Gene 84263.m00136 (T.vaginalis)

84263.m00136

Species: T.vaginalis
Alias: TvagK0679, 84263.m00136
External Links:
Annotation:

Classification

Group: Other
Family: NEK
Subfamily: NEK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
84263.m00136.AA Protein None 160 None Fasta, JSON
84263.m00136.kin_dom Protein Kinase Domain None 150 None Fasta, JSON

Protein domain

Protein domains of 84263.m00136.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 84263.m00136.AA NEK1 5-151 49 2.1e-72 246.87 In-house 1-169 (276) Show / Hide 
Range on Protein: 5-151
Range on HMM: 1-169/276
Sequence Identity: 49% (84 aa)

YKQIKELGEGSYGKAILVQERGTDKKYVIKEIRLYGVTEQERQDALKEVTILKTLQHPYIVSYIESFHERGN--LYIVMEYADGGDLSQKIEAQ--RGKH
|  || .||||.|||.||...   . ||||||..    |.||.....|| ||. . || ||.| ||| |.|.  |||||||.||||| |||..|  .|| 
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGKL

FSENEILHDFIQLSLAIKHIHDRKILHRDLNVKTFFLK--SGD----------------VKLGDFGISR
||| .|.| |.|..|| .|||||||||||.  .  ||   ...                ||||||||.|
FSEDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIAR
Kinase 84263.m00136.AA NEK 5-151 44 7.1e-70 238.46 In-house 1-171 (286) Show / Hide 
Range on Protein: 5-151
Range on HMM: 1-171/286
Sequence Identity: 44% (76 aa)

YKQIKELGEGSYGKAILVQERGTDKK-----YVIKEIRLYGVTEQERQDAL-KEVTILKTLQHPYIVSYIESFHERG--NLYIVMEYAD-GGDLSQK---
|. ||..|.||.||. .|. . . |.     ||.|.| . . .|.|.|.|. .|| ||| |.||.||.|..|| |..   |.|||||.. ||||.||   
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

IEAQR--GKHFSENEILHDFIQLSLAIKHIHDR-----KILHRDLNVKTFFLKS-GD----VKLGDFGISR
|. |.  ||.|.|..|.. |||..||.|..|||     ||||||.  .  || . .     ||.||||||.
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISK
Kinase 84263.m00136.AA NEK8 5-150 37 3.3e-57 161.81 In-house 1-167 (278) Show / Hide 
Range on Protein: 5-150
Range on HMM: 1-167/278
Sequence Identity: 37% (64 aa)

YKQIKELGEGSYGKAILVQERGTD--KKYVIKEIRLYGVTEQERQDALKEVTILKTLQHPYIVSYIESFHERGNLYIVMEYADGGDLSQKIEAQRGKHFS
|  |  .| |. | ..|   .  .  .. ..|.| ... .| |||.|. |. .|. |||| |.||...| | . | |.||||||| | |.|  |..| |.
YERIRVVGRGAFGICWLYRRKEDQSHHLVIWKQINMHRMSEKERQMAQNEIQVLSMLQHPNIISYYDHFMEDNTLMIEMEYADGGTLYQMIQHQQNKLFE

ENE-----------------ILHDFIQLSLAIKHIHDRKILHRDLNVKT---FFLKS-GDVKLGDFGIS
| .                 ||. |.| ..|. |.|.  ||||||  ||   |  .. . ||.||||||
EERQLKQVNHCFNIYFNEQMILWYFFQMCSAVHHMHQHNILHRDL--KTQNIFMTRHRMVVKIGDFGIS
Kinase 84263.m00136.AA NEK4 5-151 40 1.4e-45 157.77 In-house 1-150 (257) Show / Hide 
Range on Protein: 5-151
Range on HMM: 1-150/257
Sequence Identity: 40% (61 aa)

YKQIKELGEGSYGKAILVQERGTDKKYVIKEIRLYGVTEQERQDALKEVTILKTLQHPYIVSYIESFHERGN--LYIVMEYADGGDLSQKIEAQRGKHFS
|  .|  | ||||   ||..|   |.||.| . |     .||..|..|. .|  |.|| ||.| ||.    .  ||||| . .|||| .|   |...  .
YCHMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKLKQQKNQFLE

ENEILHDFIQLSLAIKHIHDRKILHRDLNVKTFFL-KSGDVKLGDFGISR
|. ..  |.|  .|   .|...||||||     || |   .|.|||||||
EYQVVEWFVQIAMALQYMHEKHILHRDLKTQNIFLTKKNIIKIGDFGISR
Kinase 84263.m00136.AA Pkinase 5-151 29 1.3e-41 148.23 Pfam 1-160 (293) Show / Hide 
Range on Protein: 5-151
Range on HMM: 1-160/293
Sequence Identity: 29% (47 aa)

YKQIKELGEGSYGKAILVQERGTDKKYVIKEIRLYGVTEQERQDALK--EVTILKTLQHPYIVSYIESFHERGNLYIVMEYADGG----DLSQKIEAQRG
|. .. .|.||.|.  . ...|| |....|.|.. .  ....| ...  |. |.| |.||.|| ....|......|.||||..||    ||.  |...|.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

KHF--SENEILHDFIQLSLAIKHIHDRKILHRDLNVKTFFLK-SGDV----KLGDFGISR
. |  ||.|. . . |.  .....|...|.||||    ....  |..    |..|||...
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAK
Kinase 84263.m00136.AA CAMK 10-151 20 6.8e-36 112.62 In-house 1-244 (425) Show / Hide 
Range on Protein: 10-151
Range on HMM: 1-244/425
Sequence Identity: 20% (49 aa)

ELGEGSYGKAILVQERGTD------------KKYVIKEIRLYGVT--------------------------EQERQDALKEVTILKTLQ-------HPYI
.||.||.||  |.... |             .|. || |    ..                          .. |.  ..|. |.|.||       || |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VSYIESFHERGN-------------------LYIVM---EYADGG----DLSQKIEAQRG-------------KHFSENEILHDFIQLSLAIKHIHDRKI
.. .| .  . .                   .|.||   ||..||    || ..| ....             ..|.| |  . | |.  |....|...|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

LHRDLNVKTFFLKS------------------GDVKLGDFGISR
 ||||      | .                  ...|. ||| ..
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFAN
Kinase 84263.m00136.AA Ciliate-E2 5-153 23 5e-35 117.66 In-house 1-206 (365) Show / Hide 
Range on Protein: 5-153
Range on HMM: 1-206/365
Sequence Identity: 23% (50 aa)

YKQIKELGEGSYG-----KAILVQER------------------GTDKKYVIKEIRLYGVTEQER-QDALKEVT----------ILKTLQHPYIVSYIES
|| || .|.|..|     | ..||..                   . |.| .| .. ... .... .. ..|.           ||..|.||.|. ..|.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FH--ERGNLYIVMEYADGGDLSQKIEAQRGKH---------FSENEILHDFIQLSL---------------AIKHIHDRK-ILHRDLNVKTFFLKSGDVK
|    . |.|.||||..|||| . |. .. |.         |.|.||.. . |.                 |....| .. |.|||.     ..    .|
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----IK

LGDFGISRSI
. |||.|. .
IIDFGLSKKY
Kinase 84263.m00136.AA ULK 5-153 25 3.2e-32 109.82 In-house 1-192 (329) Show / Hide 
Range on Protein: 5-153
Range on HMM: 1-192/329
Sequence Identity: 25% (50 aa)

YKQIKELGEGSYG---KAILVQERGT--DKKYVIKEIRLYGVTEQERQD-------ALK-EVTILKTL--------QHPYIVSYIESFHER--GNLYIVM
|  ...||.||.|   |.. ..   .  ..|...| | .    ... ..        || |. |.|.|        .||.|| ... | .    |.||.|
YCLNHCLGKGSFGKVYKGRNKKTK-DYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIM

EYADGGDLSQKIEAQRG--------KHFSENEILHDFIQLSLAIKHIHDRKILHRDLNVKTFFLKSGD-------------VKLGDFGISRSI
|| .||||.| |. ...        |..||.|... |.|.  . |..|...| |||.      .. |.             .|..||| ....
EYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHV
Kinase 84263.m00136.AA Ciliate-E2-Unclassified 5-153 24 4.2e-31 105.15 In-house 1-197 (352) Show / Hide 
Range on Protein: 5-153
Range on HMM: 1-197/352
Sequence Identity: 24% (48 aa)

YKQIKELGEGSYGKAILVQERGTDKKYVIKEIRLYGVTEQERQ----------DALKEVT-------------ILKTLQHPYIVSYIESFHERGNLYIVM
|| || .|.|..||  ..|.. ....|..|..  . .  |  .          .....               ||. ..||.|| ... |  . |.||||
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

EYADGGDLSQKIEAQRG---------------KHFSENEIL-----HDFIQLSLAIKHIHDRK-ILHRDLNVKTFFLKSG----DVKLGDFGISRSI
||..||||.| |. . .               |.|.|....     . | |. ......|  . |.|||.     .....     .|. |||||. .
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKY
Kinase 84263.m00136.AA ULK 5-153 26 4.5e-31 107.54 In-house 1-188 (324) Show / Hide 
Range on Protein: 5-153
Range on HMM: 1-188/324
Sequence Identity: 26% (49 aa)

YKQIKELGEGSYG----KAILVQERGTDKKYVIKEIRLYGVTEQERQ-------DALK-EVTILKTLQ---HPY--IVSYIESFHER--GNLYIVMEYAD
|  ...||.||.|    |.. ..  ...... .| | . .  ... .       . || |. |.|.|    ||.  || ... | .    |.||.||| .
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

GGDLSQKIEAQRG-------KHFSENEILHDFIQLSLAIKHIHDRKILHRDLNVKTFFLKSGD-------------VKLGDFGISRSI
||||.| |. ...       | .||.|... |.|.  . |..|...| |||.      .. |.             .|..||| ....
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHV
Kinase 84263.m00136.AA NEK11 5-151 43 1.1e-28 101.6 In-house 1-152 (259) Show / Hide 
Range on Protein: 5-151
Range on HMM: 1-152/259
Sequence Identity: 43% (66 aa)

YKQIKELGEGSYGKAILVQE----RGTDKKYVIKEIRLYGVTEQERQDALKEVTILKTLQHPYIVSYIESFHERGNLYIVMEYADGGDLSQKIEA--QRG
|   . || ||.|   || .    || . | |.|||    .   |   |  |  .|  |.|| || .  || |  |  |. || .| || ..|    | |
YVLQQKLGSGSFGTVYLVSDKKAKRGEELK-VLKEISVGELNPNETVQANVEAQLLSRLHHPAIVRFHASFMEQDNFCIITEYCEGRDLDYRIQEYKQAG

KHFSENEILHDFIQLSLAIKHIHDRKILHRDLNVKTFFLKSGDVKLGDFGISR
| |.|| |.  |||| | .  .|.|.||||||  |  |||   .|.||||.||
KIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNIFLKNNLLKIGDFGVSR
Kinase 84263.m00136.AA Pkinase_Tyr 5-130 25 1.4e-13 46.62 Pfam 1-137 (270) Show / Hide 
Range on Protein: 5-130
Range on HMM: 1-137/270
Sequence Identity: 25% (35 aa)

YKQIKELGEGSYG---KAILV-QERGTDKKYVIKEIRLYGVTEQE--RQDALKEVTILKTL-QHPYIVSYIESFH-ERGN--LYIVMEYADGGDLSQKIE
 . .|.||||..|   |...  .. .|. .  .| .   | ....  |.| ..|. |.|.| .|| ||...     ...   .||||||. .|||     
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

AQ--RGKHFSENEILHDFIQLSLAIKHIHDRKILHRDL
..   .....  ..|.  .| . .  . ..... ||||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL
Kinase 84263.m00136.AA S_TKc 5-160 19 1.5e-13 21.6 SMART 1-231 (231) Show / Hide 
Range on Protein: 5-160
Range on HMM: 1-231/231
Sequence Identity: 19% (47 aa)

YKQIKELGEGSYGKAILVQERGTDKKYVIKEIRLYGVTEQERQDALKEVTILKTLQHPYIVSYIESFHERGNLYIVMEYADG--GDLSQKIEAQRGKH--
|. ....|.|..||  ......|.... ||.|.         .....|. |||  .||.|| ....|.. ..||.||||.||  ||| . |. ....   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--FSENEILHDFIQLSLAIKHIHDRKILHRDLNVKTFFLKSGDVKLGDFGISRS---------------IRLYSF-------------------------
  |.| .. . . |. .|....|...|.||||     .| .  .|..|||..|                .  |..                         
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQLTTFCGTPWYMAPEVL-GYGKCKCDWWSCGCILYEMLCGYPPFPQM

---------------------------------N----------V
                                 .          .
QMMFKKIGSPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase 84263.m00136.AA TyrKc 5-160 15 1e-06 -115.32 SMART 1-280 (280) Show / Hide 
Range on Protein: 5-160
Range on HMM: 1-280/280
Sequence Identity: 15% (45 aa)

YKQIKELGEGSYG---KAILVQERGTDKKYVIKEIRLYGVTEQERQDALKEVTILKTL--QHPYIVSYIESFHER-------GNLYIVMEYADGGDLSQK
 . .|.|||| .|   |...        .  .| .. .      |.| ..|  |.. |  .|| ||  .    .        . |.|||||...||| . 
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

IEAQRGKHFSENEILHDFIQLSLAIKHIHDRKILHRDLNVKTFFLKSGD-VKLGDFGISRSI----------RLYSF-----------------------
. . |.| ..  . |.  .| .    ..|.... ||||      ....  || .||| || |            |.                        
LRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

-----------------------------------------------------N-------------------------------------V
                                                     |                                      
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 84263.m00136.AA Pkinase_Tyr 142-153 58 7.150286 0.19 Pfam 150-161 (270) Show / Hide 
Range on Protein: 142-153
Range on HMM: 150-161/270
Sequence Identity: 58% (7 aa)

VKLGDFGISRSI
|| .||| .| |
VKICDFGLARDI