHFMQKHDQRLHIERNVMKFICKCEYQCKYWRHFCEVHDFHQHRDWWWIVMTMHGPSMEECC

STLKRNSFSLS------SGLRISYHMLKAVKEIHDLKVIHRDLKPSNVLITKDR---AIPIKIIDFGLS-RIYINHKTGAMIPERDSPGFRGTALYCSVN
  .|. .| |.        .. .|  | ..   |   ..||..|| |.            . ..|.| . |. .  . . . . |    |||.  ||.  
MMMKNFQFTLNEKKNQLCAIQCGYQCLNVIECMHWHGFHHRHMKPNNYCYMAPSQQHQHCYYMLDYGICRRVFFVSNNHQIRQPRPITPFRGCKDYCPCS

AHLHKDLSRCDDLFSWYFVSADLING--GLPWK
 |. ....| ||. ||..   .|. .  || ||
CHQCREHGRRDDMESWFYMLYHLVHNTRGLSWK
Kinase 92247.m00071.AA S_TKc 10-284 17 8.8e-15 39.88 SMART 1-231 (231) Show / Hide 
Range on Protein: 10-284
Range on HMM: 1-231/231
Sequence Identity: 17% (51 aa)

YKIQKQFGHGSFGQVYIVKSEKDGKLYAGKAEVRNNKHSSLLFEIKLYPTLQQSQYIPRFIEGGSTNFSNYLIIEFIGP---SILSMLSTLKRNS----F
|.| .. |.|.||.|| ..  |.|...| |         ... ||..     .  .| ....   .  . |.. |...    . ....   .|.     |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

SLSSGLRISYHMLKAVKEIHDLKVIHRDLKPSNVLITKDRAIPIKIIDFGLSRIYINHKTGAMIPERDSPGFRGTALYCSVNAHLHKDLSR-CDDLFSWY
.     .. | ...|.. .|....|||||||.|.|...     |||.||||.|..                | ||  |..         ..   |  |  
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL--------------TTFCGTPWYMAPEVL---GYGKCKCDWWSCG

FVSADLINGGLPWKGIENRDEIIKYKRDHDMGQLFRSTIPEYAEIWNQIKNLKYDDQPDYQTMFTLIEMAMTRFQI------NLD-------DPYD
 . . .. |  |.    . ....|  .                                 . .  .|.  ...          |        .|. 
CILYEMLCGYPPFP---QMQMMFKKIG--------------------------------SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase 92247.m00071.AA TyrKc 10-191 14 1.4e-05 -132.48 SMART 1-280 (280) Show / Hide 
Range on Protein: 10-191
Range on HMM: 1-280/280
Sequence Identity: 14% (44 aa)

YKIQKQFGHGSFGQVYI--------VKSEKDGKLYAGKAEVRNNKHSSLLFEIKLYPTL-QQSQYIPRFIEGGSTNF--------SNYLIIEFIGPSILS
 .  |. |.| ||.||         ||. |...            .  .. |...   |  . . | |.. |  |            ... |.      .
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA------------REDFMREARIMCKLGGHHPNIVRLY-GVCTQQGRNFMYIEPLMIVMEYMPH--GD

MLSTLKRNS--FSLSSGLRISYHMLKAVKEIHDLKVIHRDLKPSNVLITKDRAIPIKIIDFGLSR------------IYINHKT--GAM--IP-------
 .. |...   ....  | ...   .    .|. ..|||||   |.|.....   .|| ||||||             |. .|.  |.   .|       
LKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPE

---------------------------ERDSPG---------------FRGTALYCSVN-------------------------------AHLHKDL
                           .   ||                .|  . .  |                               . .|...
CINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 92247.m00071.AA CK1 248-262 33 0.007181 5.95 In-house 257-271 (271) Show / Hide 
Range on Protein: 248-262
Range on HMM: 257-271/271
Sequence Identity: 33% (5 aa)

NQIKNLKYDDQPDYQ
| ...|.....|||.
NYCRQLHFEEKPDYM